tectonic family member 1 (TCTN1) - coding DNA reference sequence

(used for variant description)

(last modified February 9, 2025)


This file was created to facilitate the description of sequence variants on transcript NM_001082538.2 in the TCTN1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000012.11, covering TCTN1 transcript NM_001082538.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5036
                         atccgccccctgcctcatccaggcttcgccccagtc       c.-121

 .         .         .         .         .         .                g.5096
 agtctccggcagcttctcgcggcttcgcaagccccttcccgtgatgccccgcgcctggct       c.-61

 .         .         .         .         .         .                g.5156
 gtcgcggttgccgggcaacgcgctgtccatgtcgcgggcctcgctgggactccctgggag       c.-1

          .         .         .         .         .         .       g.5216
 ATGAGGCCGCGAGGTCTCCCGCCGCTCCTGGTGGTGCTCCTGGGCTGCTGGGCCTCCGTG       c.60
 M  R  P  R  G  L  P  P  L  L  V  V  L  L  G  C  W  A  S  V         p.20

          .         .         .         .         .         .       g.5276
 AGCGCCCAGACCGATGCCACCCCGGCGGTGACGACAGAGGGCCTCAACTCCACCGAGGCA       c.120
 S  A  Q  T  D  A  T  P  A  V  T  T  E  G  L  N  S  T  E  A         p.40

          .         .         .         .         .         .       g.5336
 GCCCTGGCCACCTTCGGAACTTTCCCGTCGACCAGGCCCCCCGGGACTCCCAGGGCTCCA       c.180
 A  L  A  T  F  G  T  F  P  S  T  R  P  P  G  T  P  R  A  P         p.60

          .         .         .         . | 02       .         .    g.10829
 GGGCCCTCCTCCGGCCCCAGGCCTACCCCAGTCACGGACG | TTGCTGTTCTCTGTGTCTGT    c.240
 G  P  S  S  G  P  R  P  T  P  V  T  D  V |   A  V  L  C  V  C      p.80

          .         .         .         .         .         .       g.10889
 GACTTATCCCCAGCACAGTGTGACATCAACTGCTGCTGTGATCCCGACTGCAGCTCCGTG       c.300
 D  L  S  P  A  Q  C  D  I  N  C  C  C  D  P  D  C  S  S  V         p.100

          .         .         .         .  | 03      .         .    g.17354
 GATTTCAGTGTCTTTTCTGCCTGCTCAGTTCCAGTTGTCAC | GGGCGACAGCCAGTTTTGT    c.360
 D  F  S  V  F  S  A  C  S  V  P  V  V  T  |  G  D  S  Q  F  C      p.120

          .         .         .         .         .         .       g.17414
 AGTCAAAAAGCAGTCATCTATTCATTGAATTTTACAGCAAACCCACCTCAAAGAGTATTT       c.420
 S  Q  K  A  V  I  Y  S  L  N  F  T  A  N  P  P  Q  R  V  F         p.140

          .         .         .         .         .   | 04     .    g.19748
 GAACTTGTTGACCAGATTAATCCATCTATTTTCTGCATTCATATTACAAACT | ATAAACCT    c.480
 E  L  V  D  Q  I  N  P  S  I  F  C  I  H  I  T  N  Y |   K  P      p.160

          .         .         .         .         .         .       g.19808
 GCATTATCCTTTATTAATCCAGAAGTACCTGATGAAAACAATTTTGATACATTGATGAAA       c.540
 A  L  S  F  I  N  P  E  V  P  D  E  N  N  F  D  T  L  M  K         p.180

          .         .         .         .         .         .       g.19868
 ACATCTGATGGTTTTACATTGAATGCTGAATCATATGTTTCCTTCACAACCAAACTGGAT       c.600
 T  S  D  G  F  T  L  N  A  E  S  Y  V  S  F  T  T  K  L  D         p.200

          .         .     | 05   .         .         .         .    g.23481
 ATTCCTACTGCTGCTAAATATGAG | TATGGGGTTCCTCTGCAGACTTCAGATTCGTTTCTG    c.660
 I  P  T  A  A  K  Y  E   | Y  G  V  P  L  Q  T  S  D  S  F  L      p.220

          .         .         .         .         .   | 06     .    g.25651
 AGATTTCCTTCGTCCCTGACATCATCTCTGTGCACTGATAATAACCCTGCAG | CGTTTCTG    c.720
 R  F  P  S  S  L  T  S  S  L  C  T  D  N  N  P  A  A |   F  L      p.240

          .         .         .         .         .         .       g.25711
 GTGAACCAGGCTGTTAAGTGCACCAGAAAAATAAATTTAGAACAGTGTGAAGAAATTGAA       c.780
 V  N  Q  A  V  K  C  T  R  K  I  N  L  E  Q  C  E  E  I  E         p.260

          .         .         .         .   | 07     .         .    g.27472
 GCCCTCAGCATGGCTTTTTACAGCAGCCCGGAAATTCTGAGG | GTACCTGATTCAAGAAAA    c.840
 A  L  S  M  A  F  Y  S  S  P  E  I  L  R   | V  P  D  S  R  K      p.280

     | 08    .         .         .         .         .         .    g.31413
 AAG | GTCCCTATCACTGTTCAGTCCATCGTCATTCAGTCTCTAAATAAAACGCTCACCCGA    c.900
 K   | V  P  I  T  V  Q  S  I  V  I  Q  S  L  N  K  T  L  T  R      p.300

          .         .         .         .         .         .       g.31473
 CGGGAGGACACTGATGTGCTGCAGCCGACTCTCGTCAACGCTGGACACTTTAGCCTTTGC       c.960
 R  E  D  T  D  V  L  Q  P  T  L  V  N  A  G  H  F  S  L  C         p.320

          .         | 09         .         .         .         .    g.32039
 GTGAATGTTGTTCTTGAG | GTAAAGTACAGCCTCACATACACAGATGCAGGTGAAGTCACC    c.1020
 V  N  V  V  L  E   | V  K  Y  S  L  T  Y  T  D  A  G  E  V  T      p.340

          .         .         .         .         .         .       g.32099
 AAAGCTGATCTCTCATTCGTTCTGGGGACAGTTAGCAGCGTAGTGGTCCCACTGCAGCAA       c.1080
 K  A  D  L  S  F  V  L  G  T  V  S  S  V  V  V  P  L  Q  Q         p.360

          .         .     | 10   .         .         .         .    g.32551
 AAGTTTGAAATTCATTTTCTTCAG | GAAAATACCCAGCCAGTCCCTCTCAGTGGAAACCCT    c.1140
 K  F  E  I  H  F  L  Q   | E  N  T  Q  P  V  P  L  S  G  N  P      p.380

          .         .         .         .         . | 11       .    g.33232
 GGTTATGTCGTGGGGCTCCCATTAGCTGCTGGATTCCAGCCTCATAAGGG | GTCTGGGATT    c.1200
 G  Y  V  V  G  L  P  L  A  A  G  F  Q  P  H  K  G  |  S  G  I      p.400

          .         .         .         .         .         .       g.33292
 ATTCAGACCACAAATAGATATGGACAGCTTACTATTCTTCATAGCACAACTGAGCAAGAC       c.1260
 I  Q  T  T  N  R  Y  G  Q  L  T  I  L  H  S  T  T  E  Q  D         p.420

          .         .         .         .         .         .       g.33352
 TGCTTAGCACTGGAGGGGGTCCGGACCCCAGTATTATTTGGTTACACTATGCAATCTGGC       c.1320
 C  L  A  L  E  G  V  R  T  P  V  L  F  G  Y  T  M  Q  S  G         p.440

          .  | 12      .         .         .         .         .    g.35989
 TGTAAACTAAG | ACTGACTGGAGCTCTCCCGTGTCAGCTCGTAGCACAGAAGGTGAAGAGC    c.1380
 C  K  L  R  |  L  T  G  A  L  P  C  Q  L  V  A  Q  K  V  K  S      p.460

          .         .         .         .         .         .       g.36049
 CTGCTGTGGGGCCAGGGCTTCCCAGATTACGTGGCCCCTTTTGGAAATTCCCAGGCCCAG       c.1440
 L  L  W  G  Q  G  F  P  D  Y  V  A  P  F  G  N  S  Q  A  Q         p.480

          .         .         .         .         .     | 13   .    g.38175
 GACATGCTGGACTGGGTGCCCATCCACTTCATCACCCAGTCATTCAACAGGAAG | CATTTT    c.1500
 D  M  L  D  W  V  P  I  H  F  I  T  Q  S  F  N  R  K   | H  F      p.500

          .         .         .         .         .         .       g.38235
 GTTTTGCAGGATTCCTGCCAGCTCCCAGGGGCTTTGGTTATAGAAGTGAAGTGGACTAAA       c.1560
 V  L  Q  D  S  C  Q  L  P  G  A  L  V  I  E  V  K  W  T  K         p.520

          .         .         .         .         .         .       g.38295
 TACGGATCCCTGCTGAATCCACAGGCCAAAATAGTCAATGTAACTGCAAATCTAATTTCA       c.1620
 Y  G  S  L  L  N  P  Q  A  K  I  V  N  V  T  A  N  L  I  S         p.540

          .      | 14  .         .         .         .         .    g.38767
 TCCTCCTTTCCTGAG | GCCAACTCAGGAAATGAAAGGACGATTCTTATTTCCACTGCGGTT    c.1680
 S  S  F  P  E   | A  N  S  G  N  E  R  T  I  L  I  S  T  A  V      p.560

          .         .         .         .         .         .       g.38827
 ACTTTTGTGGATGTGTCTGCACCTGCAGAGGCAGGCTTCAGAGCTCCACCAGCCATCAAT       c.1740
 T  F  V  D  V  S  A  P  A  E  A  G  F  R  A  P  P  A  I  N         p.580

          .         .         .                                 g.38866
 GCCAGGCTGCCCTTTAACTTCTTCTTCCCGTTTGTTTGA |                         c.1780
 A  R  L  P  F  N  F  F  F  P  F  V  X                           p.592

   | 15      .         .         .         .         .         .    g.40075
 c | aatgctcagatgcatcagttccttaatatacacgtgaaatttgaaaactgtacattcgg    c.*60

          .         .                                               g.40104
 tgagattaaattttatatacaactagcaa                                      c.*89

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Tectonic family member 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 30b
©2004-2025 Leiden University Medical Center