transmembrane protein 43 (TMEM43) - coding DNA reference sequence

(used for variant description)

(last modified September 19, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_024334.2 in the TMEM43 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008975.1, covering TMEM43 transcript NM_024334.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5014
                                               tttgcagtgcgcag       c.-241

 .         .         .         .         .         .                g.5074
 gcgcatcaatgaggtactgcaatgtcccggaccgtatagtttccaggacgtctcgccgcg       c.-181

 .         .         .         .         .         .                g.5134
 cgcatgcgcagaaacactgggcacagggggaggtaactgcagtaagtcccgcttggccct       c.-121

 .         .         .         .         .         .                g.5194
 ggagtccacgcggattttcgaagctggggctggcaagaggccgctggacaccacgctcca       c.-61

 .         .         .         .         .         .                g.5254
 gtcgtcagcccacttcctagctgaacagcgcgaggcggcggcagcgagccgggtcccacc       c.-1

          .   | 02     .         .         .         .         .    g.9520
 ATGGCCGCGAAT | TATTCCAGTACCAGTACCCGGAGAGAACATGTCAAAGTTAAAACCAGC    c.60
 M  A  A  N   | Y  S  S  T  S  T  R  R  E  H  V  K  V  K  T  S      p.20

          .         .         .         .         .         .       g.9580
 TCCCAGCCAGGCTTCCTGGAACGGCTGAGCGAGACCTCGGGTGGGATGTTTGTGGGGCTC       c.120
 S  Q  P  G  F  L  E  R  L  S  E  T  S  G  G  M  F  V  G  L         p.40

          .         .         .         .   | 03     .         .    g.10900
 ATGGCCTTCCTGCTCTCCTTCTACCTAATTTTCACCAATGAG | GGCCGCGCATTGAAGACG    c.180
 M  A  F  L  L  S  F  Y  L  I  F  T  N  E   | G  R  A  L  K  T      p.60

          .         .         .         .         .         .       g.10960
 GCAACCTCATTGGCTGAGGGGCTCTCGCTTGTGGTGTCTCCCGACAGCATCCACAGTGTG       c.240
 A  T  S  L  A  E  G  L  S  L  V  V  S  P  D  S  I  H  S  V         p.80

          .         .         .         .         .        | 04.    g.11643
 GCTCCGGAGAATGAAGGAAGGCTGGTGCACATCATTGGCGCCTTACGGACATCCAAG | CTT    c.300
 A  P  E  N  E  G  R  L  V  H  I  I  G  A  L  R  T  S  K   | L      p.100

          .         .         .         .         .         .       g.11703
 TTGTCTGATCCAAACTATGGGGTCCATCTTCCGGCTGTGAAACTGCGGAGGCACGTGGAG       c.360
 L  S  D  P  N  Y  G  V  H  L  P  A  V  K  L  R  R  H  V  E         p.120

          .         .         .   | 05     .         .         .    g.12634
 ATGTACCAATGGGTAGAAACTGAGGAGTCCAG | GGAGTACACCGAGGATGGGCAGGTGAAG    c.420
 M  Y  Q  W  V  E  T  E  E  S  R  |  E  Y  T  E  D  G  Q  V  K      p.140

          .         .   | 06     .         .         .         .    g.12964
 AAGGAGACGAGGTATTCCTACA | ACACTGAATGGAGGTCAGAAATCATCAACAGCAAAAAC    c.480
 K  E  T  R  Y  S  Y  N |   T  E  W  R  S  E  I  I  N  S  K  N      p.160

          .         .         .   | 07     .         .         .    g.13827
 TTCGACCGAGAGATTGGCCACAAAAACCCCAG | TGCCATGGCAGTGGAGTCATTCATGGCA    c.540
 F  D  R  E  I  G  H  K  N  P  S  |  A  M  A  V  E  S  F  M  A      p.180

          .         .         .         .    | 08    .         .    g.14847
 ACAGCCCCCTTTGTCCAAATTGGCAGGTTTTTCCTCTCGTCAG | GCCTCATCGACAAAGTC    c.600
 T  A  P  F  V  Q  I  G  R  F  F  L  S  S  G |   L  I  D  K  V      p.200

          .         .         .         .         .         .       g.14907
 GACAACTTCAAGTCCCTGAGCCTATCCAAGCTGGAGGACCCTCATGTGGACATCATTCGC       c.660
 D  N  F  K  S  L  S  L  S  K  L  E  D  P  H  V  D  I  I  R         p.220

          .         .         .         .      | 09  .         .    g.15233
 CGTGGAGACTTTTTCTACCACAGCGAAAATCCCAAGTATCCAGAG | GTGGGAGACTTGCGT    c.720
 R  G  D  F  F  Y  H  S  E  N  P  K  Y  P  E   | V  G  D  L  R      p.240

          .         .         .         .         .         .       g.15293
 GTCTCCTTTTCCTATGCTGGACTGAGCGGCGATGACCCTGACCTGGGCCCAGCTCACGTG       c.780
 V  S  F  S  Y  A  G  L  S  G  D  D  P  D  L  G  P  A  H  V         p.260

  | 10       .         .         .         .         .         .    g.15927
  | GTCACTGTGATTGCCCGGCAGCGGGGTGACCAGCTAGTCCCATTCTCCACCAAGTCTGGG    c.840
  | V  T  V  I  A  R  Q  R  G  D  Q  L  V  P  F  S  T  K  S  G      p.280

          .         .         .         .   | 11     .         .    g.19258
 GATACCTTACTGCTCCTGCACCACGGGGACTTCTCAGCAGAG | GAGGTGTTTCATAGAGAA    c.900
 D  T  L  L  L  L  H  H  G  D  F  S  A  E   | E  V  F  H  R  E      p.300

          .         .         .         .         .         .       g.19318
 CTAAGGAGCAACTCCATGAAGACCTGGGGCCTGCGGGCAGCTGGCTGGATGGCCATGTTC       c.960
 L  R  S  N  S  M  K  T  W  G  L  R  A  A  G  W  M  A  M  F         p.320

          .         .         .         . | 12       .         .    g.21673
 ATGGGCCTCAACCTTATGACACGGATCCTCTACACCTTGG | TGGACTGGTTTCCTGTTTTC    c.1020
 M  G  L  N  L  M  T  R  I  L  Y  T  L  V |   D  W  F  P  V  F      p.340

          .         .         .         .         .         .       g.21733
 CGAGACCTGGTCAACATTGGCCTGAAAGCCTTTGCCTTCTGTGTGGCCACCTCGCTGACC       c.1080
 R  D  L  V  N  I  G  L  K  A  F  A  F  C  V  A  T  S  L  T         p.360

          .         .         .         .         .         .       g.21793
 CTGCTGACCGTGGCGGCTGGCTGGCTCTTCTACCGACCCCTGTGGGCCCTCCTCATTGCC       c.1140
 L  L  T  V  A  A  G  W  L  F  Y  R  P  L  W  A  L  L  I  A         p.380

          .         .         .         .         .         .       g.21853
 GGCCTGGCCCTTGTGCCCATCCTTGTTGCTCGGACACGGGTGCCAGCCAAAAAGTTGGAG       c.1200
 G  L  A  L  V  P  I  L  V  A  R  T  R  V  P  A  K  K  L  E         p.400

                                                                    g.21856
 TGA                                                                c.1203
 X                                                                  p.400

          .         .         .         .         .         .       g.21916
 aaagaccctggcacccgcccgacacctgcgtgagccctaggatccaggtcctctctcacc       c.*60

          .         .         .         .         .         .       g.21976
 tctgacccagctccatgccagagcaggagccccggtcaattttggactctgcactccctc       c.*120

          .         .         .         .         .         .       g.22036
 tcctcttcaggggccagacttggcagcatgtgcaccaggttggtgttcaccagctcatgt       c.*180

          .         .         .         .         .         .       g.22096
 cttccccacatctcttcttgccagtaagcagctttggtgggcagcagcagctcatgaatg       c.*240

          .         .         .         .         .         .       g.22156
 gcaagctgacagcttctcctgctgtttccttcctctcttggactgagtgggtacggccag       c.*300

          .         .         .         .         .         .       g.22216
 ccactcagcccattggcagctgacaacgcagacacgctctacggaggcctgctgataaag       c.*360

          .         .         .         .         .         .       g.22276
 ggctcagccttgccgtgtgctgcttctcatcactgcacacaagtgccatgctttgccacc       c.*420

          .         .         .         .         .         .       g.22336
 accaccaagcacatctgtgatcctgaagggcggccgttagtcattactgctgagtcctgg       c.*480

          .         .         .         .         .         .       g.22396
 gtcaccagcagacacactgggcatggacccctcaaagcaggcacacccaaaacacaagtc       c.*540

          .         .         .         .         .         .       g.22456
 tgtggctagaacctgatgtggtgtttaaaagagaagaaacactgaagatgtcctgaggag       c.*600

          .         .         .         .         .         .       g.22516
 aaaagctggacatatactgggcttcacacttatcttatggcttggcagaatctttgtagt       c.*660

          .         .         .         .         .         .       g.22576
 gtgtgggatctctgaaggccctatttaagtttttcttcgttactttgctgcttcatgtgt       c.*720

          .         .         .         .         .         .       g.22636
 actttcctaccccaagaggaagttttctgaaataagatttaaaaacaaaacaaaaaaaac       c.*780

          .         .         .         .         .         .       g.22696
 acttaatatttcagactgttacaggaaacaccctttagtctgtcagttgaattcagagca       c.*840

          .         .         .         .         .         .       g.22756
 ctgaaaggtgttaaattggggtatgtggtttgattgataaaaagttacctctcagtattt       c.*900

          .         .         .         .         .         .       g.22816
 tgtgtcactgagaagctttacaatggatgcttttgaaacaagtatcagcaaaaggatttg       c.*960

          .         .         .         .         .         .       g.22876
 ttttcactctgggaggagagggtggagaaagcacttgctttcatcctctggcatcggaaa       c.*1020

          .         .         .         .         .         .       g.22936
 ctcccctatgcacttgaagatggtttaaaagattaaagaaacgattaagagaaaaggttg       c.*1080

          .         .         .         .         .         .       g.22996
 gaagctttatactaaatgggctccttcatggtgacgccccgtcaaccacaatcaagaact       c.*1140

          .         .         .         .         .         .       g.23056
 gaggcctgaggctggttgtacaatgcccacgcctgcctggctgctttcacctgggagtgc       c.*1200

          .         .         .         .         .         .       g.23116
 tttcgatgtgggcacctgggcttcctagggctgcttctgagtggttctttcacgtgttgt       c.*1260

          .         .         .         .         .         .       g.23176
 gtccatagctttagtcttcctaaataagatccacccacacctaagtcacagaatttctaa       c.*1320

          .         .         .         .         .         .       g.23236
 gttccccaactactctcacacccttttaaagataaagtatgttgtaaccaggatgtctta       c.*1380

          .         .         .         .         .         .       g.23296
 aatgattctttgtgtaccttttctgtcatattcagaaaccgttttgtgcctgctgggagt       c.*1440

          .         .         .         .         .         .       g.23356
 aattcctttagcaattaagtatttggtagctgaataaggggtcagaacttctgaaaccag       c.*1500

          .         .         .         .         .         .       g.23416
 agatctgtaatcatctctattggcctggggtgcctgtgctataaatgagtttcttcacat       c.*1560

          .         .         .         .         .         .       g.23476
 gaaaaacacagccagcccaagatgacttatctgggtttaggattcaatagtattcactaa       c.*1620

          .         .         .         .         .         .       g.23536
 ctgcttattacatgagcaatttcatcaaatctccaaactcttaaaggatgctttcggaaa       c.*1680

          .         .         .         .         .         .       g.23596
 acacgctgtatacctagatgatgactaaatgcaaaatccttgggctttggtttttttcta       c.*1740

          .         .         .         .         .         .       g.23656
 gtaaggattttaaataactgccgacttcaaaagtgttcttaaaacgaaagataatgttaa       c.*1800

          .         .         .         .         .         .       g.23716
 gaaaaatttgaaagctttggaaaaccaaatttgtaatatcattgtattttttattaaaag       c.*1860

          .         .                                               g.23741
 ttttgtaataaatttctaaattatc                                          c.*1885

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Transmembrane protein 43 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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