transducin (beta)-like 1 X-linked receptor 1 (TBL1XR1) - coding DNA reference sequence

(used for variant description)

(last modified December 2, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_024665.4 in the TBL1XR1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_047195.1, covering TBL1XR1 transcript NM_024665.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5021
                                        ggggttataattgcctctcac       c.-241

 .         .         .         .         .         .                g.5081
 cccccggaggggttattttgggggtggttggaggcggtggcggcggcggcgaggagggga       c.-181

 .         .         .         .         .         .         | 02    g.103720
 atttccttgtgcctccattcccgggaggggggagcggcgttggaggccaccgtttccag | c    c.-121

 .         .         .         .         .         .                g.103780
 atcaacaacagcaacttgtgattggcggtgaccggatattcagttgcacatccccacatc       c.-61

 .         .     | 03   .         .         .         .             g.137283
 aatgcactgccaatg | ggttatatcctgtgttgtgacctcatggtttaagtgggaataaag    c.-1

          .         .         .         .         .         | 04    g.148344
 ATGAGTATAAGCAGTGATGAGGTCAACTTCTTGGTATATAGATACTTGCAAGAGTCAG | GA    c.60
 M  S  I  S  S  D  E  V  N  F  L  V  Y  R  Y  L  Q  E  S  G |       p.20

          .         .         .         .         .         .       g.148404
 TTTTCTCATTCAGCATTTACCTTTGGTATAGAAAGCCATATCAGTCAGTCCAATATAAAT       c.120
 F  S  H  S  A  F  T  F  G  I  E  S  H  I  S  Q  S  N  I  N         p.40

          .         .         .         .         .         .       g.148464
 GGTGCCCTCGTCCCACCCGCTGCATTGATTTCTATCATCCAGAAAGGTCTACAGTATGTA       c.180
 G  A  L  V  P  P  A  A  L  I  S  I  I  Q  K  G  L  Q  Y  V         p.60

          .         .     | 05   .         .         .         .    g.150570
 GAAGCAGAAGTTAGTATTAATGAG | GATGGTACCTTGTTTGATGGTCGACCAATAGAGTCT    c.240
 E  A  E  V  S  I  N  E   | D  G  T  L  F  D  G  R  P  I  E  S      p.80

          .         .         .         .         .         .       g.150630
 CTGTCCCTGATAGATGCCGTAATGCCTGATGTAGTACAAACAAGACAACAAGCTTATAGA       c.300
 L  S  L  I  D  A  V  M  P  D  V  V  Q  T  R  Q  Q  A  Y  R         p.100

          .         .         .         .         .         .       g.150690
 GATAAGCTTGCACAGCAACAGGCAGCAGCTGCTGCAGCTGCCGCAGCTGCAGCCAGCCAA       c.360
 D  K  L  A  Q  Q  Q  A  A  A  A  A  A  A  A  A  A  A  S  Q         p.120

          .         .         .         .         .         .       g.150750
 CAAGGATCTGCAAAAAATGGAGAAAACACAGCAAATGGGGAGGAGAATGGAGCACATACT       c.420
 Q  G  S  A  K  N  G  E  N  T  A  N  G  E  E  N  G  A  H  T         p.140

         | 06.         .         .         .         .         .    g.151703
 ATAGCAA | ATAATCATACTGATATGATGGAAGTGGATGGGGATGTTGAAATCCCTCCTAAT    c.480
 I  A  N |   N  H  T  D  M  M  E  V  D  G  D  V  E  I  P  P  N      p.160

          .         .         .         .         .         .       g.151763
 AAAGCTGTTGTGTTGCGGGGCCATGAATCTGAAGTTTTTATCTGTGCCTGGAACCCTGTT       c.540
 K  A  V  V  L  R  G  H  E  S  E  V  F  I  C  A  W  N  P  V         p.180

          .         . | 07       .         .         .         .    g.152162
 AGTGATCTCCTAGCATCAGG | GTCTGGAGACTCAACAGCAAGAATATGGAATCTTAGTGAG    c.600
 S  D  L  L  A  S  G  |  S  G  D  S  T  A  R  I  W  N  L  S  E      p.200

          .         .         .         .         .         .       g.152222
 AACAGCACCAGTGGCTCTACACAGTTAGTACTTAGACATTGTATACGAGAAGGAGGGCAA       c.660
 N  S  T  S  G  S  T  Q  L  V  L  R  H  C  I  R  E  G  G  Q         p.220

          .         .         .         .   | 08     .         .    g.154729
 GATGTTCCAAGCAACAAGGATGTCACATCTCTAGATTGGAAT | AGTGAAGGTACACTTCTA    c.720
 D  V  P  S  N  K  D  V  T  S  L  D  W  N   | S  E  G  T  L  L      p.240

          .         .         .         .       | 09 .         .    g.154877
 GCAACTGGTTCCTATGATGGGTTTGCCAGAATATGGACTAAAGATG | GTAACCTTGCTAGC    c.780
 A  T  G  S  Y  D  G  F  A  R  I  W  T  K  D  G |   N  L  A  S      p.260

          .         .         .         .         .         .       g.154937
 ACCTTAGGGCAGCATAAAGGCCCTATATTTGCATTAAAATGGAATAAGAAAGGAAATTTC       c.840
 T  L  G  Q  H  K  G  P  I  F  A  L  K  W  N  K  K  G  N  F         p.280

          .         .     | 10   .         .         .         .    g.156107
 ATCCTAAGTGCTGGAGTAGACAAG | ACTACAATTATTTGGGACGCACATACTGGTGAAGCC    c.900
 I  L  S  A  G  V  D  K   | T  T  I  I  W  D  A  H  T  G  E  A      p.300

          .         .      | 11  .         .         .         .    g.163861
 AAGCAACAGTTTCCTTTTCATTCAG | CACCAGCATTGGATGTTGATTGGCAGAGCAACAAC    c.960
 K  Q  Q  F  P  F  H  S  A |   P  A  L  D  V  D  W  Q  S  N  N      p.320

          .         .         .         .         .         .       g.163921
 ACCTTTGCTTCTTGTAGTACAGATATGTGCATTCATGTCTGTAAATTAGGACAAGACAGA       c.1020
 T  F  A  S  C  S  T  D  M  C  I  H  V  C  K  L  G  Q  D  R         p.340

          .         .        | 12.         .         .         .    g.164121
 CCTATTAAAACATTCCAAGGACATACG | AATGAAGTAAATGCTATCAAATGGGACCCAACT    c.1080
 P  I  K  T  F  Q  G  H  T   | N  E  V  N  A  I  K  W  D  P  T      p.360

          .         .         .         .   | 13     .         .    g.167953
 GGCAATCTCTTGGCCTCCTGTTCTGACGACATGACTTTAAAG | ATATGGAGTATGAAACAA    c.1140
 G  N  L  L  A  S  C  S  D  D  M  T  L  K   | I  W  S  M  K  Q      p.380

          .         .         .         .         .         .       g.168013
 GACAATTGTGTCCATGATTTGCAAGCACATAATAAAGAAATTTATACTATCAAATGGAGT       c.1200
 D  N  C  V  H  D  L  Q  A  H  N  K  E  I  Y  T  I  K  W  S         p.400

          .         .         .         .         . | 14       .    g.169134
 CCAACAGGACCAGGGACTAATAATCCAAATGCCAACCTTATGTTAGCAAG | TGCATCCTTT    c.1260
 P  T  G  P  G  T  N  N  P  N  A  N  L  M  L  A  S  |  A  S  F      p.420

          .         .         .         .         .         .       g.169194
 GATTCTACTGTTAGGTTATGGGATGTAGACCGAGGGATATGCATCCATACCTTGACAAAA       c.1320
 D  S  T  V  R  L  W  D  V  D  R  G  I  C  I  H  T  L  T  K         p.440

          .         .         .         .         .         .       g.169254
 CACCAAGAGCCTGTGTACAGTGTAGCTTTCAGTCCTGATGGCAGGTATCTGGCAAGTGGT       c.1380
 H  Q  E  P  V  Y  S  V  A  F  S  P  D  G  R  Y  L  A  S  G         p.460

          .         .         .       | 15 .         .         .    g.175810
 TCTTTTGACAAATGTGTACACATCTGGAACACGCAG | ACAGGTGCTCTAGTTCACAGCTAT    c.1440
 S  F  D  K  C  V  H  I  W  N  T  Q   | T  G  A  L  V  H  S  Y      p.480

          .         .         .         .         .         .       g.175870
 AGGGGAACAGGTGGAATATTTGAAGTTTGCTGGAATGCAGCAGGAGACAAAGTTGGAGCC       c.1500
 R  G  T  G  G  I  F  E  V  C  W  N  A  A  G  D  K  V  G  A         p.500

          .         | 16         .         .                        g.176778
 AGTGCATCAGATGGTTCA | GTTTGTGTATTAGACCTTCGGAAATAG                   c.1545
 S  A  S  D  G  S   | V  C  V  L  D  L  R  K  X                     p.514

          .         .         .         .         .         .       g.176838
 cgctactagttggaagccatggaccgactatgaatgtgtacatagccaaaatgactgtcc       c.*60

          .         .         .         .         .         .       g.176898
 ctgacccatgtactgctatagtcccacttgaaccatggccagtccactacagccaaatct       c.*120

          .         .         .         .         .         .       g.176958
 aaaagaaatatatacatacagtgtatataaacaaaattgcaccctgaagatgacagagtt       c.*180

          .         .         .         .         .         .       g.177018
 ttgtcacagcttgtgaattctgttcaccaagtgctggaatctaatctgctgtgcccctaa       c.*240

          .         .         .         .         .         .       g.177078
 aatagcatttagaagttttggatatgaaaaacagaagagagaaaaatatacattataaaa       c.*300

          .         .         .         .         .         .       g.177138
 gcagaacatacatgtaccagtttttggatactaaatgacagccttgtttctcccctttga       c.*360

          .         .         .         .         .         .       g.177198
 atcagcagacaccatggattatattctttttttcccttcagtagtgagcagtttgtatgt       c.*420

          .         .         .         .         .         .       g.177258
 acagagaaaatggacttacaaaaacttgcagcagtagtttgttcttgctttaaaatttcg       c.*480

          .         .         .         .         .         .       g.177318
 tttttggtttagattatggatgcatgaagtaagggagtgaatcagtttcttgtttatatt       c.*540

          .         .         .         .         .         .       g.177378
 tttttcaccttttaaacaaaaaattctttaaaatattttaatgcattcttttgaagaggt       c.*600

          .         .         .         .         .         .       g.177438
 agatgtttggtacattttatggctcccagagcatatattcagttggtgcatgttgtggaa       c.*660

          .         .         .         .         .         .       g.177498
 gggggaattggaaattaaatgaaaacctatgactttggtcatgtcaatctgtaagacaca       c.*720

          .         .         .         .         .         .       g.177558
 tcagtaaaagggtattatgctctgttggttttgtttttttgttttgcttttttttttttt       c.*780

          .         .         .         .         .         .       g.177618
 ttttcttttttgttttttggtgatgtggcttaaatgcaatagtttcttttttgggacata       c.*840

          .         .         .         .         .         .       g.177678
 tttctgccaattaaagactagaagggcacaactttttttttaattaccatagagaagata       c.*900

          .         .         .         .         .         .       g.177738
 cattaaaaaaaatcttctgatgttttgtagccataactaaattatggtaaaaatgtgcac       c.*960

          .         .         .         .         .         .       g.177798
 tattgtgaaaaggagcaacgtagttttgggttttttgttgtttgtttgttttgctttgtt       c.*1020

          .         .         .         .         .         .       g.177858
 ttttaagagattaaaatgtttctggataaggattagcttctcgaagtgtccatcattctg       c.*1080

          .         .         .         .         .         .       g.177918
 tgtagaagcttaaatatgtaatgtaaccaaactccagtattaaaaatctctcatgttgtt       c.*1140

          .         .         .         .         .         .       g.177978
 ttctttatacaaagcaagataacggcatataacactgccattacatggcaaaatgtttgc       c.*1200

          .         .         .         .         .         .       g.178038
 taccttagtttaaaaaacaatctcaaacaaaagacttgcttcaaggtgtttttaaatagc       c.*1260

          .         .         .         .         .         .       g.178098
 agtgattcagaattttttttaatgaaagtataattgcactaaccttcttcctgctgctct       c.*1320

          .         .         .         .         .         .       g.178158
 gattctgcatttgtggtacttgtgactacgttttttcaaatatagatagatttaagctgc       c.*1380

          .         .         .         .         .         .       g.178218
 taatttttttttttttagtaatcactactatatcatgtcttttactctgtttataatatc       c.*1440

          .         .         .         .         .         .       g.178278
 aagtattttcttaaagatatagatattaaaccttgtgctcatgcaacttagagtaacata       c.*1500

          .         .         .         .         .         .       g.178338
 tacagacaaatgattgcatgaggccatgtttatatgtgtgactaataaggcttgtcatga       c.*1560

          .         .         .         .         .         .       g.178398
 ttaacataatccaggtatgtcatttctgaagagaatagtcatcaaatttatatctcgaag       c.*1620

          .         .         .         .         .         .       g.178458
 attttaattaaggaattgcttattgttgagcttagcaaattaataacactatttctgtca       c.*1680

          .         .         .         .         .         .       g.178518
 ctaattattttgaggccttttagtactaaaattttaacctgtgttctaagtagaaactga       c.*1740

          .         .         .         .         .         .       g.178578
 tttaacccaagtaatgcagctttgattgatttcagcattcgttgctttgctatttttaca       c.*1800

          .         .         .         .         .         .       g.178638
 aaacagcattgattgaagcaagtcttggttttactaaggtagggtagcatttgctattgg       c.*1860

          .         .         .         .         .         .       g.178698
 taaagagaataaatacacttaatttcacaatacattgttatatgtaccccagttgttgtt       c.*1920

          .         .         .         .         .         .       g.178758
 agtggggactatgatactgtaataatatttttaaaaatttacatcaagagaggcagtcat       c.*1980

          .         .         .         .         .         .       g.178818
 tcacgatggttttgtgccagctctttttagggttttggatcacattagagatatttagaa       c.*2040

          .         .         .         .         .         .       g.178878
 catattaccctgtgacttacgtaggaaacctaatatgctgagtatctggcacttgaattc       c.*2100

          .         .         .         .         .         .       g.178938
 ctgcttttattgctggaggtccacatctgtggttgacctctgttattgtttaaaaaaaat       c.*2160

          .         .         .         .         .         .       g.178998
 aaataaaaattaaaaaaatctgtgcaataattttaaaatgtgctcccaggaatagacaca       c.*2220

          .         .         .         .         .         .       g.179058
 aatgttttgagtatcttttaagctgcattttcctttagtgatgcatttgtcaattgcact       c.*2280

          .         .         .         .         .         .       g.179118
 gaatttaaatctgaaagtcagaggtgattattgatagtacttttgtattttgatatggac       c.*2340

          .         .         .         .         .         .       g.179178
 agtttattcatttgcatacagttattgactttttcccagctgattaaaagatagtcaaga       c.*2400

          .         .         .         .         .         .       g.179238
 aattctgcaatatagctgccaaaatagacagctacatttttatgatattgtcatcttttc       c.*2460

          .         .         .         .         .         .       g.179298
 tgttttttttttcttttttttctttagctattttacttaagcataatagccacaatagga       c.*2520

          .         .         .         .         .         .       g.179358
 catataaaagattataaatacagagctttattatcctgacgtcttgggtcttttaagtat       c.*2580

          .         .         .         .         .         .       g.179418
 atacttttctgaaaggtatccattttgtaggcttgggttcttcatgagcatacgattgtt       c.*2640

          .         .         .         .         .         .       g.179478
 tatttttgctgctgttctcaacatcatcattgcctgctgatgtgccacgatgctgctcca       c.*2700

          .         .         .         .         .         .       g.179538
 atagacagcaataagattgtctctaatttgagcagtaacatgattgcaagagaccaagtt       c.*2760

          .         .         .         .         .         .       g.179598
 tcacagcttgtaaagttctgtatttgggattcttgcttatttttccgcctgtgtttttct       c.*2820

          .         .         .         .         .         .       g.179658
 gagaacttattcctgatgatcaattgaatccagtagtttttctatgctatttgttgttgt       c.*2880

          .         .         .         .         .         .       g.179718
 ataagctactgtaagaaacttatcataaggaaaaatagaaaggaaaacttgaatcaatac       c.*2940

          .         .         .         .         .         .       g.179778
 tcattgattaaaatggaataaagaaagagcagctgccacttttaaacaacataaaggaat       c.*3000

          .         .         .         .         .         .       g.179838
 atctttttttgtctccgtgtaggaaatcccataagttcttatatttgttccagttcccat       c.*3060

          .         .         .         .         .         .       g.179898
 ttcctgccattgaccagataacatcattgactttcaaatgacttttagaagtgataactc       c.*3120

          .         .         .         .         .         .       g.179958
 ttaatttcctaatagatactagattgtattgaattctgttttaattattctctaggtaag       c.*3180

          .         .         .         .         .         .       g.180018
 tatgttttaggattaaataccttttacagatactgaaagtgcctccttttgtggtgtaaa       c.*3240

          .         .         .         .         .         .       g.180078
 aaacaaattatggtgcaaaaagtaatcactagattgaaatacatgaaggttttttgcttt       c.*3300

          .         .         .         .         .         .       g.180138
 ttgacatacgaaaatgtcaagagaaaggccaaagatttgtactttttcacttacaaagca       c.*3360

          .         .         .         .         .         .       g.180198
 ctcctttttcccttaaacttctttctgtcaaattagatttaatgagagagtactattttt       c.*3420

          .         .         .         .         .         .       g.180258
 aaggagctatctgtttatgtagaatgattttgttaagagtaatgtaaactattattgagt       c.*3480

          .         .         .         .         .         .       g.180318
 agaggcctaaagaggactgtgcatttttgctatttaaaggaatcacaaatgatcatactt       c.*3540

          .         .         .         .         .         .       g.180378
 aagtgagcaaaaatgacaagttttactagctaagtagagaaataaatctcaaatgcagcg       c.*3600

          .         .         .         .         .         .       g.180438
 ctacaattttcattatcttaagtacattgtacatttctacagaacctgtgattattctcg       c.*3660

          .         .         .         .         .         .       g.180498
 catgataaggatggtacttgcatatggtgaattactactgttgacagtttccgcagaaat       c.*3720

          .         .         .         .         .         .       g.180558
 cctatttcagtggaccaacattgtggcatggcagcaaatgccaacattttgtggaatagc       c.*3780

          .         .         .         .         .         .       g.180618
 agcaaatctacaagagaccctggttggtttttcgttttgttttctttgttttttccccct       c.*3840

          .         .         .         .         .         .       g.180678
 tctcctgaatcagcagggatggaaggagggtagggaagttatgaattactccttccagta       c.*3900

          .         .         .         .         .         .       g.180738
 gtagctctgaagtgtcacatttaatatcagttttttttaaacatgattctagttaaatgt       c.*3960

          .         .         .         .         .         .       g.180798
 agaagagagaagaaagaggaagtgttcacttttttaatacactgatttagaaatttgatg       c.*4020

          .         .         .         .         .         .       g.180858
 tcttatatcagtagttctgaggtattgatagcttgctttatttctgcctttacgttgaca       c.*4080

          .         .         .         .         .         .       g.180918
 gtgttgaagcagggtgaataactagggcatatattttttttttttttgtaagctgtttca       c.*4140

          .         .         .         .         .         .       g.180978
 tgatgttttctttggaatttccggataagttcaggaaaacattctgcatgttgtatctag       c.*4200

          .         .         .         .         .         .       g.181038
 tctgatgtacttatccatctcattacaaacaaaaacacacagactgcatttgtagctctg       c.*4260

          .         .         .         .         .         .       g.181098
 taatccttgaatacggaagtaaattttcttctttcctgactttgacattgtagctatact       c.*4320

          .         .         .         .         .         .       g.181158
 gtttccatttttgtttttacaaatcctttgggtctaattctgtgagcctacctatagcac       c.*4380

          .         .         .         .         .         .       g.181218
 tggattaaaatgtctgcatcatttctttagttatccagttaactttaaaactgttgtaaa       c.*4440

          .         .         .         .         .         .       g.181278
 agtgtaaaccagcccatgacaggtttttgtacatgttaaagaacttcattgttcagtttt       c.*4500

          .         .         .         .         .         .       g.181338
 catgattattgtgtaaggaagactgatgtagatgttctgtgctgtcctggaccatgttaa       c.*4560

          .         .         .         .         .         .       g.181398
 ttacacttacgacgtattttagttccacatcacaatgatttgtccccagtgaccctttta       c.*4620

          .         .         .         .         .         .       g.181458
 tcctttctaggcacatttcttgttgttgttgttgttgcagttcccctttgcattgtattg       c.*4680

          .         .         .         .         .         .       g.181518
 ctttgacaactgtaatttgaatcagatctgaaagaggtccagaataaaatatattttgat       c.*4740

                                                                    g.181522
 atta                                                               c.*4744

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Transducin (beta)-like 1 X-linked receptor 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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