TBC1 domain family, member 24 (TBC1D24) - coding DNA reference sequence

(used for variant description)

(last modified May 27, 2013)


This file was created to facilitate the description of sequence variants on transcript NM_001199107.1 in the TBC1D24 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_028170.1, covering TBC1D24 transcript NM_001199107.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5020
                                         gctgaggagaaagcggcgcg       c.-121

 .     | 02   .         .         .         .         .             g.25943
 cggag | ggtgtgagatggcagacaggtttgcaggaaaccctcagaaagggggctggaggat    c.-61

 .         .         .         .         .         .                g.26003
 ttagccactctgtcctccccttccggcagtccagggcctcctcccgagcacagcggcgct       c.-1

          .         .         .         .         .         .       g.26063
 ATGGACTCTCCAGGATACAACTGCTTCGTGGACAAAGACAAGATGGACGCTGCCATCCAG       c.60
 M  D  S  P  G  Y  N  C  F  V  D  K  D  K  M  D  A  A  I  Q         p.20

          .         .         .         .         .         .       g.26123
 GACCTGGGGCCCAAGGAGCTGAGCTGCACTGAACTGCAGGAACTGAAGCAGCTGGCGCGC       c.120
 D  L  G  P  K  E  L  S  C  T  E  L  Q  E  L  K  Q  L  A  R         p.40

          .         .         .         .         .         .       g.26183
 CAGGGCTACTGGGCCCAAAGCCACGCCCTGCGGGGAAAGGTGTACCAGCGCCTGATCCGG       c.180
 Q  G  Y  W  A  Q  S  H  A  L  R  G  K  V  Y  Q  R  L  I  R         p.60

          .         .         .         .         .         .       g.26243
 GACATTCCCTGCCGCACGGTCACGCCTGACGCCAGCGTGTACAGCGACATCGTGGGCAAG       c.240
 D  I  P  C  R  T  V  T  P  D  A  S  V  Y  S  D  I  V  G  K         p.80

          .         .         .         .         .         .       g.26303
 ATCGTGGGCAAGCACAGCAGCAGCTGCCTGCCGCTGCCCGAGTTCGTGGACAACACGCAG       c.300
 I  V  G  K  H  S  S  S  C  L  P  L  P  E  F  V  D  N  T  Q         p.100

          .         .         .         .         .         .       g.26363
 GTGCCCAGCTACTGCCTGAATGCACGCGGCGAGGGGGCCGTGCGCAAGATCCTCCTGTGC       c.360
 V  P  S  Y  C  L  N  A  R  G  E  G  A  V  R  K  I  L  L  C         p.120

          .         .         .         .         .         .       g.26423
 CTGGCCAACCAGTTCCCCGACATCTCCTTCTGCCCCGCCCTGCCGGCCGTGGTGGCCCTG       c.420
 L  A  N  Q  F  P  D  I  S  F  C  P  A  L  P  A  V  V  A  L         p.140

          .         .         .         .         .         .       g.26483
 CTGCTGCACTACAGCATCGACGAGGCCGAGTGCTTCGAGAAGGCCTGCCGCATCCTGGCC       c.480
 L  L  H  Y  S  I  D  E  A  E  C  F  E  K  A  C  R  I  L  A         p.160

          .         .         .         .         .         .       g.26543
 TGCAATGACCCCGGCAGGAGGCTGATCGACCAGAGCTTCCTGGCCTTTGAGTCGTCCTGC       c.540
 C  N  D  P  G  R  R  L  I  D  Q  S  F  L  A  F  E  S  S  C         p.180

          .         .         .         .         .         .       g.26603
 ATGACGTTTGGGGACCTGGTGAACAAGTACTGCCAGGCGGCCCACAAGCTGATGGTGGCC       c.600
 M  T  F  G  D  L  V  N  K  Y  C  Q  A  A  H  K  L  M  V  A         p.200

          .         .         .         .         .         .       g.26663
 GTGTCGGAGGATGTCCTGCAGGTCTATGCGGACTGGCAGCGCTGGCTGTTTGGGGAGCTG       c.660
 V  S  E  D  V  L  Q  V  Y  A  D  W  Q  R  W  L  F  G  E  L         p.220

          .         .         .         .         .         .       g.26723
 CCCCTCTGCTACTTCGCCCGGGTCTTTGACGTCTTCCTGGTGGAGGGCTACAAGGTGCTG       c.720
 P  L  C  Y  F  A  R  V  F  D  V  F  L  V  E  G  Y  K  V  L         p.240

          .         .         .         .         .         .       g.26783
 TACCGCGTGGCGCTGGCCATCCTCAAGTTCTTCCACAAGGTGAGGGCCGGGCAGCCGCTG       c.780
 Y  R  V  A  L  A  I  L  K  F  F  H  K  V  R  A  G  Q  P  L         p.260

          .         .         .         .         .         .       g.26843
 GAGTCGGACAGCGTGAAGCAGGACATCCGCACGTTCGTCAGAGACATCGCGAAGACGGTG       c.840
 E  S  D  S  V  K  Q  D  I  R  T  F  V  R  D  I  A  K  T  V         p.280

          .         .         .         .         .         .       g.26903
 TCCCCTGAGAAGCTGCTGGAGAAAGCGTTCGCCATCCGCCTCTTCTCCCGCAAGGAGATC       c.900
 S  P  E  K  L  L  E  K  A  F  A  I  R  L  F  S  R  K  E  I         p.300

          .         .         .         .         .         .       g.26963
 CAGCTCCTGCAGATGGCCAATGAGAAAGCCCTGAAGCAGAAGGGCATCACCGTGAAGCAG       c.960
 Q  L  L  Q  M  A  N  E  K  A  L  K  Q  K  G  I  T  V  K  Q         p.320

       | 03  .         .    | 04    .         .         .         . g.28129
 AAGAG | TGTGTCACTTTCTAAAAG | GCAGTTTGTACACTTGGCCGTCCATGCAGAGAACTTC c.1020
 K  S  |  V  S  L  S  K  R  |  Q  F  V  H  L  A  V  H  A  E  N  F   p.340

          .         .         .         .         .         .       g.28189
 CGCTCGGAGATCGTCAGCGTGAGGGAGATGAGAGACATCTGGTCCTGGGTCCCCGAGCGC       c.1080
 R  S  E  I  V  S  V  R  E  M  R  D  I  W  S  W  V  P  E  R         p.360

          .         .         .         .         .         .       g.28249
 TTTGCCCTGTGCCAGCCCCTTCTGCTGTTCTCCTCCCTGCAGCACGGGTACAGCCTGGCC       c.1140
 F  A  L  C  Q  P  L  L  L  F  S  S  L  Q  H  G  Y  S  L  A         p.380

    | 05     .         .         .         .         .         .    g.29269
 AG | GTTCTACTTCCAGTGTGAAGGACATGAGCCTACCCTCTTGCTCATCAAGACCACGCAG    c.1200
 R  |  F  Y  F  Q  C  E  G  H  E  P  T  L  L  L  I  K  T  T  Q      p.400

        | 06 .         .         .         .         .         .    g.29743
 AAGGAG | GTGTGTGGTGCTTACCTGTCCACAGACTGGAGTGAGAGAAATAAGTTTGGAGGC    c.1260
 K  E   | V  C  G  A  Y  L  S  T  D  W  S  E  R  N  K  F  G  G      p.420

          .         .         .         .   | 07     .         .    g.30140
 AAACTGGGCTTCTTTGGGACCGGAGAATGCTTTGTGTTTAGG | CTGCAGCCTGAGGTGCAG    c.1320
 K  L  G  F  F  G  T  G  E  C  F  V  F  R   | L  Q  P  E  V  Q      p.440

          .         .         .         .         .         .       g.30200
 CGCTACGAGTGGGTGGTGATCAAGCACCCCGAGCTGACCAAGCCCCCACCCTTGATGGCT       c.1380
 R  Y  E  W  V  V  I  K  H  P  E  L  T  K  P  P  P  L  M  A         p.460

          .         .         .         .         .         .       g.30260
 GCCGAGCCCACCGCCCCACTCAGCCACTCCGCCTCCTCAGACCCCGCTGACCGCCTCTCG       c.1440
 A  E  P  T  A  P  L  S  H  S  A  S  S  D  P  A  D  R  L  S         p.480

          .         .         .         .         .         .       g.30320
 CCCTTCCTGGCCGCTCGCCACTTCAACCTGCCCTCCAAGACCGAGTCCATGTTCATGGCG       c.1500
 P  F  L  A  A  R  H  F  N  L  P  S  K  T  E  S  M  F  M  A         p.500

          .         .      | 08  .         .         .         .    g.30693
 GGGGGCAGCGACTGCCTCATCGTCG | GGGGAGGAGGCGGCCAGGCGCTCTACATCGATGGG    c.1560
 G  G  S  D  C  L  I  V  G |   G  G  G  G  Q  A  L  Y  I  D  G      p.520

          .         .         .         .         .         .       g.30753
 GACCTGAACCGGGGCCGCACAAGCCACTGCGACACCTTCAACAACCAGCCCCTCTGCTCC       c.1620
 D  L  N  R  G  R  T  S  H  C  D  T  F  N  N  Q  P  L  C  S         p.540

          .         .         .         .         .         .       g.30813
 GAGAACTTCCTCATTGCTGCCGTGGAGGCCTGGGGCTTCCAGGACCCTGACACCCAGTGA       c.1680
 E  N  F  L  I  A  A  V  E  A  W  G  F  Q  D  P  D  T  Q  X         p.559

          .         .         .         .         .         .       g.30873
 cggcctgtgccacggtgactgagccgtggtggggcggtgggccgaggctgggctgccgcc       c.*60

          .         .         .         .         .         .       g.30933
 tcgggcagcagagagcagatgaaacccccatgtggtaggcagggttgggggacggcagga       c.*120

          .         .         .         .         .         .       g.30993
 ccccatggccaagcctggcgttgcctggacctgctgctgcctctacctggggtttgggct       c.*180

          .         .         .         .         .         .       g.31053
 gggcttccccagtccacctgcatctgggtcagagctggagggcctgctgtgcccccagcc       c.*240

          .         .         .         .         .         .       g.31113
 ccacccagagctggcataggaagtaccttcctcctccgtggaggcttccatagcccaagg       c.*300

          .         .         .         .         .         .       g.31173
 ccttgggagtgtctgggtcttgctgcccctgagcctctctaggcagcctgagcccctggg       c.*360

          .         .         .         .         .         .       g.31233
 gtgggagtacaacggcagtgggaacgtgcagctaagggtgggcctgtggtgccccctgct       c.*420

          .         .         .         .         .         .       g.31293
 ggtgccgcatagcatcgcgccctcctgagcagggccctgcagcctggctggctggcgact       c.*480

          .         .         .         .         .         .       g.31353
 gaatcccagcgtagatcccgagaacagactggcacccttgggcctgccccctggcggacc       c.*540

          .         .         .         .         .         .       g.31413
 ccaccccctgtcctgggcgtttgccccagttccctccccaggcctcctgggccacctctc       c.*600

          .         .         .         .         .         .       g.31473
 acattaacccttcttggctgcctctgaggctcccctgggctgcgtttgggagctgctggg       c.*660

          .         .         .         .         .         .       g.31533
 tgggaggaggagggtgggatttgtgctgggctccacccccagggagggtgggagctggag       c.*720

          .         .         .         .         .         .       g.31593
 ggggatgtcacatgtccttgtgtttctgcagagcctgaagcttttgctgggcctccctgc       c.*780

          .         .         .         .         .         .       g.31653
 gtgttcccatctgaagaggtagccccgggagaggccctcagggaccgacccagaccagca       c.*840

          .         .         .         .         .         .       g.31713
 agctccatttccaggggtctgcccagagaagcctggacccagggggcttctcagctcccc       c.*900

          .         .         .         .         .         .       g.31773
 tcccttccagcccaggcctccttgagctcctgtagcctctgcagctgcccatttcacctc       c.*960

          .         .         .         .         .         .       g.31833
 tttgtcattgcaatgacctggggcccagggtcacgcccaagcccctctttgtggcatgct       c.*1020

          .         .         .         .         .         .       g.31893
 catctcagtgcagccccaactgcttctctgcaccaggccccgtgccctcccctggccctg       c.*1080

          .         .         .         .         .         .       g.31953
 gccacacagcacctccttggccaccttgcatggatgcatgtcctccctctgtccctcttg       c.*1140

          .         .         .         .         .         .       g.32013
 tggtgctgtggctggccacgtgtcagggttttctgtgagcctctcaccttacagcctttg       c.*1200

          .         .         .         .         .         .       g.32073
 ggcccctgggcccctgccctgcctgagccctgcgctggccagacgcaggtaggtgccagg       c.*1260

          .         .         .         .         .         .       g.32133
 ggaggccttgcctctgggcactatagggggcagccccctgccttgtgacctccctccatg       c.*1320

          .         .         .         .         .         .       g.32193
 ccccatgacctccttcaactcgtcttgagggtctggtcaccacggaggggagaagggaga       c.*1380

          .         .         .         .         .         .       g.32253
 cacagaggcccaagtggctgttctgggaccatggaagcctgggtcacagaggcaggtacc       c.*1440

          .         .         .         .         .         .       g.32313
 agcagtcctgcccccacccccgtccctgctggcctccagccagtgccacttggagtcccc       c.*1500

          .         .         .         .         .         .       g.32373
 tgcaccgtgccactttccatccccacaccattgcctgctcctcccatggggctttagcct       c.*1560

          .         .         .         .         .         .       g.32433
 cccctgaccatctgctcatgtagcctctgactgggcgcacagtggtgcaggaggaaggac       c.*1620

          .         .         .         .         .         .       g.32493
 cgggaaccctgtgtggctttgggcaagctgacaaacccgtctggaactcagtttccccag       c.*1680

          .         .         .         .         .         .       g.32553
 ctgtgaaatggggccagtccccatgccctgctgtcctcctcacaggactgttgagaggct       c.*1740

          .         .         .         .         .         .       g.32613
 cgcagggggatggggtgaatccctctcacggggagaggtatgggagggaagtcgccactc       c.*1800

          .         .         .         .         .         .       g.32673
 atctcagcccaccgcagccctccaggcccccgcctgagcccctgaggccctcatctgtac       c.*1860

          .         .         .         .         .         .       g.32733
 cgccagctttggtgttcattaaacatggtcttgctgcatcaactccagggctccaagctg       c.*1920

          .         .         .         .         .         .       g.32793
 agtctgatctcttcagccagaggggcctccgggggcttcctgggcctacagccaagcagg       c.*1980

          .         .         .         .         .         .       g.32853
 tgtgggaggctgcccgctgtagtgctcacccacattctatgactggaatgctgcaagcct       c.*2040

          .         .         .         .         .         .       g.32913
 cttccagagggagccctccaggagcagggaagtcatatccgtggaccatttgtaggtttc       c.*2100

          .         .         .         .         .         .       g.32973
 cctctgcaaacttcctgaactgggtggtgatttttctggcgagttaagtccagcaggttc       c.*2160

          .         .         .         .         .         .       g.33033
 tgcgtggctgcccccagggggccccacccgggccttccagtgatctggaccaggaagacg       c.*2220

          .         .         .         .         .         .       g.33093
 gattgctgctgggtcatgatttccacatcatgagcgaagttctttgttttttgtgtgcat       c.*2280

          .         .         .         .         .         .       g.33153
 gcaaaatattgtttctttaaatttaatatcttttcctaacttttctactaacctagaagg       c.*2340

          .         .         .         .         .         .       g.33213
 tatgtgtgattattatcttttttattcttatcactgtacttgttagtatctgatattagg       c.*2400

          .         .         .         .         .         .       g.33273
 tattcccaaatagaacataatttattttgttaatgttctctatttcttcttgattattta       c.*2460

          .         .         .         .         .         .       g.33333
 ttagctttggatgttaaaaattagccaaaagtggctgctctgcctatgaagtagccattc       c.*2520

          .         .         .         .         .         .       g.33393
 tttgtttaaaaaaaaaaaaagccaacatttgttgaaactgcataataaattatcatttgt       c.*2580

          .         .         .         .         .         .       g.33453
 ttttagaaacattcaaagaattattttttgattttttttttttttgggacagagtcaccc       c.*2640

          .         .         .         .         .         .       g.33513
 aggctggagtgcagtggcatgatcttggctcactgcaacctccgcctcctgggttcaagc       c.*2700

          .         .         .         .         .         .       g.33573
 gattctcctgcctcagcctcctgagtagctgggattacaggcatacgccaccacgcccag       c.*2760

          .         .         .         .         .         .       g.33633
 ctaaattttttttgtatttttagtagaggcagggtttcactgtgttggtcaggctggtct       c.*2820

          .         .         .         .         .         .       g.33693
 tgaactcctgacctcgtgatccacccccccctcagcctcccaaagtgctgggattacagg       c.*2880

          .         .         .         .         .         .       g.33753
 cgtgagccaccgcgcctagcctattttttaatttttttgaatagaccactttgtgctgaa       c.*2940

          .         .         .         .         .         .       g.33813
 taaatgtttaacatttatttttaaaacaacaattgcacctaatttaaaatagtttattaa       c.*3000

          .         .         .         .         .         .       g.33873
 atgaattcattaaagcagattatatgcctttggggcttcagaaaatcagtttaagcaaaa       c.*3060

          .         .         .         .         .         .       g.33933
 gaacttatgagagtaagtcatttgtacttgaattttttcagagttttaatgaactaaagt       c.*3120

          .         .         .         .         .         .       g.33993
 attttaatttttctatttttgtaagccgcatacttcattttttgagtttttcagtggaat       c.*3180

          .         .         .         .         .         .       g.34053
 ttgttttaaaacgttttgaagatttcagaggccttcatatttctcttatccactttctga       c.*3240

          .         .         .         .         .         .       g.34113
 acccataaagcctttgcagtctccttgagtagtttatatttagtaatttagttgtgtacc       c.*3300

          .         .         .         .         .         .       g.34173
 tttttattttgaagtaatttttgatttgcagaagagttgcagagacggtacagggtttcc       c.*3360

          .         .         .         .         .         .       g.34233
 atgtaccctcaccttcccccaagtcaatatcaaaacaaagaaataagcattgttgcattg       c.*3420

          .         .         .         .         .         .       g.34293
 ctgttaactaaaccacaggcctattgagattgtcccttttttttttttttttttttttga       c.*3480

          .         .         .         .         .         .       g.34353
 gacagagtctcgctctgtcgcccaggctggagtgcagtggcgcgatctcggctcaccgca       c.*3540

          .         .         .         .         .         .       g.34413
 agccccgcctcccggattcacgccattctcctgcctcagcctcctgagtagctgggacta       c.*3600

          .         .         .         .         .         .       g.34473
 caggcacctgctaccacacccggctaatttttttatatttttagtagagatggggtttca       c.*3660

          .         .         .         .         .         .       g.34533
 ccgtgttagccaggatggtcttgatctcctgacctcgtgatctgccctcctcggcctccc       c.*3720

          .         .         .         .         .         .       g.34593
 aaagtgctgggattacaggcgtgagcaaccgcgcccagccgagattgccccgtttttttc       c.*3780

          .         .         .         .         .         .       g.34653
 ccactgtccaggaatcgatttaatttttacagttgtttactttctcacatttttactaag       c.*3840

          .         .         .         .         .         .       g.34713
 tccagaatatcatcaaactcacaaaaccactggtcaaaaaaacccaaatggccactaatt       c.*3900

          .         .         .         .         .         .       g.34773
 aggcaatacagcacctgcctcaaatttgggttcatatagatttttttcctccctttttgt       c.*3960

          .         .         .         .         .         .       g.34833
 ggagaacatagtcttgctgtgttgcccaggctagtcttgaactcctggactcaagcaatc       c.*4020

          .         .         .         .         .         .       g.34893
 ctcccgcctctgcctccctaaattctgggattacaggcgtgagctgctgtgcccagctca       c.*4080

          .         .         .         .         .         .       g.34953
 tccagattcttgctggttctctttctcagcctaaatgtcttgtttgcgtggagaaattat       c.*4140

          .         .         .         .         .         .       g.35013
 caaatgaagcaggagtgccaaacaagcctcataggctcttcaccctacaacatctatgtt       c.*4200

          .         .         .         .         .         .       g.35073
 aggtagaaaagtatgtggatttttaaaaatcatctggtataaagagtttttaagaactat       c.*4260

          .         .         .         .         .         .       g.35133
 cttcatcatcttagtatcagattgtgcttgagaagttaggtacaatgtaatgtgattcat       c.*4320

          .         .         .         .         .         .       g.35193
 tgctaaaaacaaaatgcctcccacaattgcagactcactcattttaccaaactatggaat       c.*4380

          .         .         .         .         .         .       g.35253
 ttgtcaacaccttttcttgggaccaaggaagcaaagtcagtggataccgtgtcctgtaga       c.*4440

          .         .         .         .         .         .       g.35313
 catgtcacttgtgataaggcacggacaacatgaactggcaaaaacattggcatttggtca       c.*4500

          .         .         .         .         .         .       g.35373
 aatgcttatgagctaaggatagaagggaaaaaatagttgtgtgaatgattttacctctta       c.*4560

          .         .         .         .         .         .       g.35433
 gttcttacgaaggatggttatcgggctggaaaaatgtttattggactgatgctttggagc       c.*4620

          .         .         .         .         .         .       g.35493
 ctctcaatgaatgtaataaaaaaaatgtgtagtgagcacaaatgtatggatttgcagcac       c.*4680

          .         .         .         .         .         .       g.35553
 aatccaactttgaaaatgtgaaaataagtgagttagtgatatgtttggttggtgttaatt       c.*4740

          .         .         .                                     g.35588
 tgagtcctaaataaaatcgagaactggtaaaagaa                                c.*4775

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The TBC1 domain family, member 24 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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