tubulin folding cofactor D (TBCD) - coding DNA reference sequence

(used for variant description)

(last modified November 28, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_005993.4 in the TBCD gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011721.1, covering TBCD transcript NM_005993.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5010
                                                   ggccagcgtc       c.-121

 .         .         .         .         .         .                g.5070
 ggttgccgccttagcgggcgcctccttttcatccctcatccttcatccctggctttcgcg       c.-61

 .         .         .         .         .         .                g.5130
 ctctagcggagtgggatctgcgaacacgtgaggcgggggcgcggtccccaggctgccgag       c.-1

          .         .         .         .         .         .       g.5190
 ATGGCCCTGAGCGACGAACCGGCCGCGGGCGGCCCCGAGGAGGAGGCGGAGGACGAGACA       c.60
 M  A  L  S  D  E  P  A  A  G  G  P  E  E  E  A  E  D  E  T         p.20

          .         .         .         .         .         .       g.5250
 CTGGCCTTTGGCGCGGCGCTGGAAGCGTTCGGCGAGAGCGCGGAGACCCGGGCGCTGCTG       c.120
 L  A  F  G  A  A  L  E  A  F  G  E  S  A  E  T  R  A  L  L         p.40

          .         .         .         .         .         .       g.5310
 GGCCGCCTGCGGGAGGTGCACGGCGGCGGCGCGGAGCGCGAGGTGGCCCTGGAGCGGTTC       c.180
 G  R  L  R  E  V  H  G  G  G  A  E  R  E  V  A  L  E  R  F         p.60

      | 02   .         .         .         .         .      | 03  . g.16906
 CGCG | TAATAATGGACAAATACCAGGAGCAGCCTCATCTGTTGGACCCGCACCTTG | AATGG c.240
 R  V |   I  M  D  K  Y  Q  E  Q  P  H  L  L  D  P  H  L  E |   W   p.80

          .         .         .         .         .         .       g.16966
 ATGATGAACTTGTTGTTGGACATAGTGCAAGATCAGACATCTCCAGCTTCCCTTGTACAT       c.300
 M  M  N  L  L  L  D  I  V  Q  D  Q  T  S  P  A  S  L  V  H         p.100

          .         .         .    | 04    .         .         .    g.19230
 CTGGCTTTTAAATTTCTTTACATCATCACCAAG | GTTCGAGGCTATAAAACATTTCTTCGT    c.360
 L  A  F  K  F  L  Y  I  I  T  K   | V  R  G  Y  K  T  F  L  R      p.120

          .         .         .         .         .         .       g.19290
 TTATTTCCTCATGAAGTTGCCGATGTAGAGCCTGTTTTAGATTTGGTCACAATTCAGAAT       c.420
 L  F  P  H  E  V  A  D  V  E  P  V  L  D  L  V  T  I  Q  N         p.140

          .      | 05  .         .         .         .         .    g.21401
 CCCAAGGACCATGAA | GCTTGGGAAACCCGCTACATGCTTTTGCTCTGGCTCTCCGTGACC    c.480
 P  K  D  H  E   | A  W  E  T  R  Y  M  L  L  L  W  L  S  V  T      p.160

          .         .         .         .         .         .       g.21461
 TGCCTGATCCCTTTTGATTTTTCTCGCCTTGACGGGAACCTCCTCACCCAGCCTGGGCAA       c.540
 C  L  I  P  F  D  F  S  R  L  D  G  N  L  L  T  Q  P  G  Q         p.180

          .         .         .         .   | 06     .         .    g.25406
 GCACGAATGTCCATAATGGACCGTATTCTCCAAATAGCAGAG | TCCTACTTGATTGTCAGT    c.600
 A  R  M  S  I  M  D  R  I  L  Q  I  A  E   | S  Y  L  I  V  S      p.200

          .         .         .         | 07         .         .    g.34547
 GACAAGGCCCGAGATGCAGCTGCTGTCCTTGTGTCCAG | ATTTATCACACGTCCTGATGTC    c.660
 D  K  A  R  D  A  A  A  V  L  V  S  R  |  F  I  T  R  P  D  V      p.220

          .         .         .         .         .         .       g.34607
 AAGCAAAGCAAGATGGCTGAGTTCCTGGACTGGAGCCTGTGCAATCTGGCCCGTTCCTCC       c.720
 K  Q  S  K  M  A  E  F  L  D  W  S  L  C  N  L  A  R  S  S         p.240

          .         .         .         .         .  | 08      .    g.50702
 TTCCAGACCATGCAGGGGGTCATCACCATGGATGGGACGCTGCAGGCCCTG | GCACAAATA    c.780
 F  Q  T  M  Q  G  V  I  T  M  D  G  T  L  Q  A  L   | A  Q  I      p.260

          .         .         .        | 09.         .         .    g.53823
 TTTAAACATGGAAAACGTGAAGACTGTTTGCCCTATG | CTGCCACTGTCCTCAGGTGCCTC    c.840
 F  K  H  G  K  R  E  D  C  L  P  Y  A |   A  T  V  L  R  C  L      p.280

          .         .         .         .         .         .       g.53883
 GATGGCTGCAGACTCCCTGAGAGCAACCAGACCCTGCTGCGGAAGCTGGGGGTGAAGCTT       c.900
 D  G  C  R  L  P  E  S  N  Q  T  L  L  R  K  L  G  V  K  L         p.300

          .         .         .         .         . | 10       .    g.58821
 GTGCAGCGACTGGGGCTGACATTCCTGAAGCCGAAGGTGGCAGCATGGAG | GTACCAGCGT    c.960
 V  Q  R  L  G  L  T  F  L  K  P  K  V  A  A  W  R  |  Y  Q  R      p.320

          .         .         .         .         .         .       g.58881
 GGCTGCCGATCTTTGGCTGCAAATCTGCAGCTCCTCACTCAGGGTCAGAGTGAGCAGAAG       c.1020
 G  C  R  S  L  A  A  N  L  Q  L  L  T  Q  G  Q  S  E  Q  K         p.340

          .         .         .         .         .         .       g.58941
 CCACTCATCCTGACCGAAGATGACGACGAAGATGACGACGTCCCAGAGGGGGTGGAGCGT       c.1080
 P  L  I  L  T  E  D  D  D  E  D  D  D  V  P  E  G  V  E  R         p.360

         | 11.         .         .         .         .         .    g.60597
 GTGATAG | AGCAGCTGCTGGTCGGGCTGAAGGACAAGGACACGGTCGTGCGGTGGTCTGCA    c.1140
 V  I  E |   Q  L  L  V  G  L  K  D  K  D  T  V  V  R  W  S  A      p.380

          | 12         .         .         .         .         .    g.62696
 GCCAAGGG | CATCGGTAGGATGGCTGGCAGGCTTCCCAGAGCCCTGGCGGATGATGTGGTC    c.1200
 A  K  G  |  I  G  R  M  A  G  R  L  P  R  A  L  A  D  D  V  V      p.400

          .         .    | 13    .         .         .         .    g.67813
 GGGTCTGTGCTGGACTGCTTCAG | TTTCCAGGAGACTGACAAGGCGTGGCATGGGGGATGT    c.1260
 G  S  V  L  D  C  F  S  |  F  Q  E  T  D  K  A  W  H  G  G  C      p.420

          .         .         .         .         .         | 14    g.123162
 CTGGCGCTGGCAGAGCTGGGCAGGAGAGGCCTGTTGCTGCCGTCTCGACTCGTGGATG | TT    c.1320
 L  A  L  A  E  L  G  R  R  G  L  L  L  P  S  R  L  V  D  V |       p.440

          .         .         .         .         .         .       g.123222
 GTCGCCGTGATCCTGAAGGCGCTGACCTACGACGAGAAGCGGGGTGCCTGCAGCGTGGGC       c.1380
 V  A  V  I  L  K  A  L  T  Y  D  E  K  R  G  A  C  S  V  G         p.460

          .         .         .         .         .         .       g.123282
 ACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGCCT       c.1440
 T  N  V  R  D  A  A  C  Y  V  C  W  A  F  A  R  A  Y  E  P         p.480

          .         .         .      | 15  .         .         .    g.137106
 CAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAG | TGCACTGGTGATTGCTGCGGTGTTT    c.1500
 Q  E  L  K  P  F  V  T  A  I  S  S  |  A  L  V  I  A  A  V  F      p.500

          .         .         .    | 16    .         .         .    g.142631
 GACCGAGACATAAACTGCAGAAGAGCAGCCTCT | GCCGCCTTCCAGGAGAATGTGGGGAGA    c.1560
 D  R  D  I  N  C  R  R  A  A  S   | A  A  F  Q  E  N  V  G  R      p.520

     | 17    .         .         .         .         .         .    g.146540
 CAG | GGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGTCGGT    c.1620
 Q   | G  T  F  P  H  G  I  D  I  L  T  T  A  D  Y  F  A  V  G      p.540

          .         .          | 18        .         .         .    g.153618
 AACAGATCCAACTGTTTCCTGGTTATAAG | TGTGTTTATTGCCGGCTTTCCTGAGTACACG    c.1680
 N  R  S  N  C  F  L  V  I  S  |  V  F  I  A  G  F  P  E  Y  T      p.560

          .         .         .         .         . | 19       .    g.156351
 CAGCCAATGATAGACCACCTGGTTACCATGAAGATCAGCCACTGGGATGG | GGTCATCCGA    c.1740
 Q  P  M  I  D  H  L  V  T  M  K  I  S  H  W  D  G  |  V  I  R      p.580

          .         .         .         .         .         .       g.156411
 GAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCACG       c.1800
 E  L  A  A  R  A  L  H  N  L  A  Q  Q  A  P  E  F  S  A  T         p.600

      | 20   .         .         .         .         .         .    g.158928
 CAAG | TCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGG    c.1860
 Q  V |   F  P  R  L  L  S  M  T  L  S  P  D  L  H  M  R  H  G      p.620

          .         .         .         .         .         .       g.158988
 TCGATTCTCGCCTGCGCAGAAGTTGCTTACGCCTTGTACAAACTTGCAGCCCAAGAGAAC       c.1920
 S  I  L  A  C  A  E  V  A  Y  A  L  Y  K  L  A  A  Q  E  N         p.640

    | 21     .         .         .         .         .         .    g.160755
 AG | GCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACCAG    c.1980
 R  |  P  V  T  D  H  L  D  E  Q  A  V  Q  G  L  K  Q  I  H  Q      p.660

     | 22    .         .       | 23 .         .         .         | 24 g.173494
 CAG | CTCTATGATCGTCAGTTATACAG | GGGTCTGGGAGGACAGCTCATGAGACAAGCAG | TG c.2040
 Q   | L  Y  D  R  Q  L  Y  R  |  G  L  G  G  Q  L  M  R  Q  A  V |    p.680

          .         .         .         .         .         .       g.173554
 TGTGTTTTAATAGAAAAGTTGTCACTTTCCAAAATGCCCTTTAGAGGTGACACCGTAATT       c.2100
 C  V  L  I  E  K  L  S  L  S  K  M  P  F  R  G  D  T  V  I         p.700

   | 25      .         .         .         .         .         .    g.174496
 G | ATGGTTGGCAATGGCTGATAAATGACACTTTGAGACATCTCCATCTCATCTCAAGTCAC    c.2160
 D |   G  W  Q  W  L  I  N  D  T  L  R  H  L  H  L  I  S  S  H      p.720

          .         | 26         .         .         .         .    g.176630
 TCCCGCCAGCAGATGAAG | GATGCAGCAGTCTCGGCCCTGGCTGCTCTATGCAGTGAATAT    c.2220
 S  R  Q  Q  M  K   | D  A  A  V  S  A  L  A  A  L  C  S  E  Y      p.740

          .         .         .         . | 27       .         .    g.177895
 TACATGAAGGAGCCGGGGGAGGCAGATCCCGCAATTCAGG | AGGAGCTGATCACGCAGTAC    c.2280
 Y  M  K  E  P  G  E  A  D  P  A  I  Q  E |   E  L  I  T  Q  Y      p.760

          .         .         .         .         .         .       g.177955
 CTGGCTGAGCTTCGGAACCCCGAGGAGATGACTCGCTGTGGCTTCTCGTTGGCCTTGGGC       c.2340
 L  A  E  L  R  N  P  E  E  M  T  R  C  G  F  S  L  A  L  G         p.780

          .         .         .          | 28        .         .    g.179357
 GCCCTTCCAGGCTTCCTTCTGAAAGGCCGGCTCCAGCAG | GTTCTCACAGGTTTAAGAGCA    c.2400
 A  L  P  G  F  L  L  K  G  R  L  Q  Q   | V  L  T  G  L  R  A      p.800

          .         .         .         .         .         .       g.179417
 GTTACCCACACTTCCCCCGAGGACGTAAGTTTTGCTGAGTCCAGGAGAGACGGCTTGAAG       c.2460
 V  T  H  T  S  P  E  D  V  S  F  A  E  S  R  R  D  G  L  K         p.820

          .  | 29      .         .         .         .         .    g.180171
 GCCATTGCGAG | GATTTGCCAGACTGTTGGTGTGAAAGCAGGAGCCCCAGACGAAGCTGTG    c.2520
 A  I  A  R  |  I  C  Q  T  V  G  V  K  A  G  A  P  D  E  A  V      p.840

          .         .         .         .         .         .       g.180231
 TGCGGAGAGAATGTTTCCCAGATTTACTGTGCGCTGCTGGGCTGCATGGACGACTACACC       c.2580
 C  G  E  N  V  S  Q  I  Y  C  A  L  L  G  C  M  D  D  Y  T         p.860

          .         .          | 30        .         .         .    g.180872
 ACGGACAGCAGAGGGGACGTGGGCACCTG | GGTCCGCAAGGCCGCCATGACCAGTCTGATG    c.2640
 T  D  S  R  G  D  V  G  T  W  |  V  R  K  A  A  M  T  S  L  M      p.880

          .         .         .         .         .    | 31    .    g.182056
 GATCTGACACTTCTGCTGGCTCGGAGCCAGCCTGAGCTGATCGAGGCCCATAC | CTGTGAG    c.2700
 D  L  T  L  L  L  A  R  S  Q  P  E  L  I  E  A  H  T  |  C  E      p.900

          .         .         .         .         .         .       g.182116
 CGCATCATGTGCTGTGTGGCCCAGCAGGCCAGTGAGAAGATTGACCGTTTCCGTGCTCAC       c.2760
 R  I  M  C  C  V  A  Q  Q  A  S  E  K  I  D  R  F  R  A  H         p.920

          .         .         .         .         .         .       g.182176
 GCCGCCAGCGTGTTCCTGACGCTCCTGCACTTTGACAGCCCTCCCATCCCCCACGTGCCC       c.2820
 A  A  S  V  F  L  T  L  L  H  F  D  S  P  P  I  P  H  V  P         p.940

          .         .         .   | 32     .         .         .    g.182326
 CACCGAGGAGAACTGGAAAAGCTGTTTCCCAG | GTCCGATGTGGCCTCCGTGAACTGGAGT    c.2880
 H  R  G  E  L  E  K  L  F  P  R  |  S  D  V  A  S  V  N  W  S      p.960

          .         .         .         .         .         .       g.182386
 GCACCTTCCCAGGCCTTCCCACGCATCACCCAGCTCCTTGGGCTGCCCACCTACCGCTAC       c.2940
 A  P  S  Q  A  F  P  R  I  T  Q  L  L  G  L  P  T  Y  R  Y         p.980

          .         .         .         .         .  | 33      .    g.183467
 CACGTCCTGCTGGGGCTAGTCGTGTCCCTGGGCGGCTTGACGGAGTCGACG | ATCCGGCAC    c.3000
 H  V  L  L  G  L  V  V  S  L  G  G  L  T  E  S  T   | I  R  H      p.1000

          .         .         .         .         .         .       g.183527
 TCCACCCAGAGCCTCTTTGAGTACATGAAGGGCATTCAGAGCGACCCGCAGGCCCTGGGC       c.3060
 S  T  Q  S  L  F  E  Y  M  K  G  I  Q  S  D  P  Q  A  L  G         p.1020

          .         .         .         .         .    | 34    .    g.185601
 AGCTTCAGCGGGACCCTTCTGCAGATCTTTGAGGACAACCTTCTGAATGAGAG | GGTGTCC    c.3120
 S  F  S  G  T  L  L  Q  I  F  E  D  N  L  L  N  E  R  |  V  S      p.1040

          .         .         .         .         .         .       g.185661
 GTGCCGCTGCTGAAGACGCTGGACCACGTGCTCACCCACGGCTGCTTCGACATCTTCACC       c.3180
 V  P  L  L  K  T  L  D  H  V  L  T  H  G  C  F  D  I  F  T         p.1060

          .  | 35      .         .         .         .         .    g.190256
 ACGGAGGAGGA | CCACCCCTTTGCTGTGAAGTTGCTTGCGCTCTGTAAGAAAGAAATCAAG    c.3240
 T  E  E  D  |  H  P  F  A  V  K  L  L  A  L  C  K  K  E  I  K      p.1080

          .         .         .         .  | 36      .         .    g.191004
 AATTCAAAAGATATCCAGAAGCTCCTGTCAGGCATCGCAGT | GTTCTGCGAGATGGTGCAG    c.3300
 N  S  K  D  I  Q  K  L  L  S  G  I  A  V  |  F  C  E  M  V  Q      p.1100

          .         .         .         .         .         .       g.191064
 TTCCCCGGCGACGTGAGGAGGCAGGCCCTCCTGCAGCTGTGTCTGCTCCTCTGCCACCGT       c.3360
 F  P  G  D  V  R  R  Q  A  L  L  Q  L  C  L  L  L  C  H  R         p.1120

           | 37        .         .         .         .         .    g.192354
 TTCCCGCTG | ATCCGGAAGACCACGGCCAGCCAGGTGTACGAGACATTGCTCACCTACAGT    c.3420
 F  P  L   | I  R  K  T  T  A  S  Q  V  Y  E  T  L  L  T  Y  S      p.1140

          .         .         .         .         .          | 38    g.194336
 GACGTCGTGGGCGCGGATGTGCTGGACGAGGTGGTGACTGTGCTCAGTGACACTGCGTG | G    c.3480
 D  V  V  G  A  D  V  L  D  E  V  V  T  V  L  S  D  T  A  W  |      p.1160

          .         .         .         .         .         .       g.194396
 GACGCGGAGCTTGCAGTGGTGAGAGAGCAGCGCAACCGTCTGTGTGACCTTCTGGGCGTA       c.3540
 D  A  E  L  A  V  V  R  E  Q  R  N  R  L  C  D  L  L  G  V         p.1180

          .         .     | 39   .                                  g.195421
 CCCAGGCCCCAGCTGGTGCCCCAG | CCTGGTGCCTGCTGA                         c.3579
 P  R  P  Q  L  V  P  Q   | P  G  A  C  X                           p.1192

          .         .         .         .         .         .       g.195481
 agccagtcctggagcccatacctcacccctgcctggtgaggatgtcttgttcctgaggga       c.*60

          .         .         .         .         .         .       g.195541
 ggccggtgtggaaagcctcgcacagtggtgcctccagctgttgaagggtagcgctggccc       c.*120

          .         .         .         .         .         .       g.195601
 ttggaggctggcactagctgacagcttttcctctctgcacctgcgctctggtgacttggg       c.*180

          .         .         .         .         .         .       g.195661
 gtggacgcctctgccttcacttgaacacaaatgtgcttcctataaaatcatgtaccaaga       c.*240

          .         .         .         .         .         .       g.195721
 agttcctgccttttgtctctgagcctgatgtgtgtaggggtgatggaaaggctcactgcc       c.*300

          .         .         .         .         .         .       g.195781
 caggggtcagccagaggggaggtgggctgcactcctcctgcctggagaccaggccccctt       c.*360

          .         .         .         .         .         .       g.195841
 cttgcctggtgctgtccctgctgtgggagacgtctggccacaggcagtgccccacccagt       c.*420

          .         .         .         .         .         .       g.195901
 cttggagagagatgaatgttaaatcagaggttcaaatgctagagaactgagaagccctgg       c.*480

          .         .         .         .         .         .       g.195961
 tggcaggcatggtctggagtgctgggcagatgctgtttctgggcccgtctgcctggtggg       c.*540

          .         .         .         .         .         .       g.196021
 ggtgctgtcctcccccctgtgcacacgtgagcatcgtgcatgtggcccctctgcagtgca       c.*600

          .         .         .         .         .         .       g.196081
 ggagtcactgattgatgggtgtgccgaccagcagcttcacaaatgtctgctgcaagggga       c.*660

          .         .         .         .         .         .       g.196141
 atcgtcagagtccaatgtgtgcctctacagtaatgtcggaaataaataccattcttgaaa       c.*720

                                                                    g.196144
 taa                                                                c.*723

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Tubulin folding cofactor D protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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