toll-like receptor 4 (TLR4) - coding DNA reference sequence

(used for variant description)

(last modified April 8, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_138554.4 in the TLR4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000009.11, covering TLR4 transcript NM_138554.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5058
   tagcttcctcttgctgtttctttagccactggtctgcaggcgttttcttcttctaact       c.-241

 .         .         .         .         .         .                g.5118
 tcctctcctgtgacaaaagagataactattagagaaacaaaagtccagaatgctaaggtt       c.-181

 .         .         .         .         .         .                g.5178
 gccgctttcacttcctctcaccctttagcccagaactgctttgaatacaccaattgctgt       c.-121

 .         .         .         .         .         .                g.5238
 ggggcggctcgaggaagagaagacaccagtgcctcagaaactgctcggtcagacggtgat       c.-61

 .         .         .         .         .         .                g.5298
 agcgagccacgcattcacagggccactgctgctcacagaagcagtgaggatgatgccagg       c.-1

          .         .         .         .         .         .       g.5358
 ATGATGTCTGCCTCGCGCCTGGCTGGGACTCTGATCCCAGCCATGGCCTTCCTCTCCTGC       c.60
 M  M  S  A  S  R  L  A  G  T  L  I  P  A  M  A  F  L  S  C         p.20

          .         .         .    | 02    .         .         .    g.9415
 GTGAGACCAGAAAGCTGGGAGCCCTGCGTGGAG | GTGGTTCCTAATATTACTTATCAATGC    c.120
 V  R  P  E  S  W  E  P  C  V  E   | V  V  P  N  I  T  Y  Q  C      p.40

          .         .         .         .         .         .       g.9475
 ATGGAGCTGAATTTCTACAAAATCCCCGACAACCTCCCCTTCTCAACCAAGAACCTGGAC       c.180
 M  E  L  N  F  Y  K  I  P  D  N  L  P  F  S  T  K  N  L  D         p.60

          .         .         .         .         .         .       g.9535
 CTGAGCTTTAATCCCCTGAGGCATTTAGGCAGCTATAGCTTCTTCAGTTTCCCAGAACTG       c.240
 L  S  F  N  P  L  R  H  L  G  S  Y  S  F  F  S  F  P  E  L         p.80

          .         . | 03       .         .         .         .    g.13254
 CAGGTGCTGGATTTATCCAG | GTGTGAAATCCAGACAATTGAAGATGGGGCATATCAGAGC    c.300
 Q  V  L  D  L  S  R  |  C  E  I  Q  T  I  E  D  G  A  Y  Q  S      p.100

          .         .         .         .         .         .       g.13314
 CTAAGCCACCTCTCTACCTTAATATTGACAGGAAACCCCATCCAGAGTTTAGCCCTGGGA       c.360
 L  S  H  L  S  T  L  I  L  T  G  N  P  I  Q  S  L  A  L  G         p.120

          .         .         .         .         .         .       g.13374
 GCCTTTTCTGGACTATCAAGTTTACAGAAGCTGGTGGCTGTGGAGACAAATCTAGCATCT       c.420
 A  F  S  G  L  S  S  L  Q  K  L  V  A  V  E  T  N  L  A  S         p.140

          .         .         .         .         .         .       g.13434
 CTAGAGAACTTCCCCATTGGACATCTCAAAACTTTGAAAGAACTTAATGTGGCTCACAAT       c.480
 L  E  N  F  P  I  G  H  L  K  T  L  K  E  L  N  V  A  H  N         p.160

          .         .         .         .         .         .       g.13494
 CTTATCCAATCTTTCAAATTACCTGAGTATTTTTCTAATCTGACCAATCTAGAGCACTTG       c.540
 L  I  Q  S  F  K  L  P  E  Y  F  S  N  L  T  N  L  E  H  L         p.180

          .         .         .         .         .         .       g.13554
 GACCTTTCCAGCAACAAGATTCAAAGTATTTATTGCACAGACTTGCGGGTTCTACATCAA       c.600
 D  L  S  S  N  K  I  Q  S  I  Y  C  T  D  L  R  V  L  H  Q         p.200

          .         .         .         .         .         .       g.13614
 ATGCCCCTACTCAATCTCTCTTTAGACCTGTCCCTGAACCCTATGAACTTTATCCAACCA       c.660
 M  P  L  L  N  L  S  L  D  L  S  L  N  P  M  N  F  I  Q  P         p.220

          .         .         .         .         .         .       g.13674
 GGTGCATTTAAAGAAATTAGGCTTCATAAGCTGACTTTAAGAAATAATTTTGATAGTTTA       c.720
 G  A  F  K  E  I  R  L  H  K  L  T  L  R  N  N  F  D  S  L         p.240

          .         .         .         .         .         .       g.13734
 AATGTAATGAAAACTTGTATTCAAGGTCTGGCTGGTTTAGAAGTCCATCGTTTGGTTCTG       c.780
 N  V  M  K  T  C  I  Q  G  L  A  G  L  E  V  H  R  L  V  L         p.260

          .         .         .         .         .         .       g.13794
 GGAGAATTTAGAAATGAAGGAAACTTGGAAAAGTTTGACAAATCTGCTCTAGAGGGCCTG       c.840
 G  E  F  R  N  E  G  N  L  E  K  F  D  K  S  A  L  E  G  L         p.280

          .         .         .         .         .         .       g.13854
 TGCAATTTGACCATTGAAGAATTCCGATTAGCATACTTAGACTACTACCTCGATGATATT       c.900
 C  N  L  T  I  E  E  F  R  L  A  Y  L  D  Y  Y  L  D  D  I         p.300

          .         .         .         .         .         .       g.13914
 ATTGACTTATTTAATTGTTTGACAAATGTTTCTTCATTTTCCCTGGTGAGTGTGACTATT       c.960
 I  D  L  F  N  C  L  T  N  V  S  S  F  S  L  V  S  V  T  I         p.320

          .         .         .         .         .         .       g.13974
 GAAAGGGTAAAAGACTTTTCTTATAATTTCGGATGGCAACATTTAGAATTAGTTAACTGT       c.1020
 E  R  V  K  D  F  S  Y  N  F  G  W  Q  H  L  E  L  V  N  C         p.340

          .         .         .         .         .         .       g.14034
 AAATTTGGACAGTTTCCCACATTGAAACTCAAATCTCTCAAAAGGCTTACTTTCACTTCC       c.1080
 K  F  G  Q  F  P  T  L  K  L  K  S  L  K  R  L  T  F  T  S         p.360

          .         .         .         .         .         .       g.14094
 AACAAAGGTGGGAATGCTTTTTCAGAAGTTGATCTACCAAGCCTTGAGTTTCTAGATCTC       c.1140
 N  K  G  G  N  A  F  S  E  V  D  L  P  S  L  E  F  L  D  L         p.380

          .         .         .         .         .         .       g.14154
 AGTAGAAATGGCTTGAGTTTCAAAGGTTGCTGTTCTCAAAGTGATTTTGGGACAACCAGC       c.1200
 S  R  N  G  L  S  F  K  G  C  C  S  Q  S  D  F  G  T  T  S         p.400

          .         .         .         .         .         .       g.14214
 CTAAAGTATTTAGATCTGAGCTTCAATGGTGTTATTACCATGAGTTCAAACTTCTTGGGC       c.1260
 L  K  Y  L  D  L  S  F  N  G  V  I  T  M  S  S  N  F  L  G         p.420

          .         .         .         .         .         .       g.14274
 TTAGAACAACTAGAACATCTGGATTTCCAGCATTCCAATTTGAAACAAATGAGTGAGTTT       c.1320
 L  E  Q  L  E  H  L  D  F  Q  H  S  N  L  K  Q  M  S  E  F         p.440

          .         .         .         .         .         .       g.14334
 TCAGTATTCCTATCACTCAGAAACCTCATTTACCTTGACATTTCTCATACTCACACCAGA       c.1380
 S  V  F  L  S  L  R  N  L  I  Y  L  D  I  S  H  T  H  T  R         p.460

          .         .         .         .         .         .       g.14394
 GTTGCTTTCAATGGCATCTTCAATGGCTTGTCCAGTCTCGAAGTCTTGAAAATGGCTGGC       c.1440
 V  A  F  N  G  I  F  N  G  L  S  S  L  E  V  L  K  M  A  G         p.480

          .         .         .         .         .         .       g.14454
 AATTCTTTCCAGGAAAACTTCCTTCCAGATATCTTCACAGAGCTGAGAAACTTGACCTTC       c.1500
 N  S  F  Q  E  N  F  L  P  D  I  F  T  E  L  R  N  L  T  F         p.500

          .         .         .         .         .         .       g.14514
 CTGGACCTCTCTCAGTGTCAACTGGAGCAGTTGTCTCCAACAGCATTTAACTCACTCTCC       c.1560
 L  D  L  S  Q  C  Q  L  E  Q  L  S  P  T  A  F  N  S  L  S         p.520

          .         .         .         .         .         .       g.14574
 AGTCTTCAGGTACTAAATATGAGCCACAACAACTTCTTTTCATTGGATACGTTTCCTTAT       c.1620
 S  L  Q  V  L  N  M  S  H  N  N  F  F  S  L  D  T  F  P  Y         p.540

          .         .         .         .         .         .       g.14634
 AAGTGTCTGAACTCCCTCCAGGTTCTTGATTACAGTCTCAATCACATAATGACTTCCAAA       c.1680
 K  C  L  N  S  L  Q  V  L  D  Y  S  L  N  H  I  M  T  S  K         p.560

          .         .         .         .         .         .       g.14694
 AAACAGGAACTACAGCATTTTCCAAGTAGTCTAGCTTTCTTAAATCTTACTCAGAATGAC       c.1740
 K  Q  E  L  Q  H  F  P  S  S  L  A  F  L  N  L  T  Q  N  D         p.580

          .         .         .         .         .         .       g.14754
 TTTGCTTGTACTTGTGAACACCAGAGTTTCCTGCAATGGATCAAGGACCAGAGGCAGCTC       c.1800
 F  A  C  T  C  E  H  Q  S  F  L  Q  W  I  K  D  Q  R  Q  L         p.600

          .         .         .         .         .         .       g.14814
 TTGGTGGAAGTTGAACGAATGGAATGTGCAACACCTTCAGATAAGCAGGGCATGCCTGTG       c.1860
 L  V  E  V  E  R  M  E  C  A  T  P  S  D  K  Q  G  M  P  V         p.620

          .         .         .         .         .         .       g.14874
 CTGAGTTTGAATATCACCTGTCAGATGAATAAGACCATCATTGGTGTGTCGGTCCTCAGT       c.1920
 L  S  L  N  I  T  C  Q  M  N  K  T  I  I  G  V  S  V  L  S         p.640

          .         .         .         .         .         .       g.14934
 GTGCTTGTAGTATCTGTTGTAGCAGTTCTGGTCTATAAGTTCTATTTTCACCTGATGCTT       c.1980
 V  L  V  V  S  V  V  A  V  L  V  Y  K  F  Y  F  H  L  M  L         p.660

          .         .         .         .         .         .       g.14994
 CTTGCTGGCTGCATAAAGTATGGTAGAGGTGAAAACATCTATGATGCCTTTGTTATCTAC       c.2040
 L  A  G  C  I  K  Y  G  R  G  E  N  I  Y  D  A  F  V  I  Y         p.680

          .         .         .         .         .         .       g.15054
 TCAAGCCAGGATGAGGACTGGGTAAGGAATGAGCTAGTAAAGAATTTAGAAGAAGGGGTG       c.2100
 S  S  Q  D  E  D  W  V  R  N  E  L  V  K  N  L  E  E  G  V         p.700

          .         .         .         .         .         .       g.15114
 CCTCCATTTCAGCTCTGCCTTCACTACAGAGACTTTATTCCCGGTGTGGCCATTGCTGCC       c.2160
 P  P  F  Q  L  C  L  H  Y  R  D  F  I  P  G  V  A  I  A  A         p.720

          .         .         .         .         .         .       g.15174
 AACATCATCCATGAAGGTTTCCATAAAAGCCGAAAGGTGATTGTTGTGGTGTCCCAGCAC       c.2220
 N  I  I  H  E  G  F  H  K  S  R  K  V  I  V  V  V  S  Q  H         p.740

          .         .         .         .         .         .       g.15234
 TTCATCCAGAGCCGCTGGTGTATCTTTGAATATGAGATTGCTCAGACCTGGCAGTTTCTG       c.2280
 F  I  Q  S  R  W  C  I  F  E  Y  E  I  A  Q  T  W  Q  F  L         p.760

          .         .         .         .         .         .       g.15294
 AGCAGTCGTGCTGGTATCATCTTCATTGTCCTGCAGAAGGTGGAGAAGACCCTGCTCAGG       c.2340
 S  S  R  A  G  I  I  F  I  V  L  Q  K  V  E  K  T  L  L  R         p.780

          .         .         .         .         .         .       g.15354
 CAGCAGGTGGAGCTGTACCGCCTTCTCAGCAGGAACACTTACCTGGAGTGGGAGGACAGT       c.2400
 Q  Q  V  E  L  Y  R  L  L  S  R  N  T  Y  L  E  W  E  D  S         p.800

          .         .         .         .         .         .       g.15414
 GTCCTGGGGCGGCACATCTTCTGGAGACGACTCAGAAAAGCCCTGCTGGATGGTAAATCA       c.2460
 V  L  G  R  H  I  F  W  R  R  L  R  K  A  L  L  D  G  K  S         p.820

          .         .         .         .         .         .       g.15474
 TGGAATCCAGAAGGAACAGTGGGTACAGGATGCAATTGGCAGGAAGCAACATCTATCTGA       c.2520
 W  N  P  E  G  T  V  G  T  G  C  N  W  Q  E  A  T  S  I  X         p.839

          .         .         .         .         .         .       g.15534
 agaggaaaaataaaaacctcctgaggcatttcttgcccagctgggtccaacacttgttca       c.*60

          .         .         .         .         .         .       g.15594
 gttaataagtattaaatgctgccacatgtcaggccttatgctaagggtgagtaattccat       c.*120

          .         .         .         .         .         .       g.15654
 ggtgcactagatatgcagggctgctaatctcaaggagcttccagtgcagagggaataaat       c.*180

          .         .         .         .         .         .       g.15714
 gctagactaaaatacagagtcttccaggtgggcatttcaaccaactcagtcaaggaaccc       c.*240

          .         .         .         .         .         .       g.15774
 atgacaaagaaagtcatttcaactcttacctcatcaagttgaataaagacagagaaaaca       c.*300

          .         .         .         .         .         .       g.15834
 gaaagagacattgttcttttcctgagtcttttgaatggaaattgtattatgttatagcca       c.*360

          .         .         .         .         .         .       g.15894
 tcataaaaccattttggtagttttgactgaactgggtgttcactttttcctttttgattg       c.*420

          .         .         .         .         .         .       g.15954
 aatacaatttaaattctacttgatgactgcagtcgtcaaggggctcctgatgcaagatgc       c.*480

          .         .         .         .         .         .       g.16014
 cccttccattttaagtctgtctccttacagaggttaaagtctagtggctaattcctaagg       c.*540

          .         .         .         .         .         .       g.16074
 aaacctgattaacacatgctcacaaccatcctggtcattctcgagcatgttctatttttt       c.*600

          .         .         .         .         .         .       g.16134
 aactaatcacccctgatatatttttatttttatatatccagttttcatttttttacgtct       c.*660

          .         .         .         .         .         .       g.16194
 tgcctataagctaatatcataaataaggttgtttaagacgtgcttcaaatatccatatta       c.*720

          .         .         .         .         .         .       g.16254
 accactatttttcaaggaagtatggaaaagtacactctgtcactttgtcactcgatgtca       c.*780

          .         .         .         .         .         .       g.16314
 ttccaaagttattgcctactaagtaatgactgtcatgaaagcagcattgaaataatttgt       c.*840

          .         .         .         .         .         .       g.16374
 ttaaagggggcactcttttaaacgggaagaaaatttccgcttcctggtcttatcatggac       c.*900

          .         .         .         .         .         .       g.16434
 aatttgggctagaggcaggaaggaagtgggatgacctcaggaggtcaccttttcttgatt       c.*960

          .         .         .         .         .         .       g.16494
 ccagaaacatatgggctgataaacccggggtgacctcatgaaatgagttgcagcagaagt       c.*1020

          .         .         .         .         .         .       g.16554
 ttatttttttcagaacaagtgatgtttgatggacctctgaatctctttagggagacacag       c.*1080

          .         .         .         .         .         .       g.16614
 atggctgggatccctcccctgtacccttctcactgccaggagaactacgtgtgaaggtat       c.*1140

          .         .         .         .         .         .       g.16674
 tcaaggcagggagtatacattgctgtttcctgttgggcaatgctccttgaccacattttg       c.*1200

          .         .         .         .         .         .       g.16734
 ggaagagtggatgttatcattgagaaaacaatgtgtctggaattaatggggttcttataa       c.*1260

          .         .         .         .         .         .       g.16794
 agaaggttcccagaaaagaatgttcatccagcctcctcagaaacagaacattcaagaaaa       c.*1320

          .         .         .         .         .         .       g.16854
 ggacaatcaggatgtcatcagggaaatgaaaataaaaaccacaatgagatatcaccttat       c.*1380

          .         .         .         .         .         .       g.16914
 accaggtagaatggctactataaaaaaatgaagtgtcatcaaggatatagagaaattgga       c.*1440

          .         .         .         .         .         .       g.16974
 acccttcttcactgctggagggaatggaaaatggtgtagccgttatgaaaaacagtacgg       c.*1500

          .         .         .         .         .         .       g.17034
 aggtttctcaaaaattaaaaatagaactgctatatgatccagcaatctcacttctgtata       c.*1560

          .         .         .         .         .         .       g.17094
 tatacccaaaataattgaaatcagaatttcaagaaaatatttacactcccatgttcattg       c.*1620

          .         .         .         .         .         .       g.17154
 tggcactcttcacaatcactgtttccaaagttatggaaacaacccaaatttccattgaaa       c.*1680

          .         .         .         .         .         .       g.17214
 aataaatggacaaagaaaatgtgcatatacgtacaatgggatattattcagcctaaaaaa       c.*1740

          .         .         .         .         .         .       g.17274
 agggggaatcctgttatttatgacaacatgaataaacccggaggccattatgctatgtaa       c.*1800

          .         .         .         .         .         .       g.17334
 aatgagcaagtaacagaaagacaaatactgcctgatttcatttatatgaggttctaaaat       c.*1860

          .         .         .         .         .         .       g.17394
 agtcaaactcatagaagcagagaatagaacagtggttcctagggaaaaggaggaagggag       c.*1920

          .         .         .         .         .         .       g.17454
 aaatgaggaaatagggagttgtctaattggtataaaattatagtatgcaagatgaattag       c.*1980

          .         .         .         .         .         .       g.17514
 ctctaaagatcagctgtatagcagagttcgtataatgaacaatactgtattatgcactta       c.*2040

          .         .         .         .         .         .       g.17574
 acattttgttaagagggtacctctcatgttaagtgttcttaccatatacatatacacaag       c.*2100

          .         .         .         .         .         .       g.17634
 gaagcttttggaggtgatggatatatttattaccttgattgtggtgatggtttgacaggt       c.*2160

          .         .         .         .         .         .       g.17694
 atgtgactatgtctaaactcatcaaattgtatacattaaatatatgcagttttataatat       c.*2220

          .         .         .         .         .         .       g.17754
 caattatgtctgaatgaagctataaaaaagaaaagacaacaaaattcagttgtcaaaact       c.*2280

          .         .         .         .         .         .       g.17814
 ggaaatatgaccacagtcagaagtgtttgttactgagtgtttcagagtgtgtttggtttg       c.*2340

          .         .         .         .         .         .       g.17874
 agcaggtctagggtgattgaacatccctgggtgtgtttccatgtctcatgtactagtgaa       c.*2400

          .         .         .         .         .         .       g.17934
 agtagatgtgtgcatttgtgcacatatccctatgtatccctatcagggctgtgtgtattt       c.*2460

          .         .         .         .         .         .       g.17994
 gaaagtgtgtgtgtccgcatgatcatatctgtatagaagagagtgtgattatatttcttg       c.*2520

          .         .         .         .         .         .       g.18054
 aagaatacatccatttgaaatggatgtctatggctgtttgagatgagttctctactcttg       c.*2580

          .         .         .         .         .         .       g.18114
 tgcttgtacagtagtctccccttatcccttatgcttggtggatacgttcttagaccccaa       c.*2640

          .         .         .         .         .         .       g.18174
 gtggatctctgagaccgcagatggtaccaaacctcatatatgcaatattttttcctatac       c.*2700

          .         .         .         .         .         .       g.18234
 ataaatacctaagataaagttcatcttctgaattaggcacagtaagagattaacaataac       c.*2760

          .         .         .         .         .         .       g.18294
 taacaataaaattgaatagttataataatatattgtaataaaagttatgtgaatgtgatc       c.*2820

          .         .                                               g.18317
 tctttctttctctctctcaaaat                                            c.*2843

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Toll-like receptor 4 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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