tousled-like kinase 2 (TLK2) - coding DNA reference sequence

(used for variant description)

(last modified January 23, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_006852.3 in the TLK2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000017.10, covering TLK2 transcript NM_006852.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5031
                              gcggccgcccgggcccgggcccgcgtcgggc       c.-241

 .         .         .         .         .         .                g.5091
 gcctggctctgtacgcgagcccggggatctgcggccttcgtgccccccctcccccgcccg       c.-181

 .         .         .         .         .         .                g.5151
 ccctctcgtggagcccggcgccggcggcggctgcccgggcggggggttgcggcgctcagg       c.-121

 .         .         .         .         .         .                g.5211
 agaggccccggctccgccccgggcctgcccagggggagagcggagcggtccgcagccggg       c.-61

 .         .         .         .         .         .     | 02       g.7101
 tcgggtcggggcccctcccgggaggagcgtggagcggcggcggcggcggcggcag | cagaa    c.-1

          .         .         .         .         .         .       g.7161
 ATGATGGAAGAATTGCATAGCCTGGACCCACGACGGCAGGAATTATTGGAGGCCAGGTTT       c.60
 M  M  E  E  L  H  S  L  D  P  R  R  Q  E  L  L  E  A  R  F         p.20

          .         .  | 03      .         .         .         .    g.46787
 ACTGGAGTAGGTGTTAGTAAG | GGACCACTTAATAGTGAGTCTTCCAACCAGAGCTTGTGC    c.120
 T  G  V  G  V  S  K   | G  P  L  N  S  E  S  S  N  Q  S  L  C      p.40

          .         .         .    | 04    .         .         .    g.48206
 AGCGTCGGATCCTTGAGTGATAAAGAAGTAGAG | ACTCCCGAGAAAAAGCAGAATGACCAG    c.180
 S  V  G  S  L  S  D  K  E  V  E   | T  P  E  K  K  Q  N  D  Q      p.60

          .         .         .         .    | 05    .         .    g.49126
 CGAAATCGGAAAAGAAAAGCTGAACCATATGAAACTAGCCAAG | GGAAAGGCACTCCTAGG    c.240
 R  N  R  K  R  K  A  E  P  Y  E  T  S  Q  G |   K  G  T  P  R      p.80

          .         .        | 06.         .         .         .    g.50244
 GGACATAAAATTAGTGATTACTTTGAG | TTTGCTGGGGGAAGCGCGCCAGGAACCAGCCCT    c.300
 G  H  K  I  S  D  Y  F  E   | F  A  G  G  S  A  P  G  T  S  P      p.100

          .         .         .         .         .         .       g.50304
 GGCAGAAGTGTTCCACCAGTTGCACGATCCTCACCGCAACATTCCTTATCCAATCCCTTA       c.360
 G  R  S  V  P  P  V  A  R  S  S  P  Q  H  S  L  S  N  P  L         p.120

     | 07    .         .         .         .         .         .    g.62202
 CCG | CGACGAGTAGAACAGCCCCTCTATGGTTTAGATGGCAGTGCTGCAAAGGAGGCAACG    c.420
 P   | R  R  V  E  Q  P  L  Y  G  L  D  G  S  A  A  K  E  A  T      p.140

          .         .         .         .         .         .       g.62262
 GAGGAGCAGTCTGCTCTGCCAACCCTCATGTCAGTGATGCTAGCAAAACCTCGGCTTGAC       c.480
 E  E  Q  S  A  L  P  T  L  M  S  V  M  L  A  K  P  R  L  D         p.160

          .         .         .         .         .  | 08      .    g.78286
 ACAGAGCAGCTGGCGCAAAGGGGAGCTGGCCTCTGCTTCACTTTTGTTTCA | GCTCAGCAA    c.540
 T  E  Q  L  A  Q  R  G  A  G  L  C  F  T  F  V  S   | A  Q  Q      p.180

          .         .         .         .         .         .       g.78346
 AACAGTCCCTCATCTACGGGATCTGGCAACACAGAGCATTCCTGCAGCTCCCAAAAACAG       c.600
 N  S  P  S  S  T  G  S  G  N  T  E  H  S  C  S  S  Q  K  Q         p.200

          .         .        | 09.         .         .         .    g.79671
 ATCTCCATCCAGCACAGACAGACCCAG | TCCGACCTCACAATAGAAAAAATATCTGCACTA    c.660
 I  S  I  Q  H  R  Q  T  Q   | S  D  L  T  I  E  K  I  S  A  L      p.220

          .         .         .         .         .         .       g.79731
 GAAAACAGTAAGAATTCTGACTTAGAGAAGAAGGAGGGAAGAATAGATGATTTATTAAGA       c.720
 E  N  S  K  N  S  D  L  E  K  K  E  G  R  I  D  D  L  L  R         p.240

  | 10       .         .         .         .         .         .    g.86051
  | GCCAACTGTGATTTGAGACGGCAGATTGATGAACAGCAAAAGATGCTAGAGAAATACAAG    c.780
  | A  N  C  D  L  R  R  Q  I  D  E  Q  Q  K  M  L  E  K  Y  K      p.260

          .         .         .         .         .  | 11      .    g.90985
 GAACGATTAAATAGATGTGTGACAATGAGCAAGAAACTCCTTATAGAAAAG | TCAAAACAA    c.840
 E  R  L  N  R  C  V  T  M  S  K  K  L  L  I  E  K   | S  K  Q      p.280

          .         .         .         .         .         .       g.91045
 GAGAAGATGGCGTGTAGAGATAAGAGCATGCAAGACCGCTTGAGACTGGGCCACTTTACT       c.900
 E  K  M  A  C  R  D  K  S  M  Q  D  R  L  R  L  G  H  F  T         p.300

          .         .         .         .         .         .       g.91105
 ACTGTCCGACACGGAGCCTCATTTACTGAACAGTGGACAGATGGTTATGCTTTTCAGAAT       c.960
 T  V  R  H  G  A  S  F  T  E  Q  W  T  D  G  Y  A  F  Q  N         p.320

          | 12         .         .         .         .         .    g.99242
 CTTATCAA | GCAACAGGAAAGGATAAATTCACAGAGGGAAGAGATAGAAAGACAACGGAAA    c.1020
 L  I  K  |  Q  Q  E  R  I  N  S  Q  R  E  E  I  E  R  Q  R  K      p.340

          .         .         .         .         .         .       g.99302
 ATGTTAGCAAAGCGGAAACCTCCTGCCATGGGTCAGGCCCCTCCTGCAACCAATGAGCAG       c.1080
 M  L  A  K  R  K  P  P  A  M  G  Q  A  P  P  A  T  N  E  Q         p.360

          .         .         .         .  | 13      .         .    g.102703
 AAACAGCGGAAAAGCAAGACCAATGGAGCTGAAAATGAAAC | GTTAACGTTAGCAGAATAC    c.1140
 K  Q  R  K  S  K  T  N  G  A  E  N  E  T  |  L  T  L  A  E  Y      p.380

          .         .         .         .         | 14         .    g.104464
 CATGAACAAGAAGAAATCTTCAAACTCAGATTAGGTCATCTTAAAAAG | GAGGAAGCAGAG    c.1200
 H  E  Q  E  E  I  F  K  L  R  L  G  H  L  K  K   | E  E  A  E      p.400

          .         .         .         .         .         .       g.104524
 ATCCAGGCAGAGCTGGAGAGACTAGAAAGGGTTAGAAATCTACATATCAGGGAACTAAAA       c.1260
 I  Q  A  E  L  E  R  L  E  R  V  R  N  L  H  I  R  E  L  K         p.420

          .         .       | 15 .         .         .         .    g.106120
 AGGATACATAATGAAGATAATTCACA | ATTTAAAGATCATCCAACGCTAAATGACAGATAT    c.1320
 R  I  H  N  E  D  N  S  Q  |  F  K  D  H  P  T  L  N  D  R  Y      p.440

          .         .         .         .         | 16         .    g.112122
 TTGTTGTTACATCTTTTGGGTAGAGGAGGTTTCAGTGAAGTTTACAAG | GCATTTGATCTA    c.1380
 L  L  L  H  L  L  G  R  G  G  F  S  E  V  Y  K   | A  F  D  L      p.460

          .         .         .         .         .         .       g.112182
 ACAGAGCAAAGATACGTAGCTGTGAAAATTCACCAGTTAAATAAAAACTGGAGAGATGAG       c.1440
 T  E  Q  R  Y  V  A  V  K  I  H  Q  L  N  K  N  W  R  D  E         p.480

          .         . | 17       .         .         .         .    g.122600
 AAAAAGGAGAATTACCACAA | GCATGCATGTAGGGAATACCGGATTCATAAAGAGCTGGAT    c.1500
 K  K  E  N  Y  H  K  |  H  A  C  R  E  Y  R  I  H  K  E  L  D      p.500

          .         .         .         .         . | 18       .    g.126636
 CATCCCAGAATAGTTAAGCTGTATGATTACTTTTCACTGGATACTGACTC | GTTTTGTACA    c.1560
 H  P  R  I  V  K  L  Y  D  Y  F  S  L  D  T  D  S  |  F  C  T      p.520

          .         .         .         .         .         .       g.126696
 GTATTAGAATACTGTGAGGGAAATGATCTGGACTTCTACCTGAAACAGCACAAATTAATG       c.1620
 V  L  E  Y  C  E  G  N  D  L  D  F  Y  L  K  Q  H  K  L  M         p.540

          .         .         .         .         .         .       g.126756
 TCGGAGAAAGAGGCCCGGTCCATTATCATGCAGATTGTGAATGCTTTAAAGTACTTAAAT       c.1680
 S  E  K  E  A  R  S  I  I  M  Q  I  V  N  A  L  K  Y  L  N         p.560

          .         .         .         . | 19       .         .    g.128037
 GAAATAAAACCTCCCATCATACACTATGACCTCAAACCAG | GTAATATTCTTTTAGTAAAT    c.1740
 E  I  K  P  P  I  I  H  Y  D  L  K  P  G |   N  I  L  L  V  N      p.580

          .         .         .         .         .         .       g.128097
 GGTACAGCGTGTGGAGAGATAAAAATTACAGATTTTGGTCTTTCGAAGATCATGGATGAT       c.1800
 G  T  A  C  G  E  I  K  I  T  D  F  G  L  S  K  I  M  D  D         p.600

          .         .         .         .         .          | 20    g.132106
 GATAGCTACAATTCAGTGGATGGCATGGAGCTAACATCACAAGGTGCTGGTACTTATTG | G    c.1860
 D  S  Y  N  S  V  D  G  M  E  L  T  S  Q  G  A  G  T  Y  W  |      p.620

          .         .         .         .         .         .       g.132166
 TATTTACCACCAGAGTGTTTTGTGGTTGGGAAAGAACCACCAAAGATCTCAAATAAAGTT       c.1920
 Y  L  P  P  E  C  F  V  V  G  K  E  P  P  K  I  S  N  K  V         p.640

          .         .         .         .         .  | 21      .    g.134025
 GATGTGTGGTCGGTGGGTGTGATCTTCTATCAGTGTCTTTATGGAAGGAAG | CCTTTTGGC    c.1980
 D  V  W  S  V  G  V  I  F  Y  Q  C  L  Y  G  R  K   | P  F  G      p.660

          .         .         .         .         .         .       g.134085
 CATAACCAGTCTCAGCAAGACATCCTACAAGAGAATACGATTCTTAAAGCTACTGAAGTG       c.2040
 H  N  Q  S  Q  Q  D  I  L  Q  E  N  T  I  L  K  A  T  E  V         p.680

          .         .         .          | 22        .         .    g.138388
 CAGTTCCCGCCAAAGCCAGTAGTAACACCTGAAGCAAAG | GCGTTTATTCGACGATGCTTG    c.2100
 Q  F  P  P  K  P  V  V  T  P  E  A  K   | A  F  I  R  R  C  L      p.700

          .         .         .         .         .         .       g.138448
 GCCTACCGAAAGGAGGACCGCATTGATGTCCAGCAGCTGGCCTGTGATCCCTACTTGTTG       c.2160
 A  Y  R  K  E  D  R  I  D  V  Q  Q  L  A  C  D  P  Y  L  L         p.720

          .         .         .         .         .         .       g.138508
 CCTCACATCCGAAAGTCAGTCTCTACAAGTAGCCCTGCTGGAGCTGCTATTGCATCAACC       c.2220
 P  H  I  R  K  S  V  S  T  S  S  P  A  G  A  A  I  A  S  T         p.740

          .         .         .                                     g.138541
 TCTGGGGCGTCCAATAACAGTTCTTCTAATTGA                                  c.2253
 S  G  A  S  N  N  S  S  S  N  X                                    p.750

          .         .         .         .         .         .       g.138601
 gactgactccaaggccacaaactgttcaacacacacaaagtggacaaatggcgttcagca       c.*60

          .         .         .         .         .         .       g.138661
 gcgggtttggaacatagcgaatccgaatggatctgatgaaacctgtaccaggtgctttta       c.*120

          .         .         .         .         .         .       g.138721
 ttttcttgcttttttcccatccatagagcatgacagcatcgattctcattgaggagaaac       c.*180

          .         .         .         .         .         .       g.138781
 cttgggcagctccggccaggccttgtaggaaaaggccccgcccgaggttccagcgtcaac       c.*240

          .         .         .         .         .         .       g.138841
 ggccactgtgtgtggctgctctgagtgaggaaaaaattaaaaagaaaaactggttccatg       c.*300

          .         .         .         .         .         .       g.138901
 tactgtgaacttgaaaacttgcagactcaggggggtccctgatgcagtgcttcagatgaa       c.*360

          .         .         .         .         .         .       g.138961
 gaatgtggacttgaaaatacagactgggctagtccagtgtctatatttaaacttgttctt       c.*420

          .         .         .         .         .         .       g.139021
 ttcttttaataaagtttaggtaacatctcctgaaaagcttgtagcacaaaggctcagctg       c.*480

          .         .         .         .         .         .       g.139081
 gggatggtgtttgacttcggaggaaaaaagttgctattgcccgttaaaggcactagagtt       c.*540

          .         .         .         .         .         .       g.139141
 agtgttttatccctaaataatttcaatttttaaaaacatgcagcttccctctcccctttt       c.*600

          .         .         .         .         .         .       g.139201
 ttatttttgaaagaatacatttggtcataaagtgaaacccgtattagcaagtacgtggca       c.*660

          .         .         .         .         .         .       g.139261
 atgttcattccaatcagatgcagctttctcctccgtctggtctcctgtttgcaattgctt       c.*720

          .         .         .         .         .         .       g.139321
 ccctcatctcagtagggaaaaaattgagtgggagtactgagatgtgtgggtttttgccat       c.*780

          .         .         .         .         .         .       g.139381
 tggacaaagaatgaggttagaagactgcagcttggagtctctctaggttttcaactattt       c.*840

          .         .         .         .         .         .       g.139441
 cttcacaatttgaacacttgacggttgtcccttttaatttatttgaagtgctattttttt       c.*900

          .         .         .         .         .         .       g.139501
 aaataaaggttcatctgtccatgcagtcctcttggattctctgaatgtagtaactatgaa       c.*960

          .         .         .         .         .         .       g.139561
 gctatgccaaaggtaggcagaaaatgggcttgggagccagacactccagggatcagtagt       c.*1020

          .         .         .         .         .         .       g.139621
 tcctacccatagtctttgtgtgcttgctaaatggtgtacatttcttgttaaccacgttat       c.*1080

          .         .         .         .         .         .       g.139681
 taaaacttgatcagcacataagctttcttctgttagatcttttggcagcaaacaaccttc       c.*1140

          .         .         .         .         .         .       g.139741
 cccccaagcctctgaattttgtgggtgtgtggtggtgtgtgtctgtgtgtgcatgtacac       c.*1200

          .         .         .         .         .         .       g.139801
 acacactttgtctagctcactttaaaagattcatcaaatggaattttaaaaataatctga       c.*1260

          .         .         .         .         .         .       g.139861
 aaagaaatagatatttcaggccgggcctggtggttcacgcctgtaatcccagcactttgg       c.*1320

          .         .         .         .         .         .       g.139921
 gaggccgaggtgggtggatcacgaggtcgggagttcgagatcagtctggtcaacatggtg       c.*1380

          .         .         .         .         .         .       g.139981
 aaacgccatctctactaaaaatataaaaattagcctggcgtggtggcgtgtgcctctagt       c.*1440

          .         .         .         .         .         .       g.140041
 cccagctacccgggaggctgaggcaggagaatttctggaacccaggaggcggaggttgca       c.*1500

          .         .         .         .         .         .       g.140101
 gtgagccgagatggcaccactgcaatccagcctaggcaacagaatgagactctgtctcag       c.*1560

          .         .         .         .         .         .       g.140161
 aaaaaaaaaaaaaaaaaaaaggagaaatagatgtttcaaatatgaacattcttttggcac       c.*1620

          .         .         .         .         .         .       g.140221
 caattttcttttttaatttggttgtttctgagatgtatgatcaactgaagatggagctga       c.*1680

          .         .         .         .         .         .       g.140281
 aatgggagacgggtggccccaccgtgcccttgaaacagcagagcactcctcagtagagag       c.*1740

          .         .         .         .         .         .       g.140341
 ggagggagccaagagcctgaacatgtggtcgccagcttggaatgttactgacatatgtgg       c.*1800

          .         .         .         .         .         .       g.140401
 cgagggcttagccagaaatatttaaagatgtagtattccggcctgtgagttgtctgggca       c.*1860

          .         .         .         .         .         .       g.140461
 gggagggggagtcagaaagggtagagagctctcaaataactcatgactctagtgttcctt       c.*1920

          .         .         .         .         .         .       g.140521
 tcacatgtgaacagtgtcactgatgacacattttctaggaccttcgtttgttttgtggac       c.*1980

          .         .         .         .         .         .       g.140581
 ctgcctcagtctcctcagtatcaggcgatcttaagggaagatggagtgtttcaaattgga       c.*2040

          .         .         .         .         .         .       g.140641
 gagaagttcatgggtaggtatcgtcctgtggaattctgaatgcaaggaagtcaaccccag       c.*2100

          .         .         .         .         .         .       g.140701
 aggccttggtacccccagctttctaaaactactttattacaatttatatgtatatacaca       c.*2160

          .         .         .         .         .         .       g.140761
 tgcacatataaacgtgtgcatttatgtatgtgtgtatagtaccttttttaaaaaaacatt       c.*2220

          .         .         .         .         .         .       g.140821
 tcctccaagctgctaagcaaagggtctcacaggtcgagcacagtgctgagaggatggtgt       c.*2280

          .         .         .         .         .         .       g.140881
 ctgcataatgaagacatggatgaagctgagaccgtgttcaaactcactgaaaacaatgaa       c.*2340

          .         .         .         .         .         .       g.140941
 gttctattccttttttcttcctctccaatgatcttgcagttgatttgtttgttttttaat       c.*2400

          .         .         .         .         .         .       g.141001
 tttttaacatttttttaacgttgaaaaaatgctgcgtctttctttaagccttcccagtaa       c.*2460

          .         .         .         .         .         .       g.141061
 cttcctgccttttttttccccgtgggcttttaagtgaagctgcaggattttatctttcaa       c.*2520

          .         .         .         .         .         .       g.141121
 tctgccctttctacccttgtcctattgaaaggatgccctcttcccttgcttttttggtct       c.*2580

          .         .         .         .         .         .       g.141181
 agggcctgtttggagctaactaggcttggctgagtccgggcaagaccttcttccgaggca       c.*2640

          .         .         .         .         .         .       g.141241
 tggacaagccccagagaacatgcagaacattgacctttccattgactgtctttcaagcag       c.*2700

          .         .         .         .         .         .       g.141301
 ccagtgaaatcactaagtggggttcttccatgacatattttgttaatatgggtttcactt       c.*2760

          .         .         .         .         .         .       g.141361
 tttccaagaatagtcccttgttgccacaatgttgatttactttacacaatgacagtatgt       c.*2820

          .         .         .         .         .         .       g.141421
 attaatttgtaattaaacccatccagattgttttagccttttcccaatggggtgggggag       c.*2880

          .         .         .                                     g.141457
 ggaagaaggatattaaaataagttttaagaagcaaa                               c.*2916

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Tousled-like kinase 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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