TGF-beta activated kinase 1/MAP3K7 binding protein 2 (TAB2) - coding DNA reference sequence

(used for variant description)

(last modified May 5, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_015093.4 in the TAB2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000006.11, covering TAB2 transcript NM_015093.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5001
                                                            a       c.-421

 .         .         .         .         .         .                g.5061
 tcgagcgcctaggagagccccgggtgggggagggcgcaaggggctcgggagggcccctcc       c.-361

 .         .         .         | 02         .         .             g.22290
 ctgcgtcggcgcccctgacccgcccccag | aggcagggttttgctgtattgcacaggctag    c.-301

 .         .         .         .         .         .                g.22350
 tctcaaactccttggctcaagtgatcctcttgctttggtctcccaaagtgctgcgattac       c.-241

 .  | 03      .         .         .         .         .             g.29443
 ag | gctccagacccagttcctggacctgccctggaaaagaagtatcccgtagagatgagct    c.-181

 .         .         .         .         .         .                g.29503
 cactgcagttacttaattaacaatttgtaagctgcaaaaatggcaatgggccaaccaaga       c.-121

 .         .         .         . | 04       .         .             g.56638
 acagctacaatttgaatttttctatttccag | aaaatgcttggacagaagagatgagtact    c.-61

 .         .         .         .         .         .                g.56698
 atttccactaaggcctagaattgcctactgtacaaatagtcctgatcaggcaatatacga       c.-1

          .         .         .         .         .         .       g.56758
 ATGGCCCAAGGAAGCCACCAAATTGATTTTCAGGTTTTACATGACCTGCGACAAAAATTC       c.60
 M  A  Q  G  S  H  Q  I  D  F  Q  V  L  H  D  L  R  Q  K  F         p.20

          .         .         .         .   | 05     .         .    g.64736
 CCTGAAGTACCTGAAGTTGTTGTATCCAGGTGCATGTTACAG | AATAATAATAACCTGGAT    c.120
 P  E  V  P  E  V  V  V  S  R  C  M  L  Q   | N  N  N  N  L  D      p.40

          .         .         .         .         .         .       g.64796
 GCCTGCTGTGCTGTTCTCTCTCAGGAGAGTACAAGATATCTTTATGGTGAAGGAGACTTG       c.180
 A  C  C  A  V  L  S  Q  E  S  T  R  Y  L  Y  G  E  G  D  L         p.60

          .         .         .         .         .         .       g.64856
 AATTTTTCAGATGATTCTGGAATTTCTGGTCTACGCAATCACATGACTTCTCTCAACTTG       c.240
 N  F  S  D  D  S  G  I  S  G  L  R  N  H  M  T  S  L  N  L         p.80

          .         .         .         .         .         .       g.64916
 GACTTGCAATCACAGAACATTTACCACCATGGAAGAGAAGGAAGTAGGATGAATGGAAGT       c.300
 D  L  Q  S  Q  N  I  Y  H  H  G  R  E  G  S  R  M  N  G  S         p.100

          .         .         .         .         .         .       g.64976
 AGGACTCTAACGCACAGCATTAGTGATGGACAACTTCAAGGTGGCCAGTCCAATAGTGAA       c.360
 R  T  L  T  H  S  I  S  D  G  Q  L  Q  G  G  Q  S  N  S  E         p.120

          .         .         .         .         .         .       g.65036
 CTATTTCAGCAGGAGCCACAGACAGCACCAGCTCAAGTTCCTCAAGGCTTTAATGTTTTT       c.420
 L  F  Q  Q  E  P  Q  T  A  P  A  Q  V  P  Q  G  F  N  V  F         p.140

          .         .         .         .         .         .       g.65096
 GGAATGTCCAGTTCCTCTGGTGCTTCAAATTCAGCACCACATCTTGGATTTCACTTAGGC       c.480
 G  M  S  S  S  S  G  A  S  N  S  A  P  H  L  G  F  H  L  G         p.160

          .         .         .         .         .         .       g.65156
 AGCAAAGGAACATCTAGCCTTTCTCAACAAACTCCCAGATTTAATCCCATTATGGTAACT       c.540
 S  K  G  T  S  S  L  S  Q  Q  T  P  R  F  N  P  I  M  V  T         p.180

          .         .         .         .         .         .       g.65216
 TTAGCCCCAAATATCCAGACTGGTCGTAATACTCCTACATCTTTGCACATACATGGTGTA       c.600
 L  A  P  N  I  Q  T  G  R  N  T  P  T  S  L  H  I  H  G  V         p.200

          .         .         .         .         .         .       g.65276
 CCTCCACCTGTACTTAACAGTCCACAGGGAAATTCTATCTATATTAGGCCTTACATTACA       c.660
 P  P  P  V  L  N  S  P  Q  G  N  S  I  Y  I  R  P  Y  I  T         p.220

          .         .         .         .         .         .       g.65336
 ACTCCTGGTGGTACAACTCGACAGACACAACAGCATTCTGGCTGGGTATCTCAGTTTAAT       c.720
 T  P  G  G  T  T  R  Q  T  Q  Q  H  S  G  W  V  S  Q  F  N         p.240

          .         .         .         .         .         .       g.65396
 CCCATGAACCCTCAGCAAGTTTATCAGCCTTCACAGCCTGGTCCCTGGACTACTTGTCCT       c.780
 P  M  N  P  Q  Q  V  Y  Q  P  S  Q  P  G  P  W  T  T  C  P         p.260

          .         .         .         .         .         .       g.65456
 GCATCTAATCCTCTGTCACATACCTCATCTCAACAGCCAAATCAGCAAGGCCACCAGACC       c.840
 A  S  N  P  L  S  H  T  S  S  Q  Q  P  N  Q  Q  G  H  Q  T         p.280

          .         .         .         .         .         .       g.65516
 TCTCATGTCTACATGCCAATCAGTTCACCTACTACTTCACAACCACCAACCATTCATTCA       c.900
 S  H  V  Y  M  P  I  S  S  P  T  T  S  Q  P  P  T  I  H  S         p.300

          .         .         .         .         .         .       g.65576
 TCTGGTAGCTCACAGTCTTCTGCCCATAGCCAATATAACATTCAGAATATTTCAACAGGA       c.960
 S  G  S  S  Q  S  S  A  H  S  Q  Y  N  I  Q  N  I  S  T  G         p.320

          .         .         .         .         .         .       g.65636
 CCTCGAAAAAACCAGATTGAAATCAAACTTGAACCCCCACAAAGAAATAATTCTTCAAAA       c.1020
 P  R  K  N  Q  I  E  I  K  L  E  P  P  Q  R  N  N  S  S  K         p.340

          .         .         .         .         .         .       g.65696
 CTGCGTTCTTCTGGACCTCGAACCTCCAGCACTTCCTCTTCAGTCAATAGCCAGACCTTA       c.1080
 L  R  S  S  G  P  R  T  S  S  T  S  S  S  V  N  S  Q  T  L         p.360

          .         .         .         .         .         .       g.65756
 AACAGAAATCAGCCCACTGTTTACATAGCTGCCAGCCCCCCAAATACGGATGAGCTGATG       c.1140
 N  R  N  Q  P  T  V  Y  I  A  A  S  P  P  N  T  D  E  L  M         p.380

          .         .         .         .         .         .       g.65816
 TCCCGTAGTCAACCTAAGGTCTATATTTCAGCGAATGCTGCCACAGGAGATGAACAGGTC       c.1200
 S  R  S  Q  P  K  V  Y  I  S  A  N  A  A  T  G  D  E  Q  V         p.400

          .         .         .         .         .         .       g.65876
 ATGCGGAATCAGCCCACACTCTTCATATCCACAAACTCTGGAGCATCTGCTGCCTCCAGG       c.1260
 M  R  N  Q  P  T  L  F  I  S  T  N  S  G  A  S  A  A  S  R         p.420

          .         .         .         .         .         .       g.65936
 AACATGTCTGGGCAAGTGAGCATGGGTCCTGCCTTTATTCATCACCATCCTCCCAAAAGT       c.1320
 N  M  S  G  Q  V  S  M  G  P  A  F  I  H  H  H  P  P  K  S         p.440

          .         .         .         .         .         .       g.65996
 CGAGCAATAGGCAATAACTCTGCAACCTCTCCTCGAGTGGTAGTCACTCAGCCCAATACG       c.1380
 R  A  I  G  N  N  S  A  T  S  P  R  V  V  V  T  Q  P  N  T         p.460

          .         .         .         .         .         .       g.66056
 AAATACACTTTCAAAATTACAGTCTCTCCCAATAAGCCCCCTGCAGTTTCACCAGGGGTG       c.1440
 K  Y  T  F  K  I  T  V  S  P  N  K  P  P  A  V  S  P  G  V         p.480

          .         .         .         .         .         .       g.66116
 GTGTCCCCTACCTTTGAACTTACAAATCTTCTTAATCATCCTGATCATTATGTAGAAACC       c.1500
 V  S  P  T  F  E  L  T  N  L  L  N  H  P  D  H  Y  V  E  T         p.500

          .         .         .         .         .         .       g.66176
 GAGAATATTCAGCACCTCACGGACCCTACATTAGCACATGTGGATAGAATAAGTGAAACA       c.1560
 E  N  I  Q  H  L  T  D  P  T  L  A  H  V  D  R  I  S  E  T         p.520

          .         .         .         .    | 06    .         .    g.84321
 CGGAAACTGAGTATGGGATCTGATGATGCTGCCTACACACAAG | CTCTTTTGGTACACCAG    c.1620
 R  K  L  S  M  G  S  D  D  A  A  Y  T  Q  A |   L  L  V  H  Q      p.540

          .         .         .         .         .         .       g.84381
 AAGGCCAGAATGGAACGACTTCAAAGAGAACTTGAGATTCAAAAGAAAAAGCTGGATAAA       c.1680
 K  A  R  M  E  R  L  Q  R  E  L  E  I  Q  K  K  K  L  D  K         p.560

          .         .         .         .         .         .       g.84441
 TTAAAATCTGAGGTTAATGAAATGGAAAATAATCTAACTCGAAGGCGCCTGAAAAGATCA       c.1740
 L  K  S  E  V  N  E  M  E  N  N  L  T  R  R  R  L  K  R  S         p.580

          .         .     | 07   .         .         .         .    g.84705
 AATTCTATATCCCAGATACCTTCC | CTTGAAGAAATGCAGCAGCTGAGAAGTTGTAATAGA    c.1800
 N  S  I  S  Q  I  P  S   | L  E  E  M  Q  Q  L  R  S  C  N  R      p.600

          .         .         .         .         .         | 08    g.85806
 CAACTCCAGATTGACATTGACTGCTTAACCAAAGAAATTGATCTTTTTCAAGCCCGAG | GA    c.1860
 Q  L  Q  I  D  I  D  C  L  T  K  E  I  D  L  F  Q  A  R  G |       p.620

          .         .         .         .         .         .       g.85866
 CCACATTTTAACCCCAGCGCTATTCATAACTTTTATGACAATATTGGATTTGTAGGTCCT       c.1920
 P  H  F  N  P  S  A  I  H  N  F  Y  D  N  I  G  F  V  G  P         p.640

          .          | 09        .         .         .         .    g.96318
 GTGCCACCAAAACCCAAAG | ATCAAAGGTCCATCATCAAAACACCAAAGACTCAAGACACA    c.1980
 V  P  P  K  P  K  D |   Q  R  S  I  I  K  T  P  K  T  Q  D  T      p.660

          .         .         .         .         .         .       g.96378
 GAAGATGATGAGGGAGCTCAGTGGAATTGTACCGCCTGTACTTTTTTGAACCATCCAGCC       c.2040
 E  D  D  E  G  A  Q  W  N  C  T  A  C  T  F  L  N  H  P  A         p.680

          .         .         .         .                           g.96420
 TTAATTCGCTGTGAACAGTGTGAGATGCCAAGGCATTTCTGA                         c.2082
 L  I  R  C  E  Q  C  E  M  P  R  H  F  X                           p.693

          .         .         .         .         .         .       g.96480
 gccaaatggccctgtatcttctctaaaaccacatctaaagttcaagaaactagtctgtca       c.*60

          .         .         .         .         .         .       g.96540
 tcgggaaaaagtttcactgctacataggattttgtcaaattgaaggtgtgacaagatggt       c.*120

          .         .         .         .         .         .       g.96600
 gttctgctaatgttaaatgtcagcccacagagctaataatacctcagtataatgtcatga       c.*180

          .         .         .         .         .         .       g.96660
 gcagttgaaattcatcacatgaaaagtaatctgctgaaagacttggttgcccactgccta       c.*240

          .         .         .         .         .         .       g.96720
 actgtgtacagtgttaccagtgtcccattatggataattctcaatatgttaacacctagg       c.*300

          .         .         .         .         .         .       g.96780
 tgttcccaatacctttttcccctcatgtcactactgaattttgacaggaggaaggaatag       c.*360

          .         .         .         .         .         .       g.96840
 aatgatagcttgttttatttgtaaagctttcagtgaaacactacatacacgaagaaaagg       c.*420

          .         .         .         .         .         .       g.96900
 aacaaggtttaactatttaagaaccatttgctgccgcatagtgccattggatagggaaga       c.*480

          .         .         .         .         .         .       g.96960
 acttcagaaatctgtggtactcttggccttgtctttgtcttccctgaacgtgtctccact       c.*540

          .         .         .         .         .         .       g.97020
 ctgtgaagccagcatctaggggctaaagatgcaaaggaaagcagcatgcattgtctgtac       c.*600

          .         .         .         .         .         .       g.97080
 aaatgtgcagcgaaataccccaaagcttttcctactgtacagatctctcgagtctgcttt       c.*660

          .         .         .         .         .         .       g.97140
 aagtgatttcttttcttcttgattattttcttatatttctatatgtatagtgtaatagcc       c.*720

          .         .         .         .         .         .       g.97200
 ttttgttaactaattttcttttttccttttagtaattaagcacgatcatgtcccttttta       c.*780

          .         .         .         .         .         .       g.97260
 agccttacctgagaggaacaatgccttaaaataaaaaagcattaatgagatgaaagtatg       c.*840

          .         .         .         .         .         .       g.97320
 cacagaataactttcctctacttattctgtactttgccctcatgagttccaatgttgtgt       c.*900

          .         .         .         .         .         .       g.97380
 gaagacaggcagatgctgcacagtgaattgcagatgatattacagaagtgatgtctgtag       c.*960

          .         .         .         .         .         .       g.97440
 gtcacattaaatactgacttgagcagtgggtgacacaacacagtgtttgtcttccacagg       c.*1020

          .         .         .         .         .         .       g.97500
 gaagcttaaaacaaaagatatttttaacccactgacagaacaacaaggttaagcttcatc       c.*1080

          .         .         .         .         .         .       g.97560
 tgcttggtgtcccacagaacttgcacaagcagttgttattgggaaagtacagtctcaaaa       c.*1140

          .         .         .         .         .         .       g.97620
 ccagcaacagcagcagtacctacagccctttttttggagagaagtttaaatgctttactg       c.*1200

          .         .         .         .         .         .       g.97680
 ttggggcagtccatttctaatcctgacttggtgacagtatcatgtgtatttataaaacaa       c.*1260

          .         .         .         .         .         .       g.97740
 ggctagccatatttaggacaactgaagaaaagctggaaaaaaaaacaagcaaacttgaac       c.*1320

          .         .         .         .         .         .       g.97800
 actgaagcaacctcaagcatctctttattttgatgatatatttttgtaaggaaaatattc       c.*1380

          .         .         .         .         .         .       g.97860
 agatgatcaggaatgtatataactgaaatcaagaaaaagaacagtatgcatttaaaaaga       c.*1440

          .         .         .         .         .         .       g.97920
 cagaattatgaaattatatgagtgcttagaatggggctaagggaagtgctgaaatagagc       c.*1500

          .         .         .         .         .         .       g.97980
 aaaggatggaagataatatagactaccacccactgtaaatgtttgcaagtggctgtgttt       c.*1560

          .         .         .         .         .         .       g.98040
 taaatgggattattacagttgatctctatgaatgtcagagccctaactttcaggctttgc       c.*1620

          .         .         .         .         .         .       g.98100
 attttgtatatgggaagaaatatgacaatcctaggtaattaaaccatagacccaaagccc       c.*1680

          .         .         .         .         .         .       g.98160
 ttacgtttgatgcaatttatttttaaaataggccttgtttttcagcttcatctgcagttc       c.*1740

          .         .         .         .         .         .       g.98220
 tatgtgaagattgataaatcagtttttacttgttttattaataaaacgtaatttggatat       c.*1800

          .         .         .         .         .         .       g.98280
 cttgagttgatggttttgtgatttagctgggtaaactatctttgtaacagataagttatt       c.*1860

          .         .         .                                     g.98312
 tataaaaattaaaaaacttatattctaatgtg                                   c.*1892

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The TGF-beta activated kinase 1/MAP3K7 binding protein 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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