transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase) (TGM1) - coding DNA reference sequence

(used for variant description)

(last modified September 6, 2013)


This file was created to facilitate the description of sequence variants on transcript NM_000359.2 in the TGM1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_007150.1, covering TGM1 transcript NM_000359.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5004
                                                         acat       c.-121

 .         .         .         .         .         .                g.5064
 aagtcacttaccaggtctgtccctgcggcatccagtctgtgggtcctgtcccatccatcc       c.-61

 .         .         .         .         .         .        | 02    g.5858
 tgacctgttccatctcagccccaggactcagtactgcggttgccaacactgctgccag | gc    c.-1

          .         .         .         .         .         .       g.5918
 ATGATGGATGGGCCACGTTCCGATGTGGGCCGTTGGGGTGGCAACCCCTTGCAGCCCCCT       c.60
 M  M  D  G  P  R  S  D  V  G  R  W  G  G  N  P  L  Q  P  P         p.20

          .         .         .         .         .         .       g.5978
 ACCACGCCATCTCCAGAGCCAGAGCCAGAGCCAGACGGACGCTCTCGCAGAGGAGGAGGC       c.120
 T  T  P  S  P  E  P  E  P  E  P  D  G  R  S  R  R  G  G  G         p.40

          .         .         .         .         .         .       g.6038
 CGTTCCTTCTGGGCTCGCTGCTGTGGCTGCTGTTCATGCCGAAATGCGGCAGATGACGAC       c.180
 R  S  F  W  A  R  C  C  G  C  C  S  C  R  N  A  A  D  D  D         p.60

          .         .         .         .         .         .       g.6098
 TGGGGACCTGAACCCTCTGACTCCAGGGGTCGAGGGTCCAGCTCTGGCACTCGAAGACCT       c.240
 W  G  P  E  P  S  D  S  R  G  R  G  S  S  S  G  T  R  R  P         p.80

          .         .         .         .         .         .       g.6158
 GGCTCCCGGGGCTCAGACTCCCGCCGGCCTGTATCCCGGGGCAGCGGTGTCAATGCAGCT       c.300
 G  S  R  G  S  D  S  R  R  P  V  S  R  G  S  G  V  N  A  A         p.100

          .          | 03        .         .         .         .    g.6368
 GGAGATGGCACCATCCGAG | AGGGCATGCTAGTAGTGAACGGTGTGGACTTGCTGAGCTCG    c.360
 G  D  G  T  I  R  E |   G  M  L  V  V  N  G  V  D  L  L  S  S      p.120

          .         .         .         .         .         .       g.6428
 CGCTCGGACCAGAACCGCCGAGAGCACCACACAGACGAGTATGAGTACGACGAGCTGATA       c.420
 R  S  D  Q  N  R  R  E  H  H  T  D  E  Y  E  Y  D  E  L  I         p.140

          .         .         .         .         .         .       g.6488
 GTGCGCCGCGGGCAGCCTTTCCATATGCTCCTCCTCCTGTCCCGGACCTATGAATCCTCT       c.480
 V  R  R  G  Q  P  F  H  M  L  L  L  L  S  R  T  Y  E  S  S         p.160

          .         .         | 04         .         .         .    g.7544
 GATCGCATCACCCTTGAGTTACTCATCG | GAAACAACCCCGAGGTGGGCAAGGGCACGCAC    c.540
 D  R  I  T  L  E  L  L  I  G |   N  N  P  E  V  G  K  G  T  H      p.180

          .         .         .         .         .         .       g.7604
 GTGATCATCCCAGTGGGCAAGGGGGGCAGTGGAGGCTGGAAAGCCCAGGTGGTCAAGGCC       c.600
 V  I  I  P  V  G  K  G  G  S  G  G  W  K  A  Q  V  V  K  A         p.200

          .         .         .         .         .         .       g.7664
 AGTGGGCAGAATCTGAACCTGCGGGTCCACACTTCCCCCAACGCCATCATCGGCAAGTTT       c.660
 S  G  Q  N  L  N  L  R  V  H  T  S  P  N  A  I  I  G  K  F         p.220

          .         .         .         .         .         .       g.7724
 CAGTTCACAGTCCGCACACAATCAGACGCTGGGGAGTTCCAGTTGCCCTTTGACCCCCGC       c.720
 Q  F  T  V  R  T  Q  S  D  A  G  E  F  Q  L  P  F  D  P  R         p.240

          .         .         .        | 05.         .         .    g.8175
 AATGAGATCTACATCCTCTTCAACCCCTGGTGCCCAG | AGGACATTGTGTACGTGGACCAT    c.780
 N  E  I  Y  I  L  F  N  P  W  C  P  E |   D  I  V  Y  V  D  H      p.260

          .         .         .         .         .         .       g.8235
 GAGGATTGGCGGCAGGAGTATGTTCTTAATGAGTCTGGGAGAATTTACTACGGGACCGAA       c.840
 E  D  W  R  Q  E  Y  V  L  N  E  S  G  R  I  Y  Y  G  T  E         p.280

          .         .         .       | 06 .         .         .    g.8423
 GCACAGATTGGTGAGCGGACCTGGAACTACGGCCAG | TTTGACCACGGGGTGCTGGATGCC    c.900
 A  Q  I  G  E  R  T  W  N  Y  G  Q   | F  D  H  G  V  L  D  A      p.300

          .         .         .         .         .         .       g.8483
 TGCTTATACATCCTGGACCGGCGGGGGATGCCATATGGAGGCCGTGGAGACCCAGTCAAT       c.960
 C  L  Y  I  L  D  R  R  G  M  P  Y  G  G  R  G  D  P  V  N         p.320

          .         .     | 07   .         .         .         .    g.8997
 GTCTCCCGGGTCATCTCTGCCATG | GTGAACTCCCTGGATGACAATGGAGTCCTGATTGGG    c.1020
 V  S  R  V  I  S  A  M   | V  N  S  L  D  D  N  G  V  L  I  G      p.340

          .         .         .         .         .         .       g.9057
 AACTGGTCTGGTGATTACTCCCGAGGCACCAACCCATCAGCGTGGGTGGGCAGCGTGGAG       c.1080
 N  W  S  G  D  Y  S  R  G  T  N  P  S  A  W  V  G  S  V  E         p.360

          .         .         .         .         .         .       g.9117
 ATCCTGCTTAGCTACCTACGCACGGGATATTCCGTCCCCTATGGCCAGTGCTGGGTCTTT       c.1140
 I  L  L  S  Y  L  R  T  G  Y  S  V  P  Y  G  Q  C  W  V  F         p.380

          .          | 08        .         .         .         .    g.9578
 GCTGGCGTGACCACCACAG | TGCTGCGCTGCCTGGGTCTGGCCACCCGTACTGTCACCAAC    c.1200
 A  G  V  T  T  T  V |   L  R  C  L  G  L  A  T  R  T  V  T  N      p.400

          .         .         .         .         .         .       g.9638
 TTCAACTCCGCCCACGACACAGACACATCCCTTACCATGGACATCTACTTCGACGAGAAC       c.1260
 F  N  S  A  H  D  T  D  T  S  L  T  M  D  I  Y  F  D  E  N         p.420

          .         .         .         | 09         .         .    g.9844
 ATGAAGCCCCTGGAGCACCTGAACCATGATTCTGTCTG | GAACTTCCATGTGTGGAACGAC    c.1320
 M  K  P  L  E  H  L  N  H  D  S  V  W  |  N  F  H  V  W  N  D      p.440

          .         .         .         .         .         .       g.9904
 TGCTGGATGAAGAGGCCGGATCTGCCCTCGGGCTTTGATGGGTGGCAGGTGGTGGATGCC       c.1380
 C  W  M  K  R  P  D  L  P  S  G  F  D  G  W  Q  V  V  D  A         p.460

          .         .   | 10     .         .         .         .    g.12171
 ACACCCCAAGAGACTAGCAGTG | GCATCTTCTGCTGCGGCCCCTGCTCTGTGGAGTCCATC    c.1440
 T  P  Q  E  T  S  S  G |   I  F  C  C  G  P  C  S  V  E  S  I      p.480

          .         .         .         .         .  | 11      .    g.12702
 AAGAATGGCCTGGTCTACATGAAGTACGACACGCCTTTCATTTTTGCTGAG | GTGAATAGT    c.1500
 K  N  G  L  V  Y  M  K  Y  D  T  P  F  I  F  A  E   | V  N  S      p.500

          .         .         .         .         .         .       g.12762
 GACAAGGTGTACTGGCAGCGGCAGGATGATGGCAGCTTCAAGATTGTTTATGTGGAGGAG       c.1560
 D  K  V  Y  W  Q  R  Q  D  D  G  S  F  K  I  V  Y  V  E  E         p.520

          .         .         .         .         .         .       g.12822
 AAGGCCATCGGCACACTCATTGTCACAAAGGCCATCAGCTCCAACATGCGGGAGGACATC       c.1620
 K  A  I  G  T  L  I  V  T  K  A  I  S  S  N  M  R  E  D  I         p.540

          .         .      | 12  .         .         .         .    g.12992
 ACCTACCTCTATAAGCACCCAGAAG | GCTCAGACGCAGAGCGGAAGGCAGTAGAGACAGCA    c.1680
 T  Y  L  Y  K  H  P  E  G |   S  D  A  E  R  K  A  V  E  T  A      p.560

          .         .         .         .         .         .       g.13052
 GCAGCCCACGGCAGCAAACCCAATGTGTATGCCAACCGGGGCTCAGCGGAGGATGTGGCC       c.1740
 A  A  H  G  S  K  P  N  V  Y  A  N  R  G  S  A  E  D  V  A         p.580

          .         .         .         .         .         .       g.13112
 ATGCAGGTGGAGGCACAGGACGCGGTGATGGGGCAGGATCTGATGGTCTCTGTGATGCTG       c.1800
 M  Q  V  E  A  Q  D  A  V  M  G  Q  D  L  M  V  S  V  M  L         p.600

          .         .         .         .         .         .       g.13172
 ATCAATCACAGCAGCAGCCGCCGCACAGTGAAACTGCACCTCTACCTCTCAGTCACTTTC       c.1860
 I  N  H  S  S  S  R  R  T  V  K  L  H  L  Y  L  S  V  T  F         p.620

          .         .         .         .         .         .       g.13232
 TATACTGGTGTCAGTGGTACCATCTTCAAGGAGACCAAGAAGGAAGTGGAGCTGGCACCA       c.1920
 Y  T  G  V  S  G  T  I  F  K  E  T  K  K  E  V  E  L  A  P         p.640

         | 13.         .         .         .         .         .    g.13439
 GGGGCCT | CGGACCGTGTGACCATGCCAGTGGCCTACAAGGAATACCGGCCCCATCTTGTG    c.1980
 G  A  S |   D  R  V  T  M  P  V  A  Y  K  E  Y  R  P  H  L  V      p.660

          .         .         .         .         .         .       g.13499
 GACCAGGGGGCCATGCTGCTCAATGTCTCAGGCCACGTCAAGGAGAGCGGGCAGGTGCTG       c.2040
 D  Q  G  A  M  L  L  N  V  S  G  H  V  K  E  S  G  Q  V  L         p.680

          .         .         .         .         | 14         .    g.13934
 GCCAAGCAGCACACCTTCCGTCTGCGCACCCCAGACCTCTCCCTCACG | TTACTGGGAGCA    c.2100
 A  K  Q  H  T  F  R  L  R  T  P  D  L  S  L  T   | L  L  G  A      p.700

          .         .         .         .         .         .       g.13994
 GCAGTGGTTGGCCAGGAGTGTGAAGTACAGATTGTCTTCAAGAACCCCCTTCCCGTCACC       c.2160
 A  V  V  G  Q  E  C  E  V  Q  I  V  F  K  N  P  L  P  V  T         p.720

          .         .         .         .         .         .       g.14054
 CTCACCAATGTCGTCTTCCGGCTCGAAGGCTCTGGGTTACAGAGGCCCAAGATCCTCAAC       c.2220
 L  T  N  V  V  F  R  L  E  G  S  G  L  Q  R  P  K  I  L  N         p.740

       | 15  .         .         .         .         .         .    g.18724
 GTTGG | GGACATTGGAGGCAATGAAACAGTGACACTGCGCCAGTCGTTTGTGCCTGTGCGA    c.2280
 V  G  |  D  I  G  G  N  E  T  V  T  L  R  Q  S  F  V  P  V  R      p.760

          .         .         .         .         .         .       g.18784
 CCAGGCCCCCGCCAGCTCATTGCCAGCTTGGACAGCCCACAGCTCTCCCAGGTGCACGGT       c.2340
 P  G  P  R  Q  L  I  A  S  L  D  S  P  Q  L  S  Q  V  H  G         p.780

          .         .         .         .         .         .       g.18844
 GTCATCCAGGTGGATGTGGCCCCAGCCCCTGGGGATGGGGGCTTCTTCTCAGACGCTGGA       c.2400
 V  I  Q  V  D  V  A  P  A  P  G  D  G  G  F  F  S  D  A  G         p.800

          .         .         .         .         .                 g.18898
 GGTGACAGTCACTTAGGAGAGACCATCCCTATGGCATCTCGAGGTGGAGCTTAG             c.2454
 G  D  S  H  L  G  E  T  I  P  M  A  S  R  G  G  A  X               p.817

          .         .         .         .         .         .       g.18958
 ccccgtgccaggagcaatgggactggagtcagatgagcaaggacattgccccaagatagg       c.*60

          .         .         .         .         .         .       g.19018
 ggcacactacagagcagctccccaggagctcaggtggggagtccagggctcccggagggg       c.*120

          .         .         .         .         .         .       g.19078
 gagtccagggctcccggagagggagtcagtcttcacttgcactgggggaacagatgctaa       c.*180

          .                                                         g.19097
 taaactgttttttaatgaa                                                c.*199

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 07
©2004-2013 Leiden University Medical Center