transmembrane protein 231 (TMEM231) - coding DNA reference sequence

(used for variant description)

(last modified January 17, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_001077416.2 in the TMEM231 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_033109.1, covering TMEM231 transcript NM_001077416.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5015
                                              gtggagaccgaggcg       c.-1

          .         .         .         .         .         .       g.5075
 ATGGCAACCAGGAGAAGCCAAACTTGGTCCCCCGGCTCGCGGAGTGCCTGCGAGCGGTGC       c.60
 M  A  T  R  R  S  Q  T  W  S  P  G  S  R  S  A  C  E  R  C         p.20

          .         .         .         .         .         .       g.5135
 TCATGGCGCTCTATGAGCTCTTCTCTCACCCGGTCGAGCGCAGTTACCGCGCGGGGCTCT       c.120
 S  W  R  S  M  S  S  S  L  T  R  S  S  A  V  T  A  R  G  S         p.40

          .         .         .         .         .         .       g.5195
 GCTCCAAAGCCGCGCTGTTCCTGCTGCTGGCCGCTGCGCTCACGTACATCCCGCCGCTGC       c.180
 A  P  K  P  R  C  S  C  C  W  P  L  R  S  R  T  S  R  R  C         p.60

          .         .         .         .         .         .       g.5255
 TGGTGGCCTTCCGGAGCCACGGTGAGCCTGCCCCGGCCGCTGTGCCACGAGGCTCCCCGG       c.240
 W  W  P  S  G  A  T  V  S  L  P  R  P  L  C  H  E  A  P  R         p.80

          .         .         .         .         .         .       g.5315
 GCGCGCTCGGCCAGGGCCGGCCTCCCTAACCGCCTCCCTACCGCCCTCTTTAACTCAGGG       c.300
 A  R  S  A  R  A  G  L  P  N  R  L  P  T  A  L  F  N  S  G         p.100

          .         .         .         .         .         .       g.5375
 TTTTGGCTGAAGCGGAGCAGCTACGAGGAGCAGCCGACCGTGCGCTTCCAACACCAGGTG       c.360
 F  W  L  K  R  S  S  Y  E  E  Q  P  T  V  R  F  Q  H  Q  V         p.120

          .         .         .         .         .         .       g.5435
 CTGCTCGTGGCCCTGCTCGGACCCGAAAGCGACGGGTTCCTCGCCTGGAGCACGTTCCCC       c.420
 L  L  V  A  L  L  G  P  E  S  D  G  F  L  A  W  S  T  F  P         p.140

          .         .         .         .         | 02         .    g.15344
 GCCTTCAACCGGCTGCAAGGGGATCGCCTGCGCGTCCCGCTCGTTTCG | ACTAGAGAAGAA    c.480
 A  F  N  R  L  Q  G  D  R  L  R  V  P  L  V  S   | T  R  E  E      p.160

          .         .         .         .         .         .       g.15404
 GACAGGAACCAGGATGGGAAGACGGACATGTTACATTTTAAGCTGGAGCTTCCCCTGCAG       c.540
 D  R  N  Q  D  G  K  T  D  M  L  H  F  K  L  E  L  P  L  Q         p.180

          .         .         .         .         .        | 03.    g.15794
 TCCACGGAGCACGTTCTCGGTGTGCAGCTCATCCTGACTTTCTCCTATCGATTACAC | AGG    c.600
 S  T  E  H  V  L  G  V  Q  L  I  L  T  F  S  Y  R  L  H   | R      p.200

          .         .         .         .         .         .       g.15854
 ATGGCGACCCTCGTGATGCAGAGCATGGCGTTTCTCCAGTCCTCCTTTCCTGTCCCGGGA       c.660
 M  A  T  L  V  M  Q  S  M  A  F  L  Q  S  S  F  P  V  P  G         p.220

          .         .         .         .         .         .       g.15914
 TCCCAGTTATACGTGAACGGAGACCTGAGGCTGCAGCAGAAGCAGCCGCTGAGCTGTGGT       c.720
 S  Q  L  Y  V  N  G  D  L  R  L  Q  Q  K  Q  P  L  S  C  G         p.240

          .         .  | 04      .         .         .         .    g.18642
 GGCCTAGATGCCCGATACAAC | ATATCCGTGATCAACGGGACCAGCCCCTTTGCCTATGAC    c.780
 G  L  D  A  R  Y  N   | I  S  V  I  N  G  T  S  P  F  A  Y  D      p.260

          .         .         .         .    | 05    .         .    g.19848
 TACGACCTCACCCATATTGTTGCTGCCTACCAGGAGAGGAACG | TTACCACCGTCCTGAAT    c.840
 Y  D  L  T  H  I  V  A  A  Y  Q  E  R  N  V |   T  T  V  L  N      p.280

          .         .         .         .         .         .       g.19908
 GATCCCAACCCCATCTGGCTGGTGGGCAGGGCCGCAGATGCTCCATTTGTGATTAATGCT       c.900
 D  P  N  P  I  W  L  V  G  R  A  A  D  A  P  F  V  I  N  A         p.300

          .         .          | 06        .         .         .    g.21143
 ATCATCCGATACCCTGTGGAAGTCATTTC | TTATCAGCCAGGATTCTGGGAGATGGTAAAG    c.960
 I  I  R  Y  P  V  E  V  I  S  |  Y  Q  P  G  F  W  E  M  V  K      p.320

          .         .         .         .         .         .       g.21203
 TTCGCCTGGGTGCAGTATGTCAGCATCCTGCTTATCTTCCTCTGGGTGTTTGAAAGAATC       c.1020
 F  A  W  V  Q  Y  V  S  I  L  L  I  F  L  W  V  F  E  R  I         p.340

          .         .         .         .         .         .       g.21263
 AAGATCTTCGTGTTTCAGAATCAGGTGGTGACCACCATTCCTGTGACAGTGACGCCCCGG       c.1080
 K  I  F  V  F  Q  N  Q  V  V  T  T  I  P  V  T  V  T  P  R         p.360

          .         .         .                                     g.21293
 GGAGACTTGTGTAAGGAGCACTTATCCTAG                                     c.1110
 G  D  L  C  K  E  H  L  S  X                                       p.369

          .         .         .         .         .         .       g.21353
 aaaggccatttctgaagactcagcaggaccgtggctgcctcattgtcatcttctgggaac       c.*60

          .         .         .         .         .         .       g.21413
 atcttaggaccttttgaaagagcccagcggacacctgcgggcttgtgtgcttttccctca       c.*120

          .         .         .         .         .         .       g.21473
 gagacaacggttctttccggttttgctctacacagttccgtatcttcagagctcctgcag       c.*180

          .         .         .         .         .         .       g.21533
 aattgtcagggactagtttgtggaaaggtctgagagttcctggaggctataattagcttt       c.*240

          .         .         .         .         .         .       g.21593
 ttgggttttccttctttgccttagcgttgaatttcaggagaaaattgcagtcagttcaga       c.*300

          .         .         .         .         .         .       g.21653
 catcttggaaagagtcccatctctggtcaagcagagacttttcctctgttgaactgagga       c.*360

          .         .         .         .         .         .       g.21713
 acacactgtgcatttctaccttctgttgtgagccactcttactcttttcagggctctctt       c.*420

          .         .         .         .         .         .       g.21773
 gtgacaaacatgccaatcactagcactttgcacccctgggcttctccatttcccattcac       c.*480

          .         .         .         .         .         .       g.21833
 agctttgatttccagagctgaggcctttaactggagacctggaggggcagggcccaaggg       c.*540

          .         .         .         .         .         .       g.21893
 caagggccgcattagcacaggcaatcagggagggccgctgaaggacacttggaccgtcca       c.*600

          .         .         .         .         .         .       g.21953
 cctgccccagcccaacagtcagtcatctgtcatcagctcagctgagcagccctggatctt       c.*660

          .         .         .         .         .         .       g.22013
 tgccgtactgtgactgggctctttgccctatttttccctctgtctgtgcccctggatggc       c.*720

          .         .         .         .         .         .       g.22073
 aggctgaagtcagaggggctgtttcattctcagccccctcagcagcactgggggaagaaa       c.*780

          .         .         .         .         .         .       g.22133
 gcattgtcacaacaggttctttctggccctcacccaacagcctgggcacttggccctcct       c.*840

          .         .         .         .         .         .       g.22193
 cctccttgacagccctcccccttcctgcaaaggacaggggcgacaggggttggtgttggg       c.*900

          .         .         .         .         .         .       g.22253
 attggctcccgctgcctgacaaccacaagtttatttggaaggctagcgggaagcccagcg       c.*960

          .         .         .         .         .         .       g.22313
 gctggcgtttcccttgactaaggaacagggtgcccatcagagtggggcgggcagctttgg       c.*1020

          .         .         .         .         .         .       g.22373
 gaaggacacaagaagcagtaagagtgtaaagaggatgctggcctgggcaggccagtccag       c.*1080

          .         .         .         .         .         .       g.22433
 cctggccactagcagaataccaagcagtccagtggattaccctcgtggctaagcaagtgt       c.*1140

          .         .         .         .         .         .       g.22493
 ctgcaggagcagagatggctggaaggggcctctgcacacggaagatggcttgttcagccc       c.*1200

          .         .         .         .         .         .       g.22553
 attcacctcctgaggatgtgggcagtctcctccaagaacacatggagctgcttcctgatc       c.*1260

          .         .         .         .         .         .       g.22613
 ccaagcaggtcattgccactggaaggacatggccccggtgatccatgcttcatgcccacc       c.*1320

          .         .         .         .         .         .       g.22673
 cagaaacacacccctcagtgtgtgcctcagtttactttggagatcagttgtcgtttttag       c.*1380

          .         .         .         .         .         .       g.22733
 tgctcctttaggcttactaaaacagttttggaaacaaagctattttgaagtattcaagca       c.*1440

          .         .         .         .         .         .       g.22793
 gaggaattccctaacactgacccccttgtctttttttaatattcaggctgttttatatgc       c.*1500

          .         .         .         .         .         .       g.22853
 ctaaatttttttcttaagatctaaacgaaaaatagtttcttgtttaaattcacataaggc       c.*1560

          .         .         .         .         .         .       g.22913
 aatgagatatggaaagatgacaagatacgtataaacattggtttgcattttattaaatta       c.*1620

          .         .         .         .         .         .       g.22973
 ttctaatgcaaatcttgtataaagaacccatgatgttttgtaactttctaattaaaatgt       c.*1680

          .         .         .         .         .         .       g.23033
 tcaaaatgaggccgagcatggtggttcattcctgtaatctcaacactttgggaggccaag       c.*1740

          .         .         .         .         .         .       g.23093
 gtgggaggatcacttgagcccaggagcttgaggctgcagtgtgctatgattgcaccactg       c.*1800

          .         .         .         .         .         .       g.23153
 tactgtagcctgggtgacagagtgagaccctatctgttaaaataaataaataaataaata       c.*1860

          .                                                         g.23170
 aaaaagtcaaaatggaa                                                  c.*1877

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Transmembrane protein 231 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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