T-box 3 (TBX3) - coding DNA reference sequence

(used for variant description)

(last modified December 8, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_016569.3 in the TBX3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008315.1, covering TBX3 transcript NM_016569.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5004
                                                         gaat       c.-961

 .         .         .         .         .         .                g.5064
 tctagaggcggcggagggtggcgaggagctctcgctttctctcgctccctccctctccga       c.-901

 .         .         .         .         .         .                g.5124
 ctccgtctctctctctctctctctctctcccctccctctctttccctctgttccattttt       c.-841

 .         .         .         .         .         .                g.5184
 tccccctctaaatcctccctgccctgcgcgcctggacacagatttaggaagcgaattcgc       c.-781

 .         .         .         .         .         .                g.5244
 tcacgttttaggacaaggaagagagagaggcacgggagaagagcccagcaagatttggat       c.-721

 .         .         .         .         .         .                g.5304
 tgaaaccgagacaccctccggaggctcggagcagaggaaggaggaggagggcggcgaacg       c.-661

 .         .         .         .         .         .                g.5364
 gaagccagtttgcaattcaagttttgatagcgctggtagaagggggtttaaatcagattt       c.-601

 .         .         .         .         .         .                g.5424
 ttttttttttaaaggagagagactttttccgctctctcgctccctgttaaagccgggtct       c.-541

 .         .         .         .         .         .                g.5484
 agcacagctgcagacgccaccagcgagaaagagggagaggaagacagatagggggcgggg       c.-481

 .         .         .         .         .         .                g.5544
 gaagaagaaaaagaaaggtaaaaagtcttctaggagaacctttcacatttgcaacaaaag       c.-421

 .         .         .         .         .         .                g.5604
 acctaggggctggagagagattcctgggacgcagggctggagtgtctatttcgagctcag       c.-361

 .         .         .         .         .         .                g.5664
 cggcagggctcgggcgcgagtcgagaccctgctcgctcctctcgcttctgaaaccgacgt       c.-301

 .         .         .         .         .         .                g.5724
 tcaggagcggctttttaaaaacgcaaggcacaaggacggtcacccgcgcgactatgtttg       c.-241

 .         .         .         .         .         .                g.5784
 ctgatttttcgccttgccctctttaaaagcggcctcccattctccaaaagacacttcccc       c.-181

 .         .         .         .         .         .                g.5844
 tcctccctttgaagtgcattagttgtgatttctgcctccttttcttttttctttcttttt       c.-121

 .         .         .         .         .         .                g.5904
 tgttttgctttttccccccttttgaattatgtgctgctgttaaacaacaacaaaaaaaca       c.-61

 .         .         .         .         .         .                g.5964
 acaaaacacagcagctgcggacttgtccccggctggagcccagcgccccgcctggagtgg       c.-1

          .         .         .         .         .         .       g.6024
 ATGAGCCTCTCCATGAGAGATCCGGTCATTCCTGGGACAAGCATGGCCTACCATCCGTTC       c.60
 M  S  L  S  M  R  D  P  V  I  P  G  T  S  M  A  Y  H  P  F         p.20

          .         .         .         .         .         .       g.6084
 CTACCTCACCGGGCGCCGGACTTCGCCATGAGCGCGGTGCTGGGTCACCAGCCGCCGTTC       c.120
 L  P  H  R  A  P  D  F  A  M  S  A  V  L  G  H  Q  P  P  F         p.40

          .         .         .         .         .         .       g.6144
 TTCCCCGCGCTGACGCTGCCTCCCAACGGCGCGGCGGCGCTCTCGCTGCCGGGCGCCCTG       c.180
 F  P  A  L  T  L  P  P  N  G  A  A  A  L  S  L  P  G  A  L         p.60

          .         .         .         .         .         .       g.6204
 GCCAAGCCGATCATGGATCAATTGGTGGGGGCGGCCGAGACCGGCATCCCGTTCTCCTCC       c.240
 A  K  P  I  M  D  Q  L  V  G  A  A  E  T  G  I  P  F  S  S         p.80

          .         .         .         .         .         .       g.6264
 CTGGGGCCCCAGGCGCATCTGAGGCCTTTGAAGACCATGGAGCCCGAAGAAGAGGTGGAG       c.300
 L  G  P  Q  A  H  L  R  P  L  K  T  M  E  P  E  E  E  V  E         p.100

          .         .         .         .         .         .       g.6324
 GACGACCCCAAGGTGCACCTGGAGGCTAAAGAACTTTGGGATCAGTTTCACAAGCGGGGC       c.360
 D  D  P  K  V  H  L  E  A  K  E  L  W  D  Q  F  H  K  R  G         p.120

          .         .          | 02        .         .         .    g.8049
 ACCGAGATGGTCATTACCAAGTCGGGAAG | GCGAATGTTTCCTCCATTTAAAGTGAGATGT    c.420
 T  E  M  V  I  T  K  S  G  R  |  R  M  F  P  P  F  K  V  R  C      p.140

          .         .         .         .         .         .       g.8109
 TCTGGGCTGGATAAAAAAGCCAAATACATTTTATTGATGGACATTATAGCTGCTGATGAC       c.480
 S  G  L  D  K  K  A  K  Y  I  L  L  M  D  I  I  A  A  D  D         p.160

          .         .         .         .         .         .       g.8169
 TGTCGTTATAAATTTCACAATTCTCGGTGGATGGTGGCTGGTAAGGCCGACCCCGAAATG       c.540
 C  R  Y  K  F  H  N  S  R  W  M  V  A  G  K  A  D  P  E  M         p.180

          .         .         .         .         .         .       g.8229
 CCAAAGAGGATGTACATTCACCCGGACAGCCCCGCTACTGGGGAACAGTGGATGTCCAAA       c.600
 P  K  R  M  Y  I  H  P  D  S  P  A  T  G  E  Q  W  M  S  K         p.200

          .         .         .         .         .        | 03.    g.9195
 GTCGTCACTTTCCACAAACTGAAACTCACCAACAACATTTCAGACAAACATGGATTT | ACT    c.660
 V  V  T  F  H  K  L  K  L  T  N  N  I  S  D  K  H  G  F   | T      p.220

          .         .         .         .         .        | 04.    g.9516
 TTGGCCTTCCCAAGTGATCACGCTACGTGGCAGGGGAATTATAGTTTTGGTACTCAG | ACT    c.720
 L  A  F  P  S  D  H  A  T  W  Q  G  N  Y  S  F  G  T  Q   | T      p.240

          .         .         .         .         .         .       g.9576
 ATATTGAACTCCATGCACAAATACCAGCCCCGGTTCCACATTGTAAGAGCCAATGACATC       c.780
 I  L  N  S  M  H  K  Y  Q  P  R  F  H  I  V  R  A  N  D  I         p.260

          .         .         .         .         .         .       g.9636
 TTGAAACTCCCTTATAGTACATTTCGGACATACTTGTTCCCCGAAACTGAATTCATCGCT       c.840
 L  K  L  P  Y  S  T  F  R  T  Y  L  F  P  E  T  E  F  I  A         p.280

          .         .     | 05   .         .         .         .    g.11544
 GTGACTGCATACCAGAATGATAAG | ATAACCCAGTTAAAAATAGACAACAACCCTTTTGCA    c.900
 V  T  A  Y  Q  N  D  K   | I  T  Q  L  K  I  D  N  N  P  F  A      p.300

          .         .         .         .  | 06      .         .    g.12713
 AAAGGTTTCCGGGACACTGGAAATGGCCGAAGAGAAAAAAG | AAAACAGCTCACCCTGCAG    c.960
 K  G  F  R  D  T  G  N  G  R  R  E  K  R  |  K  Q  L  T  L  Q      p.320

          .         .         .         .         .         .       g.12773
 TCCATGAGGGTGTTTGATGAAAGACACAAAAAGGAGAATGGGACCTCTGATGAGTCCTCC       c.1020
 S  M  R  V  F  D  E  R  H  K  K  E  N  G  T  S  D  E  S  S         p.340

          .         .         .         .         .         .       g.12833
 AGTGAACAAGCAGCTTTCAACTGCTTCGCCCAGGCTTCTTCTCCAGCCGCCTCCACTGTA       c.1080
 S  E  Q  A  A  F  N  C  F  A  Q  A  S  S  P  A  A  S  T  V         p.360

          .          | 07        .         .         .         .    g.14370
 GGGACATCGAACCTCAAAG | ATTTATGTCCCAGCGAGGGTGAGAGCGACGCCGAGGCCGAG    c.1140
 G  T  S  N  L  K  D |   L  C  P  S  E  G  E  S  D  A  E  A  E      p.380

          .         .         .         .         .         .       g.14430
 AGCAAAGAGGAGCATGGCCCCGAGGCCTGCGACGCGGCCAAGATCTCCACCACCACGTCG       c.1200
 S  K  E  E  H  G  P  E  A  C  D  A  A  K  I  S  T  T  T  S         p.400

          .         .         .         .         .         .       g.14490
 GAGGAGCCCTGCCGTGACAAGGGCAGCCCCGCGGTCAAGGCTCACCTTTTCGCTGCTGAG       c.1260
 E  E  P  C  R  D  K  G  S  P  A  V  K  A  H  L  F  A  A  E         p.420

          .         .         .         .         .         .       g.14550
 CGGCCCCGGGACAGCGGGCGGCTGGACAAAGCGTCGCCCGACTCACGCCATAGCCCCGCC       c.1320
 R  P  R  D  S  G  R  L  D  K  A  S  P  D  S  R  H  S  P  A         p.440

          .         .         .         .         .         .       g.14610
 ACCATCTCGTCCAGCACTCGCGGCCTGGGCGCGGAGGAGCGCAGGAGCCCGGTTCGCGAG       c.1380
 T  I  S  S  S  T  R  G  L  G  A  E  E  R  R  S  P  V  R  E         p.460

          .         .         .         .         .         .       g.14670
 GGCACAGCGCCGGCCAAGGTGGAAGAGGCGCGCGCGCTCCCGGGCAAGGAGGCCTTCGCG       c.1440
 G  T  A  P  A  K  V  E  E  A  R  A  L  P  G  K  E  A  F  A         p.480

          .         .         .         .         .         .       g.14730
 CCGCTCACGGTGCAGACGGACGCGGCCGCCGCGCACCTGGCCCAGGGCCCCCTGCCTGGC       c.1500
 P  L  T  V  Q  T  D  A  A  A  A  H  L  A  Q  G  P  L  P  G         p.500

          .         .         .         .         .         .       g.14790
 CTCGGCTTCGCCCCGGGCCTGGCGGGCCAACAGTTCTTCAACGGGCACCCGCTCTTCCTG       c.1560
 L  G  F  A  P  G  L  A  G  Q  Q  F  F  N  G  H  P  L  F  L         p.520

          .         .         .         .         .         .       g.14850
 CACCCCAGCCAGTTTGCCATGGGGGGCGCCTTCTCCAGCATGGCGGCCGCTGGCATGGGT       c.1620
 H  P  S  Q  F  A  M  G  G  A  F  S  S  M  A  A  A  G  M  G         p.540

          .         .         .         .         .         .       g.14910
 CCCCTCCTGGCCACGGTTTCTGGGGCCTCCACCGGTGTCTCGGGCCTGGATTCCACGGCC       c.1680
 P  L  L  A  T  V  S  G  A  S  T  G  V  S  G  L  D  S  T  A         p.560

          .         .         .         .         .         .       g.14970
 ATGGCCTCTGCCGCTGCGGCGCAGGGACTGTCCGGGGCGTCCGCGGCCACCCTGCCCTTC       c.1740
 M  A  S  A  A  A  A  Q  G  L  S  G  A  S  A  A  T  L  P  F         p.580

          .         .         . | 08       .         .         .    g.16892
 CACCTCCAGCAGCACGTCCTGGCCTCTCAG | GGCCTGGCCATGTCCCCTTTCGGAAGCCTG    c.1800
 H  L  Q  Q  H  V  L  A  S  Q   | G  L  A  M  S  P  F  G  S  L      p.600

          .         .         .         .         .         .       g.16952
 TTCCCTTACCCCTACACGTACATGGCCGCAGCGGCGGCCGCCTCCTCTGCGGCAGCCTCC       c.1860
 F  P  Y  P  Y  T  Y  M  A  A  A  A  A  A  S  S  A  A  A  S         p.620

          .         .         .         .         .         .       g.17012
 AGCTCGGTGCACCGCCACCCCTTCCTCAATCTGAACACCATGCGCCCGCGGCTGCGCTAC       c.1920
 S  S  V  H  R  H  P  F  L  N  L  N  T  M  R  P  R  L  R  Y         p.640

          .         .         .         .         .         .       g.17072
 AGCCCCTACTCCATCCCGGTGCCGGTCCCGGACGGCAGCAGTCTGCTCACCACCGCCCTG       c.1980
 S  P  Y  S  I  P  V  P  V  P  D  G  S  S  L  L  T  T  A  L         p.660

          .         .         .         .         .         .       g.17132
 CCCTCCATGGCGGCGGCCGCGGGGCCCCTGGACGGCAAAGTCGCCGCCCTGGCCGCCAGC       c.2040
 P  S  M  A  A  A  A  G  P  L  D  G  K  V  A  A  L  A  A  S         p.680

          .         .         .         .         .         .       g.17192
 CCGGCCTCGGTGGCAGTGGACTCGGGCTCTGAACTCAACAGCCGCTCCTCCACGCTCTCC       c.2100
 P  A  S  V  A  V  D  S  G  S  E  L  N  S  R  S  S  T  L  S         p.700

          .         .         .         .         .         .       g.17252
 TCCAGCTCCATGTCCTTGTCGCCCAAACTCTGCGCGGAGAAAGAGGCGGCCACCAGCGAA       c.2160
 S  S  S  M  S  L  S  P  K  L  C  A  E  K  E  A  A  T  S  E         p.720

          .         .         .         .         .         .       g.17312
 CTGCAGAGCATCCAGCGGTTGGTTAGCGGCTTGGAAGCCAAGCCGGACAGGTCCCGCAGC       c.2220
 L  Q  S  I  Q  R  L  V  S  G  L  E  A  K  P  D  R  S  R  S         p.740

          .                                                         g.17324
 GCGTCCCCGTAG                                                       c.2232
 A  S  P  X                                                         p.743

          .         .         .         .         .         .       g.17384
 acccgtcccagacacgtcttttcattccagtccagttcaggctgccgtgcactttgtcgg       c.*60

          .         .         .         .         .         .       g.17444
 atataaaataaaccacgggcccgccatggcgttagcccttccttttgcagttgcgtctgg       c.*120

          .         .         .         .         .         .       g.17504
 gaaggggccccggactccctcgagagaatgtgctagagacagcccctgtcttcttggcgt       c.*180

          .         .         .         .         .         .       g.17564
 ggtttatatgtccgggatctggatcagattctgggggctcagaaacgtcggttgcattga       c.*240

          .         .         .         .         .         .       g.17624
 gctactgggggtaggagttccaacatttatgtccagagcaacttccagcaaggctggtct       c.*300

          .         .         .         .         .         .       g.17684
 gggtctctgcccaccaggcggggaggtgttcaaagacatctccctcagtgcggatttata       c.*360

          .         .         .         .         .         .       g.17744
 tatatatttttccttcactgtgtcaagtggaaacaaaaacaaaatctttcaaaaaaaaaa       c.*420

          .         .         .         .         .         .       g.17804
 tcgggacaagtgaacacattaacatgattctgtttgtgcagattaaaaactttataggga       c.*480

          .         .         .         .         .         .       g.17864
 cttgcattatcggttctcaataaattactgagcagctttgtttggggagggaagtcccta       c.*540

          .         .         .         .         .         .       g.17924
 ccatccttgtttagtctatattaagaaaatctgtgtctttttaatattcttgtgatgttt       c.*600

          .         .         .         .         .         .       g.17984
 tcagagccgctgtaggtctcttcttgcatgtccacagtaatgtatttgtggtttttattt       c.*660

          .         .         .         .         .         .       g.18044
 tgaacgcttgcttttagagagaaaacaatatagccccctacccttttcccaatcctttgc       c.*720

          .         .         .         .         .         .       g.18104
 cctcaaatcagtgacccaagggagggggggatttaaagggaaggagtgggcaaaacacat       c.*780

          .         .         .         .         .         .       g.18164
 aaaatgaatttattatatctaagctctgtagcaggattcatgtcgttctttgacagttct       c.*840

          .         .         .         .         .         .       g.18224
 ttctctttcctgtatatgcaataacaaggttttaaaaaaataataaagaagtgagactat       c.*900

          .         .         .         .         .         .       g.18284
 tagacaaagtatttatgtaattatttgataactcttgtaaataggtggaatatgaatgct       c.*960

          .         .         .         .         .         .       g.18344
 tggaaaattaaactttaatttattgacattgtacatagctctgtgtaaatagaattgcaa       c.*1020

          .         .         .         .         .         .       g.18404
 ctgtcaggttttgtgttcttgttttcctttagttgggtttatttccaggtcacagaattg       c.*1080

          .         .         .         .         .         .       g.18464
 ctgttaacactagaaaacacacttcctgcaccaacaccaataccctttcaaaagagttgt       c.*1140

          .         .         .         .         .         .       g.18524
 ctgcaacatttttgttttcttttttaatgtccaaaagtgggggaaagtgctatttcctat       c.*1200

          .         .         .         .         .         .       g.18584
 tttcaccaaaattggggaaggagtgccactttccagctccacttcaaattccttaaaata       c.*1260

          .         .         .         .         .         .       g.18644
 taactgagattgctgtggggagggaggagggcagaggctgcggtttgactttttaatttt       c.*1320

          .         .         .         .         .         .       g.18704
 tcttttgttatttgtatttgctagtctctgatttcctcaaaacgaagtggaatttactac       c.*1380

          .         .         .         .         .         .       g.18764
 tgttgtcagtatcggtgttttgaattggtgcctgcctatagagatatattcacagttcaa       c.*1440

          .         .         .         .         .         .       g.18824
 aagtcaggtgctgagagatggtttaaagacaaattcatgaaggtatattttgtgttatag       c.*1500

          .         .         .         .         .         .       g.18884
 ttgttgatgagttctttggttttctgtatttttccccctctctttaaaacatcactgaaa       c.*1560

          .         .                                               g.18911
 tttcaataaatttttattgaaatgtct                                        c.*1587

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The T-box 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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