TBC1 domain family, member 23 (TBC1D23) - coding DNA reference sequence

(used for variant description)

(last modified September 18, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_001199198.2 in the TBC1D23 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000003.11, covering TBC1D23 transcript NM_001199198.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5022
                                       aagtctcctcccccaagacgct       c.-181

 .         .         .         .         .         .                g.5082
 gcctttcggcctcgggacgccgtgacgttgcgttcctccagtcccttgccacctccctct       c.-121

 .         .         .         .         .         .                g.5142
 ttcttcccctctggggaagctcagtgctggacttccgaagaccttttacgacattgagtc       c.-61

 .         .         .         .         .         .                g.5202
 tcggagttggtctcagcgccggatccacttttcggcaaagtgacgtggacgtcaacagca       c.-1

          .         .         .         .         .    | 02    .    g.23839
 ATGGCGGAAGGAGAAGATGTGCCGCCGCTGCCAACGTCGAGCGGCGACGGCTG | GGAAAAA    c.60
 M  A  E  G  E  D  V  P  P  L  P  T  S  S  G  D  G  W  |  E  K      p.20

          .         .         .         .         .         .       g.23899
 GATCTTGAAGAAGCTCTGGAAGCAGGAGGTTGTGATCTTGAAACGTTGAGAAATATAATT       c.120
 D  L  E  E  A  L  E  A  G  G  C  D  L  E  T  L  R  N  I  I         p.40

          .         .         .         .      | 03  .         .    g.25940
 CAAGGAAGACCGCTGCCTGCTGATCTGAGGGCCAAAGTTTGGAAG | ATTGCTCTGAATGTT    c.180
 Q  G  R  P  L  P  A  D  L  R  A  K  V  W  K   | I  A  L  N  V      p.60

          .         .         .         .         .         .       g.26000
 GCAGGAAAAGGTGATAGTTTGGCATCATGGGATGGTATTTTAGACTTGCCAGAACAGAAC       c.240
 A  G  K  G  D  S  L  A  S  W  D  G  I  L  D  L  P  E  Q  N         p.80

          .         .         .  | 04      .         .         .    g.27819
 ACTATTCACAAAGATTGCCTGCAGTTTATTG | ACCAGCTTTCAGTGCCAGAGGAGAAGGCA    c.300
 T  I  H  K  D  C  L  Q  F  I  D |   Q  L  S  V  P  E  E  K  A      p.100

          .         .         .         .         .         .       g.27879
 GCAGAATTACTTTTGGATATTGAATCTGTAATTACCTTTTATTGTAAATCACGTAACATT       c.360
 A  E  L  L  L  D  I  E  S  V  I  T  F  Y  C  K  S  R  N  I         p.120

          .         .         .         .         .         .       g.27939
 AAATATAGCACATCCCTTAGCTGGATACATCTACTGAAACCATTGGTGCATCTTCAACTG       c.420
 K  Y  S  T  S  L  S  W  I  H  L  L  K  P  L  V  H  L  Q  L         p.140

          .         .         .         .         .       | 05 .    g.34765
 CCACGCAGCGATTTATACAACTGCTTTTATGCCATAATGAATAAGTACATTCCCAG | GGAT    c.480
 P  R  S  D  L  Y  N  C  F  Y  A  I  M  N  K  Y  I  P  R  |  D      p.160

          .         .         .         .         .         .       g.34825
 TGTTCCCAGAAAGGGAGACCATTTCATCTCTTCAGGTTGCTCATCCAATACCATGAGCCT       c.540
 C  S  Q  K  G  R  P  F  H  L  F  R  L  L  I  Q  Y  H  E  P         p.180

          .         .         .         .         .         .       g.34885
 GAGCTTTGTTCTTATCTTGATACAAAGAAAATTACTCCAGACTCCTATGCACTCAACTGG       c.600
 E  L  C  S  Y  L  D  T  K  K  I  T  P  D  S  Y  A  L  N  W         p.200

  | 06       .         .         .         .         .         .    g.39330
  | CTTGGAAGTCTTTTTGCATGTTACTGTTCCACTGAAGTCACTCAGGCAATATGGGATGGA    c.660
  | L  G  S  L  F  A  C  Y  C  S  T  E  V  T  Q  A  I  W  D  G      p.220

          .         .         .         .         .         .       g.39390
 TATCTACAACAAGCAGATCCATTTTTTATTTATTTCTTAATGTTAATTATCCTTGTTAAT       c.720
 Y  L  Q  Q  A  D  P  F  F  I  Y  F  L  M  L  I  I  L  V  N         p.240

       | 07  .         .         .         .         .   | 08     . g.40363
 GCAAA | AGAAGTTATTTTAACACAAGAGTCAGACAGCAAAGAAGAAGTTATCA | AGTTCTTG c.780
 A  K  |  E  V  I  L  T  Q  E  S  D  S  K  E  E  V  I  K |   F  L   p.260

          .         .         .         .         .         .       g.40423
 GAAAATACTCCATCCAGTCTGAATATAGAAGATATAGAAGACCTTTTCTCTCTGGCTCAG       c.840
 E  N  T  P  S  S  L  N  I  E  D  I  E  D  L  F  S  L  A  Q         p.280

          .         .         .       | 09 .         .         .    g.42130
 TATTATTGCAGCAAAACACCGGCTTCTTTTAGGAAG | GATAATCACCATCTCTTTGGTAGT    c.900
 Y  Y  C  S  K  T  P  A  S  F  R  K   | D  N  H  H  L  F  G  S      p.300

          .         .         .         .         .         .       g.42190
 ACTTTGTTGGGAATTAAGGATGATGATGCAGATCTGAGTCAGGCTCTTTGTCTGGCCATC       c.960
 T  L  L  G  I  K  D  D  D  A  D  L  S  Q  A  L  C  L  A  I         p.320

          .         .         .          | 10        .         .    g.43443
 TCCGTGTCAGAGATCCTTCAAGCGAATCAGCTACAAGGG | GAAGGAGTCCGGTTCTTTGTG    c.1020
 S  V  S  E  I  L  Q  A  N  Q  L  Q  G   | E  G  V  R  F  F  V      p.340

          .         .         .         .         .         .       g.43503
 GTGGATTGCCGTCCTGCAGAACAATATAATGCTGGGCATTTATCAACTGCTTTCCACTTA       c.1080
 V  D  C  R  P  A  E  Q  Y  N  A  G  H  L  S  T  A  F  H  L         p.360

          .   | 11     .         .         .         .         .    g.46298
 GATTCAGACCTG | ATGCTTCAGAATCCATCTGAGTTTGCACAGTCAGTAAAATCCTTGCTG    c.1140
 D  S  D  L   | M  L  Q  N  P  S  E  F  A  Q  S  V  K  S  L  L      p.380

          .         .         .         .         .         .       g.46358
 GAAGCACAGAAGCAGTCCATTGAGTCTGGCTCCATAGCTGGTGGGGAGCACCTCTGTTTT       c.1200
 E  A  Q  K  Q  S  I  E  S  G  S  I  A  G  G  E  H  L  C  F         p.400

          .         .         .         .         .         .       g.46418
 ATGGGCAGTGGCAGGGAGGAAGAAGACATGTATATGAACATGGTCCTGGCACACTTTTTA       c.1260
 M  G  S  G  R  E  E  E  D  M  Y  M  N  M  V  L  A  H  F  L         p.420

     | 12    .         .         .         .       | 13 .         . g.50634
 CAG | AAAAACAAAGAATATGTGAGTATTGCCAGTGGAGGATTTATGG | CACTGCAGCAGCAC c.1320
 Q   | K  N  K  E  Y  V  S  I  A  S  G  G  F  M  A |   L  Q  Q  H   p.440

          .         .         .         .         .         .       g.50694
 CTGGCAGACATTAATGTGGATGGACCAGAAAATGGATATGGCCATTGGATTGCTAGTACC       c.1380
 L  A  D  I  N  V  D  G  P  E  N  G  Y  G  H  W  I  A  S  T         p.460

          .         .         .    | 14    .         .         .    g.54613
 TCAGGCTCAAGGAGCAGTATCAATTCTGTTGAT | GGTGAATCTCCTAATGGCTCAAGTGAT    c.1440
 S  G  S  R  S  S  I  N  S  V  D   | G  E  S  P  N  G  S  S  D      p.480

          .         .         .         .         .         .       g.54673
 AGAGGAATGAAATCACTAGTAAATAAAATGACTGTGGCTTTGAAGACAAAATCCGTTAAT       c.1500
 R  G  M  K  S  L  V  N  K  M  T  V  A  L  K  T  K  S  V  N         p.500

          .         .         .         .         .    | 15    .    g.56023
 GTCAGGGAAAAAGTTATCAGTTTTATAGAGAATACATCAACTCCTGTGGATCG | AATGTCT    c.1560
 V  R  E  K  V  I  S  F  I  E  N  T  S  T  P  V  D  R  |  M  S      p.520

          .         .         .         | 16         .         .    g.60304
 TTCAATCTTCCTTGGCCAGACAGATCATGTACAGAGCG | GCATGTGAGCAGCAGTGACAGA    c.1620
 F  N  L  P  W  P  D  R  S  C  T  E  R  |  H  V  S  S  S  D  R      p.540

          .         .         .         .         .         .       g.60364
 GTGGGCAAGCCTTACCGTGGCGTAAAGCCTGTTTTCAGCATTGGGGATGAAGAAGAATAC       c.1680
 V  G  K  P  Y  R  G  V  K  P  V  F  S  I  G  D  E  E  E  Y         p.560

         | 17.         .         .         .         .         .    g.63305
 GACACAG | ATGAAATTGACAGTTCTTCAATGTCAGATGATGATAGAAAAGAGGTTGTAAAC    c.1740
 D  T  D |   E  I  D  S  S  S  M  S  D  D  D  R  K  E  V  V  N      p.580

          .         .         .         .         .         .       g.63365
 ATTCAGACTTGGATAAACAAACCAGATGTCAAACATCATTTTCCTTGTAAAGAAGTAAAA       c.1800
 I  Q  T  W  I  N  K  P  D  V  K  H  H  F  P  C  K  E  V  K         p.600

          .         .    | 18    .         .         .         .    g.64997
 GAAAGTGGACACATGTTTCCCAG | TCATCTGTTGGTTACTGCAACACATATGTACTGTTTA    c.1860
 E  S  G  H  M  F  P  S  |  H  L  L  V  T  A  T  H  M  Y  C  L      p.620

          .         .         .         .         .         .       g.65057
 AGGGAGATTGTTTCACGGAAAGGATTGGCTTATATACAGTCTCGACAAGCGCTGAATTCT       c.1920
 R  E  I  V  S  R  K  G  L  A  Y  I  Q  S  R  Q  A  L  N  S         p.640

          .         .         .         .         .         .       g.65117
 GTAGTTAAAATTACATCCAAAAAAAAACATCCTGAACTCATTACCTTCAAGTATGGAAAT       c.1980
 V  V  K  I  T  S  K  K  K  H  P  E  L  I  T  F  K  Y  G  N         p.660

          .         .         .         | 19         .         .    g.67792
 AGCAGTGCTTCAGGAATAGAAATCTTGGCAATCGAAAG | GTATTTGATTCCAAATGCAGGG    c.2040
 S  S  A  S  G  I  E  I  L  A  I  E  R  |  Y  L  I  P  N  A  G      p.680

          .         .         .         .         .         .       g.67852
 GATGCAACTAAAGCCATAAAACAGCAGATCATGAAAGTTTTGGATGCTTTGGAAAGTTAA       c.2100
 D  A  T  K  A  I  K  Q  Q  I  M  K  V  L  D  A  L  E  S  X         p.699

          .         .         .         .         .         .       g.67912
 tataaaagaaaattatataaaaagaaattaagacaaccaagagaaacatggacatatacc       c.*60

          .         .         .         .         .         .       g.67972
 tcctgactgaatactaactggagacctttcatttgctcatggggctgcttaaatagcagg       c.*120

          .         .         .         .         .         .       g.68032
 tctaagaaagtgtaaattattataatcaatctgtggacagtaaactttttaaaaattttt       c.*180

          .         .         .         .         .         .       g.68092
 cttctgcattttggttttataaaatgatgtattataaaggtcagttattaaattactttg       c.*240

          .         .         .         .         .         .       g.68152
 aagtaactgaccctgtgcccttatggactaagtaagggtacagaatgcagttctgttttg       c.*300

          .         .         .         .         .         .       g.68212
 aagagctgttttaagggaacatgcatcactttcgggatcaaaaacaactgtacacataca       c.*360

          .         .         .         .         .         .       g.68272
 tatctgcagtgtcttcactgaaaattagagatagaattagttgaagagacttccttaatt       c.*420

          .         .         .         .         .         .       g.68332
 gctacattgttttactcactgagcaatatcagaaactaaaacatagattaataattcact       c.*480

          .         .         .         .         .         .       g.68392
 cactgtttctattcttcttaaaaagagtgaaatctttttaatggaatggttgaagattcc       c.*540

          .         .         .         .         .         .       g.68452
 tgccaactcaaaatacagtacagctagtaaaatgttgaaacatcagtttctaaatcacct       c.*600

          .         .         .         .         .         .       g.68512
 ttgctccattagctaattttttggacactaaatgcttcaaagataagaaacttcatccta       c.*660

          .         .         .         .         .         .       g.68572
 atgatttctaaagagcagttaaaagcattaaaataagtaggtaggctgttaagattaaaa       c.*720

          .         .         .         .         .         .       g.68632
 ttaacattttggggacagaattgtgtctgtaaaaatgtcattggttttattacaagcgga       c.*780

          .         .         .         .         .         .       g.68692
 ttattttattcatattttaaaacaaatgtttaagccacattgatttatcctcattgagga       c.*840

          .         .         .         .         .         .       g.68752
 ttatggtctgtgaccacagtaatatccacttatataaatgccaaataatcagagagctta       c.*900

          .         .         .         .         .         .       g.68812
 taaagtacaattgtttttgtcatcattttctgaatttctttctcttcttttggttttgtc       c.*960

          .         .         .         .         .         .       g.68872
 ctctcattgaagttccagtggtttgaaattagttttggacacattgtcttaatgtactga       c.*1020

          .         .         .         .         .         .       g.68932
 aaattgctctgctgtattttgcagcgttcttcatttaatttataatggtccatattagac       c.*1080

          .         .         .         .         .         .       g.68992
 acatttggtaagagaagtccaggaacacatttagggccatggaatagtattttgtaaaat       c.*1140

          .         .         .         .         .         .       g.69052
 ccatttgggaagttgcaatacccacaatctgacatgtcctaaaatgtaagggattatctc       c.*1200

          .         .         .         .         .         .       g.69112
 taaggggttgatgggagaaatatttagatgtaccctgttaacagccagtcattttgattt       c.*1260

          .         .         .         .         .         .       g.69172
 acttatggaaatcaagtgaataaaaggcaacataatttgggaaattttattctaatatct       c.*1320

          .         .         .         .         .         .       g.69232
 aataaaaacagtttgagtggttgaagacatctgcatgaaattgcacctaggtgcattact       c.*1380

          .         .         .         .         .         .       g.69292
 tgatataactctcccctaaaactgttgtaattgcattttttcccttttcttggcacccct       c.*1440

          .         .         .         .         .         .       g.69352
 ttagaaatgtactgaagtctcatttttcacccatttcagccatgggacatttttcataat       c.*1500

          .         .         .         .         .         .       g.69412
 attaatgtaaagatgtttgtgttactgtttataaattacaattgtaaataaattactagt       c.*1560

          .         .                                               g.69436
 ttgcccaaaactttgttcttaaag                                           c.*1584

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The TBC1 domain family, member 23 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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