threonyl-tRNA synthetase 2, mitochondrial (putative) (TARS2) - coding DNA reference sequence

(used for variant description)

(last modified February 25, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_025150.3 in the TARS2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000001.10, covering TARS2 transcript NM_025150.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5007
                                                      aaggaac       c.-1

          .         .         .         .         .         .       g.5067
 ATGGCCCTGTATCAGAGGTGGCGGTGTCTCCGGCTCCAAGGTTTACAGGCTTGCAGGCTA       c.60
 M  A  L  Y  Q  R  W  R  C  L  R  L  Q  G  L  Q  A  C  R  L         p.20

        | 02 .         .         .         .         .         .    g.5468
 CACACG | GCAGTTGTGTCGACCCCTCCACGCTGGTTGGCAGAGCGGCTTGGCCTTTTTGAG    c.120
 H  T   | A  V  V  S  T  P  P  R  W  L  A  E  R  L  G  L  F  E      p.40

          .         .         .         .         .         .       g.5528
 GAGCTGTGGGCTGCTCAGGTAAAGAGATTAGCAAGCATGGCACAGAAGGAACCCCGGACT       c.180
 E  L  W  A  A  Q  V  K  R  L  A  S  M  A  Q  K  E  P  R  T         p.60

          .         .         .         .         .         .       g.5588
 ATTAAGATATCACTTCCTGGAGGCCAGAAAATTGATGCTGTGGCATGGAACACAACCCCC       c.240
 I  K  I  S  L  P  G  G  Q  K  I  D  A  V  A  W  N  T  T  P         p.80

          .         .    | 03    .         .         .         .    g.6557
 TACCAACTAGCCCGGCAGATCAG | TTCAACACTGGCAGATACTGCAGTGGCTGCTCAAGTG    c.300
 Y  Q  L  A  R  Q  I  S  |  S  T  L  A  D  T  A  V  A  A  Q  V      p.100

          .         .         .         .         .         .       g.6617
 AATGGAGAACCTTATGATCTGGAGCGGCCCTTGGAGACAGATTCTGACCTCAGATTTCTG       c.360
 N  G  E  P  Y  D  L  E  R  P  L  E  T  D  S  D  L  R  F  L         p.120

          .         .        | 04.         .         .         .    g.8190
 ACATTCGATTCCCCAGAGGGGAAAGCA | GTGTTCTGGCACTCCAGCACCCATGTCCTGGGG    c.420
 T  F  D  S  P  E  G  K  A   | V  F  W  H  S  S  T  H  V  L  G      p.140

          .         .         .         .         .         .       g.8250
 GCAGCAGCTGAACAATTCCTAGGTGCTGTTCTCTGCAGAGGTCCAAGTACAGAATATGGC       c.480
 A  A  A  E  Q  F  L  G  A  V  L  C  R  G  P  S  T  E  Y  G         p.160

          .         .         .   | 05     .         .         .    g.8978
 TTTTACCATGATTTCTTCCTGGGAAAGGAGAG | GACAATCCGGGGCTCAGAGCTGCCTGTT    c.540
 F  Y  H  D  F  F  L  G  K  E  R  |  T  I  R  G  S  E  L  P  V      p.180

          .         .         .         .         .         .       g.9038
 TTGGAGCGGATTTGCCAGGAACTTACAGCTGCTGCTCGACCCTTCCGGAGGCTAGAGGCT       c.600
 L  E  R  I  C  Q  E  L  T  A  A  A  R  P  F  R  R  L  E  A         p.200

          .         .         . | 06       .         .         .    g.9184
 TCACGGGATCAGCTTCGCCAGTTGTTCAAG | GATAACCCCTTTAAGCTTCACTTGATTGAG    c.660
 S  R  D  Q  L  R  Q  L  F  K   | D  N  P  F  K  L  H  L  I  E      p.220

          .         .         .      | 07  .         .         .    g.9992
 GAGAAAGTGACAGGTCCAACAGCAACAGTATATGG | GTGTGGCACATTGGTTGACCTTTGC    c.720
 E  K  V  T  G  P  T  A  T  V  Y  G  |  C  G  T  L  V  D  L  C      p.240

          .         .         .         .         .     | 08   .    g.14044
 CAGGGCCCCCACCTTCGGCATACTGGACAGATTGGAGGACTGAAGCTGCTATCG | AACTCA    c.780
 Q  G  P  H  L  R  H  T  G  Q  I  G  G  L  K  L  L  S   | N  S      p.260

          .         .         .         .         .         .       g.14104
 TCATCCTTATGGAGGTCTTCAGGGGCCCCAGAGACACTGCAGAGAGTGTCAGGGATTTCC       c.840
 S  S  L  W  R  S  S  G  A  P  E  T  L  Q  R  V  S  G  I  S         p.280

          .         .         .         .         .         .       g.14164
 TTCCCCACAACAGAATTGCTGAGGGTCTGGGAAGCATGGAGGGAGGAAGCAGAATTGCGG       c.900
 F  P  T  T  E  L  L  R  V  W  E  A  W  R  E  E  A  E  L  R         p.300

          .         .  | 09      .         .         .         .    g.14405
 GACCACCGGCGCATTGGGAAG | GAACAGGAGCTCTTCTTCTTCCATGAACTGAGCCCTGGG    c.960
 D  H  R  R  I  G  K   | E  Q  E  L  F  F  F  H  E  L  S  P  G      p.320

          .         .         .         .         .         .       g.14465
 AGCTGCTTCTTCCTGCCACGAGGGACAAGGGTGTATAATGCACTAGTGGCGTTTATCAGG       c.1020
 S  C  F  F  L  P  R  G  T  R  V  Y  N  A  L  V  A  F  I  R         p.340

  | 10       .         .         .         .         .         .    g.15146
  | GCTGAGTATGCCCATCGTGGTTTCTCCGAGGTGAAAACTCCCACACTGTTTTCTACGAAG    c.1080
  | A  E  Y  A  H  R  G  F  S  E  V  K  T  P  T  L  F  S  T  K      p.360

          .         .         .         .         .         .       g.15206
 CTCTGGGAACAGTCAGGGCACTGGGAGCATTATCAGGAAGACATGTTTGCCGTGCAGCCC       c.1140
 L  W  E  Q  S  G  H  W  E  H  Y  Q  E  D  M  F  A  V  Q  P         p.380

          .         .         .         .         .         .       g.15266
 CCAGGCTCTGACAGGCCTCCCAGCTCCCAGAGTGACGATTCTACCAGGCATATCACAGAT       c.1200
 P  G  S  D  R  P  P  S  S  Q  S  D  D  S  T  R  H  I  T  D         p.400

          .         .         .         | 11         .         .    g.16080
 ACACTCGCCCTCAAGCCTATGAACTGCCCTGCACACTG | CCTGATGTTCGCCCACCGGCCC    c.1260
 T  L  A  L  K  P  M  N  C  P  A  H  C  |  L  M  F  A  H  R  P      p.420

          .         .         .         .         .         .       g.16140
 AGATCCTGGCGGGAACTGCCCCTGCGACTAGCTGACTTTGGGGCTCTACACCGGGCCGAA       c.1320
 R  S  W  R  E  L  P  L  R  L  A  D  F  G  A  L  H  R  A  E         p.440

          .         .         .         .         .         .       g.16200
 GCCTCTGGTGGTCTGGGGGGACTGACCCGACTGCGGTGCTTCCAGCAGGATGACGCTCAC       c.1380
 A  S  G  G  L  G  G  L  T  R  L  R  C  F  Q  Q  D  D  A  H         p.460

          .         .  | 12      .         .         .         .    g.16492
 ATCTTCTGTACAACAGATCAG | CTGGAAGCAGAGATCCAAAGCTGTCTTGATTTCCTCCGT    c.1440
 I  F  C  T  T  D  Q   | L  E  A  E  I  Q  S  C  L  D  F  L  R      p.480

          .         .         .         .         .         .       g.16552
 TCCGTCTATGCCGTTCTTGGCTTCTCCTTCCGCCTGGCACTGTCCACCCGGCCATCTGGC       c.1500
 S  V  Y  A  V  L  G  F  S  F  R  L  A  L  S  T  R  P  S  G         p.500

          .         .         .          | 13        .         .    g.16793
 TTCCTGGGGGACCCTTGCCTTTGGGACCAGGCCGAACAG | GTCCTTAAACAGGCCCTGAAG    c.1560
 F  L  G  D  P  C  L  W  D  Q  A  E  Q   | V  L  K  Q  A  L  K      p.520

          .         .         .         .         .        | 14.    g.21894
 GAATTTGGAGAACCCTGGGACCTCAACTCTGGAGATGGTGCCTTCTATGGACCTAAG | ATT    c.1620
 E  F  G  E  P  W  D  L  N  S  G  D  G  A  F  Y  G  P  K   | I      p.540

          .         .         .         .         .         .       g.21954
 GACGTGCACCTCCACGATGCCCTGGGCCGGCCACATCAGTGTGGGACAATTCAGCTTGAC       c.1680
 D  V  H  L  H  D  A  L  G  R  P  H  Q  C  G  T  I  Q  L  D         p.560

          .         .         .         | 15         .         .    g.22210
 TTCCAACTGCCCCTGAGATTTGACCTCCAGTATAAGGG | GCAGGCGGGTGCCCTGGAGCGT    c.1740
 F  Q  L  P  L  R  F  D  L  Q  Y  K  G  |  Q  A  G  A  L  E  R      p.580

          .         .         .         .         .         .       g.22270
 CCAGTCCTCATTCACCGAGCAGTGCTCGGTTCTGTGGAAAGACTGTTGGGAGTGCTGGCA       c.1800
 P  V  L  I  H  R  A  V  L  G  S  V  E  R  L  L  G  V  L  A         p.600

          .         . | 16       .         .         .         .    g.22502
 GAAAGCTGCGGGGGGAAATG | GCCACTGTGGCTGTCCCCGTTCCAGGTGGTGGTCATCCCT    c.1860
 E  S  C  G  G  K  W  |  P  L  W  L  S  P  F  Q  V  V  V  I  P      p.620

          .         .         .    | 17    .         .         .    g.23174
 GTGGGGAGTGAGCAAGAGGAATACGCCAAAGAG | GCACAGCAGAGCCTGCGGGCTGCAGGA    c.1920
 V  G  S  E  Q  E  E  Y  A  K  E   | A  Q  Q  S  L  R  A  A  G      p.640

          .         .         .         .         .         .       g.23234
 CTGGTCAGTGACCTGGATGCAGACTCTGGACTGACCCTCAGCCGGAGAATCCGCCGGGCC       c.1980
 L  V  S  D  L  D  A  D  S  G  L  T  L  S  R  R  I  R  R  A         p.660

          .         .         | 18         .         .         .    g.24504
 CAGCTTGCCCACTACAATTTTCAGTTTG | TGGTTGGCCAGAAAGAGCAAAGTAAGAGAACA    c.2040
 Q  L  A  H  Y  N  F  Q  F  V |   V  G  Q  K  E  Q  S  K  R  T      p.680

          .         .         .         .         .         .       g.24564
 GTGAACATTCGGACTCGAGATAATCGTCGCCTTGGGGAGTGGGACTTGCCTGAGGCTGTG       c.2100
 V  N  I  R  T  R  D  N  R  R  L  G  E  W  D  L  P  E  A  V         p.700

          .         .         .         .         .                 g.24621
 CAGCGACTGGTGGAGCTACAGAACACGAGGGTCCCAAATGCCGAAGAAATTTTCTGA          c.2157
 Q  R  L  V  E  L  Q  N  T  R  V  P  N  A  E  E  I  F  X            p.718

          .         .         .         .         .         .       g.24681
 gcctttgtacatagatgaggcaaaaacctgcgagtgccatcagcctccctcacatgggag       c.*60

          .         .         .         .         .         .       g.24741
 accccaacccagctgacaatgtggagcccccagaacttcagaactgtgtggaggcacatg       c.*120

          .         .         .         .         .         .       g.24801
 tctgctctcctgaaaagagacttggtttggggaccccacaaaaggagggaagctgtagct       c.*180

          .         .         .                                     g.24837
 gtttggatgtgaggagaatgaaactacaaaaaaaaa                               c.*216

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Threonyl-tRNA synthetase 2, mitochondrial (putative) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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