THUMP domain containing 1 (THUMPD1) - coding DNA reference sequence

(used for variant description)

(last modified February 24, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_017736.3 in the THUMPD1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000016.9, covering THUMPD1 transcript NM_017736.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5018
                                           gcagcacggaatgaggct       c.-121

 .         .         .         .         .         .                g.5078
 tcgaggccggctaggggaggccgtcgctcatatccgacgtcaccagttcgcgccggcgat       c.-61

 .         .         .         .         .         .                g.5138
 agacgaggacgccaacagcagcggagaaacgtttctctttcctctcagtttgcgcacacc       c.-1

          .         .         .         .         .         .       g.5198
 ATGGCGGCCCCTGCCCAGCAGACTACTCAGCCTGGCGGCGGGAAGCGCAAAGGCAAGGCT       c.60
 M  A  A  P  A  Q  Q  T  T  Q  P  G  G  G  K  R  K  G  K  A         p.20

          .         .         .         .         .         .       g.5258
 CAGTATGTGCTGGCCAAGCGCGCTCGGCGCTGCGACGCTGGCGGGCCCCGTCAGCTAGAG       c.120
 Q  Y  V  L  A  K  R  A  R  R  C  D  A  G  G  P  R  Q  L  E         p.40

          .         .         .         .         .         .       g.5318
 CCCGGGCTACAGGGCATCCTCATCACCTGCAATATGAACGAGCGCAAGTGCGTGGAGGAG       c.180
 P  G  L  Q  G  I  L  I  T  C  N  M  N  E  R  K  C  V  E  E         p.60

          .         .         .         .         .  | 02      .    g.7815
 GCCTACAGCCTCCTCAACGAATACGGCGACGACATGTATGGGCCAGAAAAG | TTTACAGAC    c.240
 A  Y  S  L  L  N  E  Y  G  D  D  M  Y  G  P  E  K   | F  T  D      p.80

          .         .         .         .         .         .       g.7875
 AAGGATCAGCAGCCCTCTGGAAGTGAGGGAGAGGATGATGATGCGGAGGCTGCCTTGAAG       c.300
 K  D  Q  Q  P  S  G  S  E  G  E  D  D  D  A  E  A  A  L  K         p.100

          .         .         .         .         .         .       g.7935
 AAAGAAGTTGGTGACATTAAGGCATCTACAGAGATGAGGTTAAGAAGATTCCAGTCAGTG       c.360
 K  E  V  G  D  I  K  A  S  T  E  M  R  L  R  R  F  Q  S  V         p.120

          .         .         .         .       | 03 .         .    g.8935
 GAAAGTGGAGCAAATAACGTTGTCTTCATCAGGACACTTGGGATAG | AGCCTGAGAAATTG    c.420
 E  S  G  A  N  N  V  V  F  I  R  T  L  G  I  E |   P  E  K  L      p.140

          .         .         .         .         .         .       g.8995
 GTGCATCATATTCTCCAGGATATGTACAAAACCAAGAAAAAGAAGACTCGAGTTATTTTG       c.480
 V  H  H  I  L  Q  D  M  Y  K  T  K  K  K  K  T  R  V  I  L         p.160

          .         .         .         .         .         .       g.9055
 CGAATGTTACCCATCTCAGGCACATGCAAGGCTTTTTTAGAAGATATGAAAAAATATGCA       c.540
 R  M  L  P  I  S  G  T  C  K  A  F  L  E  D  M  K  K  Y  A         p.180

          .         .         .         .         .         .       g.9115
 GAAACATTTTTGGAACCCTGGTTTAAAGCTCCAAACAAAGGGACATTTCAGATTGTGTAC       c.600
 E  T  F  L  E  P  W  F  K  A  P  N  K  G  T  F  Q  I  V  Y         p.200

          .         .         .         .         .      | 04  .    g.9596
 AAATCTCGAAATAACAGTCATGTGAATAGAGAAGAAGTTATCAGAGAATTGGCAG | GAATA    c.660
 K  S  R  N  N  S  H  V  N  R  E  E  V  I  R  E  L  A  G |   I      p.220

          .         .         .         .         .         .       g.9656
 GTGTGCACCCTCAATTCAGAAAATAAAGTGGATCTCACCAATCCACAGTACACAGTGGTA       c.720
 V  C  T  L  N  S  E  N  K  V  D  L  T  N  P  Q  Y  T  V  V         p.240

          .         .         .         .         .         .       g.9716
 GTAGAAATCATCAAAGCTGTCTGTTGCCTGAGTGTTGTGAAAGATTACATGTTGTTTAGA       c.780
 V  E  I  I  K  A  V  C  C  L  S  V  V  K  D  Y  M  L  F  R         p.260

          .         .         .         .         .         .       g.9776
 AAATACAATCTCCAGGAGGTGGTGAAGAGCCCTAAGGATCCGTCACAGCTTAACTCAAAG       c.840
 K  Y  N  L  Q  E  V  V  K  S  P  K  D  P  S  Q  L  N  S  K         p.280

          .         .         .         .         .         .       g.9836
 CAGGGAAATGGGAAAGAAGCTAAACTGGAATCTGCGGACAAATCAGACCAAAACAACACA       c.900
 Q  G  N  G  K  E  A  K  L  E  S  A  D  K  S  D  Q  N  N  T         p.300

          .         .         .         .         .         .       g.9896
 GCAGAAGGAAAAAATAACCAGCAGGTACCAGAGAATACTGAGGAGCTGGGGCAGACAAAA       c.960
 A  E  G  K  N  N  Q  Q  V  P  E  N  T  E  E  L  G  Q  T  K         p.320

          .         .         .         .         .         .       g.9956
 CCAACGTCTAATCCACAGGTGGTAAATGAGGGAGGAGCCAAACCTGAACTTGCAAGTCAA       c.1020
 P  T  S  N  P  Q  V  V  N  E  G  G  A  K  P  E  L  A  S  Q         p.340

          .         .         .         .                           g.9998
 GCCACAGAAGGATCCAAGTCAAATGAAAATGACTTCTCATAG                         c.1062
 A  T  E  G  S  K  S  N  E  N  D  F  S  X                           p.353

          .         .         .         .         .         .       g.10058
 gaagtcatttggtgttggaggtgggtttctcacctggggctctacgagatgttgctgggg       c.*60

          .         .         .         .         .         .       g.10118
 ctccaccttaaattgtgactaaaaacagttttttatttgtgtgctgcattatgctgttct       c.*120

          .         .         .         .         .         .       g.10178
 cacagtagtgagcaatgattgcgcagccctgttaacagtttttttagggatctttcagcc       c.*180

          .         .         .         .         .         .       g.10238
 tttatggtattacgtagaggcagacccatgtgctgctgttgcaaagaggggaggatagga       c.*240

          .         .         .         .         .         .       g.10298
 gggggatgttggcctctcccaggctcctcttctgcagtgccagctgacttaagggagtga       c.*300

          .         .         .         .         .         .       g.10358
 actacctgtgaagtagaaaatcagagggaagttttcattctaaggaaggagtttttacat       c.*360

          .         .         .         .         .         .       g.10418
 gccacagctcagctgtctgcctgccactttgttgtaaacattgcaaaaatgtggatcatg       c.*420

          .         .         .         .         .         .       g.10478
 taggttagaagtgaattgtttagtgaagtttttgtacttttgtgattttcttgtttatgt       c.*480

          .         .         .         .         .         .       g.10538
 ctgttttttttttttttttttaacatttgtgtgtaatatagctgacagtccagtgtcgca       c.*540

          .         .         .         .         .         .       g.10598
 attttggaaggcaagatgtgagagagacgagaaccattttaggcatagaactacagacat       c.*600

          .         .         .         .         .         .       g.10658
 ttctgaaaaggttggtgatgaagaacttcagtcttctgagtatacttcagtatactagtg       c.*660

          .         .         .         .         .         .       g.10718
 caacaagggacacaaagaaattctgtcttaataaagaaagctacttctcaagggtattat       c.*720

          .         .         .         .         .         .       g.10778
 gtggactcagtccaagctctcctgtcccattgtgcattgtctgtgacatgcaacttacaa       c.*780

          .         .         .         .         .         .       g.10838
 aactagcaattgtaacaataaatcacagccacttgacaagaaaggatattcattattttc       c.*840

          .         .         .         .         .         .       g.10898
 aaatggcttttggactatcaaaaacagtaaggcttttgttcagaaatcacctttagtcaa       c.*900

          .         .         .         .         .         .       g.10958
 aaggtttaagaagcaaattatttagtagcagaacttatctcaggaaaggaaaatatgcat       c.*960

          .         .         .         .         .         .       g.11018
 ggttggtgagaatctaataacattaaaatgctggggcaagatgcagtacaaagttgaaga       c.*1020

          .         .         .         .         .         .       g.11078
 gactttattctcaataagttgatttactgatgatatgtcatatgatgcaaaaaaggtttt       c.*1080

          .         .         .         .         .         .       g.11138
 gtgtcattaactgaaaagtagcagcttctctatccaggatgatgagtcaacaggtttcac       c.*1140

          .         .         .         .         .         .       g.11198
 taatatttgtcatgctgtagcatttgtaagatttgtaaatgatgaaattcaaagaaaact       c.*1200

          .         .         .         .         .         .       g.11258
 ttttctattgctaggagcctgccagaacaaaggccaatatataatgttgtgacatcatat       c.*1260

          .         .         .         .         .         .       g.11318
 ctgataaccagaggtctggtatctacactcctggtgccccatcagtggttgtctccataa       c.*1320

          .         .         .         .         .         .       g.11378
 gtcattttgcgttattaaaaaaaaaaaaagaaatcctgatgttgacattatagcacactg       c.*1380

          .         .         .         .         .         .       g.11438
 ctttctccacagagatgctgatatcaaaaacttgaagatacagtgaagttctgaataatg       c.*1440

          .         .         .         .         .         .       g.11498
 ttacaaaactggttacctgtatcaaagacccatttatgcaaaaatgttaaaaaaaaaaaa       c.*1500

          .         .         .         .         .         .       g.11558
 aaacacccaaaacaaaaacctggacagacagcacataaacctcctgcaccatacagacat       c.*1560

          .         .         .         .         .         .       g.11618
 ccagtggcttctcagaggaagcgttctctacaggatatttgaattgaaaggtgaattgcc       c.*1620

          .         .         .         .         .         .       g.11678
 agagtacttacaataaaacagccagcttttgctgagtgctttggaaatgaaaaatgacta       c.*1680

          .         .         .         .         .         .       g.11738
 cagaaagtagcctattttgcagacgtttttcatcacatgaacaaatggacaagtctctga       c.*1740

          .         .         .         .         .         .       g.11798
 aaggttctggggaaaaaaatttttcttaaagcgacaagactcttagatctaaaaggaaac       c.*1800

          .         .         .         .         .         .       g.11858
 tgacttgccaccttgccagaggaattcttgaaatgtttctgcagccacttggccttgaaa       c.*1860

          .         .         .         .         .         .       g.11918
 ataaagggtgcaactctcaaatcttgttctaacccggctggaggaaccacaagacccaat       c.*1920

          .         .         .         .         .         .       g.11978
 gaaatagcattttctctccttttcccagcactagtatataacctatgaggaacccttgtc       c.*1980

          .         .         .         .         .         .       g.12038
 tctgaatctgctcagcttgaaattttgtctctgaaggaagagaatgaactcagccctagt       c.*2040

          .         .         .         .         .         .       g.12098
 ctgacagtcctagatttctgtgaaataagagtattcttcaacttagtgctcacactcaca       c.*2100

          .         .         .         .         .         .       g.12158
 taccatgagggttctctgcaggggtttaggggtttcctgaatttgaaagttttttcaagg       c.*2160

          .         .         .         .         .         .       g.12218
 cctctttttgggtaaaacaattgaaaaggcagacaccaacaaagtctgcaaaattaactg       c.*2220

          .         .         .         .         .         .       g.12278
 tccagattaagaatattaaggagctgtaaaattagcttgtagaaatggacttatccttaa       c.*2280

          .         .         .         .         .         .       g.12338
 gttttaaaaagttaggaaatcctaaaaatgttaggcttcctgcacaagtggctatgttca       c.*2340

          .         .         .         .         .         .       g.12398
 tttaatggctagtgaacatgggaatgtatttttatcctcctagctggtggttctgtttgg       c.*2400

          .         .         .         .         .         .       g.12458
 taaaccagactagaatgatttgagaggggcaaagagaataggcaggaccttccttctata       c.*2460

          .         .         .         .         .         .       g.12518
 gctttacatatttagaatgttaatacttaatgacattgaagttaccttgcaatgattgat       c.*2520

          .         .         .         .         .         .       g.12578
 aagaggattattaatatcagttaggggaatagggaggataggattttggtgccttcttca       c.*2580

          .         .         .         .         .         .       g.12638
 gcagacttgctccaagacaaagattctattttgatagtgcaagacaaaaggactcggaag       c.*2640

          .         .         .         .         .         .       g.12698
 aaaattggccatatgcctacagagcatacaactctgtggaactaaattgtttttactttg       c.*2700

          .         .         .         .         .         .       g.12758
 tgaaagctgctattttacggaaagattttgattatacagtttgtttttaaattgtctttt       c.*2760

          .         .         .         .         .         .       g.12818
 atatttatttgtatttggtaagaatcggttgttacacaagctgttctttcccagttacaa       c.*2820

          .         .         .         .         .         .       g.12878
 aatcctgtgttcggttgtaacctgaactcattaaaagacttgttttcaggtttatcaact       c.*2880

          .         .         .         .         .         .       g.12938
 gtttattttcactgacatttgagcatgttattttataaatgacgggattccagggtagga       c.*2940

          .         .         .         .         .         .       g.12998
 agtgctttttattccccttttgttttttcttttaaaaaattacgtcagttaaaaaaataa       c.*3000

          .         .         .         .         .         .       g.13058
 aaaaactgcagtcttatggtttagaaaacttgtttagctccatagaggaaagaatgttaa       c.*3060

          .         .         .         .         .         .       g.13118
 actttgtattttaaaacatgattctctgaggttaaacttggttttcaaatgttattttta       c.*3120

          .         .         .         .         .         .       g.13178
 cttgtattttgcttttggtacggccagaaatcgagcttgttttttcatagttcctgatat       c.*3180

          .         .         .                                     g.13214
 tttcagaaaaatcaaaataaatttgttccctaaaaa                               c.*3216

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The THUMP domain containing 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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