TAR DNA binding protein (TARDBP) - coding DNA reference sequence

(used for variant description)

(last modified November 24, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_007375.3 in the TARDBP gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008734.1, covering TARDBP transcript NM_007375.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5014
                                               ggtgggcgggggga       c.-121

 .         .         .         .         .         .                g.5074
 ggaggcggccctagcgccattttgtgggagcgaagcggtggctgggctgcgcttgggtcc       c.-61

 .         .         .         .         .        | 02.             g.6106
 gtcgctgcttcggtgtccctgtcgggcttcccagcagcggcctagcgg | gaaaagtaaaag    c.-1

          .         .         .         .         .         .       g.6166
 ATGTCTGAATATATTCGGGTAACCGAAGATGAGAACGATGAGCCCATTGAAATACCATCG       c.60
 M  S  E  Y  I  R  V  T  E  D  E  N  D  E  P  I  E  I  P  S         p.20

          .         .         .         .         .         .       g.6226
 GAAGACGATGGGACGGTGCTGCTCTCCACGGTTACAGCCCAGTTTCCAGGGGCGTGTGGG       c.120
 E  D  D  G  T  V  L  L  S  T  V  T  A  Q  F  P  G  A  C  G         p.40

          .         .         .         .         .         .       g.6286
 CTTCGCTACAGGAATCCAGTGTCTCAGTGTATGAGAGGTGTCCGGCTGGTAGAAGGAATT       c.180
 L  R  Y  R  N  P  V  S  Q  C  M  R  G  V  R  L  V  E  G  I         p.60

          .         .         .         .         .         | 03    g.9224
 CTGCATGCCCCAGATGCTGGCTGGGGAAATCTGGTGTATGTTGTCAACTATCCAAAAG | AT    c.240
 L  H  A  P  D  A  G  W  G  N  L  V  Y  V  V  N  Y  P  K  D |       p.80

          .         .         .         .         .         .       g.9284
 AACAAAAGAAAAATGGATGAGACAGATGCTTCATCAGCAGTGAAAGTGAAAAGAGCAGTC       c.300
 N  K  R  K  M  D  E  T  D  A  S  S  A  V  K  V  K  R  A  V         p.100

          .         .         .         .         .         .       g.9344
 CAGAAAACATCCGATTTAATAGTGTTGGGTCTCCCATGGAAAACAACCGAACAGGACCTG       c.360
 Q  K  T  S  D  L  I  V  L  G  L  P  W  K  T  T  E  Q  D  L         p.120

          .         .         .         .   | 04     .         .    g.11129
 AAAGAGTATTTTAGTACCTTTGGAGAAGTTCTTATGGTGCAG | GTCAAGAAAGATCTTAAG    c.420
 K  E  Y  F  S  T  F  G  E  V  L  M  V  Q   | V  K  K  D  L  K      p.140

          .         .         .         .         .         .       g.11189
 ACTGGTCATTCAAAGGGGTTTGGCTTTGTTCGTTTTACGGAATATGAAACACAAGTGAAA       c.480
 T  G  H  S  K  G  F  G  F  V  R  F  T  E  Y  E  T  Q  V  K         p.160

          .         .         .         .         .         .       g.11249
 GTAATGTCACAGCGACATATGATAGATGGACGATGGTGTGACTGCAAACTTCCTAATTCT       c.540
 V  M  S  Q  R  H  M  I  D  G  R  W  C  D  C  K  L  P  N  S         p.180

     | 05    .         .         .         .         .         .    g.12864
 AAG | CAAAGCCAAGATGAGCCTTTGAGAAGCAGAAAAGTGTTTGTGGGGCGCTGTACAGAG    c.600
 K   | Q  S  Q  D  E  P  L  R  S  R  K  V  F  V  G  R  C  T  E      p.200

          .         .         .         .         .         .       g.12924
 GACATGACTGAGGATGAGCTGCGGGAGTTCTTCTCTCAGTACGGGGATGTGATGGATGTC       c.660
 D  M  T  E  D  E  L  R  E  F  F  S  Q  Y  G  D  V  M  D  V         p.220

          .         .         .         .         .     | 06   .    g.14508
 TTCATCCCCAAGCCATTCAGGGCCTTTGCCTTTGTTACATTTGCAGATGATCAG | ATTGCG    c.720
 F  I  P  K  P  F  R  A  F  A  F  V  T  F  A  D  D  Q   | I  A      p.240

          .         .         .         .         .         .       g.14568
 CAGTCTCTTTGTGGAGAGGACTTGATCATTAAAGGAATCAGCGTTCATATATCCAATGCC       c.780
 Q  S  L  C  G  E  D  L  I  I  K  G  I  S  V  H  I  S  N  A         p.260

          .         .         .         .         .         .       g.14628
 GAACCTAAGCACAATAGCAATAGACAGTTAGAAAGAAGTGGAAGATTTGGTGGTAATCCA       c.840
 E  P  K  H  N  S  N  R  Q  L  E  R  S  G  R  F  G  G  N  P         p.280

          .         .         .         .         .         .       g.14688
 GGTGGCTTTGGGAATCAGGGTGGATTTGGTAATAGCAGAGGGGGTGGAGCTGGTTTGGGA       c.900
 G  G  F  G  N  Q  G  G  F  G  N  S  R  G  G  G  A  G  L  G         p.300

          .         .         .         .         .         .       g.14748
 AACAATCAAGGTAGTAATATGGGTGGTGGGATGAACTTTGGTGCGTTCAGCATTAATCCA       c.960
 N  N  Q  G  S  N  M  G  G  G  M  N  F  G  A  F  S  I  N  P         p.320

          .         .         .         .         .         .       g.14808
 GCCATGATGGCTGCCGCCCAGGCAGCACTACAGAGCAGTTGGGGTATGATGGGCATGTTA       c.1020
 A  M  M  A  A  A  Q  A  A  L  Q  S  S  W  G  M  M  G  M  L         p.340

          .         .         .         .         .         .       g.14868
 GCCAGCCAGCAGAACCAGTCAGGCCCATCGGGTAATAACCAAAACCAAGGCAACATGCAG       c.1080
 A  S  Q  Q  N  Q  S  G  P  S  G  N  N  Q  N  Q  G  N  M  Q         p.360

          .         .         .         .         .         .       g.14928
 AGGGAGCCAAACCAGGCCTTCGGTTCTGGAAATAACTCTTATAGTGGCTCTAATTCTGGT       c.1140
 R  E  P  N  Q  A  F  G  S  G  N  N  S  Y  S  G  S  N  S  G         p.380

          .         .         .         .         .         .       g.14988
 GCAGCAATTGGTTGGGGATCAGCATCCAATGCAGGGTCGGGCAGTGGTTTTAATGGAGGC       c.1200
 A  A  I  G  W  G  S  A  S  N  A  G  S  G  S  G  F  N  G  G         p.400

          .         .         .         .                           g.15033
 TTTGGCTCAAGCATGGATTCTAAGTCTTCTGGCTGGGGAATGTAG                      c.1245
 F  G  S  S  M  D  S  K  S  S  G  W  G  M  X                        p.414

          .         .         .         .         .         .       g.15093
 acagtggggttgtggttggttggtatagaatggtgggaattcaaatttttctaaactcat       c.*60

          .         .         .         .         .         .       g.15153
 ggtaagtatattgtaaaatacatatgtactaagaattttcaaaattggtttgttcagtgt       c.*120

          .         .         .         .         .         .       g.15213
 ggagtatattcagcagtatttttgacatttttctttagaaaaaggaagagctaaaggaat       c.*180

          .         .         .         .         .         .       g.15273
 tttataagttttgttacatgaaaggttgaaatattgagtggttgaaagtgaactgctgtt       c.*240

          .         .         .         .         .         .       g.15333
 tgcctgattggtaaaccaacacactacaattgatatcaaaaggtttctcctgtaatattt       c.*300

          .         .         .         .         .         .       g.15393
 tatccctggacttgtcaagtgaattctttgcatgttcaaaacggaaaccattgattagaa       c.*360

          .         .         .         .         .         .       g.15453
 ctacattctttaccccttgttttaatttgaaccccaccatatggatttttttccttaaga       c.*420

          .         .         .         .         .         .       g.15513
 aaatctccttttaggagatcatggtgtcacagtgtttggttcttttgttttgttttttaa       c.*480

          .         .         .         .         .         .       g.15573
 cacttgtctcccctcatacacaaaagtacaatatgaagccttcatttaatctctgcagtt       c.*540

          .         .         .         .         .         .       g.15633
 catctcatttcaaatgtttatggaagaagcacttcattgaaagtagtgctgtaaatattc       c.*600

          .         .         .         .         .         .       g.15693
 tgccataggaatactgtctacatgctttctcattcaagaattcgtcatcacgcatcacag       c.*660

          .         .         .         .         .         .       g.15753
 gccgcgtctttgacggtgggtgtcccatttttatccgctactctttatttcatggagtcg       c.*720

          .         .         .         .         .         .       g.15813
 tatcaacgctatgaacgcaaggctgtgatatggaaccagaaggctgtctgaacttttgaa       c.*780

          .         .         .         .         .         .       g.15873
 accttgtgtgggattgatggtggtgccgaggcatgaaaggctagtatgagcgagaaaagg       c.*840

          .         .         .         .         .         .       g.15933
 agagagcgcgtgcagagacttggtggtgcataatggatattttttaacttggcgagatgt       c.*900

          .         .         .         .         .         .       g.15993
 gtctctcaatcctgtggctttggtgagagagtgtgcagagagcaatgatagcaaataatg       c.*960

          .         .         .         .         .         .       g.16053
 tacgaatgttttttgcattcaaaggacatccacatctgttggaagacttttaagtgagtt       c.*1020

          .         .         .         .         .         .       g.16113
 tttgttcttagataacccacattagatgaatgtgttaagtgaaatgatacttgtactccc       c.*1080

          .         .         .         .         .         .       g.16173
 cctacccctttgtcaactgctgtgaatgctgtatggtgtgtgttctcttctgttactgat       c.*1140

          .         .         .         .         .         .       g.16233
 atgtaagtgtggcaatgtgaactgaagctgatgggctgagaacatggactgagcttgtgg       c.*1200

          .         .         .         .         .         .       g.16293
 tgtgctttgcaggaggacttgaagcagagttcaccagtgagctcaggtgtctcaaagaag       c.*1260

          .         .         .         .         .         .       g.16353
 ggtggaagttctaatgtctgttagctacccataagaatgctgtttgctgcagttctgtgt       c.*1320

          .         .         .         .         .         .       g.16413
 cctgtgcttggatgctttttataagagttgtcattgttggaaattcttaaataaaactga       c.*1380

          .         .         .         .         .         .       g.16473
 tttaaataatatgtgtctttgttttgcagccctgaatgcaaagaattcatagcagttaat       c.*1440

          .         .         .         .         .         .       g.16533
 tccccttttttgacccttttgagatggaactttcataaagtttcttggcagtagtttatt       c.*1500

          .         .         .         .         .         .       g.16593
 ttgcttcaaataaacttatttgaaaagttgtctcaagtcaaatggattcatcacctgtca       c.*1560

          .         .         .         .         .         .       g.16653
 tgcattgacacctgatacccagacttaattggtatttgttcttgcattggccaaagtgaa       c.*1620

          .         .         .         .         .         .       g.16713
 aatttttttttttcttttgaaatctagttttgaataagtctgggtgaccgcacctaaaat       c.*1680

          .         .         .         .         .         .       g.16773
 ggtaagcagtaccctccggctttttcttagtgcctctgtgcatttgggtgatgttctatt       c.*1740

          .         .         .         .         .         .       g.16833
 tacatggcctgtgtaaatctccattgggaagtcatgccttctaaaaagattcttatttgg       c.*1800

          .         .         .         .         .         .       g.16893
 gggagtgggcaaaatgttgattattttctaatgctttgtagcaaagcatatcaattgaaa       c.*1860

          .         .         .         .         .         .       g.16953
 agggaatatcagcaccttcctagtttgggatttgaaaagtggaattaattgcagtaggga       c.*1920

          .         .         .         .         .         .       g.17013
 taaagtagaagaaaccacaaattatcttgtgcctgaaatccattaagaggcctgatagct       c.*1980

          .         .         .         .         .         .       g.17073
 ttaagaattagggtgggttgtctgtctggaagtgttaagtggaatgggctttgtcctcca       c.*2040

          .         .         .         .         .         .       g.17133
 ggaggtgggggaatgtggtaacattgaatacagttgaataaaatcgcttacaaaactcac       c.*2100

          .         .         .         .         .         .       g.17193
 actctcacaatgcattgttaagtatgtaaaagcaataacattgattctctgttgtacttt       c.*2160

          .         .         .         .         .         .       g.17253
 tttgtaactaattctgtgagagttgagctcattttctagttggaagaatgtgatatttgt       c.*2220

          .         .         .         .         .         .       g.17313
 tgtgttggtagtttacctaatgcccttacctaattagattatgataaataggtttgtcat       c.*2280

          .         .         .         .         .         .       g.17373
 tttgcaagttacataaacatttatcaatgaagtcatcctttagacttgtaatcgccacat       c.*2340

          .         .         .         .         .         .       g.17433
 tgtttcattattcagtttcctctgtaaagggatcttgagttgttttaattttttttttct       c.*2400

          .         .         .         .         .         .       g.17493
 gcatctgaatctgcatgatttccaaaccctgtaccatctgaattttgcattttagcactt       c.*2460

          .         .         .         .         .         .       g.17553
 gcactattactcagcagcagtaacatggtaacacttaaaatggtactcggggacctccaa       c.*2520

          .         .         .         .         .         .       g.17613
 agactaaactgacaagccttcaaggagcccaggggtaagttaacttgtcaacggcatggt       c.*2580

          .         .         .         .         .         .       g.17673
 ttaatcccttctttacacttgtgtaaatttcagttactggtcatagaaggctttcaatgt       c.*2640

          .         .         .         .         .         .       g.17733
 tgagtggccttttattaacatgtttatggtactgcatagatacgggtatttattttaccc       c.*2700

          .         .         .         .         .         .       g.17793
 taagaagattttgaagtttaaaagtacttaaactatttggcaaagatttgtttttaaaaa       c.*2760

          .         .         .         .         .         .       g.17853
 tctatttggtcaatctaaatgcattcattctaaaaaattttttgaaccagataaataaaa       c.*2820

          .                                                         g.17871
 tttttttttgacaccaca                                                 c.*2838

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The TAR DNA binding protein protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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