T-box 22 (TBX22) - coding DNA reference sequence

(used for variant description)

(last modified June 28, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_001109878.1 in the TBX22 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008998.1, covering TBX22 transcript NM_001109878.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5014
                                               cttctctgggctct       c.-121

 .         .         .         .         .         .                g.5074
 tgagaagagctgctgcaggcatttgcagagtgaatgagctctgactgagacttgacttca       c.-61

 .         .         .         .         .         .        | 02    g.12514
 gaaccactgggctggcctggcctcttgacacagcaacacactgcttcttgccttccag | gg    c.-1

          .         .         .         .         .         .       g.12574
 ATGGCTCTGAGCTCTCGGGCGCGTGCCTTCTCCGTGGAAGCCTTGGTGGGGAGACCCAGC       c.60
 M  A  L  S  S  R  A  R  A  F  S  V  E  A  L  V  G  R  P  S         p.20

          .         .         .         .         .         .       g.12634
 AAAAGAAAACTCCAAGACCCAATACAGGCGGAGCAGCCTGAGCTGCGGGAGAAAAAGGGC       c.120
 K  R  K  L  Q  D  P  I  Q  A  E  Q  P  E  L  R  E  K  K  G         p.40

          .         .         .         .         .      | 03  .    g.13309
 GGAGAGGAAGAGGAGGAGAGAAGGAGCAGCGCTGCAGGGAAGAGCGAGCCGCTTG | AAAAA    c.180
 G  E  E  E  E  E  R  R  S  S  A  A  G  K  S  E  P  L  E |   K      p.60

          .         .         .         .         .         .       g.13369
 CAACCTAAGACAGAGCCCTCAACATCTGCTTCCTCTGGCTGCGGCAGCGACAGCGGCTAC       c.240
 Q  P  K  T  E  P  S  T  S  A  S  S  G  C  G  S  D  S  G  Y         p.80

          .         .         .         .         .         .       g.13429
 GGCAACAGCTCTGAAAGTCTGGAAGAGAAAGATATTCAAATGGAGCTTCAAGGATCTGAA       c.300
 G  N  S  S  E  S  L  E  E  K  D  I  Q  M  E  L  Q  G  S  E         p.100

          .         .         .         .         .       | 04 .    g.14311
 CTGTGGAAAAGATTCCATGACATCGGGACTGAGATGATCATTACTAAAGCGGGCAG | GCGG    c.360
 L  W  K  R  F  H  D  I  G  T  E  M  I  I  T  K  A  G  R  |  R      p.120

          .         .         .         .         .         .       g.14371
 ATGTTCCCCTCTGTTCGGGTCAAGGTGAAAGGGTTGGATCCAGGGAAGCAGTACCATGTG       c.420
 M  F  P  S  V  R  V  K  V  K  G  L  D  P  G  K  Q  Y  H  V         p.140

          .         .         .         | 05         .         .    g.15869
 GCCATCGATGTGGTGCCGGTGGATTCCAAACGCTATAG | GTACGTCTATCACAGCTCACAG    c.480
 A  I  D  V  V  P  V  D  S  K  R  Y  R  |  Y  V  Y  H  S  S  Q      p.160

          .         .         .         .         .         .       g.15929
 TGGATGGTAGCTGGGAATACAGACCATTTGTGCATCATTCCTAGATTCTATGTTCACCCG       c.540
 W  M  V  A  G  N  T  D  H  L  C  I  I  P  R  F  Y  V  H  P         p.180

          .         .         .         .         .         .       g.15989
 GACTCACCCTGCTCGGGAGAGACCTGGATGCGGCAGATCATCAGCTTTGATCGCATGAAA       c.600
 D  S  P  C  S  G  E  T  W  M  R  Q  I  I  S  F  D  R  M  K         p.200

          .         .         .    | 06    .         .         .    g.16975
 CTCACCAACAATGAGATGGATGACAAAGGCCAC | ATCATTCTGCAATCCATGCATAAGTAC    c.660
 L  T  N  N  E  M  D  D  K  G  H   | I  I  L  Q  S  M  H  K  Y      p.220

          .         .         .         .         .         .       g.17035
 AAACCCCGAGTGCACGTGATAGAGCAAGGCAGCAGTGTTGACCTGTCCCAGATTCAGTCC       c.720
 K  P  R  V  H  V  I  E  Q  G  S  S  V  D  L  S  Q  I  Q  S         p.240

          .         .         .         .         .         .       g.17095
 TTGCCCACTGAAGGTGTTAAAACATTCTCCTTTAAAGAAACTGAGTTCACCACAGTAACG       c.780
 L  P  T  E  G  V  K  T  F  S  F  K  E  T  E  F  T  T  V  T         p.260

          .         | 07         .         .         .         .    g.17542
 GCTTACCAAAACCAACAG | ATTACGAAACTAAAAATAGAAAGAAATCCTTTTGCTAAAGGA    c.840
 A  Y  Q  N  Q  Q   | I  T  K  L  K  I  E  R  N  P  F  A  K  G      p.280

          .         .    | 08    .         .         .         .    g.18272
 TTTAGAGATACTGGAAGAAACAG | GGGTGTATTGGATGGGCTTTTAGAGACCTACCCATGG    c.900
 F  R  D  T  G  R  N  R  |  G  V  L  D  G  L  L  E  T  Y  P  W      p.300

          .         .         .         .          | 09        .    g.20753
 AGGCCTTCTTTCACTCTCGATTTTAAAACCTTTGGCGCAGACACACAAA | GTGGAAGCAGT    c.960
 R  P  S  F  T  L  D  F  K  T  F  G  A  D  T  Q  S |   G  S  S      p.320

          .         .         .         .         .         .       g.20813
 GGCTCATCTCCAGTGACCTCTAGTGGAGGGGCCCCCTCTCCTTTGAACTCCTTACTTTCT       c.1020
 G  S  S  P  V  T  S  S  G  G  A  P  S  P  L  N  S  L  L  S         p.340

          .         .         .         .         .         .       g.20873
 CCACTTTGCTTTTCACCTATGTTTCATTTACCTACAAGCTCCCTTGGAATGCCCTGTCCA       c.1080
 P  L  C  F  S  P  M  F  H  L  P  T  S  S  L  G  M  P  C  P         p.360

          .         .         .         .         .         .       g.20933
 GAGGCATACCTGCCCAATGTCAACCTGCCTCTATGCTACAAGATTTGTCCAACTAATTTT       c.1140
 E  A  Y  L  P  N  V  N  L  P  L  C  Y  K  I  C  P  T  N  F         p.380

          .         .         .         .         .         .       g.20993
 TGGCAACAGCAACCTCTTGTTTTACCGGCTCCTGAAAGACTAGCAAGCAGCAACAGTTCT       c.1200
 W  Q  Q  Q  P  L  V  L  P  A  P  E  R  L  A  S  S  N  S  S         p.400

          .         .         .         .         .         .       g.21053
 CAGTCTTTAGCCCCACTCATGATGGAAGTGCCTATGTTATCTTCCCTGGGGGTCACCAAT       c.1260
 Q  S  L  A  P  L  M  M  E  V  P  M  L  S  S  L  G  V  T  N         p.420

          .         .         .         .         .         .       g.21113
 TCAAAAAGCGGTTCATCTGAAGACTCCAGTGATCAGTATCTACAAGCACCTAATTCTACC       c.1320
 S  K  S  G  S  S  E  D  S  S  D  Q  Y  L  Q  A  P  N  S  T         p.440

          .         .         .         .         .         .       g.21173
 AATCAAATGTTATATGGATTACAGTCACCTGGAAATATTTTTCTGCCAAACTCCATCACC       c.1380
 N  Q  M  L  Y  G  L  Q  S  P  G  N  I  F  L  P  N  S  I  T         p.460

          .         .         .         .         .         .       g.21233
 CCAGAAGCACTTAGTTGCTCCTTTCATCCTTCCTATGACTTTTATAGATACAATTTCTCT       c.1440
 P  E  A  L  S  C  S  F  H  P  S  Y  D  F  Y  R  Y  N  F  S         p.480

          .         .         .         .         .         .       g.21293
 ATGCCATCTAGACTGATAAGTGGTTCCAACCATCTTAAAGTGAATGACGACAGTCAAGTT       c.1500
 M  P  S  R  L  I  S  G  S  N  H  L  K  V  N  D  D  S  Q  V         p.500

          .         .         .         .         .         .       g.21353
 TCTTTTGGAGAAGGCAAATGTAATCATGTTCATTGGTATCCAGCAATTAACCATTACCTT       c.1560
 S  F  G  E  G  K  C  N  H  V  H  W  Y  P  A  I  N  H  Y  L         p.520

                                                                    g.21356
 TAG                                                                c.1563
 X                                                                  p.520

          .         .         .         .         .         .       g.21416
 taagacaatagcatttctagaacaattacatgtaaacaaatattttctttatttgtagcc       c.*60

          .         .         .         .         .         .       g.21476
 aaagaaatttcaacagttattgggcttaaaaagcatcattacaatacagtatttctttgt       c.*120

          .         .         .         .         .         .       g.21536
 tatacatttaaagatttaaagtgccttatcaaataatattcatgaagagttgtttataat       c.*180

          .         .         .         .         .         .       g.21596
 gtcaaatgaaacctacaggaatctctgattacagtggccttgagcttcaaaatgagatat       c.*240

          .         .         .         .         .         .       g.21656
 gcaataaatattatttgatgatactccaccagtgaaaattgatgctaagtgatgggattt       c.*300

          .         .         .         .         .         .       g.21716
 tcaattatactgaagctagttcaccacgttaactgcattttacacattgacaatgacaaa       c.*360

          .         .         .         .         .         .       g.21776
 aagaagatggatgtaattctcatgaaagcagtgaagcaatttcagttttaaaaatgaaga       c.*420

          .         .         .         .         .         .       g.21836
 tcggctttcatgtaattatctagtagttgtagaagaaaatttaattatttgtttgcctca       c.*480

          .         .         .         .         .         .       g.21896
 tgcctttatactttgctgttgaagaaactactaatctcaatttaagatacaaataaggac       c.*540

          .         .         .         .         .         .       g.21956
 acaaactttcaagtattatattttatttatctttgtagcctaaagaccatttaatcttga       c.*600

          .         .         .         .         .                 g.22014
 aggaacacaaagatcaaatgaaaagtaaaacactctaaataaatttgcttttattttc         c.*658

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The T-box 22 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 19
©2004-2017 Leiden University Medical Center