transforming growth factor, beta 1 (TGFB1) - coding DNA reference sequence

(used for variant description)

(last modified December 10, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_000660.4 in the TGFB1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_013364.1, covering TGFB1 transcript NM_000660.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5042
                   ccccgccgccgccgcccttcgcgccctgggccatctccctcc       c.-841

 .         .         .         .         .         .                g.5102
 cacctccctccgcggagcagccagacagcgagggccccggccgggggcaggggggacgcc       c.-781

 .         .         .         .         .         .                g.5162
 ccgtccggggcacccccccggctctgagccgcccgcggggccggcctcggcccggagcgg       c.-721

 .         .         .         .         .         .                g.5222
 aggaaggagtcgccgaggagcagcctgaggccccagagtctgagacgagccgccgccgcc       c.-661

 .         .         .         .         .         .                g.5282
 cccgccactgcggggaggagggggaggaggagcgggaggagggacgagctggtcgggaga       c.-601

 .         .         .         .         .         .                g.5342
 agaggaaaaaaacttttgagacttttccgttgccgctgggagccggaggcgcggggacct       c.-541

 .         .         .         .         .         .                g.5402
 cttggcgcgacgctgccccgcgaggaggcaggacttggggaccccagaccgcctcccttt       c.-481

 .         .         .         .         .         .                g.5462
 gccgccggggacgcttgctccctccctgccccctacacggcgtccctcaggcgcccccat       c.-421

 .         .         .         .         .         .                g.5522
 tccggaccagccctcgggagtcgccgacccggcctcccgcaaagacttttccccagacct       c.-361

 .         .         .         .         .         .                g.5582
 cgggcgcaccccctgcacgccgccttcatccccggcctgtctcctgagcccccgcgcatc       c.-301

 .         .         .         .         .         .                g.5642
 ctagaccctttctcctccaggagacggatctctctccgacctgccacagatcccctattc       c.-241

 .         .         .         .         .         .                g.5702
 aagaccacccaccttctggtaccagatcgcgcccatctaggttatttccgtgggatactg       c.-181

 .         .         .         .         .         .                g.5762
 agacacccccggtccaagcctcccctccaccactgcgcccttctccctgaggacctcagc       c.-121

 .         .         .         .         .         .                g.5822
 tttccctcgaggccctcctaccttttgccgggagacccccagcccctgcaggggcggggc       c.-61

 .         .         .         .         .         .                g.5882
 ctccccaccacaccagccctgttcgcgctctcggcagtgccggggggcgccgcctccccc       c.-1

          .         .         .         .         .         .       g.5942
 ATGCCGCCCTCCGGGCTGCGGCTGCTGCCGCTGCTGCTACCGCTGCTGTGGCTACTGGTG       c.60
 M  P  P  S  G  L  R  L  L  P  L  L  L  P  L  L  W  L  L  V         p.20

          .         .         .         .         .         .       g.6002
 CTGACGCCTGGCCGGCCGGCCGCGGGACTATCCACCTGCAAGACTATCGACATGGAGCTG       c.120
 L  T  P  G  R  P  A  A  G  L  S  T  C  K  T  I  D  M  E  L         p.40

          .         .         .         .         .         .       g.6062
 GTGAAGCGGAAGCGCATCGAGGCCATCCGCGGCCAGATCCTGTCCAAGCTGCGGCTCGCC       c.180
 V  K  R  K  R  I  E  A  I  R  G  Q  I  L  S  K  L  R  L  A         p.60

          .         .         .         .         .         .       g.6122
 AGCCCCCCGAGCCAGGGGGAGGTGCCGCCCGGCCCGCTGCCCGAGGCCGTGCTCGCCCTG       c.240
 S  P  P  S  Q  G  E  V  P  P  G  P  L  P  E  A  V  L  A  L         p.80

          .         .         .         .         .         .       g.6182
 TACAACAGCACCCGCGACCGGGTGGCCGGGGAGAGTGCAGAACCGGAGCCCGAGCCTGAG       c.300
 Y  N  S  T  R  D  R  V  A  G  E  S  A  E  P  E  P  E  P  E         p.100

          .         .         .         .         .      | 02  .    g.10476
 GCCGACTACTACGCCAAGGAGGTCACCCGCGTGCTAATGGTGGAAACCCACAACG | AAATC    c.360
 A  D  Y  Y  A  K  E  V  T  R  V  L  M  V  E  T  H  N  E |   I      p.120

          .         .         .         .         .         .       g.10536
 TATGACAAGTTCAAGCAGAGTACACACAGCATATATATGTTCTTCAACACATCAGAGCTC       c.420
 Y  D  K  F  K  Q  S  T  H  S  I  Y  M  F  F  N  T  S  E  L         p.140

          .         .         .         .         .         .       g.10596
 CGAGAAGCGGTACCTGAACCCGTGTTGCTCTCCCGGGCAGAGCTGCGTCTGCTGAGGCTC       c.480
 R  E  A  V  P  E  P  V  L  L  S  R  A  E  L  R  L  L  R  L         p.160

          .         .         .       | 03 .         .         .    g.14086
 AAGTTAAAAGTGGAGCAGCACGTGGAGCTGTACCAG | AAATACAGCAACAATTCCTGGCGA    c.540
 K  L  K  V  E  Q  H  V  E  L  Y  Q   | K  Y  S  N  N  S  W  R      p.180

          .         .         .         .         .         .       g.14146
 TACCTCAGCAACCGGCTGCTGGCACCCAGCGACTCGCCAGAGTGGTTATCTTTTGATGTC       c.600
 Y  L  S  N  R  L  L  A  P  S  D  S  P  E  W  L  S  F  D  V         p.200

          .         .         .     | 04   .         .         .    g.16705
 ACCGGAGTTGTGCGGCAGTGGTTGAGCCGTGGAG | GGGAAATTGAGGGCTTTCGCCTTAGC    c.660
 T  G  V  V  R  Q  W  L  S  R  G  G |   E  I  E  G  F  R  L  S      p.220

          .         .         .         .         .   | 05     .    g.16904
 GCCCACTGCTCCTGTGACAGCAGGGATAACACACTGCAAGTGGACATCAACG | GGTTCACT    c.720
 A  H  C  S  C  D  S  R  D  N  T  L  Q  V  D  I  N  G |   F  T      p.240

          .         .         .         .         .         .       g.16964
 ACCGGCCGCCGAGGTGACCTGGCCACCATTCATGGCATGAACCGGCCTTTCCTGCTTCTC       c.780
 T  G  R  R  G  D  L  A  T  I  H  G  M  N  R  P  F  L  L  L         p.260

          .         .         .         .         .         .       g.17024
 ATGGCCACCCCGCTGGAGAGGGCCCAGCATCTGCAAAGCTCCCGGCACCGCCGAGCCCTG       c.840
 M  A  T  P  L  E  R  A  Q  H  L  Q  S  S  R  H  R  R  A  L         p.280

          .         . | 06       .         .         .         .    g.26685
 GACACCAACTATTGCTTCAG | CTCCACGGAGAAGAACTGCTGCGTGCGGCAGCTGTACATT    c.900
 D  T  N  Y  C  F  S  |  S  T  E  K  N  C  C  V  R  Q  L  Y  I      p.300

          .         .         .         .         .         .       g.26745
 GACTTCCGCAAGGACCTCGGCTGGAAGTGGATCCACGAGCCCAAGGGCTACCATGCCAAC       c.960
 D  F  R  K  D  L  G  W  K  W  I  H  E  P  K  G  Y  H  A  N         p.320

          .         .         .         .         .     | 07   .    g.27722
 TTCTGCCTCGGGCCCTGCCCCTACATTTGGAGCCTGGACACGCAGTACAGCAAG | GTCCTG    c.1020
 F  C  L  G  P  C  P  Y  I  W  S  L  D  T  Q  Y  S  K   | V  L      p.340

          .         .         .         .         .         .       g.27782
 GCCCTGTACAACCAGCATAACCCGGGCGCCTCGGCGGCGCCGTGCTGCGTGCCGCAGGCG       c.1080
 A  L  Y  N  Q  H  N  P  G  A  S  A  A  P  C  C  V  P  Q  A         p.360

          .         .         .         .         .         .       g.27842
 CTGGAGCCGCTGCCCATCGTGTACTACGTGGGCCGCAAGCCCAAGGTGGAGCAGCTGTCC       c.1140
 L  E  P  L  P  I  V  Y  Y  V  G  R  K  P  K  V  E  Q  L  S         p.380

          .         .         .                                     g.27875
 AACATGATCGTGCGCTCCTGCAAGTGCAGCTGA                                  c.1173
 N  M  I  V  R  S  C  K  C  S  X                                    p.390

          .         .         .         .         .         .       g.27935
 ggtcccgccccgccccgccccgccccggcaggcccggccccaccccgccccgcccccgct       c.*60

          .         .         .         .         .         .       g.27995
 gccttgcccatgggggctgtatttaaggacacccgtgccccaagcccacctggggcccca       c.*120

          .         .                                               g.28020
 ttaaagatggagagaggactgcgga                                          c.*145

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Transforming growth factor, beta 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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