transport and golgi organization 2 homolog (TANGO2) - coding DNA reference sequence

(used for variant description)

(last modified February 7, 2023)

This file was created to facilitate the description of sequence variants on transcript NM_152906.4 in the TANGO2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000022.10, covering TANGO2 transcript NM_152906.4.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
           .         .         .         .         .                g.9135
   cggaagtcggcggcggtggcggaggcggtgagtgcgcggctccggggctggccgactc       c.-121

 .         .         .         .         .         .                g.9195
 cgctagtggcccggccggcctgggctcgggggctccgggctctgggctctgggtgcgcgg       c.-61

 .         .         . | 02       .         .         .             g.24768
 accgggccaggctgcttgaag | acctcgcgacctgtgtcagcagagccgccctgcaccacc    c.-1

          .         .         .         .         .       | 03 .    g.31328
 ATGTGCATCATCTTCTTTAAGTTTGATCCTCGCCCTGTTTCCAAAAACGCGTACAG | GCTC    c.60
 M  C  I  I  F  F  K  F  D  P  R  P  V  S  K  N  A  Y  R  |  L      p.20

          .         .         .         .         .         .       g.31388
 ATCTTGGCAGCCAACAGGGATGAATTCTACAGCCGACCCTCCAAGTTAGCTGACTTCTGG       c.120
 I  L  A  A  N  R  D  E  F  Y  S  R  P  S  K  L  A  D  F  W         p.40

          .         .      | 04  .         .         .         .    g.40469
 GGGAACAACAACGAGATCCTCAGTG | GGCTGGACATGGAGGAAGGCAAGGAAGGAGGCACA    c.180
 G  N  N  N  E  I  L  S  G |   L  D  M  E  E  G  K  E  G  G  T      p.60

          .         .         .         .         .         .       g.40529
 TGGCTGGGCATCAGCACACGTGGCAAGCTGGCAGCACTCACCAACTACCTGCAGCCGCAG       c.240
 W  L  G  I  S  T  R  G  K  L  A  A  L  T  N  Y  L  Q  P  Q         p.80

          .         .      | 05  .         .         .         .    g.41441
 CTGGACTGGCAGGCCCGAGGGCGAG | GTGAACTTGTCACCCACTTTCTGACCACTGACGTG    c.300
 L  D  W  Q  A  R  G  R  G |   E  L  V  T  H  F  L  T  T  D  V      p.100

          .         .         .         .         .         .       g.41501
 GACAGCTTGTCCTACCTGAAGAAGGTCTCTATGGAGGGCCATCTGTACAATGGCTTCAAC       c.360
 D  S  L  S  Y  L  K  K  V  S  M  E  G  H  L  Y  N  G  F  N         p.120

          .         . | 06       .         .         .         .    g.43952
 CTCATAGCAGCCGACCTGAG | CACAGCAAAGGGAGACGTCATTTGCTACTATGGGAACCGA    c.420
 L  I  A  A  D  L  S  |  T  A  K  G  D  V  I  C  Y  Y  G  N  R      p.140

          .         .         .  | 07      .         .         .    g.49528
 GGGGAGCCTGATCCTATCGTTTTGACGCCAG | GCACCTACGGGCTGAGCAACGCGCTGCTG    c.480
 G  E  P  D  P  I  V  L  T  P  G |   T  Y  G  L  S  N  A  L  L      p.160

          .         .         .         .         .         .       g.49588
 GAGACTCCCTGGAGGAAGCTGTGCTTTGGGAAGCAGCTCTTCCTGGAGGCTGTGGAACGG       c.540
 E  T  P  W  R  K  L  C  F  G  K  Q  L  F  L  E  A  V  E  R         p.180

          .         .         .         .         .         .       g.49648
 AGCCAGGCGCTGCCCAAGGATGTGCTCATCGCCAGCCTCCTGGATGTGCTCAACAATGAA       c.600
 S  Q  A  L  P  K  D  V  L  I  A  S  L  L  D  V  L  N  N  E         p.200

       | 08  .         .         .         .         .         .    g.51362
 GAGGC | GCAGCTGCCAGACCCGGCCATCGAGGACCAGGGTGGGGAGTACGTGCAGCCCATG    c.660
 E  A  |  Q  L  P  D  P  A  I  E  D  Q  G  G  E  Y  V  Q  P  M      p.220

          .         .         .         .         . | 09       .    g.52521
 CTGAGCAAGTACGCGGCTGTGTGCGTGCGCTGCCCTGGCTACGGCACCAG | AACCAACACT    c.720
 L  S  K  Y  A  A  V  C  V  R  C  P  G  Y  G  T  R  |  T  N  T      p.240

          .         .         .         .         .         .       g.52581
 ATCATCCTGGTAGATGCGGACGGCCACGTGACCTTCACTGAGCGTAGCATGATGGACAAG       c.780
 I  I  L  V  D  A  D  G  H  V  T  F  T  E  R  S  M  M  D  K         p.260

          .         .         .         .         .                 g.52632
 GACCTCTCCCACTGGGAGACCAGAACCTATGAGTTCACACTGCAGAGCTAA                c.831
 D  L  S  H  W  E  T  R  T  Y  E  F  T  L  Q  S  X                  p.276

          .         .         .         .         .         .       g.52692
 ccccacctctgggcctggccagtgggctcctggggggccctgccttgaggggcactgtgg       c.*60

          .         .         .         .         .         .       g.52752
 acaggaaaccttcctttgccatactgcattgcactgcccgtggcttggccagcatccccc       c.*120

          .         .         .         .         .         .       g.52812
 ggatcagggccctgtggtttgcgtgttacccatctgtgtccccatgcccagttcagggtc       c.*180

          .         .         .         .         .         .       g.52872
 tgcctttatgccagtgaggagcagcagagtctgatactaggtctaggaccggccgaggta       c.*240

          .         .         .         .         .         .       g.52932
 taccatgaacatgtggatacacctgagcccactcttgcacatgtacacaggcactcacat       c.*300

          .         .         .         .         .         .       g.52992
 ggcacacacatacactcctgcgtgtgcacaagcacacacatgcaagccatatacatggac       c.*360

          .         .         .         .         .         .       g.53052
 accgacacaggcacatgtacgtgcacaggtgtgctacacatgtgcacacatgcacagttg       c.*420

          .         .         .         .         .         .       g.53112
 cacagacacacacacacaggtgcacacacacgatgccgaacaaggcagaagggcgactct       c.*480

          .         .         .         .         .         .       g.53172
 cacctctcatgtgcttctggccagtaggtctttgttctggtccaacgacaggagtaggct       c.*540

          .         .         .         .         .         .       g.53232
 tgtatttaaaagcggcccctcctctcctgtggccacagaacacaggcgtgcttggactct       c.*600

          .         .         .         .         .         .       g.53292
 tgacaagcagacctgctcctgcagaggagacagccacatttggaattgggcaccgagaag       c.*660

          .         .         .         .         .         .       g.53352
 acctgagaaaaacccactctctcttttttttttttttgagacggagtcttgctctgtcac       c.*720

          .         .         .         .         .         .       g.53412
 ccaggctggagtgcagtggcacgatctcggctcactgcaacctccgcctcccaagttcaa       c.*780

          .         .         .         .         .         .       g.53472
 gcaattctcctgccccagcctcctgattagctgggattacaggcgtgtgccaccatgccc       c.*840

          .         .         .         .         .         .       g.53532
 agctaatttttgtgtttttagtagagacggggtttcaccatgttggtcaggctggtcttg       c.*900

          .         .         .         .         .         .       g.53592
 aactcctgacgtggtgatccacctgcctcggcctcccaaagtgctgggattacaggcgtg       c.*960

          .         .         .         .         .         .       g.53652
 agccaccacgcctggccgaaaaacccactctcataacagaagtgcagactcattgctaga       c.*1020

          .         .         .         .         .         .       g.53712
 ttcagtgcccttgagtgtgccagaggtcctctgtgtttgagacaatcctgtgtgtgccag       c.*1080

          .         .         .         .         .         .       g.53772
 gaggctccgtgtgcaccaggggctctcagaatcccgcttacccagctggagaccatgcct       c.*1140

          .         .         .         .         .         .       g.53832
 ctggcagccccatctcagccagccctgctctctccctcttccctccaggtgaggcaaact       c.*1200

          .         .         .         .         .         .       g.53892
 tcataggaatctgtacctgaatgtgagctcctgataataaaactctgaggctttggtgag       c.*1260

                                                                    g.53894
 cg                                                                 c.*1262

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Transport and golgi organization 2 homolog protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.