TEL2, telomere maintenance 2, homolog (S. cerevisiae) (TELO2) - coding DNA reference sequence

(used for variant description)

(last modified May 28, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_016111.3 in the TELO2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000016.9, covering TELO2 transcript NM_016111.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5051
          agcgcaggcgcagatgcgccctcccgcctggcgtcctccgcagattcgcgc       c.-241

 .         .         .         .         .         .                g.5111
 tgagaggcccgcggagacccgccccagaggctcaagaaaacccgcgggagcctcgcccgg       c.-181

 .         .         .         .         .         .                g.5171
 acccaggaactcgtgctcggggccaaccggctgggccgcgatcgcgtttcgtccggggcc       c.-121

 .         .         .         .         .         .                g.5231
 gcggcggccgtggggaatcggctgcagcgaatcggtggcgcgcggcgcctgagcgcgctg       c.-61

 .         .         .    | 02    .         .         .             g.5931
 cagtcacccgggagccgggtccag | gtcgtcttcccgtgacgcccagatctgtcctgcagg    c.-1

          .         .         .         .         .         .       g.5991
 ATGGAGCCAGCACCCTCAGAGGTTCGACTCGCCGTCCGGGAAGCCATTCATGCCCTCTCG       c.60
 M  E  P  A  P  S  E  V  R  L  A  V  R  E  A  I  H  A  L  S         p.20

          .         .         .         .         .         .       g.6051
 TCTTCGGAGGATGGCGGCCACATCTTCTGCACCCTGGAGTCCCTGAAGCGGTATCTCGGT       c.120
 S  S  E  D  G  G  H  I  F  C  T  L  E  S  L  K  R  Y  L  G         p.40

          .         .         .         .         .         .       g.6111
 GAGATGGAGCCTCCAGCGCTCCCGAGGGAGAAGGAGGAGTTTGCCTCGGCCCACTTCTCG       c.180
 E  M  E  P  P  A  L  P  R  E  K  E  E  F  A  S  A  H  F  S         p.60

          .         .         .         .         .         .       g.6171
 CCTGTCCTCAGATGTCTTGCCAGCAGGCTGAGCCCAGCCTGGCTGGAGCTGCTGCCCCAT       c.240
 P  V  L  R  C  L  A  S  R  L  S  P  A  W  L  E  L  L  P  H         p.80

          .         .         .         .         .         .       g.6231
 GGCCGCCTGGAGGAGCTGTGGGCCAGCTTCTTCCTGGAGGGCCCGGCGGACCAAGCCTTC       c.300
 G  R  L  E  E  L  W  A  S  F  F  L  E  G  P  A  D  Q  A  F         p.100

          .         .         .      | 03  .         .         .    g.7020
 CTGGTGTTGATGGAGACCATCGAGGGTGCTGCGGG | CCCCAGCTTCCGGCTGATGAAGATG    c.360
 L  V  L  M  E  T  I  E  G  A  A  G  |  P  S  F  R  L  M  K  M      p.120

          .         .         .         .         .         .       g.7080
 GCGCGGCTGCTGGCCAGATTCCTGCGCGAGGGCCGGCTGGCAGTGCTGATGGAGGCGCAG       c.420
 A  R  L  L  A  R  F  L  R  E  G  R  L  A  V  L  M  E  A  Q         p.140

          .         .         .         .         .         .       g.7140
 TGTCGGCAGCAGACGCAGCCCGGCTTCATCCTGCTCCGGGAGACGCTGCTGGGCAAGGTG       c.480
 C  R  Q  Q  T  Q  P  G  F  I  L  L  R  E  T  L  L  G  K  V         p.160

          .         .         .         .         .         .       g.7200
 GTGGCCCTGCCCGATCACCTGGGCAACCGCCTGCAGCAGGAGAACTTGGCCGAGTTCTTC       c.540
 V  A  L  P  D  H  L  G  N  R  L  Q  Q  E  N  L  A  E  F  F         p.180

          .         .         .         .         .         .       g.7260
 CCCCAGAACTACTTCCGCCTGCTCGGCGAGGAGGTCGTCCGGGTGCTGCAGGCGGTTGTG       c.600
 P  Q  N  Y  F  R  L  L  G  E  E  V  V  R  V  L  Q  A  V  V         p.200

          .    | 04    .         .         .         .         .    g.8732
 GACTCTCTCCAAG | GTGGCCTGGATTCCTCCGTGTCCTTCGTGTCTCAGGTCCTTGGGAAA    c.660
 D  S  L  Q  G |   G  L  D  S  S  V  S  F  V  S  Q  V  L  G  K      p.220

          .         .   | 05     .         .         .         .    g.9048
 GCCTGTGTCCACGGGAGGCAGC | AGGAGATCCTGGGCGTGCTGGTACCCCGGCTGGCAGCG    c.720
 A  C  V  H  G  R  Q  Q |   E  I  L  G  V  L  V  P  R  L  A  A      p.240

          .         .         .         .         .         .       g.9108
 CTCACCCAGGGCAGCTACCTGCACCAGCGCGTCTGCTGGCGCCTGGTGGAGCAAGTGCCG       c.780
 L  T  Q  G  S  Y  L  H  Q  R  V  C  W  R  L  V  E  Q  V  P         p.260

          .         .         .         .         . | 06       .    g.10890
 GACCGGGCCATGGAGGCTGTGCTGACCGGGCTGGTGGAGGCCGCACTGGG | GCCTGAGGTC    c.840
 D  R  A  M  E  A  V  L  T  G  L  V  E  A  A  L  G  |  P  E  V      p.280

          .         .         .         .         .         .       g.10950
 CTTTCGAGACTGCTGGGGAACCTGGTGGTGAAGAACAAGAAGGCCCAGTTTGTGATGACC       c.900
 L  S  R  L  L  G  N  L  V  V  K  N  K  K  A  Q  F  V  M  T         p.300

          .         .         .    | 07    .         .         .    g.11772
 CAGAAGCTTCTGTTCTTACAGTCCCGGCTCACG | ACGCCCATGCTGCAGAGCCTGCTGGGC    c.960
 Q  K  L  L  F  L  Q  S  R  L  T   | T  P  M  L  Q  S  L  L  G      p.320

          .         .         .         .   | 08     .         .    g.12014
 CATCTGGCCATGGACAGCCAGCGGCGCCCGCTCCTGCTGCAG | GTGCTGAAGGAGCTGTTG    c.1020
 H  L  A  M  D  S  Q  R  R  P  L  L  L  Q   | V  L  K  E  L  L      p.340

          .         .         .         .         .         .       g.12074
 GAGACGTGGGGCAGCAGCAGTGCCATCCGCCACACTCCCCTGCCGCAGCAGCGCCACGTC       c.1080
 E  T  W  G  S  S  S  A  I  R  H  T  P  L  P  Q  Q  R  H  V         p.360

          .         .         .         .         .         .       g.12134
 AGCAAGGCTGTCCTCATCTGCCTGGCGCAACTCGGGGAGCCGGAACTGCGGGACAGCCGG       c.1140
 S  K  A  V  L  I  C  L  A  Q  L  G  E  P  E  L  R  D  S  R         p.380

      | 09   .         .         .         .         .         .    g.12268
 GATG | AACTGCTGGCCAGCATGATGGCGGGCGTGAAGTGCCGCCTGGACAGTAGCCTGCCC    c.1200
 D  E |   L  L  A  S  M  M  A  G  V  K  C  R  L  D  S  S  L  P      p.400

          .         .         .         .         .         .       g.12328
 CCCGTGCGACGCCTGGGCATGATCGTGGCAGAGGTCGTTAGTGCCCGGATCCACCCCGAG       c.1260
 P  V  R  R  L  G  M  I  V  A  E  V  V  S  A  R  I  H  P  E         p.420

          .         .  | 10      .         .         .         .    g.13108
 GGGCCTCCCCTGAAATTCCAG | TACGAAGAGGATGAACTGAGCCTCGAGCTGCTGGCCTTG    c.1320
 G  P  P  L  K  F  Q   | Y  E  E  D  E  L  S  L  E  L  L  A  L      p.440

          .         .         .         .  | 11      .         .    g.13331
 GCCTCCCCCCAGCCTGCGGGTGACGGCGCCTCGGAGGCGGG | CACGTCCCTCGTTCCAGCC    c.1380
 A  S  P  Q  P  A  G  D  G  A  S  E  A  G  |  T  S  L  V  P  A      p.460

          .         .         .         .         .         .       g.13391
 ACGGCAGAGCCCCCTGCAGAGACCCCCGCAGAGATCGTGGATGGCGGCGTCCCCCAAGCA       c.1440
 T  A  E  P  P  A  E  T  P  A  E  I  V  D  G  G  V  P  Q  A         p.480

          .         .         .   | 12     .         .         .    g.13724
 CAGCTGGCGGGCTCTGACTCGGACCTGGACAG | CGATGATGAGTTTGTCCCCTACGACATG    c.1500
 Q  L  A  G  S  D  S  D  L  D  S  |  D  D  E  F  V  P  Y  D  M      p.500

          .         .         .         .         .         .       g.13784
 TCGGGGGACAGAGAGCTGAAGAGCAGCAAGGCTCCTGCCTACGTCCGGGACTGCGTGGAA       c.1560
 S  G  D  R  E  L  K  S  S  K  A  P  A  Y  V  R  D  C  V  E         p.520

   | 13      .         .         .         .         .         .    g.14021
 G | CCCTGACCACGTCTGAGGACATAGAGCGCTGGGAGGCAGCCCTGCGGGCCCTTGAGGGC    c.1620
 A |   L  T  T  S  E  D  I  E  R  W  E  A  A  L  R  A  L  E  G      p.540

          .         .         .    | 14    .         .         .    g.14321
 CTGGTCTACAGGAGCCCCACAGCCACTCGGGAG | GTGAGCGTGGAGCTGGCCAAGGTGCTT    c.1680
 L  V  Y  R  S  P  T  A  T  R  E   | V  S  V  E  L  A  K  V  L      p.560

          .         .         .         .         .         .       g.14381
 CTGCATCTGGAGGAGAAGACCTGTGTGGTGGGATTTGCAGGGCTGCGCCAGAGAGCCCTG       c.1740
 L  H  L  E  E  K  T  C  V  V  G  F  A  G  L  R  Q  R  A  L         p.580

          .         .         . | 15       .         .         .    g.14610
 GTGGCCGTCACGGTCACAGACCCGGCCCCG | GTGGCCGACTATCTGACCTCACAGTTCTAT    c.1800
 V  A  V  T  V  T  D  P  A  P   | V  A  D  Y  L  T  S  Q  F  Y      p.600

          .         .         .         .   | 16     .         .    g.17077
 GCCCTCAACTACAGCCTCCGGCAGCGCATGGACATCCTGGAT | GTGCTGACTCTGGCTGCC    c.1860
 A  L  N  Y  S  L  R  Q  R  M  D  I  L  D   | V  L  T  L  A  A      p.620

          .         .         .         .         .         .       g.17137
 CAGGAGCTGTCTAGGCCTGGGTGCCTCGGGAGGACTCCCCAACCTGGCTCCCCAAGTCCC       c.1920
 Q  E  L  S  R  P  G  C  L  G  R  T  P  Q  P  G  S  P  S  P         p.640

          .         .         .         .         .         .       g.17197
 AACACCCCGTGCCTGCCAGAGGCAGCCGTCTCTCAGCCTGGCAGTGCCGTGGCGTCTGAC       c.1980
 N  T  P  C  L  P  E  A  A  V  S  Q  P  G  S  A  V  A  S  D         p.660

          .         .         .         .         .     | 17   .    g.17893
 TGGCGGGTGGTGGTGGAGGAGCGGATCAGAAGCAAGACCCAGCGGCTCTCCAAG | GGTGGC    c.2040
 W  R  V  V  V  E  E  R  I  R  S  K  T  Q  R  L  S  K   | G  G      p.680

          .         .         .         .         .         .       g.17953
 CCGAGGCAGGGCCCGGCAGGCAGCCCCAGCAGATTCAACTCCGTGGCCGGCCACTTCTTC       c.2100
 P  R  Q  G  P  A  G  S  P  S  R  F  N  S  V  A  G  H  F  F         p.700

          .         .       | 18 .         .         .         .    g.18635
 TTCCCCCTCCTTCAGCGCTTTGACAG | GCCTCTGGTGACCTTCGACCTCTTGGGAGAAGAC    c.2160
 F  P  L  L  Q  R  F  D  R  |  P  L  V  T  F  D  L  L  G  E  D      p.720

          .         .         .         .         .         .       g.18695
 CAGCTGGTTCTCGGAAGGCTGGCGCACACCTTAGGGGCCCTGATGTGCCTGGCTGTTAAC       c.2220
 Q  L  V  L  G  R  L  A  H  T  L  G  A  L  M  C  L  A  V  N         p.740

        | 19 .         .         .         .         .         .    g.19009
 ACCACG | GTGGCTGTGGCCATGGGCAAGGCCCTGCTGGAATTCGTGTGGGCCCTTCGCTTC    c.2280
 T  T   | V  A  V  A  M  G  K  A  L  L  E  F  V  W  A  L  R  F      p.760

          .  | 20      .         .         .         .         .    g.19299
 CACATCGATGC | CTACGTGCGCCAGGGGCTGTTGTCGGCCGTCTCCTCCGTCCTGCTCAGC    c.2340
 H  I  D  A  |  Y  V  R  Q  G  L  L  S  A  V  S  S  V  L  L  S      p.780

          .         .         .         .         .         .       g.19359
 CTGCCTGCTGCGCGCCTGCTGGAGGACCTGATGGACGAGCTGCTGGAAGCCCGGTCCTGG       c.2400
 L  P  A  A  R  L  L  E  D  L  M  D  E  L  L  E  A  R  S  W         p.800

         | 21.         .         .         .         .         .    g.21532
 CTGGCGG | ACGTGGCTGAGAAAGACCCGGACGAGGACTGCAGGACGCTGGCACTGAGGGCC    c.2460
 L  A  D |   V  A  E  K  D  P  D  E  D  C  R  T  L  A  L  R  A      p.820

          .         .         .         .         .                 g.21586
 CTGCTGCTTCTGCAGAGACTCAAGAACAGGCTCCTCCCACCCGCGTCTCCCTAG             c.2514
 L  L  L  L  Q  R  L  K  N  R  L  L  P  P  A  S  P  X               p.837

          .         .         .         .         .         .       g.21646
 tccctggaggcctccccaggaccaccctcgccgacagcaaggcaggcggctgagcagcgg       c.*60

          .         .         .         .         .         .       g.21706
 cctggagcagcagagccaggctttgtagcgaggccaggtcttcggccgcatccggtacgg       c.*120

          .         .         .         .         .         .       g.21766
 agagtgcagatgcaggaaggcccggcctgccgctatttatagtgcagccagtccgctaaa       c.*180

          .         .         .         .         .         .       g.21826
 aatacactgggcctgggcactgcccgccgggacatggcagcctggacgtggggctggggc       c.*240

          .         .         .         .         .         .       g.21886
 tgtgggcgctgctggcggggttgactcttccagtgagggcagaaccaggctggcaggagg       c.*300

          .         .         .         .         .         .       g.21946
 ggaggacggtgtacctgctgctcagagcccccaaggctctcctctgagagccaccaagca       c.*360

          .         .         .         .         .         .       g.22006
 ggacagagcagctcttgtcccaggtccctcgggctgagcgccgtgtcaccaggagaatag       c.*420

          .         .         .         .         .         .       g.22066
 tgctcacagcccaggcagggtgtgtggctcctggatgggctcgtggggcgggatgggaca       c.*480

          .         .         .         .                           g.22109
 gggcacgggctctcagaaaataaactgctttattggaattaca                        c.*523

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The TEL2, telomere maintenance 2, homolog (S. cerevisiae) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 15
©2004-2016 Leiden University Medical Center