taste receptor, type 2, member 38 (TAS2R38) - coding DNA reference sequence

(used for variant description)

(last modified July 7, 2015)

This file was created to facilitate the description of sequence variants on transcript NM_176817.4 in the TAS2R38 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_016141.1, covering TAS2R38 transcript NM_176817.4.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                                         .         .                g.5024
                                     cctttctgcactgggtggcaacca       c.-61

 .         .         .         .         .         .                g.5084
 ggtctttagattagccaactagagaagagaagtagaatagccaattagagaagtgacatc       c.-1

          .         .         .         .         .         .       g.5144
 ATGTTGACTCTAACTCGCATCCGCACTGTGTCCTATGAAGTCAGGAGTACATTTCTGTTC       c.60
 M  L  T  L  T  R  I  R  T  V  S  Y  E  V  R  S  T  F  L  F         p.20

          .         .         .         .         .         .       g.5204
 ATTTCAGTCCTGGAGTTTGCAGTGGGGTTTCTGACCAATGCCTTCGTTTTCTTGGTGAAT       c.120
 I  S  V  L  E  F  A  V  G  F  L  T  N  A  F  V  F  L  V  N         p.40

          .         .         .         .         .         .       g.5264
 TTTTGGGATGTAGTGAAGAGGCAGGCACTGAGCAACAGTGATTGTGTGCTGCTGTGTCTC       c.180
 F  W  D  V  V  K  R  Q  A  L  S  N  S  D  C  V  L  L  C  L         p.60

          .         .         .         .         .         .       g.5324
 AGCATCAGCCGGCTTTTCCTGCATGGACTGCTGTTCCTGAGTGCTATCCAGCTTACCCAC       c.240
 S  I  S  R  L  F  L  H  G  L  L  F  L  S  A  I  Q  L  T  H         p.80

          .         .         .         .         .         .       g.5384
 TTCCAGAAGTTGAGTGAACCACTGAACCACAGCTACCAAGCCATCATCATGCTATGGATG       c.300
 F  Q  K  L  S  E  P  L  N  H  S  Y  Q  A  I  I  M  L  W  M         p.100

          .         .         .         .         .         .       g.5444
 ATTGCAAACCAAGCCAACCTCTGGCTTGCTGCCTGCCTCAGCCTGCTTTACTGCTCCAAG       c.360
 I  A  N  Q  A  N  L  W  L  A  A  C  L  S  L  L  Y  C  S  K         p.120

          .         .         .         .         .         .       g.5504
 CTCATCCGTTTCTCTCACACCTTCCTGATCTGCTTGGCAAGCTGGGTCTCCAGGAAGATC       c.420
 L  I  R  F  S  H  T  F  L  I  C  L  A  S  W  V  S  R  K  I         p.140

          .         .         .         .         .         .       g.5564
 TCCCAGATGCTCCTGGGTATTATTCTTTGCTCCTGCATCTGCACTGTCCTCTGTGTTTGG       c.480
 S  Q  M  L  L  G  I  I  L  C  S  C  I  C  T  V  L  C  V  W         p.160

          .         .         .         .         .         .       g.5624
 TGCTTTTTTAGCAGACCTCACTTCACAGTCACAACTGTGCTATTCATGAATAACAATACA       c.540
 C  F  F  S  R  P  H  F  T  V  T  T  V  L  F  M  N  N  N  T         p.180

          .         .         .         .         .         .       g.5684
 AGGCTCAACTGGCAGATTAAAGATCTCAATTTATTTTATTCCTTTCTCTTCTGCTATCTG       c.600
 R  L  N  W  Q  I  K  D  L  N  L  F  Y  S  F  L  F  C  Y  L         p.200

          .         .         .         .         .         .       g.5744
 TGGTCTGTGCCTCCTTTCCTATTGTTTCTGGTTTCTTCTGGGATGCTGACTGTCTCCCTG       c.660
 W  S  V  P  P  F  L  L  F  L  V  S  S  G  M  L  T  V  S  L         p.220

          .         .         .         .         .         .       g.5804
 GGAAGGCACATGAGGACAATGAAGGTCTATACCAGAAACTCTCGTGACCCCAGCCTGGAG       c.720
 G  R  H  M  R  T  M  K  V  Y  T  R  N  S  R  D  P  S  L  E         p.240

          .         .         .         .         .         .       g.5864
 GCCCACATTAAAGCCCTCAAGTCTCTTGTCTCCTTTTTCTGCTTCTTTGTGATATCATCC       c.780
 A  H  I  K  A  L  K  S  L  V  S  F  F  C  F  F  V  I  S  S         p.260

          .         .         .         .         .         .       g.5924
 TGTGTTGCCTTCATCTCTGTGCCCCTACTGATTCTGTGGCGCGACAAAATAGGGGTGATG       c.840
 C  V  A  F  I  S  V  P  L  L  I  L  W  R  D  K  I  G  V  M         p.280

          .         .         .         .         .         .       g.5984
 GTTTGTGTTGGGATAATGGCAGCTTGTCCCTCTGGGCATGCAGCCATCCTGATCTCAGGC       c.900
 V  C  V  G  I  M  A  A  C  P  S  G  H  A  A  I  L  I  S  G         p.300

          .         .         .         .         .         .       g.6044
 AATGCCAAGTTGAGGAGAGCTGTGATGACCATTCTGCTCTGGGCTCAGAGCAGCCTGAAG       c.960
 N  A  K  L  R  R  A  V  M  T  I  L  L  W  A  Q  S  S  L  K         p.320

          .         .         .         .                           g.6086
 GTAAGAGCCGACCACAAGGCAGATTCCCGGACACTGTGCTGA                         c.1002
 V  R  A  D  H  K  A  D  S  R  T  L  C  X                           p.333

          .         .         .         .         .                 g.6143
 gaatggacatgaaatgagctcttcattaatacgcctgtgagtcttcataaatatgcc          c.*57

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Taste receptor, type 2, member 38 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.