transforming growth factor, beta receptor 1 (TGFBR1) - coding DNA reference sequence

(used for variant description)

(last modified December 13, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_004612.2 in the TGFBR1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_007461.1, covering TGFBR1 transcript NM_004612.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5016
                                             ggcgaggcgaggtttg       c.-61

 .         .         .         .         .         .                g.5076
 ctggggtgaggcagcggcgcggccgggccgggccgggccacaggcggtggcggcgggacc       c.-1

          .         .         .         .         .         .       g.5136
 ATGGAGGCGGCGGTCGCTGCTCCGCGTCCCCGGCTGCTCCTCCTCGTGCTGGCGGCGGCG       c.60
 M  E  A  A  V  A  A  P  R  P  R  L  L  L  L  V  L  A  A  A         p.20

          .         .         .        | 02.         .         .    g.28748
 GCGGCGGCGGCGGCGGCGCTGCTCCCGGGGGCGACGG | CGTTACAGTGTTTCTGCCACCTC    c.120
 A  A  A  A  A  A  L  L  P  G  A  T  A |   L  Q  C  F  C  H  L      p.40

          .         .         .         .         .         .       g.28808
 TGTACAAAAGACAATTTTACTTGTGTGACAGATGGGCTCTGCTTTGTCTCTGTCACAGAG       c.180
 C  T  K  D  N  F  T  C  V  T  D  G  L  C  F  V  S  V  T  E         p.60

          .         .         .         .         .         .       g.28868
 ACCACAGACAAAGTTATACACAACAGCATGTGTATAGCTGAAATTGACTTAATTCCTCGA       c.240
 T  T  D  K  V  I  H  N  S  M  C  I  A  E  I  D  L  I  P  R         p.80

          .         .         .         .         .         .       g.28928
 GATAGGCCGTTTGTATGTGCACCCTCTTCAAAAACTGGGTCTGTGACTACAACATATTGC       c.300
 D  R  P  F  V  C  A  P  S  S  K  T  G  S  V  T  T  T  Y  C         p.100

          .         .         .         .    | 03    .         .    g.32396
 TGCAATCAGGACCATTGCAATAAAATAGAACTTCCAACTACTG | TAAAGTCATCACCTGGC    c.360
 C  N  Q  D  H  C  N  K  I  E  L  P  T  T  V |   K  S  S  P  G      p.120

          .         .         .         .         .         .       g.32456
 CTTGGTCCTGTGGAACTGGCAGCTGTCATTGCTGGACCAGTGTGCTTCGTCTGCATCTCA       c.420
 L  G  P  V  E  L  A  A  V  I  A  G  P  V  C  F  V  C  I  S         p.140

          .         .         .         .         .         .       g.32516
 CTCATGTTGATGGTCTATATCTGCCACAACCGCACTGTCATTCACCATCGAGTGCCAAAT       c.480
 L  M  L  M  V  Y  I  C  H  N  R  T  V  I  H  H  R  V  P  N         p.160

          .         .         .         .         .         .       g.32576
 GAAGAGGACCCTTCATTAGATCGCCCTTTTATTTCAGAGGGTACTACGTTGAAAGACTTA       c.540
 E  E  D  P  S  L  D  R  P  F  I  S  E  G  T  T  L  K  D  L         p.180

          .         .         .     | 04   .         .         .    g.37755
 ATTTATGATATGACAACGTCAGGTTCTGGCTCAG | GTTTACCATTGCTTGTTCAGAGAACA    c.600
 I  Y  D  M  T  T  S  G  S  G  S  G |   L  P  L  L  V  Q  R  T      p.200

          .         .         .         .         .         .       g.37815
 ATTGCGAGAACTATTGTGTTACAAGAAAGCATTGGCAAAGGTCGATTTGGAGAAGTTTGG       c.660
 I  A  R  T  I  V  L  Q  E  S  I  G  K  G  R  F  G  E  V  W         p.220

          .         .         .         .         .         .       g.37875
 AGAGGAAAGTGGCGGGGAGAAGAAGTTGCTGTTAAGATATTCTCCTCTAGAGAAGAACGT       c.720
 R  G  K  W  R  G  E  E  V  A  V  K  I  F  S  S  R  E  E  R         p.240

          .         .         .         .         .         .       g.37935
 TCGTGGTTCCGTGAGGCAGAGATTTATCAAACTGTAATGTTACGTCATGAAAACATCCTG       c.780
 S  W  F  R  E  A  E  I  Y  Q  T  V  M  L  R  H  E  N  I  L         p.260

          .         .      | 05  .         .         .         .    g.42441
 GGATTTATAGCAGCAGACAATAAAG | ACAATGGTACTTGGACTCAGCTCTGGTTGGTGTCA    c.840
 G  F  I  A  A  D  N  K  D |   N  G  T  W  T  Q  L  W  L  V  S      p.280

          .         .         .         .         .         .       g.42501
 GATTATCATGAGCATGGATCCCTTTTTGATTACTTAAACAGATACACAGTTACTGTGGAA       c.900
 D  Y  H  E  H  G  S  L  F  D  Y  L  N  R  Y  T  V  T  V  E         p.300

          .         .         .         .         .         .       g.42561
 GGAATGATAAAACTTGCTCTGTCCACGGCGAGCGGTCTTGCCCATCTTCACATGGAGATT       c.960
 G  M  I  K  L  A  L  S  T  A  S  G  L  A  H  L  H  M  E  I         p.320

          .    | 06    .         .         .         .         .    g.44649
 GTTGGTACCCAAG | GAAAGCCAGCCATTGCTCATAGAGATTTGAAATCAAAGAATATCTTG    c.1020
 V  G  T  Q  G |   K  P  A  I  A  H  R  D  L  K  S  K  N  I  L      p.340

          .         .         .         .         .         .       g.44709
 GTAAAGAAGAATGGAACTTGCTGTATTGCAGACTTAGGACTGGCAGTAAGACATGATTCA       c.1080
 V  K  K  N  G  T  C  C  I  A  D  L  G  L  A  V  R  H  D  S         p.360

          .         .         .         .         . | 07       .    g.46365
 GCCACAGATACCATTGATATTGCTCCAAACCACAGAGTGGGAACAAAAAG | GTACATGGCC    c.1140
 A  T  D  T  I  D  I  A  P  N  H  R  V  G  T  K  R  |  Y  M  A      p.380

          .         .         .         .         .         .       g.46425
 CCTGAAGTTCTCGATGATTCCATAAATATGAAACATTTTGAATCCTTCAAACGTGCTGAC       c.1200
 P  E  V  L  D  D  S  I  N  M  K  H  F  E  S  F  K  R  A  D         p.400

          .         .         .         .         .      | 08  .    g.47529
 ATCTATGCAATGGGCTTAGTATTCTGGGAAATTGCTCGACGATGTTCCATTGGTG | GAATT    c.1260
 I  Y  A  M  G  L  V  F  W  E  I  A  R  R  C  S  I  G  G |   I      p.420

          .         .         .         .         .         .       g.47589
 CATGAAGATTACCAACTGCCTTATTATGATCTTGTACCTTCTGACCCATCAGTTGAAGAA       c.1320
 H  E  D  Y  Q  L  P  Y  Y  D  L  V  P  S  D  P  S  V  E  E         p.440

          .         .         .         .         .         .       g.47649
 ATGAGAAAAGTTGTTTGTGAACAGAAGTTAAGGCCAAATATCCCAAACAGATGGCAGAGC       c.1380
 M  R  K  V  V  C  E  Q  K  L  R  P  N  I  P  N  R  W  Q  S         p.460

        | 09 .         .         .         .         .         .    g.49104
 TGTGAA | GCCTTGAGAGTAATGGCTAAAATTATGAGAGAATGTTGGTATGCCAATGGAGCA    c.1440
 C  E   | A  L  R  V  M  A  K  I  M  R  E  C  W  Y  A  N  G  A      p.480

          .         .         .         .         .         .       g.49164
 GCTAGGCTTACAGCATTGCGGATTAAGAAAACATTATCGCAACTCAGTCAACAGGAAGGC       c.1500
 A  R  L  T  A  L  R  I  K  K  T  L  S  Q  L  S  Q  Q  E  G         p.500

          .                                                         g.49176
 ATCAAAATGTAA                                                       c.1512
 I  K  M  X                                                         p.503

          .         .         .         .         .         .       g.49236
 ttctacagctttgcctgaactctccttttttcttcagatctgctcctgggttttaatttg       c.*60

          .         .         .         .         .         .       g.49296
 ggaggtcaattgttctacctcactgagagggaacagaaggatattgcttccttttgcagc       c.*120

          .         .         .         .         .         .       g.49356
 agtgtaataaagtcaattaaaaacttcccaggatttctttggacccaggaaacagccatg       c.*180

          .         .         .         .         .         .       g.49416
 tgggtcctttctgtgcactatgaacgcttctttcccaggacagaaaatgtgtagtctacc       c.*240

          .         .         .         .         .         .       g.49476
 tttattttttattaacaaaacttgttttttaaaaagatgattgctggtcttaactttagg       c.*300

          .         .         .         .         .         .       g.49536
 taactctgctgtgctggagatcatctttaagggcaaaggagttggattgctgaattacaa       c.*360

          .         .         .         .         .         .       g.49596
 tgaaacatgtcttattactaaagaaagtgatttactcctggttagtacattctcagagga       c.*420

          .         .         .         .         .         .       g.49656
 ttctgaaccactagagtttccttgattcagactttgaatgtactgttctatagtttttca       c.*480

          .         .         .         .         .         .       g.49716
 ggatcttaaaactaacacttataaaactcttatcttgagtctaaaaatgacctcatatag       c.*540

          .         .         .         .         .         .       g.49776
 tagtgaggaacataattcatgcaattgtattttgtatactattattgttctttcacttat       c.*600

          .         .         .         .         .         .       g.49836
 tcagaacattacatgccttcaaaatgggattgtactataccagtaagtgccacttctgtg       c.*660

          .         .         .         .         .         .       g.49896
 tctttctaatggaaatgagtagaattgctgaaagtctctatgttaaaacctatagtgttt       c.*720

          .         .         .         .         .         .       g.49956
 gaattcaaaaagcttatttatctgggtaacccaaactttttctgttttgtttttggaagg       c.*780

          .         .         .         .         .         .       g.50016
 gtttttgtggtatgtcatttggtattctattctgaaaatgcctttctcctaccaaaatgt       c.*840

          .         .         .         .         .         .       g.50076
 gcttaagccactaaagaaatgaagtggcattaattagtaaattattagcatggtcatgtt       c.*900

          .         .         .         .         .         .       g.50136
 tgaatattctcacatcaagcttttgcattttaattgtgttgtctaagtatacttttaaaa       c.*960

          .         .         .         .         .         .       g.50196
 aatcaagtggcactctagatgcttatagtactttaatatttgtagcatacagactaattt       c.*1020

          .         .         .         .         .         .       g.50256
 ttctaaaagggaaagtctgtctagctgcttgtgaaaagttatgtggtattctgtaagcca       c.*1080

          .         .         .         .         .         .       g.50316
 tttttttctttatctgttcaaagacttattttttaagacatgaattacatttaaaattag       c.*1140

          .         .         .         .         .         .       g.50376
 aatatggttaatattaaataataggcctttttctaggaaggcgaaggtagttaataattt       c.*1200

          .         .         .         .         .         .       g.50436
 gaatagataacagatgtgcaagaaagtcacatttgttatgtatgtaggagtaaacgttcg       c.*1260

          .         .         .         .         .         .       g.50496
 gtggatcctctgtctttgtaactgaggttagagctagtgtggttttgaggtctcactaca       c.*1320

          .         .         .         .         .         .       g.50556
 ctttgaggaaggcagcttttaattcagtgtttccttatgtgtgcgtacattgcaactgct       c.*1380

          .         .         .         .         .         .       g.50616
 tacatgtaatttatgtaatgcattcagtgcacccttgttacttgggagaggtggtagcta       c.*1440

          .         .         .         .         .         .       g.50676
 aagaacattctgagtataggtttttctccatttacagatgtctttggtcaaatattgaaa       c.*1500

          .         .         .         .         .         .       g.50736
 gcaaacttgtcatggtcttcttacattaagttgaaactagcttataataactggttttta       c.*1560

          .         .         .         .         .         .       g.50796
 cttccaatgctatgaagtctctgcagggcttttacagttttcgaagtccttttatcactg       c.*1620

          .         .         .         .         .         .       g.50856
 tgatcttattctgaggggagaaaaaactatcatagctctgaggcaagacttcgactttat       c.*1680

          .         .         .         .         .         .       g.50916
 agtgctatcagttccccgatacagggtcagagtaacccatacagtattttggtcaggaag       c.*1740

          .         .         .         .         .         .       g.50976
 agaaagtggccatttacactgaatgagttgcattctgataatgtcttatctcttatacgt       c.*1800

          .         .         .         .         .         .       g.51036
 agaataaatttgaaagactatttgatcttaaaaccaaagtaattttagaatgagtgacat       c.*1860

          .         .         .         .         .         .       g.51096
 attacataggaatttagtgtcaatttcatgtgtttaaaaacatcatgggaaaaatgctta       c.*1920

          .         .         .         .         .         .       g.51156
 gaggttactattttgactacaaagttgagtttttttctgtagttaccataatttcattga       c.*1980

          .         .         .         .         .         .       g.51216
 agcaaatgaatgagtttgagaggtttgtttttatagttgtgttgtattacttgtttaata       c.*2040

          .         .         .         .         .         .       g.51276
 ataatctctaattctgtgatcaggtactttttttgtgggggttttttttttgtttttttt       c.*2100

          .         .         .         .         .         .       g.51336
 tttttgttgttgtttttgggccatttctaagcctaccagatctgctttatgaaatccagg       c.*2160

          .         .         .         .         .         .       g.51396
 ggaccaatgcattttatcactaaaactatttttatataattttaagaatataccaaaagt       c.*2220

          .         .         .         .         .         .       g.51456
 tgtctgatttaaagttgtaatacatgatttctcactttcatgtaaggttatccacttttg       c.*2280

          .         .         .         .         .         .       g.51516
 ctgaagatattttttattgaatcaaagattgagttacaattatacttttcttacctaagt       c.*2340

          .         .         .         .         .         .       g.51576
 ggataaaatgtacttttgatgaatcagggaatttttttaaagttggagtttagttctaaa       c.*2400

          .         .         .         .         .         .       g.51636
 ttgactttacgtattactgcagttaattccttttttggctagggatggtttgataaacca       c.*2460

          .         .         .         .         .         .       g.51696
 caattggctgatattgaaaatgaaagaaacttaaaaggtgggatggatcatgattactgt       c.*2520

          .         .         .         .         .         .       g.51756
 cgataactgcagataaatttgattagagtaataattttgtcatttaaaaacacagttgtt       c.*2580

          .         .         .         .         .         .       g.51816
 tatactgcccatcctaggatgctcaccttccaagattcaacgtggctaaaacatcttctg       c.*2640

          .         .         .         .         .         .       g.51876
 gtaaattgtgcgtccatattcattttgtcagtagccaggagaaatggggatgggggaaat       c.*2700

          .         .         .         .         .         .       g.51936
 acgacttagtgaggcatagacatccctggtccatcctttctgtctccagctgtttcttgg       c.*2760

          .         .         .         .         .         .       g.51996
 aacctgctctcctgcttgctggtccctgacgcagagaccgttgcctcccccacagccgtt       c.*2820

          .         .         .         .         .         .       g.52056
 tgactgaaggctgctctggagacctagagtaaaacggctgatggaagttgtgggacccac       c.*2880

          .         .         .         .         .         .       g.52116
 ttccatttccttcagtcattagaggtggaagggaggggtctccaagtttggagattgagc       c.*2940

          .         .         .         .         .         .       g.52176
 agatgaggcttgggatgcccctgctttgacttcagccatggatgaggagtgggatggcag       c.*3000

          .         .         .         .         .         .       g.52236
 caaggtggctcctgtggcagtggagttgtgccagaaacagtggccagttgtatcgcctat       c.*3060

          .         .         .         .         .         .       g.52296
 aagacagggtaaggtctgaagagctgagcctgtaattctgctgtaataatgatagtgctc       c.*3120

          .         .         .         .         .         .       g.52356
 aagaagtgccttgagttggtgtacagtgccatggccatcaagaatcccagatttcaggtt       c.*3180

          .         .         .         .         .         .       g.52416
 ttattacaaaatgtaagtggtcacttggcgattttgtagtacatgcatgagttacctttt       c.*3240

          .         .         .         .         .         .       g.52476
 ttctctatgtctgagaactgtcagattaaaacaagatggcaaagagatcgttagagtgca       c.*3300

          .         .         .         .         .         .       g.52536
 caacaaaatcactatcccattagacacatcatcaaaagcttatttttattcttgcactgg       c.*3360

          .         .         .         .         .         .       g.52596
 aagaatcgtaagtcaactgtttcttgaccatggcagtgttctggctccaaatggtagtga       c.*3420

          .         .         .         .         .         .       g.52656
 ttccaaataatggttctgttaacactttggcagaaaatgccagctcagatattttgagat       c.*3480

          .         .         .         .         .         .       g.52716
 actaaggattatctttggacatgtactgcagcttcttgtctctgttttggattactggaa       c.*3540

          .         .         .         .         .         .       g.52776
 tacccatgggccctctcaagagtgctggacttctaggacattaagatgattgtcagtaca       c.*3600

          .         .         .         .         .         .       g.52836
 ttaaacttttcaatcccattatgcaatcttgtttgtaaatgtaaacttctaaaaatatgg       c.*3660

          .         .         .         .         .         .       g.52896
 ttaataacattcaacctgtttattacaacttaaaaggaacttcagtgaatttgtttttat       c.*3720

          .         .         .         .         .         .       g.52956
 tttttaacaagatttgtgaactgaatatcatgaaccatgttttgatacccctttttcacg       c.*3780

          .         .         .         .         .         .       g.53016
 ttgtgccaacggaatagggtgtttgatatttcttcatatgttaaggagatgcttcaaaat       c.*3840

          .         .         .         .         .         .       g.53076
 gtcaattgctttaaacttaaattacctctcaagagaccaaggtacatttacctcattgtg       c.*3900

          .         .         .         .         .         .       g.53136
 tatataatgtttaatatttgtcagagcattctccaggtttgcagttttatttctataaag       c.*3960

          .         .         .         .         .         .       g.53196
 tatgggtattatgttgctcagttactcaaatggtactgtattgtttatatttgtacccca       c.*4020

          .         .         .         .         .         .       g.53256
 aataacatcgtctgtactttctgttttctgtattgtatttgtgcaggattctttaggctt       c.*4080

          .         .         .         .         .         .       g.53316
 tatcagtgtaatctctgccttttaagatatgtacagaaaatgtccatataaatttccatt       c.*4140

          .         .         .         .         .         .       g.53376
 gaagtcgaatgatactgagaagcctgtaaagaggagaaaaaaacataagctgtgtttccc       c.*4200

          .         .         .         .         .         .       g.53436
 cataagtttttttaaattgtatattgtatttgtagtaatattccaaaagaatgtaaatag       c.*4260

          .         .         .         .         .         .       g.53496
 gaaatagaagagtgatgcttatgttaagtcctaacactacagtagaagaatggaagcagt       c.*4320

          .         .         .         .         .         .       g.53556
 gcaaataaattacatttttcccaagtgccagtggcatattttaaaataaagtgtatacgt       c.*4380

          .         .         .         .         .         .       g.53616
 tggaatgagtcatgccatatgtagttgctgtagatggcaactagaacctttgagttacaa       c.*4440

          .         .         .         .         .         .       g.53676
 gagtctttagaagttttctaaccctgcctagtgcaagttacaatattatagcgtgttcgg       c.*4500

          .         .         .         .         .         .       g.53736
 ggagtgccctcctgtctgcaggtgtgtctctgtgcctgggggcttttctccacatgctta       c.*4560

          .         .         .         .         .         .       g.53796
 ggggtgtgggtcttccattggggcatgatggacctgtctacaggtgatctctgttgcctt       c.*4620

          .         .         .         .         .         .       g.53856
 tgggtcagcacatttgttagtctcctgggggtgaaaacttggcttacaagagaactggaa       c.*4680

          .         .         .         .         .         .       g.53916
 aaatgatgagatgtggtccccaaacccttgattgactctggggaggggctttgtgaatag       c.*4740

          .         .         .         .         .         .       g.53976
 gattgctctcacattaaagatagttacttcaatttgaaggctggatttagggattttttt       c.*4800

          .         .         .         .         .         .       g.54036
 ttttccttataacaaagacatcaccaggatatgaagcttttgttgaaagttggaaaaaaa       c.*4860

          .         .                                               g.54063
 gtgaaattaaagacattcccagacaaa                                        c.*4887

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Transforming growth factor, beta receptor 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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