T cell-interacting, activating receptor on myeloid cells 1 (TARM1) - coding DNA reference sequence

(used for variant description)

(last modified June 21, 2018)

This file was created to facilitate the description of sequence variants on transcript NM_001135686.1 in the TARM1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000019.9, covering TARM1 transcript NM_001135686.1.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                                         .         .                g.5025
                                    actctgggagggctaaggagccatc       c.-1

          .         .         .     | 02   .         .         .    g.10490
 ATGATCCCTAAGCTGCTTTCCCTCCTCTGTTTCA | GACTGTGCGTGGGCCAAGGAGACACA    c.60
 M  I  P  K  L  L  S  L  L  C  F  R |   L  C  V  G  Q  G  D  T      p.20

          . | 03       .         .         .         .         .    g.11318
 AGGGGAGATG | GGTCACTGCCCAAGCCGTCCCTCAGTGCCTGGCCCAGCTCGGTGGTCCCT    c.120
 R  G  D  G |   S  L  P  K  P  S  L  S  A  W  P  S  S  V  V  P      p.40

          .         .         .         .         .         .       g.11378
 GCCAACAGCAATGTGACGCTGCGATGTTGGACTCCTGCCAGAGGTGTGAGCTTTGTTCTC       c.180
 A  N  S  N  V  T  L  R  C  W  T  P  A  R  G  V  S  F  V  L         p.60

          .         .         .         .         .         .       g.11438
 AGGAAGGGAGGAATTATTCTGGAGTCCCCGAAGCCCCTTGATTCTACAGAGGGCGCGGCC       c.240
 R  K  G  G  I  I  L  E  S  P  K  P  L  D  S  T  E  G  A  A         p.80

          .         .         .         .         .         .       g.11498
 GAATTTCACCTCAATAATCTAAAAGTCAGAAATGCTGGAGAGTACACCTGTGAATACTAC       c.300
 E  F  H  L  N  N  L  K  V  R  N  A  G  E  Y  T  C  E  Y  Y         p.100

          .         .         .         .         .         .       g.11558
 AGAAAAGCATCCCCCCACATCCTTTCACAGCGCAGTGACGTCCTTCTACTGTTGGTGACA       c.360
 R  K  A  S  P  H  I  L  S  Q  R  S  D  V  L  L  L  L  V  T         p.120

   | 04      .         .         .         .         .         .    g.12225
 G | GACATTTATCTAAACCTTTCCTCCGAACCTACCAAAGGGGTACAGTGACCGCAGGTGGA    c.420
 G |   H  L  S  K  P  F  L  R  T  Y  Q  R  G  T  V  T  A  G  G      p.140

          .         .         .         .         .         .       g.12285
 AGGGTGACTCTGCAGTGCCAGAAGCGAGACCAATTGTTTGTGCCTATCATGTTCGCTCTA       c.480
 R  V  T  L  Q  C  Q  K  R  D  Q  L  F  V  P  I  M  F  A  L         p.160

          .         .         .         .         .         .       g.12345
 CTGAAGGCAGGGACGCCATCACCCATCCAGCTGCAGAGTCCAGCGGGGAAGGAGATAGAC       c.540
 L  K  A  G  T  P  S  P  I  Q  L  Q  S  P  A  G  K  E  I  D         p.180

          .         .         .         .         .         .       g.12405
 TTCTCTCTGGTGGACGTGACAGCCGGCGATGCTGGGAACTACAGCTGCATGTACTACCAG       c.600
 F  S  L  V  D  V  T  A  G  D  A  G  N  Y  S  C  M  Y  Y  Q         p.200

          .         .         .         .         .         | 05    g.16222
 ACAAAGTCTCCCTTCTGGGCCTCAGAACCCAGTGATCAGCTTGAGATATTGGTGACAG | TT    c.660
 T  K  S  P  F  W  A  S  E  P  S  D  Q  L  E  I  L  V  T  V |       p.220

          .         .         .         .         .         .       g.16282
 CCCCCAGGTACCACATCGAGCAACTACTCCCTGGGTAACTTCGTACGACTGGGTCTGGCT       c.720
 P  P  G  T  T  S  S  N  Y  S  L  G  N  F  V  R  L  G  L  A         p.240

          .         .         .         .         .         .       g.16342
 GCCGTAATTGTGGTTATCATGGGAGCTTTCCTGGTGGAGGCCTGGTACAGCCGGAATGTG       c.780
 A  V  I  V  V  I  M  G  A  F  L  V  E  A  W  Y  S  R  N  V         p.260

          .         .         .                                     g.16378
 TCTCCAGGTGAATCAGAGGCCTTCAAACCAGAGTGA                               c.816
 S  P  G  E  S  E  A  F  K  P  E  X                                 p.271

          .         .         .         .         .                 g.16434
 ctccatcttgaaccggggctgggtaaactgaggctgcaacctgctggactgcattc           c.*56

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The T cell-interacting, activating receptor on myeloid cells 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.