transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase) (TGM3) - coding DNA reference sequence

(used for variant description)

(last modified June 2, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_003245.3 in the TGM3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_052959.1, covering TGM3 transcript NM_003245.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5037
                        attctataaatggtaaggcaatccttggcagcctgtc       c.-61

 .         .         .         .         .         .                g.5097
 tgtcagcactgtccgtgccattcccagaggagcctgagaagaggcagaggaaggcgaaac       c.-1

         | 02.         .         .         .         .         .    g.18743
 ATGGCTG | CTCTAGGAGTCCAGAGTATCAACTGGCAGACGGCCTTCAACCGACAAGCGCAT    c.60
 M  A  A |   L  G  V  Q  S  I  N  W  Q  T  A  F  N  R  Q  A  H      p.20

          .         .         .         .         .         .       g.18803
 CACACAGACAAGTTCTCCAGCCAGGAGCTCATCTTGCGGAGAGGCCAAAACTTCCAGGTC       c.120
 H  T  D  K  F  S  S  Q  E  L  I  L  R  R  G  Q  N  F  Q  V         p.40

          .         .         .         .         .         .       g.18863
 TTAATGATCATGAACAAAGGCCTTGGCTCTAACGAAAGACTGGAGTTCATTGTCTCCACA       c.180
 L  M  I  M  N  K  G  L  G  S  N  E  R  L  E  F  I  V  S  T         p.60

   | 03      .         .         .         .         .         .    g.19270
 G | GGCCTTACCCCTCAGAGTCGGCCATGACGAAGGCTGTGTTTCCACTCTCCAATGGCAGT    c.240
 G |   P  Y  P  S  E  S  A  M  T  K  A  V  F  P  L  S  N  G  S      p.80

          .         .         .         .         .         .       g.19330
 AGTGGTGGCTGGAGTGCGGTGCTTCAGGCCAGCAATGGCAATACTCTGACTATCAGCATC       c.300
 S  G  G  W  S  A  V  L  Q  A  S  N  G  N  T  L  T  I  S  I         p.100

          .         .         .         .         .         .       g.19390
 TCCAGTCCTGCCAGCGCACCCATAGGACGGTACACAATGGCCCTCCAGATCTTCTCCCAG       c.360
 S  S  P  A  S  A  P  I  G  R  Y  T  M  A  L  Q  I  F  S  Q         p.120

          .         .         .         .         .         .       g.19450
 GGCGGCATCTCCTCTGTGAAACTTGGGACGTTCATACTGCTTTTTAACCCCTGGCTGAAT       c.420
 G  G  I  S  S  V  K  L  G  T  F  I  L  L  F  N  P  W  L  N         p.140

   | 04      .         .         .         .         .         .    g.20103
 G | TGGATAGCGTCTTTATGGGTAACCACGCTGAGAGAGAAGAGTATGTTCAGGAAGATGCC    c.480
 V |   D  S  V  F  M  G  N  H  A  E  R  E  E  Y  V  Q  E  D  A      p.160

          .         .         .         .         .         .       g.20163
 GGCATCATCTTTGTGGGAAGCACAAACCGAATTGGCATGATTGGCTGGAACTTTGGACAG       c.540
 G  I  I  F  V  G  S  T  N  R  I  G  M  I  G  W  N  F  G  Q         p.180

  | 05       .         .         .         .         .         .    g.21991
  | TTTGAAGAAGACATTCTCAGCATCTGCCTCTCAATCTTGGATAGGAGTCTGAATTTCCGC    c.600
  | F  E  E  D  I  L  S  I  C  L  S  I  L  D  R  S  L  N  F  R      p.200

          .         .         .         .         .         .       g.22051
 CGTGACGCTGCTACTGATGTGGCCAGCAGAAATGACCCCAAATACGTTGGCCGGGTGCTG       c.660
 R  D  A  A  T  D  V  A  S  R  N  D  P  K  Y  V  G  R  V  L         p.220

           | 06        .         .         .         .         .    g.26152
 AGTGCCATG | ATCAATAGCAATGATGACAATGGTGTGCTTGCTGGGAATTGGAGCGGCACT    c.720
 S  A  M   | I  N  S  N  D  D  N  G  V  L  A  G  N  W  S  G  T      p.240

          .         .         .         .         .         .       g.26212
 TACACCGGTGGCCGGGACCCAAGGAGCTGGAACGGCAGCGTGGAGATCCTCAAAAATTGG       c.780
 Y  T  G  G  R  D  P  R  S  W  N  G  S  V  E  I  L  K  N  W         p.260

          .         .         .         .         .         .       g.26272
 AAAAAATCTGGCTTCAGCCCAGTCCGATATGGCCAGTGCTGGGTCTTTGCTGGGACCCTC       c.840
 K  K  S  G  F  S  P  V  R  Y  G  Q  C  W  V  F  A  G  T  L         p.280

         | 07.         .         .         .         .         .    g.26436
 AACACAG | CGCTGCGGTCTTTGGGGATTCCTTCCCGGGTGATCACCAACTTCAACTCAGCT    c.900
 N  T  A |   L  R  S  L  G  I  P  S  R  V  I  T  N  F  N  S  A      p.300

          .         .         .         .         .         .       g.26496
 CATGACACAGACCGAAATCTCAGTGTGGATGTGTACTACGACCCCATGGGAAACCCCCTG       c.960
 H  D  T  D  R  N  L  S  V  D  V  Y  Y  D  P  M  G  N  P  L         p.320

          .         .    | 08    .         .         .         .    g.34919
 GACAAGGGTAGTGATAGCGTATG | GAATTTCCATGTCTGGAATGAAGGCTGGTTTGTGAGG    c.1020
 D  K  G  S  D  S  V  W  |  N  F  H  V  W  N  E  G  W  F  V  R      p.340

          .         .         .         .         .         .       g.34979
 TCTGACCTGGGCCCCTCGTACGGTGGATGGCAGGTGTTGGATGCTACCCCGCAGGAAAGA       c.1080
 S  D  L  G  P  S  Y  G  G  W  Q  V  L  D  A  T  P  Q  E  R         p.360

         | 09.         .         .         .         .         .    g.37206
 AGCCAAG | GGGTGTTCCAGTGCGGCCCCGCTTCGGTCATTGGTGTTCGAGAGGGTGATGTG    c.1140
 S  Q  G |   V  F  Q  C  G  P  A  S  V  I  G  V  R  E  G  D  V      p.380

          .         .         .         .         .         .       g.37266
 CAGCTGAACTTCGACATGCCCTTTATCTTCGCGGAGGTTAATGCCGACCGCATCACCTGG       c.1200
 Q  L  N  F  D  M  P  F  I  F  A  E  V  N  A  D  R  I  T  W         p.400

          .         .         .         .         .         .       g.37326
 CTGTACGACAACACCACTGGCAAACAGTGGAAGAATTCCGTGAACAGTCACACCATTGGC       c.1260
 L  Y  D  N  T  T  G  K  Q  W  K  N  S  V  N  S  H  T  I  G         p.420

          .         .         .         .         .         .       g.37386
 AGGTACATCAGCACCAAGGCGGTGGGCAGCAATGCTCGCATGGACGTCACGGACAAGTAC       c.1320
 R  Y  I  S  T  K  A  V  G  S  N  A  R  M  D  V  T  D  K  Y         p.440

          .    | 10    .         .         .         .         .    g.41082
 AAGTACCCAGAAG | GCTCTGACCAGGAAAGACAAGTGTTCCAAAAGGCTTTGGGGAAACTT    c.1380
 K  Y  P  E  G |   S  D  Q  E  R  Q  V  F  Q  K  A  L  G  K  L      p.460

          .         .         .         .         .         .       g.41142
 AAACCCAACACGCCATTTGCCGCGACGTCTTCAATGGGTTTGGAAACAGAGGAACAGGAG       c.1440
 K  P  N  T  P  F  A  A  T  S  S  M  G  L  E  T  E  E  Q  E         p.480

          .         .         .         .         .         .       g.41202
 CCCAGCATCATCGGGAAGCTGAAGGTCGCTGGCATGCTGGCAGTAGGCAAAGAAGTCAAC       c.1500
 P  S  I  I  G  K  L  K  V  A  G  M  L  A  V  G  K  E  V  N         p.500

          .         .         .         .         .         .       g.41262
 CTGGTCCTACTGCTCAAAAACCTGAGCAGGGATACGAAGACAGTGACAGTGAACATGACA       c.1560
 L  V  L  L  L  K  N  L  S  R  D  T  K  T  V  T  V  N  M  T         p.520

          .         .         .         .         .         .       g.41322
 GCCTGGACCATCATCTACAACGGCACGCTTGTACATGAAGTGTGGAAGGACTCTGCCACA       c.1620
 A  W  T  I  I  Y  N  G  T  L  V  H  E  V  W  K  D  S  A  T         p.540

          .         .   | 11     .         .         .         .    g.44187
 ATGTCCCTGGACCCTGAGGAAG | AGGCAGAACATCCCATAAAGATCTCGTACGCTCAGTAT    c.1680
 M  S  L  D  P  E  E  E |   A  E  H  P  I  K  I  S  Y  A  Q  Y      p.560

          .         .         .         .         .         .       g.44247
 GAGAAGTACCTGAAGTCAGACAACATGATCCGGATCACAGCGGTGTGCAAGGTCCCAGAT       c.1740
 E  K  Y  L  K  S  D  N  M  I  R  I  T  A  V  C  K  V  P  D         p.580

          .         .         .         .         .         .       g.44307
 GAGTCTGAGGTGGTGGTGGAGCGGGACATCATCCTGGACAACCCCACCTTGACCCTGGAG       c.1800
 E  S  E  V  V  V  E  R  D  I  I  L  D  N  P  T  L  T  L  E         p.600

  | 12       .         .         .         .         .         .    g.48947
  | GTGCTGAACGAGGCTCGTGTGCGGAAGCCTGTGAACGTGCAGATGCTCTTCTCCAATCCA    c.1860
  | V  L  N  E  A  R  V  R  K  P  V  N  V  Q  M  L  F  S  N  P      p.620

          .         .         .         .         .         .       g.49007
 CTGGATGAGCCGGTGAGGGACTGCGTGCTGATGGTGGAGGGAAGCGGCCTGCTGTTGGGT       c.1920
 L  D  E  P  V  R  D  C  V  L  M  V  E  G  S  G  L  L  L  G         p.640

          .     | 13   .         .         .         .         .    g.49513
 AACCTGAAGATCGA | CGTGCCGACCCTAGGGCCCAAGGAGGGGTCCCGGGTCCGTTTTGAT    c.1980
 N  L  K  I  D  |  V  P  T  L  G  P  K  E  G  S  R  V  R  F  D      p.660

          .         .         .         .         .         .       g.49573
 ATCCTGCCCTCCCGGAGTGGCACCAAGCAACTGCTCGCCGACTTCTCCTGCAACAAGTTC       c.2040
 I  L  P  S  R  S  G  T  K  Q  L  L  A  D  F  S  C  N  K  F         p.680

          .         .         .         .                           g.49615
 CCTGCAATCAAGGCCATGTTGTCCATCGATGTAGCCGAATGA                         c.2082
 P  A  I  K  A  M  L  S  I  D  V  A  E  X                           p.693

          .         .         .         .         .         .       g.49675
 agggcgctggtggcctcccgtacaaacttggacaacacggagcagggagagctcaccatg       c.*60

          .         .         .         .         .         .       g.49735
 gaatgaaccccccgcccatgctgtccggcctgggaaaccctctccatctcccaaggctgc       c.*120

          .         .         .         .         .         .       g.49795
 cagacatggacctccaggctccagcacatccccctctcctctcccccaggttggggctgg       c.*180

          .         .         .         .         .         .       g.49855
 gtccaccctgtcctatgacttgatcacttttgcacattccctggccgcttctccccagag       c.*240

          .         .         .         .         .         .       g.49915
 ctgcctgctctgtgagccccacagccctgctcattcctcacgcccttcaatgctgcagga       c.*300

          .         .         .         .         .         .       g.49975
 tggactggcccctgacccagggactctccaaacgggatacaggagagaagctggtctaga       c.*360

          .         .         .         .         .         .       g.50035
 ctgtttgctgatccccaacctgcacggggcattcctgcttctctctcaggccaccacaga       c.*420

          .         .         .         .         .         .       g.50095
 gggcaggggatggttagtcacctgccccagcactcacaccctaactcaaaataaatgtta       c.*480

          .                                                         g.50113
 aataagtgcgatcacaca                                                 c.*498

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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