synaptophysin (SYP) - coding DNA reference sequence

(used for variant description)

(last modified May 11, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_003179.2 in the SYP gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012532.1, covering SYP transcript NM_003179.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5016
                                             gccccctgcattgctg       c.-1

          .         .         .       | 02 .         .         .    g.6193
 ATGCTGCTGCTGGCGGACATGGACGTGGTGAATCAG | CTGGTGGCTGGGGGTCAGTTCCGG    c.60
 M  L  L  L  A  D  M  D  V  V  N  Q   | L  V  A  G  G  Q  F  R      p.20

          .         .         .         .   | 03     .         .    g.7381
 GTGGTCAAGGAGCCCCTCGGCTTTGTGAAGGTGCTGCAATGG | GTCTTCGCCATCTTCGCC    c.120
 V  V  K  E  P  L  G  F  V  K  V  L  Q  W   | V  F  A  I  F  A      p.40

          .         .         .         .         .         .       g.7441
 TTTGCCACATGCGGCAGCTACAGTGGGGAGCTCCAGCTGAGCGTGGATTGTGCCAACAAG       c.180
 F  A  T  C  G  S  Y  S  G  E  L  Q  L  S  V  D  C  A  N  K         p.60

          .         .         .         .        | 04.         .    g.10856
 ACCGAGAGTGACCTCAGCATCGAGGTCGAGTTCGAGTACCCCTTCAG | GCTGCACCAAGTG    c.240
 T  E  S  D  L  S  I  E  V  E  F  E  Y  P  F  R  |  L  H  Q  V      p.80

          .         .         .         .         .         .       g.10916
 TACTTTGATGCACCCACCTGCCGAGGGGGCACCACCAAGGTCTTCTTAGTTGGGGACTAC       c.300
 Y  F  D  A  P  T  C  R  G  G  T  T  K  V  F  L  V  G  D  Y         p.100

          .         .         .         .         .         .       g.10976
 TCCTCGTCAGCCGAATTCTTTGTCACCGTGGCCGTGTTTGCCTTCCTCTACTCCATGGGG       c.360
 S  S  S  A  E  F  F  V  T  V  A  V  F  A  F  L  Y  S  M  G         p.120

          .         .         .         .         .         .       g.11036
 GCTCTGGCCACCTACATCTTCCTGCAGAACAAGTACCGAGAGAATAACAAAGGGCCCATG       c.420
 A  L  A  T  Y  I  F  L  Q  N  K  Y  R  E  N  N  K  G  P  M         p.140

     | 05    .         .         .         .         .         .    g.11798
 CTG | GACTTTCTGGCCACGGCTGTGTTCGCCTTCATGTGGCTAGTTAGCTCATCGGCATGG    c.480
 L   | D  F  L  A  T  A  V  F  A  F  M  W  L  V  S  S  S  A  W      p.160

          .         .         .         .         .         .       g.11858
 GCCAAGGGGCTGTCAGATGTGAAGATGGCCACAGACCCAGAGAACATTATCAAGGAGATG       c.540
 A  K  G  L  S  D  V  K  M  A  T  D  P  E  N  I  I  K  E  M         p.180

          .         .         .         .         .         .       g.11918
 CCTGTCTGCCGCCAGACAGGGAACACATGCAAGGAGCTGAGAGACCCTGTGACCTCGGGA       c.600
 P  V  C  R  Q  T  G  N  T  C  K  E  L  R  D  P  V  T  S  G         p.200

          .      | 06  .         .         .         .         .    g.13486
 CTCAACACCTCGGTG | GTGTTCGGCTTCCTGAACCTGGTGCTCTGGGTCGGCAACCTGTGG    c.660
 L  N  T  S  V   | V  F  G  F  L  N  L  V  L  W  V  G  N  L  W      p.220

          .         .         .         .         .         .       g.13546
 TTCGTGTTTAAGGAGACAGGCTGGGCCGCCCCGTTCCTGCGCGCGCCTCCCGGCGCCCCC       c.720
 F  V  F  K  E  T  G  W  A  A  P  F  L  R  A  P  P  G  A  P         p.240

          .         .         .         .         .         .       g.13606
 GAGAAACAACCGGCACCCGGGGACGCCTACGGCGATGCAGGCTACGGGCAGGGCCCCGGC       c.780
 E  K  Q  P  A  P  G  D  A  Y  G  D  A  G  Y  G  Q  G  P  G         p.260

          .         .         .         .         .         .       g.13666
 GGGTACGGGCCCCAGGATTCCTACGGGCCTCAGGGCGGCTACCAGCCTGACTATGGTCAA       c.840
 G  Y  G  P  Q  D  S  Y  G  P  Q  G  G  Y  Q  P  D  Y  G  Q         p.280

          .         .         .         .         .         .       g.13726
 CCAGCCGGCAGCGGTGGCAGTGGCTACGGGCCTCAGGGCGACTATGGGCAGCAAGGCTAC       c.900
 P  A  G  S  G  G  S  G  Y  G  P  Q  G  D  Y  G  Q  Q  G  Y         p.300

          .         .         .         .                       g.13768
 GGCCCGCAGGGTGCACCCACCTCCTTCTCCAATCAGATGTAG |                      c.943
 G  P  Q  G  A  P  T  S  F  S  N  Q  M  X                        p.313

      | 07   .         .         .         .         .         .    g.15982
 tctg | gtcagtgaagcccaggaggacctggggggggcaagagctcaggagaaggcctgccc    c.*60

          .         .         .         .         .         .       g.16042
 cccttcccacccctataccctaggtctccacccctcaagccaggagaccctgtctttgct       c.*120

          .         .         .         .         .         .       g.16102
 gtttatatatatatatattatatataaatatctatttatctgtctgagccctgccctcac       c.*180

          .         .         .         .         .         .       g.16162
 tccactcccctcatccactaggtgcccagtcttgagtgggccccctctcttaccccgtcc       c.*240

          .         .         .         .         .         .       g.16222
 ctttccctgcatcccttggcccctctctgtttaccctccctgtcccctgaggttaagggg       c.*300

          .         .         .         .         .         .       g.16282
 atctaaaaggaggacagggagggaacagacctcggctgtgtggggagggtgggcgtgact       c.*360

          .         .         .         .         .         .       g.16342
 tcagactctctcctctctctccctccactcctcccaactctggccttggttcctccagca       c.*420

          .         .         .         .         .         .       g.16402
 atgcctgcctgaacaaaggccgttagggaaatccaactccagggttaaagaaaggcagag       c.*480

          .         .         .         .         .         .       g.16462
 attgggggggcttggggtagagaggacagtttaggacccaaggtggtcttggagaggagg       c.*540

          .         .         .         .         .         .       g.16522
 tgtggagtggaggggtcagcaggggggttgggttccagacagagtggatctggagtctga       c.*600

          .         .         .         .         .         .       g.16582
 aggagaggagtgcgctagagcattctggggtggggcttggaagggcgctgagggcagggt       c.*660

          .         .         .         .         .         .       g.16642
 tctagaaggggcgaggctttaagcgaggcagaatggtgggctccagagtaggtgggtctt       c.*720

          .         .         .         .         .         .       g.16702
 ggattggtaccagagcctatggaaagggtgtggcttggaacatttgggagactgagcttg       c.*780

          .         .         .         .         .         .       g.16762
 attctaaaggggacagatcttgagcaaggcaagaagtgggattcaggaatgggccaagcc       c.*840

          .         .         .         .         .         .       g.16822
 agggttccagacagggtggggcttagaatggggcttccatggtggtttcagaaagggcag       c.*900

          .         .         .         .         .         .       g.16882
 cccctccccatggtgcagtgaagaaaatgttttacaatggctgggtttgggcagtggaga       c.*960

          .         .         .         .         .         .       g.16942
 ggggacttggataggagcttccagatgggttttgttaggggtgggggagaatggctctgg       c.*1020

          .         .         .         .         .         .       g.17002
 ctacgacttgggacggaagtggcctgagaagagtcgagtgatatggcttgtagggtgagg       c.*1080

          .         .         .         .         .         .       g.17062
 cgtgggatccagagagaagcaccccaccacacacacccttccccactcccgtgatgaaac       c.*1140

          .         .         .         .         .         .       g.17122
 agctaggttaataggaggacagaaccaacgggtctgtgggactggcccacccctcttccc       c.*1200

          .         .         .         .         .         .       g.17182
 ccttcccctgcgccctccctccctccacacctccacccgtcctggggtggttggaggcct       c.*1260

          .         .         .         .         .         .       g.17242
 ggtctggagcccctatcctgcaccctctgctatgtctgtgatgtcagtagtgcctgtgat       c.*1320

          .         .         .         .         .         .       g.17302
 cgtgtgttgccattttgtctggctgtggcccctccttctcccctccagacccctaccctt       c.*1380

          .         .         .         .         .         .       g.17362
 tcccaaacccttcggtattgttcaaagaacccccctccccaaggaagaacaaatatgatt       c.*1440

          .         .         .                                     g.17397
 ctcctctcccaaataaactccttaaccacctagtc                                c.*1475

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Synaptophysin protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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