synaptotagmin II (SYT2) - coding DNA reference sequence

(used for variant description)

(last modified August 28, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_177402.4 in the SYT2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_041776.1, covering SYT2 transcript NM_177402.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5003
                                                          aaa       c.-181

 .         .         .         .         .         .                g.5063
 ggcacttcggagccgagttggggcagcggtggagcggggacttcgcgcccccaggggaac       c.-121

 .         .         .         .         .         .                g.5123
 gggcgcccctgcgaaaccgtcgccagccacgcgtccttgccgtccgacgccccctcacat       c.-61

 .         .         .         .         .   | 02     .             g.109651
 tggagaccccggatctctcccgcctccttcgggtcgctctccg | ctgtttcctctgccacc    c.-1

          .         .         .         .         .         .       g.109711
 ATGAGGAACATTTTCAAGAGGAACCAGGAGCCTATTGTGGCTCCTGCCACCACCACCGCC       c.60
 M  R  N  I  F  K  R  N  Q  E  P  I  V  A  P  A  T  T  T  A         p.20

          .         .         .         .         .         .       g.109771
 ACGATGCCCATTGGACCCGTGGACAACTCCACTGAGAGTGGGGGTGCTGGGGAGAGCCAG       c.120
 T  M  P  I  G  P  V  D  N  S  T  E  S  G  G  A  G  E  S  Q         p.40

          .         .         .         .         .         | 03    g.110804
 GAGGACATGTTTGCCAAACTGAAGGAGAAGTTATTCAATGAGATAAACAAGATTCCCT | TA    c.180
 E  D  M  F  A  K  L  K  E  K  L  F  N  E  I  N  K  I  P  L |       p.60

          .         .         .         .         .         .       g.110864
 CCACCCTGGGCACTGATCGCCATTGCTGTGGTTGCTGGGCTCCTGCTTCTCACCTGCTGC       c.240
 P  P  W  A  L  I  A  I  A  V  V  A  G  L  L  L  L  T  C  C         p.80

          .         .         .         .         .         .       g.110924
 TTCTGCATCTGCAAGAAATGCTGCTGCAAGAAGAAGAAGAACAAGAAGGAGAAGGGCAAA       c.300
 F  C  I  C  K  K  C  C  C  K  K  K  K  N  K  K  E  K  G  K         p.100

          .         .         .         .      | 04  .         .    g.112320
 GGCATGAAGAATGCCATGAACATGAAGGACATGAAAGGGGGTCAG | GATGACGACGACGCA    c.360
 G  M  K  N  A  M  N  M  K  D  M  K  G  G  Q   | D  D  D  D  A      p.120

          .         .         .         .         .         .       g.112380
 GAGACAGGCCTGACTGAGGGGGAAGGTGAAGGGGAGGAGGAGAAAGAGCCAGAGAACCTG       c.420
 E  T  G  L  T  E  G  E  G  E  G  E  E  E  K  E  P  E  N  L         p.140

          .         .         .         .      | 05  .         .    g.112893
 GGCAAACTGCAGTTTTCCCTGGACTATGATTTTCAGGCTAATCAG | CTTACTGTGGGCGTT    c.480
 G  K  L  Q  F  S  L  D  Y  D  F  Q  A  N  Q   | L  T  V  G  V      p.160

          .         .         .         .         .         .       g.112953
 CTGCAGGCTGCTGAACTGCCTGCCCTGGACATGGGAGGCACCTCAGACCCTTATGTCAAG       c.540
 L  Q  A  A  E  L  P  A  L  D  M  G  G  T  S  D  P  Y  V  K         p.180

          .         .         .         .         .         .       g.113013
 GTCTTCCTCCTTCCTGACAAGAAGAAGAAATATGAGACCAAAGTCCATCGGAAGACACTG       c.600
 V  F  L  L  P  D  K  K  K  K  Y  E  T  K  V  H  R  K  T  L         p.200

          .         .         .    | 06    .         .         .    g.113393
 AACCCTGCCTTCAATGAAACCTTCACCTTCAAG | GTGCCATACCAGGAGCTTGGGGGCAAA    c.660
 N  P  A  F  N  E  T  F  T  F  K   | V  P  Y  Q  E  L  G  G  K      p.220

          .         .         .         .         .         .       g.113453
 ACTCTGGTGATGGCCATCTATGACTTTGACCGCTTCTCCAAACATGACATCATTGGAGAG       c.720
 T  L  V  M  A  I  Y  D  F  D  R  F  S  K  H  D  I  I  G  E         p.240

          .         .         .         .         .         .       g.113513
 GTAAAGGTGCCTATGAACACAGTGGACCTCGGCCAGCCCATTGAGGAGTGGAGAGACCTG       c.780
 V  K  V  P  M  N  T  V  D  L  G  Q  P  I  E  E  W  R  D  L         p.260

          .         .  | 07      .         .         .         .    g.114988
 CAAGGCGGGGAAAAGGAGGAG | CCGGAGAAGCTGGGCGACATCTGCACCTCCCTGCGCTAT    c.840
 Q  G  G  E  K  E  E   | P  E  K  L  G  D  I  C  T  S  L  R  Y      p.280

          .         .         .         .         .         .       g.115048
 GTGCCCACGGCCGGGAAGCTCACTGTCTGCATCCTGGAGGCTAAGAACCTCAAGAAGATG       c.900
 V  P  T  A  G  K  L  T  V  C  I  L  E  A  K  N  L  K  K  M         p.300

          .          | 08        .         .         .         .    g.116113
 GACGTGGGCGGCCTTTCAG | ACCCGTACGTGAAGATCCACCTGATGCAGAATGGCAAGAGG    c.960
 D  V  G  G  L  S  D |   P  Y  V  K  I  H  L  M  Q  N  G  K  R      p.320

          .         .         .         .         .         .       g.116173
 CTCAAGAAGAAGAAGACAACCGTGAAGAAGAAGACCCTGAACCCATACTTCAACGAGTCC       c.1020
 L  K  K  K  K  T  T  V  K  K  K  T  L  N  P  Y  F  N  E  S         p.340

          .         .         .    | 09    .         .         .    g.118487
 TTCAGCTTTGAGATCCCCTTCGAGCAGATTCAG | AAAGTCCAGGTAGTGGTCACCGTGCTG    c.1080
 F  S  F  E  I  P  F  E  Q  I  Q   | K  V  Q  V  V  V  T  V  L      p.360

          .         .         .         .         .         .       g.118547
 GACTATGACAAGCTGGGCAAGAACGAAGCCATAGGCAAGATCTTCGTGGGCAGCAATGCC       c.1140
 D  Y  D  K  L  G  K  N  E  A  I  G  K  I  F  V  G  S  N  A         p.380

          .         .         .         .         .         .       g.118607
 ACGGGCACAGAGCTGCGGCACTGGTCCGACATGCTGGCCAACCCCCGGAGGCCCATCGCC       c.1200
 T  G  T  E  L  R  H  W  S  D  M  L  A  N  P  R  R  P  I  A         p.400

          .         .         .         .         .         .       g.118667
 CAGTGGCACTCGCTCAAGCCTGAGGAGGAGGTGGATGCACTCCTGGGCAAGAACAAGTAG       c.1260
 Q  W  H  S  L  K  P  E  E  E  V  D  A  L  L  G  K  N  K  X         p.419

          .         .         .         .         .         .       g.118727
 acagcagcggctgggaccccacacctttcacggacactgacaagatccagagctatcaat       c.*60

          .         .         .         .         .         .       g.118787
 acctcagttatgcaaccttagaggttttcttttttctttcatttgttgggtggttgtgtc       c.*120

          .         .         .         .         .         .       g.118847
 cttgtttttccttgtttttctctttttaaagaccaacttccctttgatggctgtgtgagg       c.*180

          .         .         .         .         .         .       g.118907
 agagtcccctaagaggtgaaagagaagcctggctctgttcacggtcccaggagctgtcct       c.*240

          .         .         .         .         .         .       g.118967
 tgctgcatgccctgtcacagttccctcgactctttcaaagcttcacatctgcctcacccc       c.*300

          .         .         .         .         .         .       g.119027
 aagcgaggctctctactggcacaaacttgcagcagttcctgttttttgagccttctggac       c.*360

          .         .         .         .         .         .       g.119087
 caacaaaatggcagcacatcctgcttcctgacagggaaggcatcacagtggccaatgatc       c.*420

          .         .         .         .         .         .       g.119147
 gtgtgtgtgtgtgtgtgtgtgtgtgtgtatgtgtgtgtgtgtgtgtgtgtgtgtgtgtgt       c.*480

          .         .         .         .         .         .       g.119207
 gtgtgtgtctttgagcatttctcttcattcctggaatgtgtgtgtgtgtgtgtctctttg       c.*540

          .         .         .         .         .         .       g.119267
 agcatctctcttcattcctggaatgagccatggacagtaaagttgtgtgggaaaagaagg       c.*600

          .         .         .         .         .         .       g.119327
 ctctttggggaccctgacatgaagaagtccactaagtgggagatcttctctcatctatgg       c.*660

          .         .         .         .         .         .       g.119387
 caaagtctcaggatcctgttcagatatcggggctttcatactcctgttggtggctatttg       c.*720

          .         .         .         .         .         .       g.119447
 ggaggcagcaagatgtgaagactggatgtgttcagaactaggaccaaacgatgccatcaa       c.*780

          .         .         .         .         .         .       g.119507
 atacttcctcctgccagtcatggtttccccagaagtgtagttcctgggacattcatggat       c.*840

          .         .         .         .         .         .       g.119567
 atgagctattcactagttgggtcagactaacagggactctcagtcccaaaatctcactct       c.*900

          .         .         .         .         .         .       g.119627
 tattgacaataaatatcaaactatgaagaaacagaagtcccattaccagaaagaccaaaa       c.*960

          .         .         .         .         .         .       g.119687
 ttaaactcctggatcttcaccccatccagtgggaaacacagatgctttctccctttccag       c.*1020

          .         .         .         .         .         .       g.119747
 aatataagcagccaagttcatttgcatttattccccattgtgcttttgcttctgtttctc       c.*1080

          .         .         .         .         .         .       g.119807
 ttttaagtggagcaacactgtctgaagacacgttatctgtgcagagccagagaactttaa       c.*1140

          .         .         .         .         .         .       g.119867
 aaggaaagtttaaatgttcttagttctcctgaggtccaggtaagaagggggtggtaagaa       c.*1200

          .         .         .         .         .         .       g.119927
 gaggatgggggacagatggctgagatcccttgggaggagatataggggagcactggaatt       c.*1260

          .         .         .         .         .         .       g.119987
 cccccgactcccactccttgctcccttggccctctgccctccatgctggagagctgatag       c.*1320

          .         .         .         .         .         .       g.120047
 gtagctggagtggcccagggagacctatgggaaggacccgtcctaccattagggggcttc       c.*1380

          .         .         .         .         .         .       g.120107
 tctctatgaatgctaagaaacaaagggcatccattccaaatgagtagcagaggtgacctt       c.*1440

          .         .         .         .         .         .       g.120167
 ctagggtttctacccatgctcagttgtatcccattccctgttcaccttttgtccccagca       c.*1500

          .         .         .         .         .         .       g.120227
 ctgatataaaagccatatatatgttagtcaggtttgcactgagtcttcttccaatccttc       c.*1560

          .         .         .         .         .         .       g.120287
 agcctggacaacagagtgaggtccccttgtggccagaggccagccctccttgcctgcctt       c.*1620

          .         .         .         .         .         .       g.120347
 cctttgacctctcttttccatccatgaagccctcaggcccttgccattttttcaccacag       c.*1680

          .         .         .         .         .         .       g.120407
 aaaactcatggcttctccagaagcctgagtatctctctttcccagcacaaatggcagcat       c.*1740

          .         .         .         .         .         .       g.120467
 ctctatcctgccccatctgggccacttcagcttcctgtagacacccaagacagatggaca       c.*1800

          .         .         .         .         .         .       g.120527
 gtgttggagggaatcaggctttgaggatccagtgtgaagaagttgcagagtgtcttttta       c.*1860

          .         .         .         .         .         .       g.120587
 ttttattttaaaaagggggaaggggcttttggttttgctttgttttttggatgaaggagt       c.*1920

          .         .         .         .         .         .       g.120647
 gagggaaatgagggaatacccccaccagaaacagactggaaagcctgcctgtctcttgga       c.*1980

          .         .         .         .         .         .       g.120707
 gatccttctttgtcttgttagtggtacatgggaagttatgtttttactggtgtgtgtgtg       c.*2040

          .         .         .         .         .         .       g.120767
 tgtgtgtgtgtgtgtacttaatgatgggaaggtaagactctgatcaggattatgaactgc       c.*2100

          .         .         .         .         .         .       g.120827
 ggtccttgggaccaaaggtgtggtcatggtagagagttgtaggacaatagggtgttttca       c.*2160

          .         .         .         .         .         .       g.120887
 gaatctgggtggccacagagtgggatttcctggtatggacatcagaagtcactggactct       c.*2220

          .         .         .         .         .         .       g.120947
 tctcccaaccccagagttatgggattttggtgctttctcagggtctctccccagactcac       c.*2280

          .         .         .         .         .         .       g.121007
 tcttctcacccatatcccacagactcactcatggagacccccttgtcaatatcccctcta       c.*2340

          .         .         .         .         .         .       g.121067
 cctttactcctttgccctttcccaattcatcttctaccacctggattcttttccattcat       c.*2400

          .         .         .         .         .         .       g.121127
 gaacttcattcagcccttccaaagcccaagatttgcattcccttgacagggaggaaaggc       c.*2460

          .         .         .         .         .         .       g.121187
 aatggtaggaacctctggtggtctgggtgtctatgtgcctggtgaccagggctggatttt       c.*2520

          .         .         .         .         .         .       g.121247
 tattactctgagcccactgctagtgaggagccttgaggggtggggacaggttgctgagtg       c.*2580

          .         .         .         .         .         .       g.121307
 attttgaacgttgacaccagtgtggagccagtgtgggtgtggggagcagtgccttcctca       c.*2640

          .         .         .         .         .         .       g.121367
 ggtcccagctggtcctgatatgccacgtagtggatggcatctgtcttggtccatgggctt       c.*2700

          .         .         .         .         .         .       g.121427
 ggtgggaacatgcttctgcttgtgtgttttccatacctgagggctgacgtagcttaaacc       c.*2760

          .         .         .         .         .         .       g.121487
 acagggcatcatgccaaacactcactgctgggcaggtttatttctggggatgtcagggta       c.*2820

          .         .         .         .         .         .       g.121547
 ctggggtgtaggcactaagcaggatagagttagggtgtctggctagtaaggggttctgga       c.*2880

          .         .         .         .         .         .       g.121607
 cgcctctggggctgtgagttttcatctcaaagtctgttccagagaaaggaaagtagtata       c.*2940

          .         .         .         .         .         .       g.121667
 gaggtgatttttagagaagctgagaccatgaaaacaagcctaatcccatccagaaactgg       c.*3000

          .         .         .         .         .         .       g.121727
 ggtaaagtctgaaagttcgttttcttcttcctccctgaataattgttccagaagggatgc       c.*3060

          .         .         .         .         .         .       g.121787
 taactctgccagagctacaggcagatttttgggctttggaagtggaagctgaggcctggg       c.*3120

          .         .         .         .         .         .       g.121847
 gaaggctgggtaaggaatgctggggcaatctcagacagtaggcaggtgcttggcatgaat       c.*3180

          .         .         .         .         .         .       g.121907
 gagaagtgactttcctggagtccctcagtagaggatgagatagcagggattaggccacag       c.*3240

          .         .         .         .         .         .       g.121967
 tctcagatcctgatcttttttcttcctaggaaagcatacataacttgtgtctgcagaatc       c.*3300

          .         .         .         .         .         .       g.122027
 agtgtgggatgattttgctggcccaaggcttcagcgagagggagaagagaggtcactaca       c.*3360

          .         .         .         .         .         .       g.122087
 gccctcctgtgggtaaaagcagctctcttataaacctgcctccatgcagtggggtggggg       c.*3420

          .         .         .         .         .         .       g.122147
 taagggtgggtgacagcaaagaggttgaggaacctccctgggtttggggagtgagagctt       c.*3480

          .         .         .         .         .         .       g.122207
 ccatgttcccttaatgtcctaggttaattcataaggcatctgagtcctgggtctcaccca       c.*3540

          .         .         .         .         .         .       g.122267
 gcctcacagagagaaaaactgtccctgagggtgtcccctcccactcaaaggtagaaagag       c.*3600

          .         .         .         .         .         .       g.122327
 attgagccaggaactgccctcatatcctctgctctgccccttcccttccctttcctctgc       c.*3660

          .         .         .         .         .         .       g.122387
 ccctcccacctaaagctgtttggggccctttctcagagccctgggtggtggcaggcaggg       c.*3720

          .         .         .         .         .         .       g.122447
 aggagtcccaagatcctggtggccctgagccccatgctatggttgccagatttggcaaat       c.*3780

          .         .         .         .         .         .       g.122507
 aaaaatacaggatgtccagttacatttgaatttcagttcaacaacaaacaattattaagt       c.*3840

          .         .         .         .         .         .       g.122567
 gtaaatatgtcctaggcaaatagttgggacatatactaaaaaataatttgttgtttatct       c.*3900

          .         .         .         .         .         .       g.122627
 gaaattcaaatgtaactggtcatcctgcattgtgtctgggaaccctaccctatgactttt       c.*3960

          .         .         .         .         .         .       g.122687
 ccccctctccctttggtcccaaggggccaggaaccccaaggatttgacttaaccagtttt       c.*4020

          .         .         .         .         .         .       g.122747
 ttgaactgcaatattgagaaggggacactgtgacttgaagacacatgaattactttattt       c.*4080

          .         .         .         .         .         .       g.122807
 tttaagcaacaacaaaataagaaccttctgaagccatttgagcctcatctgcccccatcc       c.*4140

          .         .         .         .         .         .       g.122867
 gtgtatatttaattatatataaaagaagataattacctagaaacatatgaacagaatctt       c.*4200

          .         .         .         .         .         .       g.122927
 gtttaatcaagatgcatgtctataactttctgtaaatagccgcatggcaatgctgagagt       c.*4260

          .         .         .         .         .         .       g.122987
 ccccttgatccccaacctcaaacccattttacagaactggttgaggctgctcctttgatt       c.*4320

          .         .         .         .         .         .       g.123047
 ttatgtcgtgtaaagtctttgttccccagccccacccctgcctcctcccatcgggaaacc       c.*4380

          .         .         .         .         .         .       g.123107
 ccccatgggagtcatcagtgggcgggagtcggtgcctgctccagtccagccctgccttgg       c.*4440

          .         .         .         .         .         .       g.123167
 gagatgctggaggaccctgtcgccctgaaggcctgtttgctgcacatctgcctgcagagc       c.*4500

          .         .         .         .         .         .       g.123227
 caaacctcagggcccggtgcagtgtccagcctggtatctggcatcccagtagcttccatg       c.*4560

          .         .         .         .         .         .       g.123287
 ttctgtgtatgtgtgtggtgtgccccttcctcccactgtttgaattcactgaaaagccat       c.*4620

          .         .         .         .         .         .       g.123347
 aaagggggcctcctgctggagatttggcctcccttggctcctcccaggagcccccatgtc       c.*4680

          .         .         .         .         .         .       g.123407
 tctccaactggctccccacagaccacttctgaagggctcacctgttgtcactccctcctg       c.*4740

          .         .         .         .         .         .       g.123467
 ctccctcagtcccgtgtcatgagaatggacggtgtccagggcttccggtggggtctcagg       c.*4800

          .         .         .         .         .         .       g.123527
 agatgcccatgctggccctgcccgagctggctttctcggcctgggttcacagttcagctc       c.*4860

          .         .         .         .         .         .       g.123587
 catctctacgctgggcgaggagcagacagcagtgggactccatggttctggatacctttc       c.*4920

          .         .         .         .         .         .       g.123647
 ctggggtccctgtggaggcaaccaggattttcaggagcagccagtcagcagctcagccag       c.*4980

          .         .         .         .         .         .       g.123707
 ggatgacagaaccatccctgcttactcacctctgtagtgtgagggtctgtgggtggtgat       c.*5040

          .         .         .         .         .         .       g.123767
 ggaggagggactcagggagaggccggtgaatacaggggctgacgctcttccctcgtgcat       c.*5100

          .         .         .         .         .         .       g.123827
 cctcctgcagtctgacagaaagcagcccaatagcggggcaacctcagggctaccagcgat       c.*5160

          .         .         .         .         .         .       g.123887
 cccctgagagtggggtgggcaggttcagctgtgagagaggctcaggcagagcaggtgtgg       c.*5220

          .         .         .         .         .         .       g.123947
 actaagtcccctgaccttcacacctgctccccagagaagccccagccagttgcaccaagt       c.*5280

          .         .         .         .         .         .       g.124007
 agcagaggtgagtagaggggcctgggggcttccaaggccccaggtcatcctgttgaactg       c.*5340

          .         .         .         .         .         .       g.124067
 agagggacaggtagcccccctgcctgcggcccctggccccatgggcacctgagggcagta       c.*5400

          .         .         .         .         .         .       g.124127
 ctgcatgggaagagcccaggatgcctcaggcctggcaactgtgacaagtatgaggaagga       c.*5460

          .         .         .         .         .         .       g.124187
 gagagaacgggaagggaatcaggcagggcgcattcgaggaggccagaggtggcgaggcag       c.*5520

          .         .         .         .         .         .       g.124247
 gcttgccctgcacaaaccacaacagaagttgcacacagaagtcccagggacctttgtgct       c.*5580

          .         .         .         .         .         .       g.124307
 gggaactgaaagagtggggaaggtggaggggaccatttcagagcaggctggaatcaggtg       c.*5640

          .         .         .         .         .         .       g.124367
 cttggaccagtgaagacatgtcttgcttcctccagctctctctggggccctcccactctc       c.*5700

          .         .         .         .         .         .       g.124427
 cacacccacagcagagacaaattgaggcaagagttgagagagcatctgtctggtgaggtg       c.*5760

          .         .         .         .         .         .       g.124487
 atgggagcagtgtgcatggggcaccaggagttcctccatcccacctgccttagcgatcag       c.*5820

          .         .         .         .         .         .       g.124547
 gactttaggggggcctcttcaaagatagtgacccttctgccctgactcctgcccatctaa       c.*5880

          .         .         .         .         .         .       g.124607
 ggacttgatttgctgctttctgaaaaccctggggctgaaaacttcaaaatcagggcctgg       c.*5940

          .         .         .         .         .         .       g.124667
 cagagcctagcttcgccaaggtcagcccaccaggagccctgccttcgtctccataggaag       c.*6000

          .         .         .         .         .         .       g.124727
 gacacatgtacagcccttgcccccggccctctcattcccacttctgcttggcaatgctct       c.*6060

          .         .         .         .         .         .       g.124787
 ccatctcccttatgtggactcttgttcttgtctgatctcttgtcaaattgttattttgta       c.*6120

          .         .         .         .                           g.124828
 atgaactgcgtctccttattaaagaaatgagctgaaagaaa                          c.*6161

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Synaptotagmin II protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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