transmembrane protein 63A (TMEM63A) - coding DNA reference sequence

(used for variant description)

(last modified October 18, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_014698.2 in the TMEM63A gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000001.10, covering TMEM63A transcript NM_014698.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5022
                                       acgtttgcagatgctctccctg       c.-601

 .         .         .         .         .         .                g.5082
 cgccgcgaccaccctgtgcttggcccagttctcccggaggcgtccagagactgggctcgt       c.-541

 .         .         .         .         .         .                g.5142
 gccgggggacggaagagggtgcgccccggcggatcccttcttggagcctggacgtgagct       c.-481

 .         .         .         .         .         .                g.5202
 ggccggtccggggcttgcagacctccgggaggagctgcggggctgagcggcgaccaggag       c.-421

 .         .         .         .         .         .                g.5262
 gccaggccggggcagaggaccgccgagggccaccgcgggaggcgcagtcagctgcgtaca       c.-361

 .         .         .         .         .         .                g.5322
 ggcttgcgccgccgcgggccaagactccaaattgggaaaggggtggccgcagctctgcgc       c.-301

 .         .         .         .         .         .                g.5382
 atgtgcaggaggcgccggagtttcactttgtaacttttaagtggtcggaacacgccccgc       c.-241

 .         .         .         .     | 02   .         .             g.8335
 gctgctgggtcccgccagacacgccgccgccgcag | gaaagtctacagtttggtaccccag    c.-181

 .         .         .         .         .         .                g.8395
 gactcgctggtcaggaaagccctgcaggacatgagtgttaggcccgacgcctggcccttg       c.-121

 .         .         .         .         .         .                g.8455
 gcagcttgggaggtggctggggctgcttttgcctttgccagagacagctccaactgagga       c.-61

 .         .         .         .         .      | 03  .             g.10140
 cctctccaacgggcccatccacagtccttccttcccctagtgtctg | ggaagacaggcgcg    c.-1

          .         .         .         .         .         .       g.10200
 ATGATGGACTCCCCGTTCCTGGAGCTGTGGCAGTCCAAGGCAGTGTCCATCAGGGAGCAG       c.60
 M  M  D  S  P  F  L  E  L  W  Q  S  K  A  V  S  I  R  E  Q         p.20

          .         .         .         .         .         .       g.10260
 CTGGGACTCGGGGACCGGCCCAACGACTCCTATTGCTACAACTCGGCCAAAAACAGCACC       c.120
 L  G  L  G  D  R  P  N  D  S  Y  C  Y  N  S  A  K  N  S  T         p.40

          .         .         .         .         .         .       g.10320
 GTGCTCCAGGGGGTCACCTTTGGTGGCATCCCCACTGTCCTGCTCATAGACGTCAGCTGC       c.180
 V  L  Q  G  V  T  F  G  G  I  P  T  V  L  L  I  D  V  S  C         p.60

        | 04 .         .         .         .         .         .    g.13407
 TTCCTG | TTCTTAATCTTGGTGTTTTCTATTATAAGAAGAAGATTCTGGGACTATGGCCGC    c.240
 F  L   | F  L  I  L  V  F  S  I  I  R  R  R  F  W  D  Y  G  R      p.80

          .         .       | 05 .         .         .         .    g.15701
 ATTGCCCTGGTGTCAGAAGCAGACAG | CGAGTCCAGATTTCAGAGATTGTCATCGACTTCC    c.300
 I  A  L  V  S  E  A  D  S  |  E  S  R  F  Q  R  L  S  S  T  S      p.100

          .         .         .    | 06    .         .         .    g.16634
 TCCTCAGGTCAACAAGACTTTGAAAATGAGCTG | GGATGCTGTCCCTGGCTGACTGCCATC    c.360
 S  S  G  Q  Q  D  F  E  N  E  L   | G  C  C  P  W  L  T  A  I      p.120

          .  | 07      .         .         .         .         .    g.19739
 TTCCGTCTGCA | TGATGACCAGATCCTGGAATGGTGTGGGGAGGACGCCATCCACTACCTG    c.420
 F  R  L  H  |  D  D  Q  I  L  E  W  C  G  E  D  A  I  H  Y  L      p.140

          .         .         .         .         .         .       g.19799
 TCCTTCCAGAGGCACATCATCTTCCTGTTGGTGGTGGTCAGCTTTTTGTCCCTGTGTGTC       c.480
 S  F  Q  R  H  I  I  F  L  L  V  V  V  S  F  L  S  L  C  V         p.160

          .         .         .     | 08   .         .         .    g.20583
 ATCCTGCCTGTCAACCTCTCAGGGGACTTGCTGG | ACAAAGACCCGTATAGTTTTGGGAGG    c.540
 I  L  P  V  N  L  S  G  D  L  L  D |   K  D  P  Y  S  F  G  R      p.180

          .         .       | 09 .         .         .         .    g.21072
 ACAACAATAGCAAACCTACAGACTGA | CAATGACCTCCTTTGGCTGCACACCATCTTTGCT    c.600
 T  T  I  A  N  L  Q  T  D  |  N  D  L  L  W  L  H  T  I  F  A      p.200

          .         .         .         .         .         .       g.21132
 GTCATTTACCTCTTCCTCACTGTGGGTTTCATGCGGCACCACACTCAGTCCATTAAGTAC       c.660
 V  I  Y  L  F  L  T  V  G  F  M  R  H  H  T  Q  S  I  K  Y         p.220

          .      | 10  .         .         .         .         .    g.21798
 AAAGAGGAGAACCTG | GTGAGGCGGACCCTGTTCATCACAGGACTCCCCAGAGATGCCAGG    c.720
 K  E  E  N  L   | V  R  R  T  L  F  I  T  G  L  P  R  D  A  R      p.240

          .         .       | 11 .         .         .         .    g.24903
 AAGGAGACTGTGGAGAGCCACTTCCG | GGACGCGTATCCCACGTGTGAGGTGGTTGATGTG    c.780
 K  E  T  V  E  S  H  F  R  |  D  A  Y  P  T  C  E  V  V  D  V      p.260

          .         .         .         .        | 12.         .    g.25155
 CAGCTGTGCTACAACGTGGCCAAACTGATCTACCTGTGCAAGGAGAA | AAAGAAGACTGAG    c.840
 Q  L  C  Y  N  V  A  K  L  I  Y  L  C  K  E  K  |  K  K  T  E      p.280

          .         .         .         .         .         .       g.25215
 AAGAGCCTGACCTATTACACAAACCTGCAGGTGAAGACAGGCCAGCGGACCCTCATCAAC       c.900
 K  S  L  T  Y  Y  T  N  L  Q  V  K  T  G  Q  R  T  L  I  N         p.300

          .         .         .         .         .  | 13      .    g.25378
 CCCAAGCCCTGTGGCCAGTTTTGCTGCTGTGAAGTGCTGGGCTGTGAGTGG | GAAGACGCC    c.960
 P  K  P  C  G  Q  F  C  C  C  E  V  L  G  C  E  W   | E  D  A      p.320

          .         .         .         .         .         .       g.25438
 ATCTCTTACTACACACGGATGAAGGACAGGCTGCTGGAGAGGATCACAGAGGAAGAACGC       c.1020
 I  S  Y  Y  T  R  M  K  D  R  L  L  E  R  I  T  E  E  E  R         p.340

          .         .         .         .         .         .       g.25498
 CACGTCCAGGACCAGCCCCTGGGAATGGCCTTCGTCACCTTCCAGGAGAAGTCCATGGCC       c.1080
 H  V  Q  D  Q  P  L  G  M  A  F  V  T  F  Q  E  K  S  M  A         p.360

       | 14  .         .         .         .         .         .    g.26778
 ACCTA | CATCCTGAAAGATTTCAATGCCTGCAAGTGTCAGAGCCTTCAGTGCAAAGGTGAG    c.1140
 T  Y  |  I  L  K  D  F  N  A  C  K  C  Q  S  L  Q  C  K  G  E      p.380

          .         .         .         .         .         .       g.26838
 CCCCAGCCGTCCTCCCATAGCAGGGAGCTCTATACCTCCAAGTGGACAGTCACCTTTGCT       c.1200
 P  Q  P  S  S  H  S  R  E  L  Y  T  S  K  W  T  V  T  F  A         p.400

          .         .    | 15    .         .         .         .    g.28408
 GCTGACCCTGAGGACATCTGCTG | GAAGAACCTCTCTATCCAGGGCCTCCGCTGGTGGCTA    c.1260
 A  D  P  E  D  I  C  W  |  K  N  L  S  I  Q  G  L  R  W  W  L      p.420

          .         .         .         .         .         .       g.28468
 CAGTGGCTGGGCATCAACTTCACCCTCTTCCTGGGGCTATTTTTCCTGACCACACCCTCC       c.1320
 Q  W  L  G  I  N  F  T  L  F  L  G  L  F  F  L  T  T  P  S         p.440

          .         .         .         .         .        | 16.    g.30706
 ATCATCCTGTCCACCATGGACAAGTTTAATGTCACCAAACCCATCCATGCGCTGAAT | AAC    c.1380
 I  I  L  S  T  M  D  K  F  N  V  T  K  P  I  H  A  L  N   | N      p.460

          .         .         .         .         .         .       g.30766
 CCGATCATCAGCCAGTTCTTCCCCACCCTCCTGCTCTGGTCCTTCTCGGCCCTGCTCCCC       c.1440
 P  I  I  S  Q  F  F  P  T  L  L  L  W  S  F  S  A  L  L  P         p.480

          .         .         .         .     | 17   .         .    g.30997
 TCCATTGTCTACTACTCTACACTGCTGGAGTCTCACTGGACCAA | GTCGGGGGAAAACCAG    c.1500
 S  I  V  Y  Y  S  T  L  L  E  S  H  W  T  K  |  S  G  E  N  Q      p.500

          .         .         .         .         .         .       g.31057
 ATCATGATGACCAAAGTCTACATATTCTTGATCTTCATGGTGCTGATCCTGCCCTCCCTG       c.1560
 I  M  M  T  K  V  Y  I  F  L  I  F  M  V  L  I  L  P  S  L         p.520

          .  | 18      .         .         .         .         .    g.31828
 GGTCTCACCAG | TCTAGATTTTTTCTTCCGGTGGCTCTTTGACAAAACTTCCTCGGAGGCC    c.1620
 G  L  T  S  |  L  D  F  F  F  R  W  L  F  D  K  T  S  S  E  A      p.540

          .     | 19   .         .         .         .         .    g.33974
 TCCATCAGGTTGGA | GTGCGTCTTCCTGCCTGACCAGGGTGCCTTCTTTGTGAACTATGTC    c.1680
 S  I  R  L  E  |  C  V  F  L  P  D  Q  G  A  F  F  V  N  Y  V      p.560

          .         .         .         .         .         .       g.34034
 ATCGCCTCGGCCTTCATCGGCAATGGCATGGAGCTGCTGCGGCTGCCAGGTCTCATCCTC       c.1740
 I  A  S  A  F  I  G  N  G  M  E  L  L  R  L  P  G  L  I  L         p.580

          .         .         .         .         .        | 20.    g.34953
 TATACCTTCCGCATGATCATGGCCAAGACGGCTGCTGACCGCAGGAATGTCAAGCAG | AAC    c.1800
 Y  T  F  R  M  I  M  A  K  T  A  A  D  R  R  N  V  K  Q   | N      p.600

          .         .         .         .         .         .       g.35013
 CAGGCCTTCCAGTACGAGTTTGGAGCCATGTATGCATGGATGCTGTGTGTCTTCACTGTC       c.1860
 Q  A  F  Q  Y  E  F  G  A  M  Y  A  W  M  L  C  V  F  T  V         p.620

          .         .         .         .    | 21    .         .    g.37657
 ATCGTGGCCTACAGCATCACTTGTCCCATCATCGCGCCATTTG | GCCTCATCTACATCCTG    c.1920
 I  V  A  Y  S  I  T  C  P  I  I  A  P  F  G |   L  I  Y  I  L      p.640

          .         .         .         .         .         .       g.37717
 CTCAAGCACATGGTGGACCGGCACAACCTCTACTTCGTCTACCTCCCAGCCAAGCTGGAG       c.1980
 L  K  H  M  V  D  R  H  N  L  Y  F  V  Y  L  P  A  K  L  E         p.660

          .         .         .         .         .         .       g.37777
 AAGGGGATCCACTTTGCCGCTGTGAACCAGGCCTTGGCAGCCCCCATCCTGTGCCTCTTC       c.2040
 K  G  I  H  F  A  A  V  N  Q  A  L  A  A  P  I  L  C  L  F         p.680

          .         .         .  | 22      .         .         .    g.38736
 TGGCTCTACTTCTTTTCCTTCCTGCGCCTGG | GTATGAAGGCCCCCGCCACTCTGTTCACC    c.2100
 W  L  Y  F  F  S  F  L  R  L  G |   M  K  A  P  A  T  L  F  T      p.700

          .         .         .         .         .         .       g.38796
 TTCCTGGTGCTGCTGCTCACCATCCTGGTCTGCCTGGCTCACACCTGCTTTGGATGCTTC       c.2160
 F  L  V  L  L  L  T  I  L  V  C  L  A  H  T  C  F  G  C  F         p.720

          .         .        | 23.         .         .         .    g.39198
 AAGCACCTCAGCCCTCTGAACTACAAA | ACAGAAGAGCCTGCAAGTGACAAAGGAAGTGAG    c.2220
 K  H  L  S  P  L  N  Y  K   | T  E  E  P  A  S  D  K  G  S  E      p.740

          .         .         . | 24       .         .         .    g.40536
 GCAGAGGCCCACATGCCCCCACCGTTCACA | CCCTACGTGCCTCGGATTCTGAACGGCTTG    c.2280
 A  E  A  H  M  P  P  P  F  T   | P  Y  V  P  R  I  L  N  G  L      p.760

          .         .         .         .         .         .       g.40596
 GCCTCGGAGAGGACAGCACTGTCTCCGCAGCAGCAGCAGCAGCAGACCTATGGTGCCATC       c.2340
 A  S  E  R  T  A  L  S  P  Q  Q  Q  Q  Q  Q  T  Y  G  A  I         p.780

          .         .         .         .         .         .       g.40656
 CACAACATCAGCGGGACTATCCCTGGACAGTGCTTGGCGCAGAGCGCCACGGGCAGTGTG       c.2400
 H  N  I  S  G  T  I  P  G  Q  C  L  A  Q  S  A  T  G  S  V         p.800

          .         .                                           g.40680
 GCTGCTGCCCCCCAGGAGGCCTGA |                                        c.2425
 A  A  A  P  Q  E  A  X                                          p.807

        | 25 .         .         .         .         .         .    g.40841
 ggctgg | gtctcactgctctgaaaagacacaaccagaatggcctggggctcaggcccttgg    c.*60

          .         .         .         .         .         .       g.40901
 ctgagtgggaatgcgttgggactgcccagctgagctatcaggtgcccatcttttctggtc       c.*120

          .         .         .         .         .         .       g.40961
 ccagcagtggtgaggagagcacaggcaggcctcgcccctcccttgctcacccagtttccc       c.*180

          .         .         .         .         .         .       g.41021
 ctccggcacaagcttccagctctgcagctggggtgacatccccagtggtttgtcgccaag       c.*240

          .         .         .         .         .         .       g.41081
 accatgtggtggacttttcgccccccaaactgatgagtccgggagaatatatggagagag       c.*300

          .         .         .         .         .         .       g.41141
 agatgtaacaaggggaaggcctcctcccttctgagcacacacacaaccgataaccaaaga       c.*360

          .         .         .         .         .         .       g.41201
 gatgctgcagtccaggtctgaggtcccgctggcatccagctccctgctccatggccagtc       c.*420

          .         .         .         .         .         .       g.41261
 cctccccagcccagcagtccctccaggctacatccaggagtaagctatggggaacaggtt       c.*480

          .         .         .         .         .         .       g.41321
 gggaggtggccagtgctcctgccagctgtgcacacatctctgtatcccgctagagttctg       c.*540

          .         .         .         .         .         .       g.41381
 tgtttttgtatcatgttgtcagggacgctagctgggtcagggttaccccatagcaggcag       c.*600

          .         .         .         .         .         .       g.41441
 ggacaaggaccactcataatatgcccattggaccacagttaagatccagcctctctcacc       c.*660

          .         .         .         .         .         .       g.41501
 tcttcagggctgagtgcatgagtctgcacctccaggcaggctctgtgcagtactcacccc       c.*720

          .         .         .         .         .         .       g.41561
 ctccgtctgctccctccaaggtgtgggggtgggcagtgctcagggcctcctcggagccaa       c.*780

          .         .         .         .         .         .       g.41621
 aggacagcatggtcggcacagaggaaggggtacctgggctgggtgcagggccatcccact       c.*840

          .         .         .         .         .         .       g.41681
 gcccttgagctgtggctctggcaggaaggaggggcagcccatccctcttctccctcctgg       c.*900

          .         .         .         .         .         .       g.41741
 ggattctggggaatgggatgcaacttaagacttctgcctgagaagcctcctccctgctgc       c.*960

          .         .         .         .         .         .       g.41801
 ctccagggggcaccaaggcacaagcctgtgcagtaggggcgggatgggggtgtggaagag       c.*1020

          .         .         .         .         .         .       g.41861
 caggtccaggctcctagcacaactggcctggggccttggcacctctgtaggccctgcctg       c.*1080

          .         .         .         .         .         .       g.41921
 tgcctgtccgctggcctggggggcctgggcttatctgggccttctcactcagggactctc       c.*1140

          .         .         .         .         .         .       g.41981
 ttgacgctgacttgcccccgcagtggtggccagtgctgcctctgctccaagctgcccctg       c.*1200

          .         .         .         .         .         .       g.42041
 cgctgggaggggtgggggcggtgccattggtctggtgcagcatagccctggccagtggcc       c.*1260

          .         .         .         .         .         .       g.42101
 tcatccccagcaggcctcccgtgcctctgccagcaaggaggggccggccagctctgcttg       c.*1320

          .         .         .         .         .         .       g.42161
 cacagggggccccatgtggggtcagcgcacgctcatgtcactgagttccagccgctttta       c.*1380

          .         .                                               g.42188
 gagtaaagtcgtttatcatcaaagcca                                        c.*1407

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Transmembrane protein 63A protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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