T-box 15 (TBX15) - coding DNA reference sequence

(used for variant description)

(last modified May 28, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_152380.2 in the TBX15 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000001.10, covering TBX15 transcript NM_152380.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5015
                                              tctttccggcttctt       c.-301

 .         .         .         .         .         .                g.5075
 tgcaaaaggatagaaccgtctcgaccagggcactaggactggaagatcgggctgtgtcta       c.-241

 .         .         .         .         .         .                g.5135
 ggccgctgtccgcgaaatccgagacgttttttcagcttggctaggaccgacttcgctgcc       c.-181

 .         .         .         .         .         .                g.5195
 ggtttgagctttctctgcactcgggggtctcctgccgtcctcgaccggtggcgtaacttg       c.-121

 .       | 02 .         .         .         .         .             g.62777
 ggaagag | attctgagcagagcactggttcagattctgaggtcctcactgagcggacttcc    c.-61

 .         .         .         .         .         .                g.62837
 tgctccttcagtactcacactgacctggcctctggtgctgcaggccctgtgcctgctgcc       c.-1

          .         .         .         .         .         .       g.62897
 ATGTCTTCCATGGAGGAGATTCAGGTGGAGCTGCAATGTGCTGACCTCTGGAAGCGGTTC       c.60
 M  S  S  M  E  E  I  Q  V  E  L  Q  C  A  D  L  W  K  R  F         p.20

          .         .         .         .  | 03      .         .    g.67964
 CATGATATTGGAACTGAAATGATCATCACCAAAGCAGGCAG | GAGGATGTTTCCTGCCATG    c.120
 H  D  I  G  T  E  M  I  I  T  K  A  G  R  |  R  M  F  P  A  M      p.40

          .         .         .         .         .         .       g.68024
 AGAGTGAAAATCACTGGCCTAGATCCACATCAGCAGTACTACATAGCAATGGACATTGTG       c.180
 R  V  K  I  T  G  L  D  P  H  Q  Q  Y  Y  I  A  M  D  I  V         p.60

          .         .    | 04    .         .         .         .    g.69776
 CCTGTGGACAATAAAAGATACAG | ATATGTGTATCATAGCTCCAAGTGGATGGTGGCTGGC    c.240
 P  V  D  N  K  R  Y  R  |  Y  V  Y  H  S  S  K  W  M  V  A  G      p.80

          .         .         .         .         .         .       g.69836
 AATGCTGATTCCCCTGTGCCCCCAAGAGTTTATATACACCCTGATTCTCTAGCTTCTGGA       c.300
 N  A  D  S  P  V  P  P  R  V  Y  I  H  P  D  S  L  A  S  G         p.100

          .         .         .         .         .         .       g.69896
 GACACCTGGATGAGACAGGTGGTCAGTTTTGACAAACTCAAGCTTACCAACAATGAGTTG       c.360
 D  T  W  M  R  Q  V  V  S  F  D  K  L  K  L  T  N  N  E  L         p.120

          .      | 05  .         .         .         .         .    g.70998
 GATGATCAAGGACAT | ATCATTCTGCACTCTATGCACAAATACCAGCCTCGAGTTCATGTG    c.420
 D  D  Q  G  H   | I  I  L  H  S  M  H  K  Y  Q  P  R  V  H  V      p.140

          .         .         .         .         .         .       g.71058
 ATTCGCAAAGACTTCAGCAGTGACCTTTCACCCACTAAGCCTGTTCCTGTTGGGGATGGG       c.480
 I  R  K  D  F  S  S  D  L  S  P  T  K  P  V  P  V  G  D  G         p.160

          .         .         .         .         .         .       g.71118
 GTGAAAACGTTCAACTTTCCTGAGACTGTGTTCACCACAGTTACGGCCTATCAGAATCAG       c.540
 V  K  T  F  N  F  P  E  T  V  F  T  T  V  T  A  Y  Q  N  Q         p.180

     | 06    .         .         .         .         .         .    g.80434
 CAG | ATTACCAGATTAAAAATTGACCGAAACCCTTTTGCTAAAGGATTCAGAGATTCTGGG    c.600
 Q   | I  T  R  L  K  I  D  R  N  P  F  A  K  G  F  R  D  S  G      p.200

          | 07         .         .         .         .         .    g.95483
 AGAAACAG | AACTGGACTTGAAGCCATCATGGAGACATATGCATTCTGGAGACCTCCTGTG    c.660
 R  N  R  |  T  G  L  E  A  I  M  E  T  Y  A  F  W  R  P  P  V      p.220

          .         .         .         .       | 08 .         .    g.109054
 CGCACACTCACCTTCGAAGACTTCACCACCATGCAGAAGCAGCAAG | GAGGCAGCACAGGC    c.720
 R  T  L  T  F  E  D  F  T  T  M  Q  K  Q  Q  G |   G  S  T  G      p.240

          .         .         .         .         .         .       g.109114
 ACTTCCCCAACCACCTCCAGCACTGGGACACCATCCCCTTCGGCTTCTTCTCATCTTTTA       c.780
 T  S  P  T  T  S  S  T  G  T  P  S  P  S  A  S  S  H  L  L         p.260

          .         .         .         .         .         .       g.109174
 TCTCCATCCTGTTCTCCTCCAACTTTTCATCTGGCCCCCAACACTTTCAATGTGGGCTGC       c.840
 S  P  S  C  S  P  P  T  F  H  L  A  P  N  T  F  N  V  G  C         p.280

          .         .         .         .         .         .       g.109234
 CGAGAAAGCCAGCTGTGTAATCTAAACCTCTCTGATTATCCACCATGTGCCCGAAGCAAC       c.900
 R  E  S  Q  L  C  N  L  N  L  S  D  Y  P  P  C  A  R  S  N         p.300

          .         .         .         .         .         .       g.109294
 ATGGCTGCCTTGCAGAGCTACCCAGGGCTGAGTGACAGTGGCTACAACAGGCTTCAGAGT       c.960
 M  A  A  L  Q  S  Y  P  G  L  S  D  S  G  Y  N  R  L  Q  S         p.320

          .         .         .         .         .         .       g.109354
 GGCACCACTTCAGCCACTCAGCCCTCTGAAACCTTCATGCCTCAGAGGACTCCATCCCTG       c.1020
 G  T  T  S  A  T  Q  P  S  E  T  F  M  P  Q  R  T  P  S  L         p.340

          .         .         .         .         .         .       g.109414
 ATCTCAGGAATACCAACTCCTCCCTCGTTGCCTGGCAACAGCAAGATGGAAGCCTACGGT       c.1080
 I  S  G  I  P  T  P  P  S  L  P  G  N  S  K  M  E  A  Y  G         p.360

          .         .         .         .         .         .       g.109474
 GGCCAGCTGGGGTCCTTTCCCACTTCCCAGTTTCAGTATGTCATGCAGGCAGGCAATGCT       c.1140
 G  Q  L  G  S  F  P  T  S  Q  F  Q  Y  V  M  Q  A  G  N  A         p.380

          .         .         .         .         .         .       g.109534
 GCCTCCAGCTCCTCATCACCACACATGTTCGGGGGCAGCCACATGCAGCAGAGCTCCTAC       c.1200
 A  S  S  S  S  S  P  H  M  F  G  G  S  H  M  Q  Q  S  S  Y         p.400

          .         .         .         .         .         .       g.109594
 AATGCCTTCTCCCTTCACAACCCTTACAACCTGTATGGATACAATTTCCCCACTTCCCCT       c.1260
 N  A  F  S  L  H  N  P  Y  N  L  Y  G  Y  N  F  P  T  S  P         p.420

          .         .         .         .         .         .       g.109654
 AGGCTAGCTGCAAGCCCGGAAAAACTGAGCGCCTCTCAAAGCACTTTACTCTGTTCTTCT       c.1320
 R  L  A  A  S  P  E  K  L  S  A  S  Q  S  T  L  L  C  S  S         p.440

          .         .         .         .         .         .       g.109714
 CCTTCCAACGGGGCCTTTGGAGAGAGGCAGTACCTGCCGTCAGGGATGGAGCACAGCATG       c.1380
 P  S  N  G  A  F  G  E  R  Q  Y  L  P  S  G  M  E  H  S  M         p.460

          .         .         .         .         .         .       g.109774
 CACATGATTAGCCCTTCACCCAATAACCAACAGGCAACCAACACTTGTGATGGCCGGCAG       c.1440
 H  M  I  S  P  S  P  N  N  Q  Q  A  T  N  T  C  D  G  R  Q         p.480

          .         .         .         .         .                 g.109825
 TATGGGGCAGTTCCAGGCTCCTCCTCCCAGATGTCCGTGCACATGGTTTAA                c.1491
 Y  G  A  V  P  G  S  S  S  Q  M  S  V  H  M  V  X                  p.496

          .         .         .         .         .         .       g.109885
 aggccagtccaaacaccacggagcatttggcaatcaaggccccagagtctccgtggtcag       c.*60

          .         .         .         .         .         .       g.109945
 atcctcctctttgggagtccagtgtctttgaaaaacaggaaccgtgtttttttttttttt       c.*120

          .         .         .         .         .         .       g.110005
 ttttttctggccgaagacatatacccaagaacaagagatacctttaagccagtgaaggat       c.*180

          .         .         .         .         .         .       g.110065
 acttgcgatagaatcatccgcaactcagtggccattcttctgccttcccagaccttagtt       c.*240

          .         .         .         .         .         .       g.110125
 ttataaagcattgtctgttccagagtggcctttgaagagactgaataatcacttcgtcat       c.*300

          .         .         .         .         .         .       g.110185
 aatgttaagggagatgctagtgtgtggcagccatgaaaagttacacatacacacccacat       c.*360

          .         .         .         .         .         .       g.110245
 acagacagacctacctatacatacgtgcacacacacatacatattcatacacaattcata       c.*420

          .         .         .         .         .         .       g.110305
 cacatgcaatcatacatgcacactgactctgaactgggtgaactctgtggagggaggccc       c.*480

          .         .         .         .         .         .       g.110365
 agaatgggtgctttcaccaagaatttgtctgtgtacaactctagatggagtgggccagca       c.*540

          .         .         .         .         .         .       g.110425
 gtagctgccagtctttctcccctgcagcttcctctgcttctggaatgaaccatgtatcct       c.*600

          .         .         .         .         .         .       g.110485
 ggagaccctcccaatggatgagagtggaaagacatcagtacaactggacttggcttccgg       c.*660

          .         .         .         .         .         .       g.110545
 aaaaagattgcttttgaactttggctctcttcacttgtatgctatcattgatattcccag       c.*720

          .         .         .         .         .         .       g.110605
 tggtgcccgtggaaagagggagaaagagaagctgaacaggagaaagacaaacagaaagaa       c.*780

          .         .         .         .         .         .       g.110665
 tagagaacaggaacgaggtggagagcaagactgacagagaaagtgtgagcaatgatgaga       c.*840

          .         .         .         .         .         .       g.110725
 attttaattcaccaaggagacgtgtttttggtttgtccccccaaaccccgcccgccccac       c.*900

          .         .         .         .         .         .       g.110785
 tacaggttatggaaagaatcatggcattactgaggagtaaacctctctggcacactgagc       c.*960

          .         .         .         .         .         .       g.110845
 atggtcagggcattggtcagagggacagagcaaggaatgcatcctgagcccacagctttg       c.*1020

          .         .         .         .         .         .       g.110905
 accactgtgatccagaagagaggtgcactacgtgggaagtgctgattccacagcatgcag       c.*1080

          .         .         .         .         .         .       g.110965
 cctggtaggggaaggaaaataaaagggtgtgaagaaggaatagttttataatctcggaag       c.*1140

          .         .         .         .         .         .       g.111025
 atgataccaagagcagaggcaacaaatagaggcctggcctccaggtgccggatccagaca       c.*1200

          .         .         .         .         .         .       g.111085
 cctgacctagaatgcctgcccgctatccctgtggcaggaaatatcccctcatgtcccagg       c.*1260

          .         .         .         .         .         .       g.111145
 gaattgcagatgggtcttctatacccttctacctgcccttagatctccatttttatcaaa       c.*1320

          .         .         .         .         .         .       g.111205
 tagtacattgcattttgaagttttgggttttgtccttcatctttccctttcccttcaaat       c.*1380

          .         .         .         .         .         .       g.111265
 cttttaatggtaagaaagcaagtgaagcttggtgcaagctaaaatttttaaatggtgtgg       c.*1440

          .         .         .         .         .         .       g.111325
 aaatgcaaataataccaagtaaaataatacagatattattaaagtttctggttttgaggt       c.*1500

          .         .         .         .         .         .       g.111385
 gttgtagataaatgtatttatgtgcctagtggggaatccaatattatgaatatgaaaaag       c.*1560

          .         .         .         .         .         .       g.111445
 ggggcaataaaagggtatgtaaaatatgtatgaagaaaaggtgtacaaaaatttgccctt       c.*1620

          .         .         .         .         .         .       g.111505
 atgcacggaactctgtttctaagtgccaagcacagaaagccgctaaataaaatctttgca       c.*1680

                                                                    g.111514
 attgttttc                                                          c.*1689

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The T-box 15 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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