transferrin (TF) - coding DNA reference sequence

(used for variant description)

(last modified June 9, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_001063.3 in the TF gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_013080.1, covering TF transcript NM_001063.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5008
                                                     tggcaccg       c.-301

 .         .         .         .         .         .                g.5068
 agcgagccgcgatgacaatggctgcattgtgcttcatgtcccttcccatcaacatttctg       c.-241

 .         .         .         .         .         .                g.5128
 tgctggactccttccactcgcgggtcgtctccagagctcagaaaatgaggtgatcagtgg       c.-181

 .         .         .         .         .         .                g.5188
 gacgagtaaggaaggggggttgggagaggggcgattgggcaacccggctgcacaaacacg       c.-121

 .         .         .         .         .         .                g.5248
 ggaggtcaaagattgcgcccagcccgcccaggccgggaatggaataaagggacgcggggc       c.-61

 .         .         .         .         .         .                g.5308
 gccggaggctgcacagaagcgagtccgactgtgctcgctgctcagcgccgcacccggaag       c.-1

          .         .         .         .    | 02    .         .    g.7296
 ATGAGGCTCGCCGTGGGAGCCCTGCTGGTCTGCGCCGTCCTGG | GGCTGTGTCTGGCTGTC    c.60
 M  R  L  A  V  G  A  L  L  V  C  A  V  L  G |   L  C  L  A  V      p.20

          .         .         .         .         .         .       g.7356
 CCTGATAAAACTGTGAGATGGTGTGCAGTGTCGGAGCATGAGGCCACTAAGTGCCAGAGT       c.120
 P  D  K  T  V  R  W  C  A  V  S  E  H  E  A  T  K  C  Q  S         p.40

          .         .         .         .         .         .       g.7416
 TTCCGCGACCATATGAAAAGCGTCATTCCATCCGATGGTCCCAGTGTTGCTTGTGTGAAG       c.180
 F  R  D  H  M  K  S  V  I  P  S  D  G  P  S  V  A  C  V  K         p.60

          .         .         .       | 03 .         .         .    g.12486
 AAAGCCTCCTACCTTGATTGCATCAGGGCCATTGCG | GCAAACGAAGCGGATGCTGTGACA    c.240
 K  A  S  Y  L  D  C  I  R  A  I  A   | A  N  E  A  D  A  V  T      p.80

          .         .         .         .         .         .       g.12546
 CTGGATGCAGGTTTGGTGTATGATGCTTACCTGGCTCCCAATAACCTGAAGCCTGTGGTG       c.300
 L  D  A  G  L  V  Y  D  A  Y  L  A  P  N  N  L  K  P  V  V         p.100

          .         .      | 04  .         .         .         .    g.13397
 GCAGAGTTCTATGGGTCAAAAGAGG | ATCCACAGACTTTCTATTATGCTGTTGCTGTGGTG    c.360
 A  E  F  Y  G  S  K  E  D |   P  Q  T  F  Y  Y  A  V  A  V  V      p.120

          .         .         .         .         .         .       g.13457
 AAGAAGGATAGTGGCTTCCAGATGAACCAGCTTCGAGGCAAGAAGTCCTGCCACACGGGT       c.420
 K  K  D  S  G  F  Q  M  N  Q  L  R  G  K  K  S  C  H  T  G         p.140

          .         .         .         .         .         .       g.13517
 CTAGGCAGGTCCGCTGGGTGGAACATCCCCATAGGCTTACTTTACTGTGACTTACCTGAG       c.480
 L  G  R  S  A  G  W  N  I  P  I  G  L  L  Y  C  D  L  P  E         p.160

          .         .   | 05     .         .         .         .    g.14268
 CCACGTAAACCTCTTGAGAAAG | CAGTGGCCAATTTCTTCTCGGGCAGCTGTGCCCCTTGT    c.540
 P  R  K  P  L  E  K  A |   V  A  N  F  F  S  G  S  C  A  P  C      p.180

          .         .         .         .         .         .       g.14328
 GCGGATGGGACGGACTTCCCCCAGCTGTGTCAACTGTGTCCAGGGTGTGGCTGCTCCACC       c.600
 A  D  G  T  D  F  P  Q  L  C  Q  L  C  P  G  C  G  C  S  T         p.200

          .         .         .      | 06  .         .         .    g.15174
 CTTAACCAATACTTCGGCTACTCGGGAGCCTTCAA | GTGTCTGAAGGATGGTGCTGGGGAT    c.660
 L  N  Q  Y  F  G  Y  S  G  A  F  K  |  C  L  K  D  G  A  G  D      p.220

          .         .         .  | 07      .         .         .    g.15727
 GTGGCCTTTGTCAAGCACTCGACTATATTTG | AGAACTTGGCAAACAAGGCTGACAGGGAC    c.720
 V  A  F  V  K  H  S  T  I  F  E |   N  L  A  N  K  A  D  R  D      p.240

          .         .         .         .         .         .       g.15787
 CAGTATGAGCTGCTTTGCCTGGACAACACCCGGAAGCCGGTAGATGAATACAAGGACTGC       c.780
 Q  Y  E  L  L  C  L  D  N  T  R  K  P  V  D  E  Y  K  D  C         p.260

          .         .         .         .         .         .       g.15847
 CACTTGGCCCAGGTCCCTTCTCATACCGTCGTGGCCCGAAGTATGGGCGGCAAGGAGGAC       c.840
 H  L  A  Q  V  P  S  H  T  V  V  A  R  S  M  G  G  K  E  D         p.280

          .         .         . | 08       .         .         .    g.16666
 TTGATCTGGGAGCTTCTCAACCAGGCCCAG | GAACATTTTGGCAAAGACAAATCAAAAGAA    c.900
 L  I  W  E  L  L  N  Q  A  Q   | E  H  F  G  K  D  K  S  K  E      p.300

          .         .         .         .         .         .       g.16726
 TTCCAACTATTCAGCTCTCCTCATGGGAAGGACCTGCTGTTTAAGGACTCTGCCCACGGG       c.960
 F  Q  L  F  S  S  P  H  G  K  D  L  L  F  K  D  S  A  H  G         p.320

          .         .         .         .         .         .       g.16786
 TTTTTAAAAGTCCCCCCCAGGATGGATGCCAAGATGTACCTGGGCTATGAGTATGTCACT       c.1020
 F  L  K  V  P  P  R  M  D  A  K  M  Y  L  G  Y  E  Y  V  T         p.340

          .         .         | 09         .         .         .    g.18074
 GCCATCCGGAATCTACGGGAAGGCACAT | GCCCAGAAGCCCCAACAGATGAATGCAAGCCT    c.1080
 A  I  R  N  L  R  E  G  T  C |   P  E  A  P  T  D  E  C  K  P      p.360

          .         .         .         .         .         .       g.18134
 GTGAAGTGGTGTGCGCTGAGCCACCACGAGAGGCTCAAGTGTGATGAGTGGAGTGTTAAC       c.1140
 V  K  W  C  A  L  S  H  H  E  R  L  K  C  D  E  W  S  V  N         p.380

          .         .         .         .         .         .       g.18194
 AGTGTAGGGAAAATAGAGTGTGTATCAGCAGAGACCACCGAAGACTGCATCGCCAAGATC       c.1200
 S  V  G  K  I  E  C  V  S  A  E  T  T  E  D  C  I  A  K  I         p.400

     | 10    .         .         .         .         .         .    g.23106
 ATG | AATGGAGAAGCTGATGCCATGAGCTTGGATGGAGGGTTTGTCTACATAGCGGGCAAG    c.1260
 M   | N  G  E  A  D  A  M  S  L  D  G  G  F  V  Y  I  A  G  K      p.420

          .         .         .        | 11.         .         .    g.23765
 TGTGGTCTGGTGCCTGTCTTGGCAGAAAACTACAATA | AGAGCGATAATTGTGAGGATACA    c.1320
 C  G  L  V  P  V  L  A  E  N  Y  N  K |   S  D  N  C  E  D  T      p.440

          . | 12       .         .         .         .         .    g.25195
 CCAGAGGCAG | GGTATTTTGCTGTAGCAGTGGTGAAGAAATCAGCTTCTGACCTCACCTGG    c.1380
 P  E  A  G |   Y  F  A  V  A  V  V  K  K  S  A  S  D  L  T  W      p.460

          .         .         .         .         .         .       g.25255
 GACAATCTGAAAGGCAAGAAGTCCTGCCATACGGCAGTTGGCAGAACCGCTGGCTGGAAC       c.1440
 D  N  L  K  G  K  K  S  C  H  T  A  V  G  R  T  A  G  W  N         p.480

          .         .         .         .       | 13 .         .    g.26910
 ATCCCCATGGGCCTGCTCTACAATAAGATCAACCACTGCAGATTTG | ATGAATTTTTCAGT    c.1500
 I  P  M  G  L  L  Y  N  K  I  N  H  C  R  F  D |   E  F  F  S      p.500

          .         .         .         .         .         .       g.26970
 GAAGGTTGTGCCCCTGGGTCTAAGAAAGACTCCAGTCTCTGTAAGCTGTGTATGGGCTCA       c.1560
 E  G  C  A  P  G  S  K  K  D  S  S  L  C  K  L  C  M  G  S         p.520

          .         .         .         .         .         .       g.27030
 GGCCTAAACCTGTGTGAACCCAACAACAAAGAGGGATACTACGGCTACACAGGCGCTTTC       c.1620
 G  L  N  L  C  E  P  N  N  K  E  G  Y  Y  G  Y  T  G  A  F         p.540

    | 14     .         .         .         .         .         .    g.29433
 AG | GTGTCTGGTTGAGAAGGGAGATGTGGCCTTTGTGAAACACCAGACTGTCCCACAGAAC    c.1680
 R  |  C  L  V  E  K  G  D  V  A  F  V  K  H  Q  T  V  P  Q  N      p.560

         | 15.         .         .         .         .         .    g.34353
 ACTGGGG | GAAAAAACCCTGATCCATGGGCTAAGAATCTGAATGAAAAAGACTATGAGTTG    c.1740
 T  G  G |   K  N  P  D  P  W  A  K  N  L  N  E  K  D  Y  E  L      p.580

          .         .         .         .         .         .       g.34413
 CTGTGCCTTGATGGTACCAGGAAACCTGTGGAGGAGTATGCGAACTGCCACCTGGCCAGA       c.1800
 L  C  L  D  G  T  R  K  P  V  E  E  Y  A  N  C  H  L  A  R         p.600

          .         .         .         .         .         .       g.34473
 GCCCCGAATCACGCTGTGGTCACACGGAAAGATAAGGAAGCTTGCGTCCACAAGATATTA       c.1860
 A  P  N  H  A  V  V  T  R  K  D  K  E  A  C  V  H  K  I  L         p.620

          .   | 16     .         .         .         .         .    g.35964
 CGTCAACAGCAG | CACCTATTTGGAAGCAACGTAACTGACTGCTCGGGCAACTTTTGTTTG    c.1920
 R  Q  Q  Q   | H  L  F  G  S  N  V  T  D  C  S  G  N  F  C  L      p.640

          .         .         .         .         .         .       g.36024
 TTCCGGTCGGAAACCAAGGACCTTCTGTTCAGAGATGACACAGTATGTTTGGCCAAACTT       c.1980
 F  R  S  E  T  K  D  L  L  F  R  D  D  T  V  C  L  A  K  L         p.660

          .         .         .         .         .         .       g.36084
 CATGACAGAAACACATATGAAAAATACTTAGGAGAAGAATATGTCAAGGCTGTTGGTAAC       c.2040
 H  D  R  N  T  Y  E  K  Y  L  G  E  E  Y  V  K  A  V  G  N         p.680

          .         .   | 17     .         .         .              g.37491
 CTGAGAAAATGCTCCACCTCAT | CACTCCTGGAAGCCTGCACTTTCCGTAGACCTTAA       c.2097
 L  R  K  C  S  T  S  S |   L  L  E  A  C  T  F  R  R  P  X         p.698

          .         .         .         .         .         .       g.37551
 aatctcagaggtagggctgccaccaaggtgaagatgggaacgcagatgatccatgagttt       c.*60

          .         .         .         .         .         .       g.37611
 gccctggtttcactggcccaagtggtttgtgctaaccacgtctgtcttcacagctctgtg       c.*120

          .         .         .         .         .         .       g.37671
 ttgccatgtgtgctgaacaaaaaataaaaattattattgattttatatttcaaaaactcc       c.*180

          .         .         .         .         .         .       g.37731
 attctttcctaaatattttcaacaaaggatttctttatgcattctgcctaaatacctatg       c.*240

          .         .         .         .         .         .       g.37791
 caactgagcccttccttctcagctcaagattcgtctggtctttccctacagctttgtgtg       c.*300

          .         .         .         .         .         .       g.37851
 tgccatggccacatctcctgggtacagttcaaggagacatcttttctaaaagggtctgcg       c.*360

          .         .                                               g.37877
 tgatcattaaaatataatcaaatgta                                         c.*386

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Transferrin protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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