transforming growth factor, beta receptor III (TGFBR3) - coding DNA reference sequence

(used for variant description)

(last modified October 13, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_001195684.1 in the TGFBR3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_027757.1, covering TGFBR3 transcript NM_001195684.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5051
          tctttaagatttgtagctactaagaaagaaaggagctttttttccttgggc       c.-301

 .         .         .         .         .         .                g.5111
 cttcaaactgaaagaaccgcatgagcctgaagctgcgcatggtcttaacatcaggctgtg       c.-241

 .         .         .         .         .         .                g.5171
 caggaagaagctatctgcagatggatgccagcacacacaaggaagcagagctctggcaac       c.-181

 .      | 02  .         .         .         .         .             g.11359
 attgag | tcaaagcaaggacacaacatcagagggacggcagagaatccttgtgtgtagatc    c.-121

 .       | 03 .         .         .         .         .             g.49411
 tttggtg | gcagtttgaaaattgcaaggagggactttaagactacttctgatttgcaaaga    c.-61

 .         .         .         .         .         .                g.49471
 ttgtctgtgctctgagcaggctgaagtgactggacgagacgcactgttggagaaataaaa       c.-1

          .         .         .         .         .         .       g.49531
 ATGACTTCCCATTATGTGATTGCCATCTTTGCCCTGATGAGCTCCTGTTTAGCCACTGCA       c.60
 M  T  S  H  Y  V  I  A  I  F  A  L  M  S  S  C  L  A  T  A         p.20

   | 04      .         .         .         .         .         .    g.113590
 G | GTCCAGAGCCTGGTGCACTGTGTGAACTGTCACCTGTCAGTGCCTCCCATCCTGTCCAG    c.120
 G |   P  E  P  G  A  L  C  E  L  S  P  V  S  A  S  H  P  V  Q      p.40

          .         .         .         .         .         .       g.113650
 GCCTTGATGGAGAGCTTCACTGTTTTGTCAGGCTGTGCCAGCAGAGGCACAACTGGGCTG       c.180
 A  L  M  E  S  F  T  V  L  S  G  C  A  S  R  G  T  T  G  L         p.60

          .         .         .         .         .         .       g.113710
 CCACAGGAGGTGCATGTCCTGAATCTCCGCACTGCAGGCCAGGGGCCTGGCCAGCTACAG       c.240
 P  Q  E  V  H  V  L  N  L  R  T  A  G  Q  G  P  G  Q  L  Q         p.80

        | 05 .         .         .         .         .         .    g.152306
 AGAGAG | GTCACACTTCACCTGAATCCCATCTCCTCAGTCCACATCCACCACAAGTCTGTT    c.300
 R  E   | V  T  L  H  L  N  P  I  S  S  V  H  I  H  H  K  S  V      p.100

          .         .         .         .         .         .       g.152366
 GTGTTCCTGCTCAACTCCCCACACCCCCTGGTGTGGCATCTGAAGACAGAGAGACTTGCC       c.360
 V  F  L  L  N  S  P  H  P  L  V  W  H  L  K  T  E  R  L  A         p.120

          .         .     | 06   .         .         .         .    g.176079
 ACTGGGGTCTCCAGACTGTTTTTG | GTGTCTGAGGGTTCTGTGGTCCAGTTTTCATCAGCA    c.420
 T  G  V  S  R  L  F  L   | V  S  E  G  S  V  V  Q  F  S  S  A      p.140

          .         .         .         .         .         .       g.176139
 AACTTCTCCTTGACAGCAGAAACAGAAGAAAGGAACTTCCCCCATGGAAATGAACATCTG       c.480
 N  F  S  L  T  A  E  T  E  E  R  N  F  P  H  G  N  E  H  L         p.160

          .         .         .         .         .         .       g.176199
 TTAAATTGGGCCCGAAAAGAGTATGGAGCAGTTACTTCATTCACCGAACTCAAGATAGCA       c.540
 L  N  W  A  R  K  E  Y  G  A  V  T  S  F  T  E  L  K  I  A         p.180

          .         .         | 07         .         .         .    g.181061
 AGAAACATTTATATTAAAGTGGGGGAAG | ATCAAGTGTTCCCTCCAAAGTGCAACATAGGG    c.600
 R  N  I  Y  I  K  V  G  E  D |   Q  V  F  P  P  K  C  N  I  G      p.200

          .         .         .         .         .         .       g.181121
 AAGAATTTTCTCTCACTCAATTACCTTGCTGAGTACCTTCAACCCAAAGCAGCAGAAGGG       c.660
 K  N  F  L  S  L  N  Y  L  A  E  Y  L  Q  P  K  A  A  E  G         p.220

          .         .         .         .         .         .       g.181181
 TGTGTGATGTCCAGCCAGCCCCAGAATGAGGAAGTACACATCATCGAGCTAATCACCCCC       c.720
 C  V  M  S  S  Q  P  Q  N  E  E  V  H  I  I  E  L  I  T  P         p.240

          .        | 08.         .         .         .         .    g.183239
 AACTCTAACCCCTACAG | TGCTTTCCAGGTGGATATAACAATTGATATAAGACCTTCTCAA    c.780
 N  S  N  P  Y  S  |  A  F  Q  V  D  I  T  I  D  I  R  P  S  Q      p.260

          .         .         .         .         .         .       g.183299
 GAGGATCTTGAAGTGGTCAAAAATCTCATCCTGATCTTGAAGTGCAAAAAGTCTGTCAAC       c.840
 E  D  L  E  V  V  K  N  L  I  L  I  L  K  C  K  K  S  V  N         p.280

          .         .         .         .      | 09  .         .    g.188873
 TGGGTGATCAAATCTTTTGATGTTAAGGGAAGCCTGAAAATTATT | GCTCCTAACAGTATT    c.900
 W  V  I  K  S  F  D  V  K  G  S  L  K  I  I   | A  P  N  S  I      p.300

          .         .         .         .         .         .       g.188933
 GGCTTTGGAAAAGAGAGTGAAAGATCTATGACAATGACCAAATCAATAAGAGATGACATT       c.960
 G  F  G  K  E  S  E  R  S  M  T  M  T  K  S  I  R  D  D  I         p.320

          .         .         .         .         .         .       g.188993
 CCTTCAACCCAAGGGAATCTGGTGAAGTGGGCTTTGGACAATGGCTATAGTCCAATAACT       c.1020
 P  S  T  Q  G  N  L  V  K  W  A  L  D  N  G  Y  S  P  I  T         p.340

          .         .         .         .         .      | 10  .    g.190780
 TCATACACAATGGCTCCTGTGGCTAATAGATTTCATCTTCGGCTTGAAAATAATG | AGGAG    c.1080
 S  Y  T  M  A  P  V  A  N  R  F  H  L  R  L  E  N  N  E |   E      p.360

          .         .         .         .         .         .       g.190840
 ATGGGAGATGAGGAAGTCCACACTATTCCTCCTGAGCTACGGATCCTGCTGGACCCTGGT       c.1140
 M  G  D  E  E  V  H  T  I  P  P  E  L  R  I  L  L  D  P  G         p.380

          .         .         .         .         .         .       g.190900
 GCCCTGCCTGCCCTGCAGAACCCGCCCATCCGGGGAGGGGAAGGCCAAAATGGAGGCCTT       c.1200
 A  L  P  A  L  Q  N  P  P  I  R  G  G  E  G  Q  N  G  G  L         p.400

          .         .         .         .         .         .       g.190960
 CCGTTTCCTTTCCCAGATATTTCCAGGAGAGTCTGGAATGAAGAGGGAGAAGATGGGCTC       c.1260
 P  F  P  F  P  D  I  S  R  R  V  W  N  E  E  G  E  D  G  L         p.420

          .         .         .         .         .         .       g.191020
 CCTCGGCCAAAGGACCCTGTCATTCCCAGCATACAACTGTTTCCTGGTCTCAGAGAGCCA       c.1320
 P  R  P  K  D  P  V  I  P  S  I  Q  L  F  P  G  L  R  E  P         p.440

          .         .         .         .         .         .       g.191080
 GAAGAGGTGCAAGGGAGCGTGGATATTGCCCTGTCTGTCAAATGTGACAATGAGAAGATG       c.1380
 E  E  V  Q  G  S  V  D  I  A  L  S  V  K  C  D  N  E  K  M         p.460

          .         .         . | 11       .         .         .    g.191568
 ATCGTGGCTGTAGAAAAAGATTCTTTTCAG | GCCAGTGGCTACTCGGGGATGGACGTCACC    c.1440
 I  V  A  V  E  K  D  S  F  Q   | A  S  G  Y  S  G  M  D  V  T      p.480

          .         .         .         .         .         .       g.191628
 CTGTTGGATCCTACCTGCAAGGCCAAGATGAATGGCACACACTTTGTTTTGGAGTCTCCT       c.1500
 L  L  D  P  T  C  K  A  K  M  N  G  T  H  F  V  L  E  S  P         p.500

          .         .         .         .         .         .       g.191688
 CTGAATGGCTGCGGTACTCGGCCCCGGTGGTCAGCCCTTGATGGTGTGGTCTACTATAAC       c.1560
 L  N  G  C  G  T  R  P  R  W  S  A  L  D  G  V  V  Y  Y  N         p.520

     | 12    .         .         .         .         .         .    g.194351
 TCC | ATTGTGATACAGGTTCCAGCCCTTGGGGACAGTAGTGGTTGGCCAGATGGTTATGAA    c.1620
 S   | I  V  I  Q  V  P  A  L  G  D  S  S  G  W  P  D  G  Y  E      p.540

          .         .         .         .         .         .       g.194411
 GATCTGGAGTCAGGTGATAATGGATTTCCGGGAGATATGGATGAAGGAGATGCTTCCCTG       c.1680
 D  L  E  S  G  D  N  G  F  P  G  D  M  D  E  G  D  A  S  L         p.560

          .         .     | 13   .         .         .         .    g.194644
 TTCACCCGACCTGAAATCGTGGTG | TTTAATTGCAGCCTTCAGCAGGTGAGGAACCCCAGC    c.1740
 F  T  R  P  E  I  V  V   | F  N  C  S  L  Q  Q  V  R  N  P  S      p.580

          .         .         .         .         .         .       g.194704
 AGCTTCCAGGAACAGCCCCACGGAAACATCACCTTCAACATGGAGCTATACAACACTGAC       c.1800
 S  F  Q  E  Q  P  H  G  N  I  T  F  N  M  E  L  Y  N  T  D         p.600

          .         .         .         .         .         .       g.194764
 CTCTTTTTGGTGCCCTCCCAGGGCGTCTTCTCTGTGCCAGAGAATGGACACGTTTATGTT       c.1860
 L  F  L  V  P  S  Q  G  V  F  S  V  P  E  N  G  H  V  Y  V         p.620

     | 14    .         .         .         .         .         .    g.198517
 GAG | GTATCTGTTACTAAGGCTGAACAAGAACTGGGATTTGCCATCCAAACGTGCTTTATC    c.1920
 E   | V  S  V  T  K  A  E  Q  E  L  G  F  A  I  Q  T  C  F  I      p.640

          .         .         .         .         .         .       g.198577
 TCTCCATATTCGAACCCTGATAGGATGTCTCATTACACCATTATTGAGAATATTTGTCCT       c.1980
 S  P  Y  S  N  P  D  R  M  S  H  Y  T  I  I  E  N  I  C  P         p.660

          .         .         .         .         .         .       g.198637
 AAAGATGAATCTGTGAAATTCTACAGTCCCAAGAGAGTGCACTTTCCTATCCCGCAAGCT       c.2040
 K  D  E  S  V  K  F  Y  S  P  K  R  V  H  F  P  I  P  Q  A         p.680

          .         .         .         .         .         .       g.198697
 GACATGGATAAGAAGCGATTCAGCTTTGTCTTCAAGCCTGTCTTCAACACCTCACTGCTC       c.2100
 D  M  D  K  K  R  F  S  F  V  F  K  P  V  F  N  T  S  L  L         p.700

          .         .         .         .         .         .       g.198757
 TTTCTACAGTGTGAGCTGACGCTGTGTACGAAGATGGAGAAGCACCCCCAGAAGTTGCCT       c.2160
 F  L  Q  C  E  L  T  L  C  T  K  M  E  K  H  P  Q  K  L  P         p.720

     | 15    .         .         .         .         .         .    g.202276
 AAG | TGTGTGCCTCCTGACGAAGCCTGCACCTCGCTGGACGCCTCGATAATCTGGGCCATG    c.2220
 K   | C  V  P  P  D  E  A  C  T  S  L  D  A  S  I  I  W  A  M      p.740

          .         .         .         .         .         .       g.202336
 ATGCAGAATAAGAAGACGTTCACTAAGCCCCTTGCTGTGATCCACCATGAAGCAGAATCT       c.2280
 M  Q  N  K  K  T  F  T  K  P  L  A  V  I  H  H  E  A  E  S         p.760

      | 16   .         .         .         .       | 17 .         . g.215237
 AAAG | AAAAAGGTCCAAGCATGAAGGAACCAAATCCAATTTCTCCAC | CAATTTTCCATGGT c.2340
 K  E |   K  G  P  S  M  K  E  P  N  P  I  S  P  P |   I  F  H  G   p.780

          .         .         .         .         .         .       g.215297
 CTGGACACCCTAACCGTGATGGGCATTGCGTTTGCAGCCTTTGTGATCGGAGCACTCCTG       c.2400
 L  D  T  L  T  V  M  G  I  A  F  A  A  F  V  I  G  A  L  L         p.800

          .         .         .     | 18   .         .         .    g.227171
 ACGGGGGCCTTGTGGTACATCTATTCTCACACAG | GGGAGACAGCAGGAAGGCAGCAAGTC    c.2460
 T  G  A  L  W  Y  I  Y  S  H  T  G |   E  T  A  G  R  Q  Q  V      p.820

          .         .         .         .         .         .       g.227231
 CCCACCTCCCCGCCAGCCTCGGAAAACAGCAGTGCTGCCCACAGCATCGGCAGCACGCAG       c.2520
 P  T  S  P  P  A  S  E  N  S  S  A  A  H  S  I  G  S  T  Q         p.840

          .         .         .                                     g.227264
 AGCACGCCTTGCTCCAGCAGCAGCACGGCCTAG                                  c.2553
 S  T  P  C  S  S  S  S  T  A  X                                    p.850

          .         .         .         .         .         .       g.227324
 cccaacccagcccaacccggcccaacccagcccagcccagctcagctcagctactgccaa       c.*60

          .         .         .         .         .         .       g.227384
 gggcaggaccaatggctgagcctcgtgtccagactcagagggctggattttggttccctt       c.*120

          .         .         .         .         .         .       g.227444
 gtaaagacagagtgaatttcagtataaagatcacccgttgtattcaccccacacccaggg       c.*180

          .         .         .         .         .         .       g.227504
 ctagtataaacatgaccctgggcttctgtaccacactagaattcatgtgagaaagctaaa       c.*240

          .         .         .         .         .         .       g.227564
 atggtggtcttctccaccagcccctcacaggcttgggggttttcaatgtgaaacacatgc       c.*300

          .         .         .         .         .         .       g.227624
 cagtttttaaaatgctgctttgtccaggtgagaacatccataatttggggccctgagttt       c.*360

          .         .         .         .         .         .       g.227684
 tacccagactcaaggagttggtaaagggttaatagccagatagtagaaccagtgaggaga       c.*420

          .         .         .         .         .         .       g.227744
 tgcggccaaagattctttatatctgaaccaagatgtaaaacaagaaatgctttgaggctt       c.*480

          .         .         .         .         .         .       g.227804
 tctaagcgatcctcctgtctaatttgcacctttgtctggatgcacacttctgaccttgct       c.*540

          .         .         .         .         .         .       g.227864
 gccacaacctgtggggtctgatgtgtcccttgatgggtgctgccctcagggactgcaccc       c.*600

          .         .         .         .         .         .       g.227924
 tgacaagtgttaaggcaacattcctttcttgtgccctgggccaaaaccaatgctgatgac       c.*660

          .         .         .         .         .         .       g.227984
 cttatcagcttcctgtttcttcccatacttgcatacaccactgcaaaatgtcttaatgca       c.*720

          .         .         .         .         .         .       g.228044
 aattttgtatttcttacaggcctacagaaattgaaaatgaccaaaatcaggaaccacaga       c.*780

          .         .         .         .         .         .       g.228104
 tttgtgcccattcctaatattttgttctgcaaattaatgtataatttgaggtgaaattca       c.*840

          .         .         .         .         .         .       g.228164
 gttataaagtcaaggacgaatttgcacagtgatatatttctatgtgtatgcaagtacaag       c.*900

          .         .         .         .         .         .       g.228224
 tatataatatgtcacctggcacattcattttctcagttgaagaagagaaaatttgaaaat       c.*960

          .         .         .         .         .         .       g.228284
 gtccttatgcttttagagttgcaacttaagtatatttggtagggtgagtgtttccactca       c.*1020

          .         .         .         .         .         .       g.228344
 aaatatgtcaacttaaaaaaaaataggccctttcataaaaaccaaactgtagcaagatgc       c.*1080

          .         .         .         .         .         .       g.228404
 aaatgcatggcaaatcctgtcggtctccagttggttatctgaatagtgtcaccaattcca       c.*1140

          .         .         .         .         .         .       g.228464
 ccaagacagtgctgagattggaaaagggcactcatttggattgccttacttctcttgcct       c.*1200

          .         .         .         .         .         .       g.228524
 taaatatatcccatatatttaatatgtcaaaaagggcttgaggtgaatttcattaaatgg       c.*1260

          .         .         .         .         .         .       g.228584
 aataatatgatgccactttgcagctaaaataagctcagtgatacctccttgttaaaaaaa       c.*1320

          .         .         .         .         .         .       g.228644
 aaaaaaaaaaaaaagaatgccaggggggaattatcatgctaaattattttactgctgaag       c.*1380

          .         .         .         .         .         .       g.228704
 atagcttcattgcaaattattctttttccagaatttcccccaaacaacttagaattccat       c.*1440

          .         .         .         .         .         .       g.228764
 aagtagaacaagatagattctacccccaaaatattcataagcaaatcccactgcccttaa       c.*1500

          .         .         .         .         .         .       g.228824
 aataaggaagttatgcctggttgtctgtgaatggaacctcagtaggtaatcctgatgaag       c.*1560

          .         .         .         .         .         .       g.228884
 cttaaaaccttagggcagtgtctacatgggaaacaagtatgtggaaattgacaatcattt       c.*1620

          .         .         .         .         .         .       g.228944
 ttaccaaatcgttgagtaataatatgacttacctgatagatatacacattcaataaggaa       c.*1680

          .         .         .         .         .         .       g.229004
 catttttttttttcaataaggaacattttaactaaaacattactttagggctgagatttc       c.*1740

          .         .         .         .         .         .       g.229064
 caggctatctacattgatctactgaaaaatttctagatttccatatacaaacgaagaaga       c.*1800

          .         .         .         .         .         .       g.229124
 catgagtttagagaatttttttcctttaatttttttttaacagaagggtatcagagtgga       c.*1860

          .         .         .         .         .         .       g.229184
 ggacctagattacgctacctgtgtttgaaaatattgcgctttgcctaaccttcggtggaa       c.*1920

          .         .         .         .         .         .       g.229244
 tgtattgtttcagcatattctatgtataaaaaagtttaaagatgtcttcaaagaagacta       c.*1980

          .         .         .         .         .         .       g.229304
 gagtctttaagtcacttatagctatattttactacaaaatttgtgtataaagatatattt       c.*2040

          .         .         .         .         .         .       g.229364
 aagtgttttagataaatttaagttactccatatgaaatgtttaatttcagctactgtgaa       c.*2100

          .         .         .         .         .         .       g.229424
 ttctttcgatcagtcctttgcttttttaaaaaatcttttccatcgtgttaaaaagaaaat       c.*2160

          .         .         .         .         .         .       g.229484
 tagctattaggagatattaaaagattgatgtcttagaaggacagggttaaaaccttctgt       c.*2220

          .         .         .         .         .         .       g.229544
 aatatatttaaatatatatttttaagagagatgctacattgccaatgattttataaataa       c.*2280

          .         .         .         .         .         .       g.229604
 tttaaaattaatttacaaatttatagatgcaaaccaaaagatctttttaaaagagagaga       c.*2340

          .         .         .         .         .         .       g.229664
 gaggaaaaaaatcaccttttatttgtttgggtctcattgtcagaattattattcagatca       c.*2400

          .         .         .         .         .         .       g.229724
 agaaatctgtgtcgataaaacctaatctcatattggagagtgaatgtcgttaagtatttc       c.*2460

          .         .         .         .         .         .       g.229784
 tgaaatgtttctaaaaaatgaacatgaaaaaaataaggtattttctccctagcttctcat       c.*2520

          .         .         .         .         .         .       g.229844
 tacagtatttctaattgcttcacactttacagttttaatacaaagtacaagctctacttt       c.*2580

          .         .         .         .         .         .       g.229904
 tataacgtgtactacaagtttctttaaaagtattgttgtatttcagctgaactcttgtat       c.*2640

          .         .         .         .         .         .       g.229964
 ctgcagtcttttgttatttctgcaggctacacccttaatttgcagaggccattttgttgt       c.*2700

          .         .         .         .         .         .       g.230024
 ttgtttgatgctgaagctgttgttaaaatgccccaaactccaaggcagattgtctgtata       c.*2760

          .         .         .         .         .         .       g.230084
 atacgctatagcttttcaccatgtggtgtttaccagctgttactctgtattttaaaaagc       c.*2820

          .         .         .         .         .         .       g.230144
 cagagatttcttctgtctaaactgtttctatagcattttctaaacaaaaaaaatggtttt       c.*2880

          .         .         .         .         .         .       g.230204
 tttctttgccttgtaataagattgtaaatccatttcctgcttgtgttcttagtgggcatg       c.*2940

          .         .         .         .         .         .       g.230264
 attgtgagtgtgtgtggggtgctcacacgcgtgccagtctttttgtactgtaactacctc       c.*3000

          .         .         .         .         .         .       g.230324
 atggtttgaatgatgattgtactgctggttgtgttaacagagcacattttgttgggtgag       c.*3060

          .         .         .         .         .         .       g.230384
 tcctatgtgatttttttcatgtttgttttatctgggggttgttcatgaaactgacagatg       c.*3120

          .         .         .         .         .         .       g.230444
 tttttctaaaaaggactattatcagtttccaaatacaatacttctctcttctggtttttc       c.*3180

          .         .         .         .         .         .       g.230504
 ctgaatgagcctgattttgttgctggttttcatcatctatgagggtaaaacgagtaccct       c.*3240

          .         .         .         .         .         .       g.230564
 taaaatccctgtggccagtttgaacacccctgttgtattcttttctctgttcagtgtgtc       c.*3300

          .         .         .         .         .         .       g.230624
 agctattttgtgaagatgcttagatgtatagttttgataaccacagttttaaatctttta       c.*3360

          .         .         .                                     g.230660
 tctgtgcataataaaaagatatatatcagttattaa                               c.*3396

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Transforming growth factor, beta receptor III protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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