transmembrane protein 63B (TMEM63B) - coding DNA reference sequence

(used for variant description)

(last modified August 7, 2023)


This file was created to facilitate the description of sequence variants on transcript NM_018426.1 in the TMEM63B gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000006.11, covering TMEM63B transcript NM_018426.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5004
                                                         aacc       c.-61

 .         .         .         .      | 02  .         .             g.11946
 cggggctccgagccggagccgagtctgcgcctgggg | gaggaccatgcggcagtagcagcc    c.-1

          .         .         .         .         .         .       g.12006
 ATGCTGCCCTTTCTGCTGGCCACACTGGGCACCACAGCCCTCAACAACAGCAACCCCAAG       c.60
 M  L  P  F  L  L  A  T  L  G  T  T  A  L  N  N  S  N  P  K         p.20

          .         .         .         .         .         .       g.12066
 GACTACTGCTACAGCGCCCGCATCCGCAGCACTGTCCTGCAGGGCCTGCCCTTTGGGGGC       c.120
 D  Y  C  Y  S  A  R  I  R  S  T  V  L  Q  G  L  P  F  G  G         p.40

          .         .         .          | 03        .         .    g.12399
 GTCCCCACCGTGCTGGCTCTCGACTTCATGTGCTTCCTT | GCACTGCTGTTCTTATTCTCT    c.180
 V  P  T  V  L  A  L  D  F  M  C  F  L   | A  L  L  F  L  F  S      p.60

          .         .         .         .         .          | 04    g.12690
 ATCCTCCGGAAGGTGGCCTGGGACTATGGGCGGCTGGCCTTGGTGACAGATGCAGACAG | G    c.240
 I  L  R  K  V  A  W  D  Y  G  R  L  A  L  V  T  D  A  D  R  |      p.80

          .         .         .         | 05         .         .    g.13732
 CTTCGGCGGCAGGAGAGGGACCGAGTGGAACAGGAATA | TGTGGCTTCAGCTATGCACGGG    c.300
 L  R  R  Q  E  R  D  R  V  E  Q  E  Y  |  V  A  S  A  M  H  G      p.100

          .         .         .         .         .         .       g.13792
 GACAGCCATGACCGGTATGAGCGTCTCACCTCTGTCTCCAGCTCCGTTGACTTTGACCAA       c.360
 D  S  H  D  R  Y  E  R  L  T  S  V  S  S  S  V  D  F  D  Q         p.120

           | 06        .         .         .        | 07.         . g.16841
 AGGGACAAT | GGTTTCTGTTCCTGGCTGACAGCCATCTTCAGGATAAA | GGATGATGAGATC c.420
 R  D  N   | G  F  C  S  W  L  T  A  I  F  R  I  K  |  D  D  E  I   p.140

          .         .         .         .         .         .       g.16901
 CGGGACAAATGTGGGGGCGATGCCGTGCACTACCTGTCCTTTCAGCGGCACATCATCGGG       c.480
 R  D  K  C  G  G  D  A  V  H  Y  L  S  F  Q  R  H  I  I  G         p.160

          .         .         .         .         .         .       g.16961
 CTGCTGGTGGTTGTGGGCGTCCTCTCCGTAGGCATCGTGCTGCCTGTCAACTTCTCAGGG       c.540
 L  L  V  V  V  G  V  L  S  V  G  I  V  L  P  V  N  F  S  G         p.180

          . | 08       .         .         .         .         .    g.17119
 GACCTGCTGG | AGAACAATGCCTACAGCTTTGGGAGAACCACCATTGCCAACTTGAAATCA    c.600
 D  L  L  E |   N  N  A  Y  S  F  G  R  T  T  I  A  N  L  K  S      p.200

    | 09     .         .         .         .         .         .    g.17671
 GG | GAACAACCTGCTATGGCTGCACACCTCCTTCGCCTTCCTGTATCTGCTGCTCACCGTC    c.660
 G  |  N  N  L  L  W  L  H  T  S  F  A  F  L  Y  L  L  L  T  V      p.220

          .         .         .         .         .  | 10      .    g.18398
 TACAGCATGCGTAGACACACCTCCAAGATGCGCTACAAGGAGGATGATCTG | GTGAAGCGG    c.720
 Y  S  M  R  R  H  T  S  K  M  R  Y  K  E  D  D  L   | V  K  R      p.240

          .         .         .         .         .         .       g.18458
 ACCCTCTTCATCAATGGAATCTCCAAATATGCAGAGTCAGAAAAGATCAAGAAGCATTTT       c.780
 T  L  F  I  N  G  I  S  K  Y  A  E  S  E  K  I  K  K  H  F         p.260

    | 11     .         .         .         .         .         .    g.24266
 GA | GGAAGCCTACCCCAACTGCACAGTTCTCGAAGCCCGCCCGTGTTACAACGTGGCTCGC    c.840
 E  |  E  A  Y  P  N  C  T  V  L  E  A  R  P  C  Y  N  V  A  R      p.280

          .         .    | 12    .         .         .         .    g.24775
 CTAATGTTCCTCGATGCAGAGAG | GAAGAAGGCCGAGCGGGGAAAGCTGTACTTCACAAAC    c.900
 L  M  F  L  D  A  E  R  |  K  K  A  E  R  G  K  L  Y  F  T  N      p.300

          .         .         .         .         .         .       g.24835
 CTCCAGAGCAAGGAGAACGTGCCTACCATGATCAACCCCAAGCCCTGTGGCCACCTCTGC       c.960
 L  Q  S  K  E  N  V  P  T  M  I  N  P  K  P  C  G  H  L  C         p.320

          .         .        | 13.         .         .         .    g.25646
 TGCTGTGTGGTGCGAGGCTGTGAGCAG | GTGGAGGCCATTGAGTACTACACAAAGCTGGAG    c.1020
 C  C  V  V  R  G  C  E  Q   | V  E  A  I  E  Y  Y  T  K  L  E      p.340

          .         .         .         .         .         .       g.25706
 CAGAAGCTGAAGGAAGACTACAAGCGGGAGAAGGAGAAGGTGAATGAGAAGCCTCTTGGC       c.1080
 Q  K  L  K  E  D  Y  K  R  E  K  E  K  V  N  E  K  P  L  G         p.360

          .         .         .         .  | 14      .         .    g.25893
 ATGGCCTTTGTCACCTTCCACAATGAGACTATCACCGCCAT | CATCCTGAAGGACTTCAAC    c.1140
 M  A  F  V  T  F  H  N  E  T  I  T  A  I  |  I  L  K  D  F  N      p.380

          .         .         .         .         .         .       g.25953
 GTGTGTAAATGCCAGGGCTGCACCTGCCGTGGGGAGCCACGCCCCTCATCCTGCAGCGAG       c.1200
 V  C  K  C  Q  G  C  T  C  R  G  E  P  R  P  S  S  C  S  E         p.400

          .         .         .         .         .          | 15    g.26154
 TCCCTGCACATCTCCAACTGGACCGTGTCCTATGCCCCTGACCCTCAGAACATCTACTG | G    c.1260
 S  L  H  I  S  N  W  T  V  S  Y  A  P  D  P  Q  N  I  Y  W  |      p.420

          .         .         .         .         .         .       g.26214
 GAGCACCTCTCCATCCGAGGCTTCATCTGGTGGCTGCGCTGCCTGGTCATCAATGTCGTC       c.1320
 E  H  L  S  I  R  G  F  I  W  W  L  R  C  L  V  I  N  V  V         p.440

          .         .         .         .         .         .       g.26274
 CTCTTCATCCTCCTCTTCTTCCTCACCACTCCAGCCATCATCATCACCACCATGGACAAG       c.1380
 L  F  I  L  L  F  F  L  T  T  P  A  I  I  I  T  T  M  D  K         p.460

          .         .         .    | 16    .         .         .    g.27247
 TTCAACGTCACCAAGCCTGTGGAGTACCTCAAC | AACCCCATCATCACCCAGTTCTTCCCC    c.1440
 F  N  V  T  K  P  V  E  Y  L  N   | N  P  I  I  T  Q  F  F  P      p.480

          .         .         .         .         .         .       g.27307
 ACCCTGCTGCTGTGGTGCTTCTCGGCCCTCCTTCCCACCATCGTCTACTACTCAGCCTTC       c.1500
 T  L  L  L  W  C  F  S  A  L  L  P  T  I  V  Y  Y  S  A  F         p.500

          .         . | 17       .         .         .         .    g.27625
 TTTGAAGCCCACTGGACACG | CTCTGGGGAGAACAGGACAACCATGCACAAGTGCTACACT    c.1560
 F  E  A  H  W  T  R  |  S  G  E  N  R  T  T  M  H  K  C  Y  T      p.520

          .         .         .         .        | 18.         .    g.27938
 TTCCTCATCTTCATGGTGCTGCTCCTACCCTCGCTGGGACTGAGCAG | CCTGGACCTCTTC    c.1620
 F  L  I  F  M  V  L  L  L  P  S  L  G  L  S  S  |  L  D  L  F      p.540

          .         .         .         .         .    | 19    .    g.29214
 TTCCGCTGGCTCTTTGATAAGAAATTCTTGGCTGAGGCAGCTATTCGGTTTGA | GTGTGTG    c.1680
 F  R  W  L  F  D  K  K  F  L  A  E  A  A  I  R  F  E  |  C  V      p.560

          .         .         .         .         .         .       g.29274
 TTCCTGCCCGACAACGGCGCCTTCTTCGTGAACTACGTCATTGCCTCAGCCTTTATCGGC       c.1740
 F  L  P  D  N  G  A  F  F  V  N  Y  V  I  A  S  A  F  I  G         p.580

          .         .         .         .         .         .       g.29334
 AACGCCATGGACCTGCTGCGCATCCCAGGCCTGCTCATGTACATGATCCGGCTCTGCCTG       c.1800
 N  A  M  D  L  L  R  I  P  G  L  L  M  Y  M  I  R  L  C  L         p.600

          .         .         .       | 20 .         .         .    g.29978
 GCGCGCTCGGCCGCCGAGAGGCGCAACGTGAAGCGG | CATCAGGCCTACGAGTTCCAGTTT    c.1860
 A  R  S  A  A  E  R  R  N  V  K  R   | H  Q  A  Y  E  F  Q  F      p.620

          .         .         .         .         .         .       g.30038
 GGCGCAGCCTACGCCTGGATGATGTGCGTCTTCACGGTGGTCATGACCTACAGTATCACC       c.1920
 G  A  A  Y  A  W  M  M  C  V  F  T  V  V  M  T  Y  S  I  T         p.640

          .         .   | 21     .         .         .         .    g.31075
 TGCCCCATCATCGTGCCCTTCG | GGCTCATGTACATGCTGCTGAAGCACCTGGTAGACAGG    c.1980
 C  P  I  I  V  P  F  G |   L  M  Y  M  L  L  K  H  L  V  D  R      p.660

          .         .         .         .         .         .       g.31135
 TACAATCTCTACTACGCCTACCTGCCGGCCAAGCTGGACAAGAAGATCCACTCGGGGGCT       c.2040
 Y  N  L  Y  Y  A  Y  L  P  A  K  L  D  K  K  I  H  S  G  A         p.680

          .         .         .         .         .         .       g.31195
 GTGAACCAGGTGGTGGCCGCGCCCATCCTCTGCCTCTTCTGGCTGCTCTTCTTTTCCACC       c.2100
 V  N  Q  V  V  A  A  P  I  L  C  L  F  W  L  L  F  F  S  T         p.700

          . | 22       .         .         .         .         .    g.31484
 ATGCGCACGG | GGTTCCTAGCTCCCACGTCTATGTTCACATTTGTGGTCCTGGTCATCACC    c.2160
 M  R  T  G |   F  L  A  P  T  S  M  F  T  F  V  V  L  V  I  T      p.720

          .         .         .         .         .         .       g.31544
 ATCGTCATCTGTCTCTGCCACGTCTGCTTTGGACACTTCAAATACCTCAGTGCCCACAAC       c.2220
 I  V  I  C  L  C  H  V  C  F  G  H  F  K  Y  L  S  A  H  N         p.740

        | 23 .         .         .         .         .         .    g.31780
 TACAAG | ATTGAGCACACGGAGACAGATACTGTGGACCCCAGAAGCAATGGACGGCCCCCC    c.2280
 Y  K   | I  E  H  T  E  T  D  T  V  D  P  R  S  N  G  R  P  P      p.760

          .         .        | 24.         .         .         .    g.32086
 ACTGCTGCTGCTGTCCCCAAATCTGCG | AAATACATCGCTCAGGTGCTGCAGGACTCAGAG    c.2340
 T  A  A  A  V  P  K  S  A   | K  Y  I  A  Q  V  L  Q  D  S  E      p.780

          .         .         .         .         .         .       g.32146
 GTGGACGGGGATGGGGATGGGGCTCCTGGGAGCTCAGGGGATGAGCCCCCATCATCCTCA       c.2400
 V  D  G  D  G  D  G  A  P  G  S  S  G  D  E  P  P  S  S  S         p.800

          .         .         .         .         .         .       g.32206
 TCCCAAGATGAGGAGTTGCTGATGCCACCCGACGCCCTCACGGACACAGACTTCCAGTCT       c.2460
 S  Q  D  E  E  L  L  M  P  P  D  A  L  T  D  T  D  F  Q  S         p.820

          .         .         .                                     g.32245
 TGCGAGGACAGCCTCATAGAGAATGAGATTCACCAGTAA                            c.2499
 C  E  D  S  L  I  E  N  E  I  H  Q  X                              p.832

          .         .         .         .         .         .       g.32305
 ggggagggaggggccctggaggccacatcctgccccaccccacccccactcccacggaca       c.*60

          .         .         .         .         .         .       g.32365
 ctaaaacgctaataatttattagatctaaagccccttcctccccagcccctgctttcatt       c.*120

          .         .         .         .         .         .       g.32425
 aaggtatttaaacttgggggtttcactgctctcccccatgatggagggagggagcccccc       c.*180

          .         .         .         .         .         .       g.32485
 aacctcagtgaggagagccccgagccggccccggggcaaagaggggtgcagagggagttc       c.*240

          .         .         .         .         .         .       g.32545
 ccccagatcagtaccccccacccctccccagctagtagcatgaccaggagagggttaatg       c.*300

          .         .         .         .         .         .       g.32605
 agagccaagaggagtacctggtgcacctggtgccggtggctggagacctggggggcaggt       c.*360

          .         .         .         .         .         .       g.32665
 ggatctggggctgttcccccccctccgttttttccaccccacagttcctcctgggatctg       c.*420

          .         .         .         .         .         .       g.32725
 gccctccagggaagtggagcctccagcccctaggggatgcatgaggggggagggggtgct       c.*480

          .         .         .         .         .         .       g.32785
 gagtgggaggaagagtcaggctcacagctggggtggcctgggggtgggggtgggcaaggc       c.*540

          .         .         .         .         .         .       g.32845
 tgacactggaaaatgggtttttgcactgttttttttttggtttttttgttcttttttgtt       c.*600

          .         .         .                                     g.32881
 tttttcctttaaaataaaaacaaagaaaagctctga                               c.*636

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Transmembrane protein 63B protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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