transmembrane protein 184B (TMEM184B) - coding DNA reference sequence

(used for variant description)

(last modified October 13, 2025)


This file was created to facilitate the description of sequence variants on transcript NM_012264.4 in the TMEM184B gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000022.10, covering TMEM184B transcript NM_012264.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5029
                                agagcgcatgcgcgccgcggctgcactcc       c.-181

 .         .         .         .         .         .                g.5089
 actgggcccgggacgcgccggcggcggcggagactccggggctgcggcgccgcccgcccc       c.-121

 .         .         .         .         .         .                g.5149
 gcccgcagagtccggctgccgcgcatcgtccgcagacgccgccaccgccatgggctcctg       c.-61

 .  | 02      .         .         .         .         .             g.30073
 ag | gctagcttgtcactttctgcaaaggtttccctcagggagcctcctgctgccaggcacc    c.-1

          .         .         .         .         .         .       g.30133
 ATGACAGTGAGGGGGGATGTGCTGGCCCCGGATCCAGCGTCGCCCACGACCGCAGCAGCC       c.60
 M  T  V  R  G  D  V  L  A  P  D  P  A  S  P  T  T  A  A  A         p.20

          .         .         .         .         .         .       g.30193
 TCGCCCAGCGTCTCCGTGATCCCCGAGGGCAGCCCCACTGCCATGGAGCAGCCTGTGTTC       c.120
 S  P  S  V  S  V  I  P  E  G  S  P  T  A  M  E  Q  P  V  F         p.40

          .         .         .         .         .         .       g.30253
 CTGATGACAACTGCCGCTCAGGCCATCTCTGGCTTCTTCGTGTGGACGGCCCTGCTCATC       c.180
 L  M  T  T  A  A  Q  A  I  S  G  F  F  V  W  T  A  L  L  I         p.60

          .   | 03     .         .         .         .         .    g.31982
 ACATGCCACCAG | ATCTACATGCACCTGCGCTGCTACAGCTGCCCCAACGAGCAGCGCTAC    c.240
 T  C  H  Q   | I  Y  M  H  L  R  C  Y  S  C  P  N  E  Q  R  Y      p.80

          .         .         .         .         .         .       g.32042
 ATCGTGCGCATCCTCTTCATCGTGCCCATCTACGCCTTTGACTCCTGGCTCAGCCTCCTC       c.300
 I  V  R  I  L  F  I  V  P  I  Y  A  F  D  S  W  L  S  L  L         p.100

          .         .         .         .         .         | 04    g.46702
 TTCTTCACCAACGACCAGTACTACGTGTACTTCGGCACCGTCCGCGACTGCTATGAGG | CC    c.360
 F  F  T  N  D  Q  Y  Y  V  Y  F  G  T  V  R  D  C  Y  E  A |       p.120

          .         .         .         .         .         .       g.46762
 TTGGTCATCTATAATTTCCTGAGCCTGTGCTATGAGTACCTAGGAGGAGAAAGTTCCATC       c.420
 L  V  I  Y  N  F  L  S  L  C  Y  E  Y  L  G  G  E  S  S  I         p.140

          .         .          | 05        .         .         .    g.47321
 ATGTCGGAGATCAGAGGAAAACCCATTGA | GTCCAGCTGTATGTATGGCACCTGCTGCCTC    c.480
 M  S  E  I  R  G  K  P  I  E  |  S  S  C  M  Y  G  T  C  C  L      p.160

          .         .         .         .      | 06  .         .    g.51178
 TGGGGAAAGACTTATTCCATCGGATTTCTGAGGTTCTGCAAACAG | GCCACCCTGCAGTTC    c.540
 W  G  K  T  Y  S  I  G  F  L  R  F  C  K  Q   | A  T  L  Q  F      p.180

          .         .         .         .         .         .       g.51238
 TGTGTGGTGAAGCCACTCATGGCGGTCAGCACTGTGGTCCTCCAGGCCTTCGGCAAGTAC       c.600
 C  V  V  K  P  L  M  A  V  S  T  V  V  L  Q  A  F  G  K  Y         p.200

          .        | 07.         .         .         .         .    g.52483
 CGGGATGGGGACTTTGA | CGTCACCAGTGGCTACCTCTACGTGACCATCATCTACAACATC    c.660
 R  D  G  D  F  D  |  V  T  S  G  Y  L  Y  V  T  I  I  Y  N  I      p.220

          .         .         .         .         .         .       g.52543
 TCCGTCAGCCTGGCCCTCTACGCCCTCTTCCTCTTCTACTTCGCCACCCGGGAGCTGCTC       c.720
 S  V  S  L  A  L  Y  A  L  F  L  F  Y  F  A  T  R  E  L  L         p.240

          .         .         .         .         .         .       g.52603
 AGCCCCTACAGCCCCGTCCTCAAGTTCTTCATGGTCAAGTCCGTCATCTTTCTTTCCTTC       c.780
 S  P  Y  S  P  V  L  K  F  F  M  V  K  S  V  I  F  L  S  F         p.260

         | 08.         .         .         .         .         .    g.53107
 TGGCAAG | GCATGCTCCTGGCCATCCTGGAGAAGTGTGGGGCCATCCCCAAAATCCACTCG    c.840
 W  Q  G |   M  L  L  A  I  L  E  K  C  G  A  I  P  K  I  H  S      p.280

          .         .         .         .         .         .       g.53167
 GCCCGCGTGTCGGTGGGCGAGGGCACCGTGGCTGCCGGCTACCAGGACTTCATCATCTGT       c.900
 A  R  V  S  V  G  E  G  T  V  A  A  G  Y  Q  D  F  I  I  C         p.300

          .         .         .         .         .         .       g.53227
 GTGGAGATGTTCTTTGCAGCCCTGGCCCTGCGGCACGCCTTCACCTACAAGGTCTATGCT       c.960
 V  E  M  F  F  A  A  L  A  L  R  H  A  F  T  Y  K  V  Y  A         p.320

          .         .   | 09     .         .         .         .    g.56361
 GACAAGAGGCTGGACGCACAAG | GCCGCTGTGCCCCCATGAAGAGCATCTCCAGCAGCCTC    c.1020
 D  K  R  L  D  A  Q  G |   R  C  A  P  M  K  S  I  S  S  S  L      p.340

          .         .         .         .         .         .       g.56421
 AAGGAGACCATGAACCCGCACGACATCGTGCAGGACGCCATCCACAACTTCTCACCTGCC       c.1080
 K  E  T  M  N  P  H  D  I  V  Q  D  A  I  H  N  F  S  P  A         p.360

          .         .         .         .         .         .       g.56481
 TACCAGCAGTACACGCAGCAGTCCACCCTGGAGCCTGGGCCCACCTGGCGTGGTGGCGCC       c.1140
 Y  Q  Q  Y  T  Q  Q  S  T  L  E  P  G  P  T  W  R  G  G  A         p.380

          .         .         .         .         .         .       g.56541
 CACGGCCTCTCCCGCTCCCACAGCCTCAGTGGCGCCCGCGACAACGAGAAGACTCTCCTG       c.1200
 H  G  L  S  R  S  H  S  L  S  G  A  R  D  N  E  K  T  L  L         p.400

          .         .                                               g.56565
 CTCAGCTCTGATGATGAATTCTAG                                           c.1224
 L  S  S  D  D  E  F  X                                             p.407

          .         .         .         .         .         .       g.56625
 gtgcgggctgcagtggcggaagtgctggcgccatagccacggtcaggctgtgccccacct       c.*60

          .         .         .         .         .         .       g.56685
 ccagcctcaccaccaggccaggaggcagctggcacagtgctcacgccgcctttatttatt       c.*120

          .         .         .         .         .         .       g.56745
 ggaccagaaacactcacatgtcacttccagaggaacgggggacagccaggctcgcccatg       c.*180

          .         .         .         .         .         .       g.56805
 ggccttcaggaatatttatacatggcccagcctgcactgcccgggcgagggcagaggaca       c.*240

          .         .         .         .         .         .       g.56865
 ctgggagcaaggcttatgcccctgctgcccgtcctgtgctgggggcatgctgggaccagc       c.*300

          .         .         .         .         .         .       g.56925
 cgcacccaggccccaatgcttgtgtgtggaccagcggctgcagccttctagcccctcctc       c.*360

          .         .         .         .         .         .       g.56985
 cccgcgagactctcaggctgaggtcggcaagccgtggctcccccacacaccgtgcaatac       c.*420

          .         .         .         .         .         .       g.57045
 cctgtctgacctgggctcttcccgcctgcatccctcccctgtccacctttgtccagtgct       c.*480

          .         .         .         .         .         .       g.57105
 agattcacctcaccccgggcaggagtggggatgtgggcgctctgtggtcctcccctcctg       c.*540

          .         .         .         .         .         .       g.57165
 acccaggcctctgtggcatgctgcaaggatcagagccagacaccaggagtcacaggcccc       c.*600

          .         .         .         .         .         .       g.57225
 acccaggaagggcattcagggcccctgggcaccgcttctgttgaagcaggggcttctggg       c.*660

          .         .         .         .         .         .       g.57285
 cccctgggtatccccacctgtcgtggccacacctctgcctgcctcatgccccttccccct       c.*720

          .         .         .         .         .         .       g.57345
 ggcctaccaaggacagcccacagcccgcactgccggctcacttgggtccttcctcgatag       c.*780

          .         .         .         .         .         .       g.57405
 ctttgggcagagcccttgcttcctggctgcttcagggctcaggggctcccagccctcctt       c.*840

          .         .         .         .         .         .       g.57465
 cccaggctgatgctgggtcctctctctctttggggcttctccctcccgtttcaggggaaa       c.*900

          .         .         .         .         .         .       g.57525
 ggtctgagtctccacgtttcagaccagcttctgggggaaggcagtccggcagggagaccg       c.*960

          .         .         .         .         .         .       g.57585
 ggaggggtggccacacagtggggagctgggaggtggggggaatggtcccagactcctctc       c.*1020

          .         .         .         .         .         .       g.57645
 ggggcccctatccacacagggcctggtgttctaccccatctggcccctggcccatctctt       c.*1080

          .         .         .         .         .         .       g.57705
 ctgtgccttagtcacatatgaaagcgcccctccctggctccccatctgtcccacacgctc       c.*1140

          .         .         .         .         .         .       g.57765
 cctggggctcttagttcagctgctggcactcgcaggatcctgcagtgctgggcccagagc       c.*1200

          .         .         .         .         .         .       g.57825
 ccttggacaggcctcaggagtggtcaggaccaccaagcccctcctctccccctccacacc       c.*1260

          .         .         .         .         .         .       g.57885
 tctagacctggggcctccggaacccccagcaggctgggcttatactagctcctgacttag       c.*1320

          .         .         .         .         .         .       g.57945
 gaagagcctcgtgtcacaacacgtgtccctacaggcaaagtgtcctggcatttaaaaccc       c.*1380

          .         .         .         .         .         .       g.58005
 agattatccctgggtttgggctgcagtcacctggagaagctggtagggtaagggagaggg       c.*1440

          .         .         .         .         .         .       g.58065
 accctgccggtgttcactggggattctttcttttggtccttcctggaatgaacaggttcc       c.*1500

          .         .         .         .         .         .       g.58125
 ctccctgccacctgtgaggagagttggggcccagccgtcttcctggcctccttcctttcc       c.*1560

          .         .         .         .         .         .       g.58185
 tcgtggcagaggcctgcatgtgggtgccagaggccagctctccccctccatcttgggggg       c.*1620

          .         .         .         .         .         .       g.58245
 gcggagcagttgggcccaagctgcccgggagggtgggtgcagacacaggctgaggaccag       c.*1680

          .         .         .         .         .         .       g.58305
 ccctggccctgccccgccatctgctttcaccaagctgtctctccaccgtggcttcccttc       c.*1740

          .         .         .         .         .         .       g.58365
 tccctccaggccaaagtgctgctgattcccactcccttggttttcgcctgcccagcgttg       c.*1800

          .         .         .         .         .         .       g.58425
 ctgtttgcgtggagggtggggggagctcagtggcagggaatcagcggtccgtggggtcgt       c.*1860

          .         .         .         .         .         .       g.58485
 ggggacgggaacatgtgcccgaccgctccatcccctcctcctccttaggatgcataacct       c.*1920

          .         .         .         .         .         .       g.58545
 accttgtcttttttttttttaattttctttccaggtagagtagctctttgtacataaaga       c.*1980

          .         .         .         .         .         .       g.58605
 atacttgaaaaattaattgtatgatgtatgagaagacagagtctcctagttttgtatctt       c.*2040

          .         .         .         .         .         .       g.58665
 gttgtatgactgccatgagttccaccagaaagccactctattttggtctctgtgacattt       c.*2100

          .         .         .         .         .         .       g.58725
 taaatgcgtgacagaagtgagcaaataaagtgaggaagaaatctatatatgagataatat       c.*2160

          .                                                         g.58743
 agattgtattgaaatctc                                                 c.*2178

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Transmembrane protein 184B protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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