transmembrane protein 237 (TMEM237) - coding DNA reference sequence

(used for variant description)

(last modified November 26, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_001044385.2 in the TMEM237 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_032049.1, covering TMEM237 transcript NM_001044385.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5009
                                                    agggggcgg       c.-121

 .         .         .         .         .         .                g.5069
 ctgcctcgccaggcgccacgaagccccggcgtcccacaggtcccggaggccgctgcgtcg       c.-61

 .         .         .         .         .         .                g.5129
 cggggagctgggctcgggccgccggcggttgcgccggggcagccccgcggggagagcacc       c.-1

          .         .         .         .   | 02     .         .    g.7623
 ATGAGGACTGACTCGGGGGCTCGGCTGGAGGAGGGCCACCTG | CGTCCTCCACGAGCTCTT    c.60
 M  R  T  D  S  G  A  R  L  E  E  G  H  L   | R  P  P  R  A  L      p.20

          .     | 03    | 04        .         .         .         . g.9525
 CCACCTGTGCCAAG | TCAAG | ATGATATTCCACTTAGTCGTCCTAAGAAAAAGAAGCCCAGA c.120
 P  P  V  P  S  |  Q  D |   D  I  P  L  S  R  P  K  K  K  K  P  R   p.40

          .       | 05 .         .         .         .         .    g.11688
 ACAAAAAACACACCAG | CAAGTGCTTCTTTGGAAGGCCTTGCTCAGACTGCTGGTCGAAGG    c.180
 T  K  N  T  P  A |   S  A  S  L  E  G  L  A  Q  T  A  G  R  R      p.60

          .         .         .         .         .         .       g.11748
 CCCTCTGAGGGCAATGAGCCATCAACTAAAGAACTCAAAGAGCACCCAGAGGCTCCTGTT       c.240
 P  S  E  G  N  E  P  S  T  K  E  L  K  E  H  P  E  A  P  V         p.80

          .         .         .     | 06   .         .         .    g.15124
 CAAAGAAGACAGAAAAAGACAAGGCTACCTCTTG | AATTGGAGACTTCCTCCACCCAAAAG    c.300
 Q  R  R  Q  K  K  T  R  L  P  L  E |   L  E  T  S  S  T  Q  K      p.100

          .         .         .         .         .         .       g.15184
 AAGTCATCTAGTTCATCTTTATTACGAAATGAAAATGGTATTGATGCGGAGCCAGCTGAG       c.360
 K  S  S  S  S  S  L  L  R  N  E  N  G  I  D  A  E  P  A  E         p.120

          .         .         .      | 07  .         .         .    g.16346
 GAGGCAGTTATTCAAAAACCTCGGAGGAAGACAAA | GAAAACCCAGCCAGCAGAATTACAG    c.420
 E  A  V  I  Q  K  P  R  R  K  T  K  |  K  T  Q  P  A  E  L  Q      p.140

          .         .         .         .         .         .       g.16406
 TATGCCAATGAGCTAGGAGTAGAAGATGAAGACATAATCACTGATGAGCAAACTACTGTG       c.480
 Y  A  N  E  L  G  V  E  D  E  D  I  I  T  D  E  Q  T  T  V         p.160

          .         .         .         .         .         .       g.16466
 GAACAGCAGTCTGTATTCACTGCACCCACTGGCATTAGCCAGCCTGTAGGCAAAGTATTT       c.540
 E  Q  Q  S  V  F  T  A  P  T  G  I  S  Q  P  V  G  K  V  F         p.180

          .    | 08    .         .         .         .         .    g.18724
 GTGGAAAAAAGCC | GGAGATTCCAGGCTGCTGATCGTTCAGAGTTGATAAAGACCACAGAA    c.600
 V  E  K  S  R |   R  F  Q  A  A  D  R  S  E  L  I  K  T  T  E      p.200

          .         .         .         .         .         .       g.18784
 AACATAGATGTGTCAATGGACGTGAAGCCTTCCTGGACCACCAGAGATGTGGCACTTACA       c.660
 N  I  D  V  S  M  D  V  K  P  S  W  T  T  R  D  V  A  L  T         p.220

          .        | 09.         .         .         .         .    g.19151
 GTGCACCGGGCTTTCAG | GATGATTGGTCTCTTTTCTCATGGATTCTTGGCTGGCTGTGCT    c.720
 V  H  R  A  F  R  |  M  I  G  L  F  S  H  G  F  L  A  G  C  A      p.240

          .         .         .         .         .         .       g.19211
 GTGTGGAATATTGTTGTGATATATGTTCTAGCAGGAGATCAGCTATCCAACCTCTCAAAC       c.780
 V  W  N  I  V  V  I  Y  V  L  A  G  D  Q  L  S  N  L  S  N         p.260

          .         .         .         .         .         .       g.19271
 CTTCTGCAACAATACAAGACCCTAGCGTATCCATTCCAGAGTCTTCTGTACTTGCTTTTG       c.840
 L  L  Q  Q  Y  K  T  L  A  Y  P  F  Q  S  L  L  Y  L  L  L         p.280

          .         .          | 10        .         .         .    g.20411
 GCTCTGAGTACAATTTCAGCTTTTGACAG | GATTGACTTTGCTAAAATATCAGTAGCAATC    c.900
 A  L  S  T  I  S  A  F  D  R  |  I  D  F  A  K  I  S  V  A  I      p.300

          .         .         .         .    | 11    .         .    g.21132
 CGAAATTTTTTGGCCCTGGATCCTACAGCTTTAGCATCTTTCT | TGTACTTTACTGCTCTT    c.960
 R  N  F  L  A  L  D  P  T  A  L  A  S  F  L |   Y  F  T  A  L      p.320

          .         .         .         .         .         .       g.21192
 ATACTATCTCTGAGTCAGCAAATGACAAGTGACAGAATCCACCTTTACACACCTTCTTCT       c.1020
 I  L  S  L  S  Q  Q  M  T  S  D  R  I  H  L  Y  T  P  S  S         p.340

          .        | 12.         .         .         .         .    g.22425
 GTTAATGGTAGCCTCTG | GGAAGCAGGAATTGAGGAACAGATTCTCCAGCCATGGATTGTG    c.1080
 V  N  G  S  L  W  |  E  A  G  I  E  E  Q  I  L  Q  P  W  I  V      p.360

          .         .         .         .         .         .       g.22485
 GTGAATCTCGTGGTGGCTCTTCTGGTTGGATTATCTTGGCTATTTTTGTCTTATAGGCCA       c.1140
 V  N  L  V  V  A  L  L  V  G  L  S  W  L  F  L  S  Y  R  P         p.380

          .          | 13        .         .         .         .    g.24248
 GGCATGGATCTTAGTGAAG | AGTTAATGTTCTCCTCAGAGGTGGAAGAATATCCTGATAAA    c.1200
 G  M  D  L  S  E  E |   L  M  F  S  S  E  V  E  E  Y  P  D  K      p.400

          .         .                                               g.24275
 GAGAAAGAAATCAAAGCCTCTTCATAA                                        c.1227
 E  K  E  I  K  A  S  S  X                                          p.408

          .         .         .         .         .         .       g.24335
 taccagctcacctttggaggaataatgacccagtatttgtcccatttttgtttttaaatg       c.*60

          .         .         .         .         .         .       g.24395
 tatttttataagatgtatacatgtgtatttgtaatagattttttgattatataatactga       c.*120

          .         .         .         .         .         .       g.24455
 aacatctctcaatattatgaaaaatgttaaaattgtgtttgctgtttatgtctaaacatt       c.*180

          .         .         .         .         .         .       g.24515
 aatttgtctagcattatcatcttaatgacaaagggaataatgaactagaaaccagcaagt       c.*240

          .         .         .         .         .         .       g.24575
 gaaagtgtttatttcctattttctcaaaacagttgtatttataactattaccttaaaaag       c.*300

          .         .         .         .         .         .       g.24635
 cactggtttagaaaaagccataacttaaatagtgttataaaatatatatcaggtttaaac       c.*360

          .         .         .         .         .         .       g.24695
 ataaatttagcgaatatggtagaagggaaaaaagccttcatttttgacctccccttactg       c.*420

          .         .         .         .         .         .       g.24755
 aataaattgaaatatgaagtttgtcttttctgaaactggcttagtgattgagtatcatgt       c.*480

          .         .         .         .         .         .       g.24815
 aataattataatataatttagcttgaaagatgctctacattatgaccaataaaaagggaa       c.*540

          .         .         .         .         .         .       g.24875
 tgtatgttttgtttgaaaaattatataacctaaattttttacctagaagtaactaaaaag       c.*600

          .         .         .         .         .         .       g.24935
 ttgcttctcattataatctgtactagtggttctcatatctggttgtacatcaggatcata       c.*660

          .         .         .         .         .         .       g.24995
 gagggagattttaaaaatctatgtagcaaaagaggctgagcagggcaaggctcaggggaa       c.*720

          .         .         .         .         .         .       g.25055
 taaaggagagacctgtgagcttgtgggctcccagttgacatctgcagtaccctttcctct       c.*780

          .         .         .         .         .         .       g.25115
 gtcccttttttctgagtgacaagaaataggagtagaaattcaccatctctgttctccagc       c.*840

          .         .         .         .         .         .       g.25175
 tctttgtcagagaggtttctggttttccaggaaatccccctcttgagatgggtcctgcac       c.*900

          .         .         .         .         .         .       g.25235
 tgggaaagatctcttcagaactatatccaatggtacctcagctgttgtatatgagaccct       c.*960

          .         .         .         .         .         .       g.25295
 aaagctcaagttgaggagaagactagctatgggaaaaaatgtttcaaaggctgttgagca       c.*1020

          .         .         .         .         .         .       g.25355
 catcaataaaactattgagcctgccctgattagcaagcacctgaatgttatagaacagaa       c.*1080

          .         .         .         .         .         .       g.25415
 gaggattgacaaattgatgatagagacagttgaccctgacaataggtctaaatttggagt       c.*1140

          .         .         .         .         .         .       g.25475
 gaacattatactgggaatctcttttgctgtttgtaaggctggagctgccgaaaagggatt       c.*1200

          .         .         .         .         .         .       g.25535
 ctccctgctgtcacagaattgtgaatttgctggcaattctgaaggcatcctgctagttcc       c.*1260

          .         .         .         .         .         .       g.25595
 agctttcactgtgaccagcaatggttctcaatctggcaataagctggcagtataggagtt       c.*1320

          .         .         .         .         .         .       g.25655
 cataatcttccccgtcagcaaacttcagggaagccatgctcgttagagccaaggcttagc       c.*1380

          .         .         .         .         .         .       g.25715
 acacttgagccgtgtcatcaaagagaaatgtgagaaagctgctgccaatgtgggggattg       c.*1440

          .         .         .         .         .         .       g.25775
 tggtaggctgcataatgtctcctaaagatgtccatgtcctaatccctggaacttgtgaat       c.*1500

          .         .         .         .         .         .       g.25835
 atactactttacttggccaaagggatttgcagatatgattaaggttatgaaccttaaaac       c.*1560

          .         .         .         .         .         .       g.25895
 ggggacattatcctgtattatccagaagggtccagtgtaatcttatgagtccttaaaagc       c.*1620

          .         .         .         .         .         .       g.25955
 agagaagaaagccttttatgtctgtggtcagagaggtcagaagttatgatattgctggct       c.*1680

          .         .         .         .         .         .       g.26015
 ttgaagatggaagagggggccatgagccaaggagagtgatgaccttgcagctgagtacgg       c.*1740

          .         .         .         .         .         .       g.26075
 cccttggccaacaatgagcaaggaaatggatttcagtcacataaccacaaggaactgagt       c.*1800

          .         .         .         .         .         .       g.26135
 tctatgagtatcccaaatgagcaaggaaacaaatcctcccctagagccaagaaaggaagg       c.*1860

          .         .         .         .         .         .       g.26195
 cagctctgtggataccttggttttggcctggtgctgcccatgtcatacttttgacataca       c.*1920

          .         .         .         .         .         .       g.26255
 gaactgtaagatagcaagtgtatgttgactaagctgctaaattggtggtgattgcttatg       c.*1980

          .         .         .         .         .         .       g.26315
 gcagcaatagaaagctatatatcctagagaataaagaaggctagagctgctgtggaatgc       c.*2040

          .         .         .         .         .         .       g.26375
 acttgggaaagctggctacattgataatatgtaactgccatgggcatagttgcctttgta       c.*2100

          .         .         .         .         .         .       g.26435
 ttcttccaggtctgggaagtacaacttagacttcagatctcgtaatgacccaggaggcat       c.*2160

          .         .         .         .         .         .       g.26495
 ataaacctgagcagctagtggccctgtacaagtccttcatcagggaaaaacattgagtat       c.*2220

          .         .         .         .         .         .       g.26555
 tccctgattaaggacttgtacagaggactctgttttccctggtgtttctggtgtgtctca       c.*2280

          .         .         .         .         .         .       g.26615
 aaaattgtttgactgtgatgacagggaagtttggaagaagttcactgctaatgcatgtct       c.*2340

          .         .         .         .         .         .       g.26675
 ccaggaagcagggaatgatctcacagtgacacttgaggcacattgctgaggccgtcgatg       c.*2400

          .         .         .         .         .         .       g.26735
 agaattcatgtaactttctccagcttacagtggactagattgacatgcaagctgatccag       c.*2460

          .         .         .         .         .         .       g.26795
 tccaattggtagggcatcatggtttctcattactcactgacttaaaatacttttattgcc       c.*2520

          .         .         .         .         .         .       g.26855
 atcctggtgaagcactgcactgggtagataacacaggggcaccttgctgatcagagccct       c.*2580

          .         .         .         .         .         .       g.26915
 tggccaggtacaaagagctcagtttctaaaactctgtcatttcaataatgttataaattg       c.*2640

          .         .         .         .         .         .       g.26975
 aatcatacagtatgtaattttatgggattcgctttttttctgttgatctctttttttctg       c.*2700

          .         .         .         .         .         .       g.27035
 agtcatctcagctgttgtgtgtatcaatagttcatttccttttactgttttgtttggttt       c.*2760

          .         .         .         .         .         .       g.27095
 aactcattgacctattgaaggatatctgggctcattccagtctgtgaataatgctgctgt       c.*2820

          .         .         .         .         .         .       g.27155
 ggacattcatgtgcaagtttttgtgtgaacattaagttttcatttctttaagataaatgc       c.*2880

          .         .         .         .         .         .       g.27215
 ccaggagtgaaactgatgggttgtatgtagttacaaactgccaagctgttttccagagtt       c.*2940

          .         .         .         .         .         .       g.27275
 ggcggtaccattctaatttcccatgacaattttttgaagagtccaagctagttgctttag       c.*3000

          .         .         .         .         .         .       g.27335
 agtgcctcacctacattttttaattgtctgactttttcctaatgacatcacttaatttgt       c.*3060

          .         .         .         .         .         .       g.27395
 tcctcaatctcctgaatttcctatagactggaggttaggtctggtggtttgattagattt       c.*3120

          .         .         .         .         .         .       g.27455
 tttaaaaaaatatgacttcatctgtgatgctgtgtactttatgttgcataacatgaaccc       c.*3180

          .         .         .         .         .         .       g.27515
 taagaacagagtgagctgctggacagcaagtttcatggggtgcagtaattaacacaccac       c.*3240

          .         .         .         .         .         .       g.27575
 atagtataaatctgaaataatgacaaatgtgttaagggccttgggatattgggccatgta       c.*3300

          .         .         .         .         .         .       g.27635
 ctctgaggagcacaaggtgaggtgcaggttcctgcccctaaagaactctatcttttgaga       c.*3360

          .         .         .         .         .         .       g.27695
 ttagcaactaacagtgtgagcccactaataggatgtgaaagttgtcaaaatcaagttctg       c.*3420

          .         .         .         .         .         .       g.27755
 gtcattgtgttaaaaatcctaacaaatagagctggggaaggccgtgaaaggacgattttc       c.*3480

          .         .         .         .         .         .       g.27815
 atgcacagatgtctgataatgaggactatcattaaaagactgcacaaaaccacaccttgc       c.*3540

          .         .         .         .         .         .       g.27875
 acaaaggccatcacaacctgacacacacaaaaaatacttctatgaggacatttgcccagc       c.*3600

          .         .         .         .         .         .       g.27935
 aactccctgtccaatgtccaactggcaacatccttgttattgatccttgtagccaaggat       c.*3660

          .         .         .         .         .         .       g.27995
 aattctctcaaaacaatcatttttgctttaaaaaccgttgtcttccttgacctccctgta       c.*3720

          .         .         .         .         .         .       g.28055
 tatgcacatagtttactgtggcacttgtattcttattgcaatgcctactcctgaataaac       c.*3780

          .         .         .         .         .         .       g.28115
 atcattttctttcagagagtctccctctctgttatttaggctgacaaggatatgccaaga       c.*3840

          .         .         .         .         .         .       g.28175
 agtagcttggatatagcagttaactctgcctttaggatatgtgtatggggatataagagt       c.*3900

          .         .         .         .         .         .       g.28235
 taactaaaagctgacctttgagttggtccttgaataaaagaagaatagattccaaaaata       c.*3960

          .         .         .         .         .         .       g.28295
 agaggaataaataatgatcctgagctaggagagtacattttgcagacctttggtttccat       c.*4020

          .         .         .         .         .                 g.28346
 attaagaaattcagatttttatgtacaataaagaagttctggaattctctg                c.*4071

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Transmembrane protein 237 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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