tyrosyl-DNA phosphodiesterase 2 (TDP2) - coding DNA reference sequence

(used for variant description)

(last modified January 23, 2020)

This file was created to facilitate the description of sequence variants on transcript NM_016614.2 in the TDP2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_052787.1, covering TDP2 transcript NM_016614.2.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                                         .         .                g.5025
                                    ggggcggtgcagaggcggcaggaag       c.-1

          .         .         .         .         .         .       g.5085
 ATGGAGTTGGGGAGTTGCCTGGAGGGCGGGAGGGAGGCGGCGGAGGAAGAGGGCGAGCCT       c.60
 M  E  L  G  S  C  L  E  G  G  R  E  A  A  E  E  E  G  E  P         p.20

          .         .         .         .         .         .       g.5145
 GAGGTGAAAAAGCGGCGACTTCTGTGTGTGGAGTTTGCCTCGGTCGCAAGCTGCGATGCC       c.120
 E  V  K  K  R  R  L  L  C  V  E  F  A  S  V  A  S  C  D  A         p.40

          .         .         .         .      | 02  .         .    g.5291
 GCAGTGGCTCAGTGCTTCCTGGCCGAGAACGACTGGGAGATGGAA | AGGGCTCTGAACTCC    c.180
 A  V  A  Q  C  F  L  A  E  N  D  W  E  M  E   | R  A  L  N  S      p.60

          .         .         .         .         .         .       g.5351
 TACTTCGAGCCTCCGGTGGAGGAGAGCGCCTTGGAACGCCGACCTGAAACCATCTCTGAG       c.240
 Y  F  E  P  P  V  E  E  S  A  L  E  R  R  P  E  T  I  S  E         p.80

          .  | 03      .         .         .         .         .    g.13202
 CCCAAGACCTA | TGTTGACCTAACCAATGAAGAAACAACTGATTCCACCACTTCTAAAATC    c.300
 P  K  T  Y  |  V  D  L  T  N  E  E  T  T  D  S  T  T  S  K  I      p.100

          .         .         .         .         .         .       g.13262
 AGCCCATCTGAAGATACTCAGCAAGAAAATGGCAGCATGTTCTCTCTCATTACCTGGAAT       c.360
 S  P  S  E  D  T  Q  Q  E  N  G  S  M  F  S  L  I  T  W  N         p.120

          .         .         .         .         .         .       g.13322
 ATTGATGGATTAGATCTAAACAATCTGTCAGAGAGGGCTCGAGGGGTGTGTTCCTACTTA       c.420
 I  D  G  L  D  L  N  N  L  S  E  R  A  R  G  V  C  S  Y  L         p.140

       | 04  .         .         .         .         .         .    g.14039
 GCTTT | GTACAGCCCAGATGTGATATTTCTACAGGAAGTTATTCCCCCATATTATAGCTAC    c.480
 A  L  |  Y  S  P  D  V  I  F  L  Q  E  V  I  P  P  Y  Y  S  Y      p.160

          .         .         .        | 05.         .         .    g.17380
 CTAAAGAAGAGATCAAGTAATTATGAGATTATTACAG | GTCATGAAGAAGGATATTTCACA    c.540
 L  K  K  R  S  S  N  Y  E  I  I  T  G |   H  E  E  G  Y  F  T      p.180

          .         .         .         .         .         .       g.17440
 GCTATAATGTTGAAGAAATCAAGAGTGAAATTAAAAAGCCAAGAGATTATTCCTTTTCCA       c.600
 A  I  M  L  K  K  S  R  V  K  L  K  S  Q  E  I  I  P  F  P         p.200

          .         .         .       | 06 .         .         .    g.18758
 AGTACCAAAATGATGAGAAACCTTTTATGTGTGCAT | GTGAACGTGTCAGGAAATGAGCTT    c.660
 S  T  K  M  M  R  N  L  L  C  V  H   | V  N  V  S  G  N  E  L      p.220

          .         .         .         .         .         .       g.18818
 TGCCTTATGACATCCCATTTGGAGAGCACCAGAGGGCATGCTGCGGAACGAATGAATCAG       c.720
 C  L  M  T  S  H  L  E  S  T  R  G  H  A  A  E  R  M  N  Q         p.240

          .         .         .         .         .         .       g.18878
 TTAAAAATGGTTTTAAAGAAAATGCAAGAGGCTCCAGAGTCAGCTACAGTTATATTTGCA       c.780
 L  K  M  V  L  K  K  M  Q  E  A  P  E  S  A  T  V  I  F  A         p.260

          .         .        | 07.         .         .         .    g.20851
 GGAGATACAAATCTAAGGGATCGAGAG | GTTACCAGATGTGGTGGTTTACCCAACAACATT    c.840
 G  D  T  N  L  R  D  R  E   | V  T  R  C  G  G  L  P  N  N  I      p.280

          .         .         .         .         .         .       g.20911
 GTGGATGTCTGGGAGTTTTTGGGCAAACCTAAACATTGCCAGTATACATGGGATACACAA       c.900
 V  D  V  W  E  F  L  G  K  P  K  H  C  Q  Y  T  W  D  T  Q         p.300

          .         .         .         .         .         .       g.20971
 ATGAACTCTAATCTTGGAATAACTGCTGCTTGTAAACTTCGTTTTGATCGAATATTTTTC       c.960
 M  N  S  N  L  G  I  T  A  A  C  K  L  R  F  D  R  I  F  F         p.320

          .         .         .         .         .         .       g.21031
 AGAGCAGCAGCAGAAGAGGGACACATTATTCCCCGAAGTTTGGACCTTCTTGGATTAGAA       c.1020
 R  A  A  A  E  E  G  H  I  I  P  R  S  L  D  L  L  G  L  E         p.340

          .         .         .         .         .         .       g.21091
 AAACTGGACTGTGGTAGATTTCCTAGTGATCACTGGGGTCTTCTGTGCAACTTAGATATA       c.1080
 K  L  D  C  G  R  F  P  S  D  H  W  G  L  L  C  N  L  D  I         p.360

                                                                    g.21100
 ATATTGTAA                                                          c.1089
 I  L  X                                                            p.362

          .         .         .         .         .         .       g.21160
 aatgcttttcaagtgtgggttttgccctgattgttgcaaatacaatttccaccttctgga       c.*60

          .         .         .         .         .         .       g.21220
 aaggtaggtttgctgtggaggaaataatgtactagatcattgtcacagaaaaaccaacta       c.*120

          .         .         .         .         .         .       g.21280
 tgatttatggttgtgttttcagaattcaacattaaagattaatgtttatttaaacgaaca       c.*180

          .         .         .         .         .         .       g.21340
 cattcctgcattcaggatgtgaggccatttaataaaaagggcacaaagcctgtcagagtt       c.*240

          .         .         .         .         .         .       g.21400
 ttcaacggtgcttatagctgccagctggattccaaacaggtaccacattgtctctgagct       c.*300

          .         .         .         .         .         .       g.21460
 aatgtttatatttttccattcaggcaccgaaatagttaatatttgaaataagtcttcaaa       c.*360

          .         .         .         .         .         .       g.21520
 agaaaacataagagattattgagttcttgggactggatcctttatttcataagttcagat       c.*420

          .         .         .         .         .         .       g.21580
 catcttaaatgaaaatgccatgattatctgcagttaagtagatgacagctattctacatc       c.*480

          .         .         .         .         .         .       g.21640
 agacttgatttttgtcagctaattacataattggtaagctataattgaaaccttatggct       c.*540

          .         .         .         .         .         .       g.21700
 taaaattccttaactcctttttgattcatgtttgtagtcatgttgtcaacagaggcaaag       c.*600

          .         .         .         .         .         .       g.21760
 ttaagcttgatgatggttaaaatcggtttgatagcaccatgggacatttttctaacaaaa       c.*660

          .         .         .         .         .         .       g.21820
 ataaatgcatgaagagacatagccttttagttttgctaattgtgaaatggaaatgcttta       c.*720

          .         .         .         .         .         .       g.21880
 caggaagtaaatgcaaattacttttaagtgtgctttaaagaaaaatattttccccacaag       c.*780

          .         .         .                                     g.21911
 agaaatttaaataaagaattttatttgttta                                    c.*811

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Tyrosyl-DNA phosphodiesterase 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.