T-box 5 (TBX5) - coding DNA reference sequence

(used for variant description)

(last modified October 11, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_000192.3 in the TBX5 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_007373.1, covering TBX5 transcript NM_000192.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5007
                                                      catgcct       c.-661

 .         .         .         .         .         .                g.5067
 tatgcaagagacctcagtcccccggaacaactcgatttccttccaatagaggtctgaggt       c.-601

 .         .         .         .         .         .                g.5127
 ggactcccacctcccttcgtgaagagttccctcctctcccccttcctaagaaagtcgatc       c.-541

 .         .         .         .         .         .                g.5187
 ttggctctatttgtgtcttatgttcatcaccctcattcctccggagaaagccgggttggt       c.-481

 .         .         .         .         .         .                g.5247
 ttatgtctttatttattcccggggccaagacgtccggaacctgtggctgcgcagacccgg       c.-421

 .         .         .         .         .         .                g.5307
 cactgataggcgaagacggagagaaatttacctcccgccgctgccccccagccaaacgtg       c.-361

 .         .         .         .         .         .                g.5367
 acagcgcgcgggccggttgcgtgactcgtgacgtctccaagtcctataggtgcagcggct       c.-301

 .         .         .         .         .         .                g.5427
 ggtgagatagtcgctatcgcctggttgcctctttattttactggggtatgcctggtaata       c.-241

 .         .         .         .         .         .                g.5487
 aacagtaatatttaatttgtcggagaccacaaaccaaccttgagctgggaggtacgtgct       c.-181

 .         .         .         .         .         .                g.5547
 cttcttgacagacgttggaagaagacctggcctaaagaggtctcttttggtggtcctttt       c.-121

 .         .         .         .         .         .                g.5607
 caaagtcttcacctgagccctgctctccagcgaggcgcactcctggcttttgcgctccaa       c.-61

 .         .         .  | 02      .         .         .             g.9544
 agaagaggtgggatagttggag | agcagaaccttgcgcgggcacagggccctgggcgcacc    c.-1

          .         .         .         .         .         .       g.9604
 ATGGCCGACGCAGACGAGGGCTTTGGCCTGGCGCACACGCCTCTGGAGCCTGACGCAAAA       c.60
 M  A  D  A  D  E  G  F  G  L  A  H  T  P  L  E  P  D  A  K         p.20

          .         .         .         .         .         .       g.9664
 GACCTGCCCTGCGATTCGAAACCCGAGAGCGCGCTCGGGGCCCCCAGCAAGTCCCCGTCG       c.120
 D  L  P  C  D  S  K  P  E  S  A  L  G  A  P  S  K  S  P  S         p.40

          .         .        | 03.         .         .         .    g.11555
 TCCCCGCAGGCCGCCTTCACCCAGCAG | GGCATGGAGGGAATCAAAGTGTTTCTCCATGAA    c.180
 S  P  Q  A  A  F  T  Q  Q   | G  M  E  G  I  K  V  F  L  H  E      p.60

          .         .         .         .         .         .       g.11615
 AGAGAACTGTGGCTAAAATTCCACGAAGTGGGCACGGAAATGATCATAACCAAGGCTGGA       c.240
 R  E  L  W  L  K  F  H  E  V  G  T  E  M  I  I  T  K  A  G         p.80

    | 04     .         .         .         .         .         .    g.13868
 AG | GCGGATGTTTCCCAGTTACAAAGTGAAGGTGACGGGCCTTAATCCCAAAACGAAGTAC    c.300
 R  |  R  M  F  P  S  Y  K  V  K  V  T  G  L  N  P  K  T  K  Y      p.100

          .         .         .         .         .         .       g.13928
 ATTCTTCTCATGGACATTGTACCTGCCGACGATCACAGATACAAATTCGCAGATAATAAA       c.360
 I  L  L  M  D  I  V  P  A  D  D  H  R  Y  K  F  A  D  N  K         p.120

    | 05     .         .         .         .         .         .    g.14780
 TG | GTCTGTGACGGGCAAAGCTGAGCCCGCCATGCCTGGCCGCCTGTACGTGCACCCAGAC    c.420
 W  |  S  V  T  G  K  A  E  P  A  M  P  G  R  L  Y  V  H  P  D      p.140

          .         .         .         .         .         .       g.14840
 TCCCCCGCCACCGGGGCGCATTGGATGAGGCAGCTCGTCTCCTTCCAGAAACTCAAGCTC       c.480
 S  P  A  T  G  A  H  W  M  R  Q  L  V  S  F  Q  K  L  K  L         p.160

          .         .         . | 06       .         .         .    g.18579
 ACCAACAACCACCTGGACCCATTTGGGCAT | ATTATTCTAAATTCCATGCACAAATACCAG    c.540
 T  N  N  H  L  D  P  F  G  H   | I  I  L  N  S  M  H  K  Y  Q      p.180

          .         .         .         .         .         .       g.18639
 CCTAGATTACACATCGTGAAAGCGGATGAAAATAATGGATTTGGCTCAAAAAATACAGCG       c.600
 P  R  L  H  I  V  K  A  D  E  N  N  G  F  G  S  K  N  T  A         p.200

          .         .         .         .         .         .       g.18699
 TTCTGCACTCACGTCTTTCCTGAGACTGCGTTTATAGCAGTGACTTCCTACCAGAACCAC       c.660
 F  C  T  H  V  F  P  E  T  A  F  I  A  V  T  S  Y  Q  N  H         p.220

     | 07    .         .         .         .         .         .    g.27932
 AAG | ATCACGCAATTAAAGATTGAGAATAATCCCTTTGCCAAAGGATTTCGGGGCAGTGAT    c.720
 K   | I  T  Q  L  K  I  E  N  N  P  F  A  K  G  F  R  G  S  D      p.240

          .         .         .      | 08  .         .         .    g.47076
 GACATGGAGCTGCACAGAATGTCAAGAATGCAAAG | TAAAGAATATCCCGTGGTCCCCAGG    c.780
 D  M  E  L  H  R  M  S  R  M  Q  S  |  K  E  Y  P  V  V  P  R      p.260

          .         .         .         .         .         .       g.47136
 AGCACCGTGAGGCAAAAAGTGGCCTCCAACCACAGTCCTTTCAGCAGCGAGTCTCGAGCT       c.840
 S  T  V  R  Q  K  V  A  S  N  H  S  P  F  S  S  E  S  R  A         p.280

          .         .         .         .         .         .       g.47196
 CTCTCCACCTCATCCAATTTGGGGTCCCAATACCAGTGTGAGAATGGTGTTTCCGGCCCC       c.900
 L  S  T  S  S  N  L  G  S  Q  Y  Q  C  E  N  G  V  S  G  P         p.300

          .         .         .         .         .         .       g.47256
 TCCCAGGACCTCCTGCCTCCACCCAACCCATACCCACTGCCCCAGGAGCATAGCCAAATT       c.960
 S  Q  D  L  L  P  P  P  N  P  Y  P  L  P  Q  E  H  S  Q  I         p.320

          .         .   | 09     .         .         .         .    g.57374
 TACCATTGTACCAAGAGGAAAG | AGGAAGAATGTTCCACCACAGACCATCCCTATAAGAAG    c.1020
 Y  H  C  T  K  R  K  E |   E  E  C  S  T  T  D  H  P  Y  K  K      p.340

          .         .         .         .         .         .       g.57434
 CCCTACATGGAGACATCACCCAGTGAAGAAGATTCCTTCTACCGCTCTAGCTATCCACAG       c.1080
 P  Y  M  E  T  S  P  S  E  E  D  S  F  Y  R  S  S  Y  P  Q         p.360

          .         .         .         .         .         .       g.57494
 CAGCAGGGCCTGGGTGCCTCCTACAGGACAGAGTCGGCACAGCGGCAAGCTTGCATGTAT       c.1140
 Q  Q  G  L  G  A  S  Y  R  T  E  S  A  Q  R  Q  A  C  M  Y         p.380

          .         .         .         .         .         .       g.57554
 GCCAGCTCTGCGCCCCCCAGCGAGCCTGTGCCCAGCCTAGAGGACATCAGCTGCAACACG       c.1200
 A  S  S  A  P  P  S  E  P  V  P  S  L  E  D  I  S  C  N  T         p.400

          .         .         .         .         .         .       g.57614
 TGGCCAAGCATGCCTTCCTACAGCAGCTGCACCGTCACCACCGTGCAGCCCATGGACAGG       c.1260
 W  P  S  M  P  S  Y  S  S  C  T  V  T  T  V  Q  P  M  D  R         p.420

          .         .         .         .         .         .       g.57674
 CTACCCTACCAGCACTTCTCCGCTCACTTCACCTCGGGGCCCCTGGTCCCTCGGCTGGCT       c.1320
 L  P  Y  Q  H  F  S  A  H  F  T  S  G  P  L  V  P  R  L  A         p.440

          .         .         .         .         .         .       g.57734
 GGCATGGCCAACCATGGCTCCCCACAGCTGGGAGAGGGAATGTTCCAGCACCAGACCTCC       c.1380
 G  M  A  N  H  G  S  P  Q  L  G  E  G  M  F  Q  H  Q  T  S         p.460

          .         .         .         .         .         .       g.57794
 GTGGCCCACCAGCCTGTGGTCAGGCAGTGTGGGCCTCAGACTGGCCTGCAGTCCCCTGGC       c.1440
 V  A  H  Q  P  V  V  R  Q  C  G  P  Q  T  G  L  Q  S  P  G         p.480

          .         .         .         .         .         .       g.57854
 ACCCTTCAGCCCCCTGAGTTCCTCTACTCTCATGGCGTGCCAAGGACTCTATCCCCTCAT       c.1500
 T  L  Q  P  P  E  F  L  Y  S  H  G  V  P  R  T  L  S  P  H         p.500

          .         .         .         .         .                 g.57911
 CAGTACCACTCTGTGCACGGAGTTGGCATGGTGCCAGAGTGGAGCGACAATAGCTAA          c.1557
 Q  Y  H  S  V  H  G  V  G  M  V  P  E  W  S  D  N  S  X            p.518

          .         .         .         .         .         .       g.57971
 agtgaggcctgcttcacaacagacatttcctagagaaagagagagagagaggagaaagag       c.*60

          .         .         .         .         .         .       g.58031
 agagaaggagagagacagtagccaagagaaccccacggacaagatttttcatttcaccca       c.*120

          .         .         .         .         .         .       g.58091
 atgttcacatctgcactcaaggtcgctggatgctgatctaatcagtagcttgaaaccaca       c.*180

          .         .         .         .         .         .       g.58151
 attttaaaaatgtgactttcttgttttgtctcaaaacttaaaaaaacaaacacaaaaaga       c.*240

          .         .         .         .         .         .       g.58211
 tgagtcccaccccccactaccaccacacccatcaaccagccacattcacgctactcccca       c.*300

          .         .         .         .         .         .       g.58271
 gatctcttcccccattccttcttttgggctctagaaagtcttgcctcattgagtgttttt       c.*360

          .         .         .         .         .         .       g.58331
 ccctagtgcgtagttggagtctgtccctgtcttggtgttaatgttgacattgttatataa       c.*420

          .         .         .         .         .         .       g.58391
 taaatgataatatatttttttctttcaattttcttaatgggacccagtcccttatttggg       c.*480

          .         .         .         .         .         .       g.58451
 gggaggtctgaggcaagtatatttcaaaatatgtacttgcgggattcccttcaagtaaac       c.*540

          .         .         .         .         .         .       g.58511
 catccctgaaacctaaattcacgtttccccttgactaagaaaagcacctacctctgccat       c.*600

          .         .         .         .         .         .       g.58571
 gtgatgtttctgaaaagcctctgtatgtccccatttgctttggttttgtcctgccttctc       c.*660

          .         .         .         .         .         .       g.58631
 caatatcacgtgctcagttttgcctctacttacccatggagtcaggataacactgacgct       c.*720

          .         .         .         .         .         .       g.58691
 ccctggcatcctatcttattcagccctaccatcttgccagctctgtctttccagctgtct       c.*780

          .         .         .         .         .         .       g.58751
 gtcgctaaaacgtggcctatagcttcccttccggaaagcttgctttgaaaaacttaaaaa       c.*840

          .         .         .         .         .         .       g.58811
 gcccccgtttacatgtaggcaggactgtgataacagtgcaagctctgtgttgacaagagt       c.*900

          .         .         .         .         .         .       g.58871
 tgtggacaaaaagccaaaataaatattcttcctgattaaaaaaattttttttgaaaaaaa       c.*960

          .         .         .         .         .         .       g.58931
 caaggccagccccaaccttccaaacctccatcaccaacaacccaaactggatgtcaagca       c.*1020

          .         .         .         .         .         .       g.58991
 aaatgcacaattcctacagaagaggcaagacacagtcaccaatgatatctcgccaaagaa       c.*1080

          .         .         .         .         .         .       g.59051
 accacgcccacaccaatgccaacacaaaactgtgtttactgaaagccgaaaacagtatta       c.*1140

          .         .         .         .         .         .       g.59111
 aaaaaagtgtgtaagtaaagtgttatggtagggttcttcagatgtaatattttactggta       c.*1200

          .         .         .         .         .         .       g.59171
 ctatttatttataaataggaattctaattaagtaataacatgaaatgaaacccagcatag       c.*1260

          .         .         .         .         .         .       g.59231
 gagctggccaagagcttttaattttattgatactcaaaaccaagtttgtgtttttttgtt       c.*1320

          .         .         .         .         .         .       g.59291
 tttttttgtttttttcctctttcgaatgtgctttgctttttttgattaaaaagaattttt       c.*1380

          .         .         .         .         .         .       g.59351
 tttttccttttttataaacagaccctaataaagagaacagggtaagatgtgaggctgagt       c.*1440

          .         .         .         .         .         .       g.59411
 gtgtttaagtacgtgagagagtgtgagtgtgtttgtaagtgagtgtccctatgcgattat       c.*1500

          .         .         .         .         .         .       g.59471
 gtctctttacgttgctaaggggggagggtgaggattaagtactcgtgccttatatttgtg       c.*1560

          .         .         .         .                           g.59513
 tgccaattaatgcctaataaataccatgtgcttaaacaagta                         c.*1602

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The T-box 5 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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