tectonic family member 1 (TCTN1) - coding DNA reference sequence

(used for variant description)

(last modified January 28, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_024549.5 in the TCTN1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_030381.1, covering TCTN1 transcript NM_024549.5.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5036
                         atccgccccctgcctcatccaggcttcgccccagtc       c.-121

 .         .         .         .         .         .                g.5096
 agtctccggcagcttctcgcggcttcgcaagccccttcccgtgatgccccgcgcctggct       c.-61

 .         .         .         .         .         .                g.5156
 gtcgcggttgccgggcaacgcgctgtccatgtcgcgggcctcgctgggactccctgggag       c.-1

          .         .         .         .         .         .       g.5216
 ATGAGGCCGCGAGGTCTCCCGCCGCTCCTGGTGGTGCTCCTGGGCTGCTGGGCCTCCGTG       c.60
 M  R  P  R  G  L  P  P  L  L  V  V  L  L  G  C  W  A  S  V         p.20

          .         .         .         .         .         .       g.5276
 AGCGCCCAGACCGATGCCACCCCGGCGGTGACGACAGAGGGCCTCAACTCCACCGAGGCA       c.120
 S  A  Q  T  D  A  T  P  A  V  T  T  E  G  L  N  S  T  E  A         p.40

          .         .         .         .         .         .       g.5336
 GCCCTGGCCACCTTCGGAACTTTCCCGTCGACCAGGCCCCCCGGGACTCCCAGGGCTCCA       c.180
 A  L  A  T  F  G  T  F  P  S  T  R  P  P  G  T  P  R  A  P         p.60

          .         .         .         . | 02       .         .    g.10829
 GGGCCCTCCTCCGGCCCCAGGCCTACCCCAGTCACGGACG | TTGCTGTTCTCTGTGTCTGT    c.240
 G  P  S  S  G  P  R  P  T  P  V  T  D  V |   A  V  L  C  V  C      p.80

          .         .         .         .         .         .       g.10889
 GACTTATCCCCAGCACAGTGTGACATCAACTGCTGCTGTGATCCCGACTGCAGCTCCGTG       c.300
 D  L  S  P  A  Q  C  D  I  N  C  C  C  D  P  D  C  S  S  V         p.100

          .         .         .         .  | 03      .         .    g.17354
 GATTTCAGTGTCTTTTCTGCCTGCTCAGTTCCAGTTGTCAC | GGGCGACAGCCAGTTTTGT    c.360
 D  F  S  V  F  S  A  C  S  V  P  V  V  T  |  G  D  S  Q  F  C      p.120

          .         .         .         .         .         .       g.17414
 AGTCAAAAAGCAGTCATCTATTCATTGAATTTTACAGCAAACCCACCTCAAAGAGTATTT       c.420
 S  Q  K  A  V  I  Y  S  L  N  F  T  A  N  P  P  Q  R  V  F         p.140

          .         .         .         .         .   | 04     .    g.19748
 GAACTTGTTGACCAGATTAATCCATCTATTTTCTGCATTCATATTACAAACT | ATAAACCT    c.480
 E  L  V  D  Q  I  N  P  S  I  F  C  I  H  I  T  N  Y |   K  P      p.160

          .         .         .         .         .         .       g.19808
 GCATTATCCTTTATTAATCCAGAAGTACCTGATGAAAACAATTTTGATACATTGATGAAA       c.540
 A  L  S  F  I  N  P  E  V  P  D  E  N  N  F  D  T  L  M  K         p.180

          .         .         .         .         .         .       g.19868
 ACATCTGATGGTTTTACATTGAATGCTGAATCATATGTTTCCTTCACAACCAAACTGGAT       c.600
 T  S  D  G  F  T  L  N  A  E  S  Y  V  S  F  T  T  K  L  D         p.200

          .         .     | 05   .         .         .         .    g.23481
 ATTCCTACTGCTGCTAAATATGAG | TATGGGGTTCCTCTGCAGACTTCAGATTCGTTTCTG    c.660
 I  P  T  A  A  K  Y  E   | Y  G  V  P  L  Q  T  S  D  S  F  L      p.220

          .         .         .         .         .   | 06     .    g.25377
 AGATTTCCTTCGTCCCTGACATCATCTCTGTGCACTGATAATAACCCTGCAG | GCCAGGCG    c.720
 R  F  P  S  S  L  T  S  S  L  C  T  D  N  N  P  A  G |   Q  A      p.240

          .         .         .         .         .         .       g.25437
 TACTGGTTCACACCTGTAATCCCAGCACTCTGGGAGGCCGAGGCGAGAGGATCACTTGAG       c.780
 Y  W  F  T  P  V  I  P  A  L  W  E  A  E  A  R  G  S  L  E         p.260

  | 07       .         .  | 08      .         .         .         . g.31395
  | GTACCTGATTCAAGAAAAAAG | GTCCCTATCACTGTTCAGTCCATCGTCATTCAGTCTCTA c.840
  | V  P  D  S  R  K  K   | V  P  I  T  V  Q  S  I  V  I  Q  S  L   p.280

          .         .         .         .         .         .       g.31455
 AATAAAACGCTCACCCGACGGGAGGACACTGATGTGCTGCAGCCGACTCTCGTCAACGCT       c.900
 N  K  T  L  T  R  R  E  D  T  D  V  L  Q  P  T  L  V  N  A         p.300

          .         .         .       | 09 .         .         .    g.32021
 GGACACTTTAGCCTTTGCGTGAATGTTGTTCTTGAG | GTAAAGTACAGCCTCACATACACA    c.960
 G  H  F  S  L  C  V  N  V  V  L  E   | V  K  Y  S  L  T  Y  T      p.320

          .         .         .         .         .         .       g.32081
 GATGCAGGTGAAGTCACCAAAGCTGATCTCTCATTCGTTCTGGGGACAGTTAGCAGCGTA       c.1020
 D  A  G  E  V  T  K  A  D  L  S  F  V  L  G  T  V  S  S  V         p.340

          .         .         .         .   | 10     .         .    g.32533
 GTGGTCCCACTGCAGCAAAAGTTTGAAATTCATTTTCTTCAG | GAAAATACCCAGCCAGTC    c.1080
 V  V  P  L  Q  Q  K  F  E  I  H  F  L  Q   | E  N  T  Q  P  V      p.360

          .         .         .         .         .         .       g.32593
 CCTCTCAGTGGAAACCCTGGTTATGTCGTGGGGCTCCCATTAGCTGCTGGATTCCAGCCT       c.1140
 P  L  S  G  N  P  G  Y  V  V  G  L  P  L  A  A  G  F  Q  P         p.380

          | 11         .         .         .         .         .    g.33274
 CATAAGGG | GTCTGGGATTATTCAGACCACAAATAGATATGGACAGCTTACTATTCTTCAT    c.1200
 H  K  G  |  S  G  I  I  Q  T  T  N  R  Y  G  Q  L  T  I  L  H      p.400

          .         .         .         .         .         .       g.33334
 AGCACAACTGAGCAAGACTGCTTAGCACTGGAGGGGGTCCGGACCCCAGTATTATTTGGT       c.1260
 S  T  T  E  Q  D  C  L  A  L  E  G  V  R  T  P  V  L  F  G         p.420

          .         .          | 12        .         .         .    g.35971
 TACACTATGCAATCTGGCTGTAAACTAAG | ACTGACTGGAGCTCTCCCGTGTCAGCTCGTA    c.1320
 Y  T  M  Q  S  G  C  K  L  R  |  L  T  G  A  L  P  C  Q  L  V      p.440

          .         .         .         .         .         .       g.36031
 GCACAGAAGGTGAAGAGCCTGCTGTGGGGCCAGGGCTTCCCAGATTACGTGGCCCCTTTT       c.1380
 A  Q  K  V  K  S  L  L  W  G  Q  G  F  P  D  Y  V  A  P  F         p.460

          .         .         .         .         .         .       g.36091
 GGAAATTCCCAGGCCCAGGACATGCTGGACTGGGTGCCCATCCACTTCATCACCCAGTCA       c.1440
 G  N  S  Q  A  Q  D  M  L  D  W  V  P  I  H  F  I  T  Q  S         p.480

          .   | 13     .         .         .         .         .    g.38232
 TTCAACAGGAAG | GATTCCTGCCAGCTCCCAGGGGCTTTGGTTATAGAAGTGAAGTGGACT    c.1500
 F  N  R  K   | D  S  C  Q  L  P  G  A  L  V  I  E  V  K  W  T      p.500

          .         .         .         .         .         .       g.38292
 AAATACGGATCCCTGCTGAATCCACAGGCCAAAATAGTCAATGTAACTGCAAATCTAATT       c.1560
 K  Y  G  S  L  L  N  P  Q  A  K  I  V  N  V  T  A  N  L  I         p.520

          .         | 14         .         .         .         .    g.38764
 TCATCCTCCTTTCCTGAG | GCCAACTCAGGAAATGAAAGGACGATTCTTATTTCCACTGCG    c.1620
 S  S  S  F  P  E   | A  N  S  G  N  E  R  T  I  L  I  S  T  A      p.540

          .         .         .         .         .         .       g.38824
 GTTACTTTTGTGGATGTGTCTGCACCTGCAGAGGCAGGCTTCAGAGCTCCACCAGCCATC       c.1680
 V  T  F  V  D  V  S  A  P  A  E  A  G  F  R  A  P  P  A  I         p.560

          .         .         .         .                       g.38866
 AATGCCAGGCTGCCCTTTAACTTCTTCTTCCCGTTTGTTTGA |                      c.1723
 N  A  R  L  P  F  N  F  F  F  P  F  V  X                        p.573

   | 15      .         .         .         .         .         .    g.40075
 c | aatgctcagatgcatcagttccttaatatacacgtgaaatttgaaaactgtacattcgg    c.*60

          .         .                                               g.40104
 tgagattaaattttatatacaactagcaa                                      c.*89

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Tectonic family member 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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