TGF-beta activated kinase 1/MAP3K7 binding protein 3 (TAB3) - coding DNA reference sequence

(used for variant description)

(last modified January 5, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_152787.3 in the TAB3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012845.1, covering TAB3 transcript NM_152787.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5003
                                                          ccc       c.-661

 .         .         .         .         .         .                g.5063
 gacggaagccctgaagccagagcttgcttgccaagctctcgctcagaccggatctaggaa       c.-601

 .         .         .         .         .         .                g.5123
 atacgaggcgggcctcggtgggagggacgcactgagggaggagggaggaaagggggcggc       c.-541

 .         .         .         .         .         .                g.5183
 ggcggcggcggcggctcacaccggatcccggccctgcacggcgcgtaccctgggggttcg       c.-481

 .         .         .         .         .         .                g.5243
 ggcggggaagcggcgccggcccggaccccccgcgggagtaggcgacgggcgtgagggcga       c.-421

 .         .         .         .        | 02.         .             g.22615
 ggcggcggcggcggcggccagagagcagcagccgcctg | gacactgtcttcagccttttct    c.-361

 .         .         .         .         .         .                g.22675
 tcaagtttttgaccgtggattgtgttgtgtcaaactggatgaattatcttagttgaattt       c.-301

 .         .         . | 03       .         .         .             g.26884
 tcaccagttgaaaaattggag | atttctagactactgaaaagaagttgctttcagagctgg    c.-241

 .         .         .         .         .      | 04  .             g.27190
 agatgtgaataaaatttctgtgccagggttgataaaccatcttgag | gattccatccagga    c.-181

 .         .         .         .         .         .                g.27250
 aaccccatcacagttggttgttatgtctccttagactcctcttggctgtgacagtttctc       c.-121

 .         .         .          | 05        .         .             g.34746
 agacttttgttcttgaggagtactgatcag | aaaatgactgtggtgctagaagatcattac    c.-61

 .         .         .         .         .         .                g.34806
 ttttggaaagccggttaacatccatttcctaagagaaacttggccaccatttgctctggc       c.-1

          .         .         .         .         .         .       g.34866
 ATGGCGCAAAGCAGCCCACAGCTTGATATTCAGGTTCTCCATGATCTTCGACAACGTTTC       c.60
 M  A  Q  S  S  P  Q  L  D  I  Q  V  L  H  D  L  R  Q  R  F         p.20

          .         .         .         .   | 06     .         .    g.38850
 CCTGAAATTCCAGAGGGCGTGGTGTCTCAGTGCATGTTACAG | AATAACAACAATCTTGAA    c.120
 P  E  I  P  E  G  V  V  S  Q  C  M  L  Q   | N  N  N  N  L  E      p.40

          .         .         .         .         .         .       g.38910
 GCCTGTTGCCGAGCCCTTTCCCAGGAGAGTAGCAAATACTTATATATGGAATACCATAGT       c.180
 A  C  C  R  A  L  S  Q  E  S  S  K  Y  L  Y  M  E  Y  H  S         p.60

          .         .         .         .         .         .       g.38970
 CCAGATGACAATAGGATGAATAGAAATCGCCTTTTACATATTAACCTGGGTATCCATTCT       c.240
 P  D  D  N  R  M  N  R  N  R  L  L  H  I  N  L  G  I  H  S         p.80

          .         .         .         .         .         .       g.39030
 CCTAGTAGCTATCACCCAGGAGATGGAGCCCAACTTAATGGTGGTCGAACACTGGTACAT       c.300
 P  S  S  Y  H  P  G  D  G  A  Q  L  N  G  G  R  T  L  V  H         p.100

          .         .         .         .         .         .       g.39090
 AGCTCAAGTGATGGACATATTGATCCTCAGCATGCAGCAGGTAAACAGCTGATATGTTTA       c.360
 S  S  S  D  G  H  I  D  P  Q  H  A  A  G  K  Q  L  I  C  L         p.120

          .         .         .         .         .         .       g.39150
 GTTCAAGAACCACACTCAGCTCCAGCTGTTGTTGCTGCTACTCCCAACTACAATCCATTT       c.420
 V  Q  E  P  H  S  A  P  A  V  V  A  A  T  P  N  Y  N  P  F         p.140

          .         .         .         .         .         .       g.39210
 TTTATGAACGAACAGAACAGAAGTGCAGCTACTCCTCCTTCACAACCACCTCAACAGCCA       c.480
 F  M  N  E  Q  N  R  S  A  A  T  P  P  S  Q  P  P  Q  Q  P         p.160

          .         .         .         .         .         .       g.39270
 TCTTCCATGCAAACAGGAATGAATCCGTCTGCTATGCAAGGGCCTTCACCACCACCGCCA       c.540
 S  S  M  Q  T  G  M  N  P  S  A  M  Q  G  P  S  P  P  P  P         p.180

          .         .         .         .         .         .       g.39330
 CCTCCTTCATACATGCACATACCTCGGTATAGTACAAATCCAATTACTGTTACAGTATCC       c.600
 P  P  S  Y  M  H  I  P  R  Y  S  T  N  P  I  T  V  T  V  S         p.200

          .         .         .         .         .         .       g.39390
 CAGAACCTCCCTTCTGGACAGACTGTACCAAGAGCTTTACAAATTCTTCCACAAATTCCA       c.660
 Q  N  L  P  S  G  Q  T  V  P  R  A  L  Q  I  L  P  Q  I  P         p.220

          .         .         .         .         .         .       g.39450
 AGCAATCTCTATGGGTCTCCTGGTTCTATTTATATTAGACAGACATCTCAGAGTTCATCA       c.720
 S  N  L  Y  G  S  P  G  S  I  Y  I  R  Q  T  S  Q  S  S  S         p.240

          .         .         .         .         .         .       g.39510
 GGAAGACAAACTCCTCAGAGTACGCCGTGGCAGTCCTCACCACAGGGCCCAGTGCCTCAC       c.780
 G  R  Q  T  P  Q  S  T  P  W  Q  S  S  P  Q  G  P  V  P  H         p.260

          .         .         .         .         .         .       g.39570
 TATAGCCAGCGTCCTTTACCTGTTTATCCACACCAACAGAACTATCAGCCTTCTCAGTAT       c.840
 Y  S  Q  R  P  L  P  V  Y  P  H  Q  Q  N  Y  Q  P  S  Q  Y         p.280

          .         .         .         .         .         .       g.39630
 TCTCCCAAACAGCAGCAGATCCCTCAGTCTGCTTACCATTCACCACCTCCTTCTCAATGT       c.900
 S  P  K  Q  Q  Q  I  P  Q  S  A  Y  H  S  P  P  P  S  Q  C         p.300

          .         .         .         .         .         .       g.39690
 CCTTCACCCTTCAGCTCTCCACAGCATCAAGTGCAACCTTCCCAGTTGGGCCACATCTTT       c.960
 P  S  P  F  S  S  P  Q  H  Q  V  Q  P  S  Q  L  G  H  I  F         p.320

          .         .         .         .         .         .       g.39750
 ATGCCACCTAGTCCTTCAACTACTCCACCCCATCCATATCAACAAGGACCTCCTAGCTAT       c.1020
 M  P  P  S  P  S  T  T  P  P  H  P  Y  Q  Q  G  P  P  S  Y         p.340

          .         .         .         .         .         .       g.39810
 CAGAAACAGGGAAGCCATTCAGTAGCCTATCTTCCATACACAGCATCTAGTTTATCCAAA       c.1080
 Q  K  Q  G  S  H  S  V  A  Y  L  P  Y  T  A  S  S  L  S  K         p.360

          .         .         .         .         .         .       g.39870
 GGTTCCATGAAGAAGATAGAAATTACAGTTGAACCTTCTCAAAGACCTGGGACAGCAATT       c.1140
 G  S  M  K  K  I  E  I  T  V  E  P  S  Q  R  P  G  T  A  I         p.380

          .         .         .         .         .         .       g.39930
 AATAGGAGTCCTTCACCCATCAGTAATCAACCATCTCCATGGAATCAACACTCACTGTAC       c.1200
 N  R  S  P  S  P  I  S  N  Q  P  S  P  W  N  Q  H  S  L  Y         p.400

          .         .         .         .         .         .       g.39990
 ACAGCCACCACGCCACCTTCAAGTTCTCCTTCAAGAGGGATATCTAGTCAACCAAAACCT       c.1260
 T  A  T  T  P  P  S  S  S  P  S  R  G  I  S  S  Q  P  K  P         p.420

          .         .         .         .         .         .       g.40050
 CCATTTAGTGTTAATCCTGTGTATATTACATATACACAGCCAACTGGACCTTCTTGTACT       c.1320
 P  F  S  V  N  P  V  Y  I  T  Y  T  Q  P  T  G  P  S  C  T         p.440

          .         .         .         .         .         .       g.40110
 CCATCACCATCTCCTCGAGTGATACCAAACCCAACTACAGTTTTTAAAATTACCGTAGGC       c.1380
 P  S  P  S  P  R  V  I  P  N  P  T  T  V  F  K  I  T  V  G         p.460

          .         .         .         .         .         .       g.40170
 CGAGCAACGACTGAAAATCTTTTAAATTTAGTGGACCAAGAAGAGCGCTCTGCAGCACCA       c.1440
 R  A  T  T  E  N  L  L  N  L  V  D  Q  E  E  R  S  A  A  P         p.480

          .         .         .         .         .         .       g.40230
 GAACCTATTCAGCCCATTTCAGTGATACCAGGCTCTGGGGGAGAAAAGGGAAGCCATAAA       c.1500
 E  P  I  Q  P  I  S  V  I  P  G  S  G  G  E  K  G  S  H  K         p.500

          .         .         .         .          | 07        .    g.41467
 TATCAGAGAAGTTCTAGTTCTGGATCAGATGACTATGCCTACACACAAG | CCTTGCTGTTA    c.1560
 Y  Q  R  S  S  S  S  G  S  D  D  Y  A  Y  T  Q  A |   L  L  L      p.520

          .         .         .         .         .         .       g.41527
 CATCAACGAGCAAGGATGGAGAGGTTAGCAAAGCAACTGAAACTTGAGAAAGAGGAGCTA       c.1620
 H  Q  R  A  R  M  E  R  L  A  K  Q  L  K  L  E  K  E  E  L         p.540

          .         .         .         .         .         .       g.41587
 GAGCGGTTGAAGTCTGAAGTTAATGGTATGGAGCATGACCTGATGCAGAGACGGCTCAGA       c.1680
 E  R  L  K  S  E  V  N  G  M  E  H  D  L  M  Q  R  R  L  R         p.560

          .         .         . | 08       .         .         .    g.47780
 AGAGTCAGCTGCACCACTGCGATCCCTACG | CCTGAGGAAATGACAAGATTGAGAAGCATG    c.1740
 R  V  S  C  T  T  A  I  P  T   | P  E  E  M  T  R  L  R  S  M      p.580

          .         .         .         .         .         .       g.47840
 AACAGACAACTCCAGATAAATGTTGACTGTACACTGAAAGAAGTTGACCTCCTTCAATCT       c.1800
 N  R  Q  L  Q  I  N  V  D  C  T  L  K  E  V  D  L  L  Q  S         p.600

      | 09   .         .         .         .         .         .    g.51401
 AGAG | GAAACTTTGATCCAAAAGCCATGAATAATTTTTATGACAACATAGAACCTGGCCCA    c.1860
 R  G |   N  F  D  P  K  A  M  N  N  F  Y  D  N  I  E  P  G  P      p.620

          .         .         | 10         .         .         .    g.60274
 GTTGTACCACCCAAGCCATCTAAAAAAG | ACTCCTCAGACCCCTGCACAATTGAGAGAAAA    c.1920
 V  V  P  P  K  P  S  K  K  D |   S  S  D  P  C  T  I  E  R  K      p.640

          .         .         .         .         .         .       g.60334
 GCCCGAAGAATTAGCGTGACCTCCAAAGTACAGGCAGACATCCATGACACCCAGGCAGCA       c.1980
 A  R  R  I  S  V  T  S  K  V  Q  A  D  I  H  D  T  Q  A  A         p.660

          . | 11       .         .         .         .         .    g.62869
 GCTGCAGATG | AGCATCGAACTGGCTCCACACAAAGTCCTCGGACACAACCTCGAGATGAA    c.2040
 A  A  D  E |   H  R  T  G  S  T  Q  S  P  R  T  Q  P  R  D  E      p.680

          .         .         .         .         .         .       g.62929
 GACTACGAAGGGGCTCCATGGAATTGTGATAGCTGCACCTTTCTTAACCACCCAGCACTA       c.2100
 D  Y  E  G  A  P  W  N  C  D  S  C  T  F  L  N  H  P  A  L         p.700

          .         .         .                                     g.62968
 AATCGCTGTGAGCAGTGCGAGATGCCACGGTACACCTGA                            c.2139
 N  R  C  E  Q  C  E  M  P  R  Y  T  X                              p.712

          .         .         .         .         .         .       g.63028
 attcagaaaagtctgcgccaggttgaaagtgaaactttgagcactaccagaagaaaagga       c.*60

          .         .         .         .         .         .       g.63088
 aacctcgggactctattcatccacccagccttttcattttcgattgcacagcggggagga       c.*120

          .         .         .         .         .         .       g.63148
 ggaatggctttgtggtcgtcgttgtgctcacgaaaggaaaaatggggaggtctttttttt       c.*180

          .         .         .         .         .         .       g.63208
 ctcctttcttaactcactacagagtgagagatagaaagggatacttgaaactgggaaagg       c.*240

          .         .         .         .         .         .       g.63268
 attcactctgtgaaagaatgtacacacagaagtcaagagctcttctgtggtggaatccca       c.*300

          .         .         .         .         .         .       g.63328
 attgttaaagttactgctgagtggcccttattttttaaagtagtactttgaatcatagta       c.*360

          .         .         .         .         .         .       g.63388
 tgaaatgctacagtttatgcaaactgtgaattcccagagcagacttacctggtcaccgct       c.*420

          .         .         .         .         .         .       g.63448
 ctctggaaaaccaaggctccccgtgcttcttcccattgcttcctactaaagaggacaaca       c.*480

          .         .         .         .         .         .       g.63508
 ggaaaaagcacctagaatatttggggggggggggcaaattaattaagggtatttgtaatt       c.*540

          .         .         .         .         .         .       g.63568
 gctgcttttttcaggggtaatttccaacacacatacatgcacacaaacaaaatgttttaa       c.*600

          .         .         .         .         .         .       g.63628
 aatgtgatttgtagcagtcaggaactaggcatatcatgcctttgtttaaaagtacaatca       c.*660

          .         .         .         .         .         .       g.63688
 gaggtggtaagatgcctttggcttgtacagtgtgattcatcgagctctatcaacactggt       c.*720

          .         .         .         .         .         .       g.63748
 aactaagacctacttatgccacataagagatgcatttttttaagttactgcatgttttta       c.*780

          .         .         .         .         .         .       g.63808
 ttaaggccattggttttcaaaataacaagtccttacaaagtatgattttataaatgatat       c.*840

          .         .         .         .         .         .       g.63868
 tctcgtaaaactgcgctttgccagtagcacagtgaatgtatgccaaatgcaagtccattc       c.*900

          .         .         .         .         .         .       g.63928
 caaaatccatttggaaatcttgagctcagctgtggttcttaaacttttgcagtccatagg       c.*960

          .         .         .         .         .         .       g.63988
 gccttttttttttccttccaattttgtgataaattcatgatgtttacagcacagataaaa       c.*1020

          .         .         .         .         .         .       g.64048
 ctttgtgccataatcctaatttagctgaaatcaatattaactgttcaataaaaacttact       c.*1080

          .         .         .         .         .         .       g.64108
 tgcatatgttaacaaaccagtgtgaggggaattacagttggccaacgacaaagttgcaca       c.*1140

          .         .         .         .         .         .       g.64168
 ctgcattatttaggaaaggagggattgtcaaaaattattaagagaaaggtgaatatagag       c.*1200

          .         .         .         .         .         .       g.64228
 gactttgaaacaacttttaaaatttaacataactgtatctagaggtcaattgagtctcta       c.*1260

          .         .         .         .         .         .       g.64288
 caggcagttcagatcattttaaagcactccttatttatgaaatagaacttcagggtgcgg       c.*1320

          .         .         .         .         .         .       g.64348
 ataagagatataaagtcatgtgactcactagggtgcatcgctggaaacttaatagcacat       c.*1380

          .         .         .         .         .         .       g.64408
 ttcattaaggtctctgccattgttggagttccttcttagctcagaattggagttttggaa       c.*1440

          .         .         .         .         .         .       g.64468
 tcttcccctcattttggtgagtataaacagcaataaagttagtaggttctcccatcctaa       c.*1500

          .         .         .         .         .         .       g.64528
 aggattttacctgaggatatcgtcttaggaatatccatagacgctcccatcaggtttctc       c.*1560

          .         .         .         .         .         .       g.64588
 ccccaacccccctacaccgcccccccacttctaatttagcagtaatctctggcagacctg       c.*1620

          .         .         .         .         .         .       g.64648
 gaaaaacaagctgctcttaatagcataatgaaaccaaaggcgtaataactcatcatagtt       c.*1680

          .         .         .         .         .         .       g.64708
 ttccatcagaatcatttcacactctgcctacagctttgaaaacattttttcatatgtgaa       c.*1740

          .         .         .         .         .         .       g.64768
 aaactccccaaaatatatccactagtctcccaaaggaagcatggtaattaacactgataa       c.*1800

          .         .         .         .         .         .       g.64828
 aaacatctctcacacaacaactgtggcaaaactgtgaaaataacggtgagaaagcagatg       c.*1860

          .         .         .         .         .         .       g.64888
 ggcttaaaagcatggtccccaaaacaacgttcttcaaaggtttttgtaacactggtctct       c.*1920

          .         .         .         .         .         .       g.64948
 gtctccaataacagtctagccgtcctactgttctgtaatatgcctttgcctttgtatggt       c.*1980

          .         .         .         .         .         .       g.65008
 ttcatatctctttagtgatggtcaaccccacttggttttaagttacaatttaggggaaat       c.*2040

          .         .         .         .         .         .       g.65068
 atatatatatatactgcttggtgtcctagctaaaaggtttaccagtattcatagtgatat       c.*2100

          .         .         .         .         .         .       g.65128
 gctgaagtggaggcaattaacttggcagttgtcagttgagaatgaaagtagcatgtctga       c.*2160

          .         .         .         .         .         .       g.65188
 aaacagtctgatgctttataaaaccatgtagatgactttaaaactattgcatgaaaatac       c.*2220

          .         .         .         .         .         .       g.65248
 atcaaggttaataagctgttatacagtagatgcatggtttcaatcctttggtgatattat       c.*2280

          .         .         .         .         .         .       g.65308
 ctagtcaatcattgttttcacctgccaggaaaagagagaaaacagtctattggataggtg       c.*2340

          .         .         .         .         .         .       g.65368
 taaagggtggggtatgcggtatcagattgattttaaggaagttttgtacatgttaatttt       c.*2400

          .         .         .         .         .         .       g.65428
 taattgtgcacaagtttcatatgccaacataggctgtattcagttttaaaataggcaaaa       c.*2460

          .         .         .         .         .         .       g.65488
 tgacttgacactgataaatctggtatgtttaactgtgtcccatatgtagactgctttttg       c.*2520

          .         .         .         .         .         .       g.65548
 cctatgaccagtttgaacaagaattcacccaactttcaagatgccttttcaaaaggatct       c.*2580

          .         .         .         .         .         .       g.65608
 tgtagtcagttggtatgtacagacaattggcatggaagtggtaggatataaatcggatga       c.*2640

          .         .         .         .         .         .       g.65668
 cgcctggctgctgaggtgccagctggatcagctggtgcacttcttgtttcttgtaagagg       c.*2700

          .         .         .         .         .         .       g.65728
 tttctttaaaatgactagtttgatgtatctggtaacatataggcctgactatacatttta       c.*2760

          .         .         .         .         .         .       g.65788
 cattatttcgctattttgtaaactgggattttagaaagcacgtttgccattttgttaaag       c.*2820

          .         .         .         .         .         .       g.65848
 tacattgccccttaaattttggagtagtttttaaaagtttaaaatggtaatagaggagcc       c.*2880

          .         .         .         .         .         .       g.65908
 agaaactttttaagcattgtaaaatgttttgaattgatattgactttgtttggaagagag       c.*2940

          .         .         .         .         .         .       g.65968
 tagaggcagggggctttaaagaaacaaagaaatgcattgtaaaaatgtagttttagagca       c.*3000

          .         .         .         .         .         .       g.66028
 aattaataatgatggtggggaaagtgttgctaatttgtttatttccctggaagaaatggg       c.*3060

          .         .         .         .         .         .       g.66088
 aagtgtgataagcagtttaatttttaaggagctggtctcaattttagtactttttaatta       c.*3120

          .         .         .         .         .         .       g.66148
 tgcaaataaatcaatgtttccttaaattttgtcattgctttgtcacagttgtctagggtt       c.*3180

          .         .         .         .         .         .       g.66208
 catatccaaccttctgtggcaattcaattttatatagtcttttaagaggtaattgtaatg       c.*3240

          .         .         .         .         .         .       g.66268
 tatttctgacagtataaacaaaaagaatataaggcatagaagaattgtcctctaaaaata       c.*3300

          .         .         .         .         .         .       g.66328
 tcaatgatgtatcctggaatgtgaagatgtccctttatagttaaaaattgaattatttta       c.*3360

          .         .         .         .         .         .       g.66388
 atattgtaccattgttagaccttgaatgagtccatgttaccgtgtgtgtctgtatatcta       c.*3420

          .         .         .         .         .         .       g.66448
 tctgtagagaaagaaaaatgacaactgaaatgttacttttaaaaatcagaataaattggg       c.*3480

          .         .         .         .         .         .       g.66508
 cactgtctgtgttgcaccactactgtatcttttcgaaagaattaacagtatttgcctatt       c.*3540

          .         .         .         .         .         .       g.66568
 gtaaaggttaattctgatgacgttttcacattcaccagactttttttcctgtattatttg       c.*3600

          .         .         .         .         .         .       g.66628
 catccccaaatatttaatacaagtagattctgcatggcttgggcattcagagattaatag       c.*3660

          .         .         .         .         .         .       g.66688
 aatgatgactcaattttaattctaaagccatgaaaagttactttgagactgaacaattct       c.*3720

          .         .         .         .         .         .       g.66748
 gaattatttatgatacccaatgtccatgtttctttccctactgtaaaagaattgatcagt       c.*3780

          .         .         .         .         .         .       g.66808
 ttcttcattaaagcagcaaaaacttattaaatcttgtaaataccatgtctcttttagatt       c.*3840

          .         .         .         .         .         .       g.66868
 tctgtgtatgctgtgaatgaaatcattttgagatgaaattgtacaaaggcattttaaaag       c.*3900

          .         .         .         .         .         .       g.66928
 gctctgcatgcatcgtacctccaaacagtacatattcggaaagtcaaagattcctgcaaa       c.*3960

          .         .                                               g.66953
 ataaataaactaaaagcaaacacta                                          c.*3985

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The TGF-beta activated kinase 1/MAP3K7 binding protein 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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