transmembrane protein 67 (TMEM67) - coding DNA reference sequence

(used for variant description)

(last modified January 17, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_153704.5 in the TMEM67 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009190.1, covering TMEM67 transcript NM_153704.5.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5011
                                                  aatcagctcag       c.-61

 .         .         .         .         .         .                g.5071
 cgaagccgccgcagaggctgatggggggctggaggctgtgaggcttccagcgtcggtacc       c.-1

          .         .         .         .         .         .       g.5131
 ATGGCGACGCGCGGTGGGGCTGGGGTGGCAATGGCGGTTTGGTCCCTCTTATCCGCCCGG       c.60
 M  A  T  R  G  G  A  G  V  A  M  A  V  W  S  L  L  S  A  R         p.20

          .         .         .         .         .         .       g.5191
 GCCGTGACCGCGTTCCTTCTGTTGTTCCTCCCTCGCTTCTTACAGGCCCAGACCTTCTCT       c.120
 A  V  T  A  F  L  L  L  F  L  P  R  F  L  Q  A  Q  T  F  S         p.40

          .         .         .         .         .         .       g.5251
 TTCCCTTTCCAGCAGCCGGAGAAGTGCGACAACAACCAGTACTTTGATATCTCCGCCCTC       c.180
 F  P  F  Q  Q  P  E  K  C  D  N  N  Q  Y  F  D  I  S  A  L         p.60

          .         .         .         .    | 02    .         .    g.5951
 TCGTGTGTTCCTTGTGGAGCTAACCAGAGGCAAGATGCCCGAG | GAACTTCATGTGTATGT    c.240
 S  C  V  P  C  G  A  N  Q  R  Q  D  A  R  G |   T  S  C  V  C      p.80

          .         .         .         .         .         .       g.6011
 CTACCAGGATTTCAGATGATCTCTAATAATGGAGGACCTGCTATTATTTGTAAAAAGTGC       c.300
 L  P  G  F  Q  M  I  S  N  N  G  G  P  A  I  I  C  K  K  C         p.100

          .   | 03     .         .         .         .         .    g.8687
 CCAGAAAACATG | AAAGGTGTTACAGAAGATGGCTGGAACTGCATTTCTTGCCCTAGTGAC    c.360
 P  E  N  M   | K  G  V  T  E  D  G  W  N  C  I  S  C  P  S  D      p.120

          .         .         .         .       | 04 .         .    g.14012
 TTAACTGCCGAAGGAAAATGTCACTGTCCCATTGGCCATATTTTAG | TGGAAAGAGACATT    c.420
 L  T  A  E  G  K  C  H  C  P  I  G  H  I  L  V |   E  R  D  I      p.140

          .         .         .         .         .         .       g.14072
 AATGGAACATTGTTGTCTCAAGCAACTTGTGAGCTCTGTGATGGAAATGAAAACTCTTTT       c.480
 N  G  T  L  L  S  Q  A  T  C  E  L  C  D  G  N  E  N  S  F         p.160

          .         .       | 05 .         .         .         .    g.15596
 ATGGTAGTAAATGCTTTAGGAGACAG | GTGCGTCCGATGTGAGCCAACATTTGTTAATACC    c.540
 M  V  V  N  A  L  G  D  R  |  C  V  R  C  E  P  T  F  V  N  T      p.180

          .         .         .       | 06 .         .         .    g.15752
 AGCAGGTCCTGTGCATGTTCAGAACCTAACATTTTA | ACAGGGGGATTATGTTTCAGCAGC    c.600
 S  R  S  C  A  C  S  E  P  N  I  L   | T  G  G  L  C  F  S  S      p.200

          .         .         .         .         .  | 07      .    g.22754
 ACAGGGAATTTTCCTCTACGTAGAATTTCAGCTGCACGTTATGGAGAAGTT | GGCATGTCT    c.660
 T  G  N  F  P  L  R  R  I  S  A  A  R  Y  G  E  V   | G  M  S      p.220

          .         .         .         .         .     | 08   .    g.30755
 TTAACTTCAGAATGGTTTGCAAAGTATTTGCAATCATCAGCAGCTGCATGTTGG | GTATAT    c.720
 L  T  S  E  W  F  A  K  Y  L  Q  S  S  A  A  A  C  W   | V  Y      p.240

          .         .         .         .         .         .       g.30815
 GCCAATCTAACATCTTGTCAAGCTCTTGGAAATATGTGTGTGATGAACATGAATTCTTAC       c.780
 A  N  L  T  S  C  Q  A  L  G  N  M  C  V  M  N  M  N  S  Y         p.260

          .         .         .         .         .         .       g.30875
 GACTTTGCCACATTTGATGCATGTGGACTATTTCAGTTTATCTTTGAAAATACTGCTGGA       c.840
 D  F  A  T  F  D  A  C  G  L  F  Q  F  I  F  E  N  T  A  G         p.280

          .         .          | 09        .         .         .    g.31061
 CTGAGCACTGTTCATTCTATTTCATTTTG | GAGACAGAATCTTCCTTGGCTGTTTTATGGA    c.900
 L  S  T  V  H  S  I  S  F  W  |  R  Q  N  L  P  W  L  F  Y  G      p.300

          .         .         .         .         .         .       g.31121
 GACCAGTTAGGATTAGCACCTCAAGTGCTCAGTTCTACCTCTCTTCCTACAAATTTCAGT       c.960
 D  Q  L  G  L  A  P  Q  V  L  S  S  T  S  L  P  T  N  F  S         p.320

          .         | 10         .         .         .         .    g.31856
 TTTAAAGGAGAAAACCAG | AATACAAAACTGAAGTTTGTTGCTGCTTCCTATGATATAAGA    c.1020
 F  K  G  E  N  Q   | N  T  K  L  K  F  V  A  A  S  Y  D  I  R      p.340

          .         .         .         .      | 11  .         .    g.32566
 GGAAATTTTCTCAAGTGGCAAACTTTAGAAGGAGGTGTTTTACAG | CTTTGTCCAGACACA    c.1080
 G  N  F  L  K  W  Q  T  L  E  G  G  V  L  Q   | L  C  P  D  T      p.360

          .         .         .         .         .  | 12      .    g.35387
 GAGACAAGGCTAAATGCTGCTTATTCATTTGGAACAACCTACCAACAAAAT | TGTGAGATT    c.1140
 E  T  R  L  N  A  A  Y  S  F  G  T  T  Y  Q  Q  N   | C  E  I      p.380

          .         .         .         .         .         .       g.35447
 CCTATCTCTAAGATCTTAATTGACTTTCCCACTCCTATATTTTATGATGTGTACCTTGAA       c.1200
 P  I  S  K  I  L  I  D  F  P  T  P  I  F  Y  D  V  Y  L  E         p.400

          .         .         .         .         .         .       g.35507
 TATACTGATGAAAATCAACATCAATATATTTTGGCTGTGCCTGTGTTAAACCTAAATCTT       c.1260
 Y  T  D  E  N  Q  H  Q  Y  I  L  A  V  P  V  L  N  L  N  L         p.420

          .         .         | 13         .         .         .    g.36411
 CAACATAATAAGATATTTGTGAACCAAG | ACAGCAACTCTGGAAAGTGGCTTCTAACTCGG    c.1320
 Q  H  N  K  I  F  V  N  Q  D |   S  N  S  G  K  W  L  L  T  R      p.440

          .         .         .         .         .         .       g.36471
 CGCATTTTCTTAGTGGATGCAGTAAGTGGACGAGAAAATGACTTAGGAACTCAGCCAAGA       c.1380
 R  I  F  L  V  D  A  V  S  G  R  E  N  D  L  G  T  Q  P  R         p.460

          .         .         .   | 14     .         .         .    g.38028
 GTAATTCGAGTTGCTACTCAAATATCACTGAG | TGTCCACCTTGTACCCAACACAATAAAT    c.1440
 V  I  R  V  A  T  Q  I  S  L  S  |  V  H  L  V  P  N  T  I  N      p.480

          .         .         .         .         .         .       g.38088
 GGAAACATCTACCCTCCCTTAATCACCATTGCCTACAGTGACATTGATATCAAAGATGCC       c.1500
 G  N  I  Y  P  P  L  I  T  I  A  Y  S  D  I  D  I  K  D  A         p.500

          .         | 15         .         .         .         .    g.41461
 AACAGCCAGTCTGTGAAG | GTTTCTTTCTCAGTCACATATGAAATGGATCATGGAGAAGCA    c.1560
 N  S  Q  S  V  K   | V  S  F  S  V  T  Y  E  M  D  H  G  E  A      p.520

          .      | 16  .         .         .         .         .    g.43399
 CATGTCCAGACAGAT | ATTGCTTTGGGTGTATTGGGTGGGCTAGCTGTTTTAGCATCTCTT    c.1620
 H  V  Q  T  D   | I  A  L  G  V  L  G  G  L  A  V  L  A  S  L      p.540

          .         .         .         .         .     | 17   .    g.45571
 TTGAAGACAGCAGGATGGAAGAGGCGCATTGGGAGTCCCATGATTGATTTACAG | ACAGTT    c.1680
 L  K  T  A  G  W  K  R  R  I  G  S  P  M  I  D  L  Q   | T  V      p.560

          .         .         .         .         .         .       g.45631
 GTGAAATTCTTGGTGTACTATGCTGGTGATCTGGCCAATGTTTTCTTTATCATCACAGTG       c.1740
 V  K  F  L  V  Y  Y  A  G  D  L  A  N  V  F  F  I  I  T  V         p.580

          .         .         .    | 18    .         .         .    g.46084
 GGAACAGGTCTTTACTGGCTTATTTTCTTCAAA | GCACAGAAGTCTGTGTCTGTTTTGCTG    c.1800
 G  T  G  L  Y  W  L  I  F  F  K   | A  Q  K  S  V  S  V  L  L      p.600

          .         .         .         .         .         .       g.46144
 CCAATGCCAATTCAGGAAGAACGTTTTGTCACTTATGTTGGATGTGCCTTTGCTCTGAAG       c.1860
 P  M  P  I  Q  E  E  R  F  V  T  Y  V  G  C  A  F  A  L  K         p.620

  | 19       .         .         .         .         .         .    g.47350
  | GCACTACAATTTTTGCATAAGCTCATATCCCAGATTACAATAGATGTATTCTTTATTGAT    c.1920
  | A  L  Q  F  L  H  K  L  I  S  Q  I  T  I  D  V  F  F  I  D      p.640

          .         .         .         . | 20       .         .    g.47507
 TGGGAGCGACCTAAAGGAAAGGTTCTTAAAGCTGTTGAAG | GTGAGGGTGGTGTACGAAGT    c.1980
 W  E  R  P  K  G  K  V  L  K  A  V  E  G |   E  G  G  V  R  S      p.660

          .         .         .         .         .         .       g.47567
 GCCACTGTTCCTGTAAGCATATGGAGAACATATTTTGTAGCAAATGAATGGAATGAAATT       c.2040
 A  T  V  P  V  S  I  W  R  T  Y  F  V  A  N  E  W  N  E  I         p.680

          .         .         .         .         .         .       g.47627
 CAGACTGTGAGAAAAATTAATTCACTCTTTCAAGTACTTACTGTCCTCTTCTTTTTGGAG       c.2100
 Q  T  V  R  K  I  N  S  L  F  Q  V  L  T  V  L  F  F  L  E         p.700

  | 21       .         .         .         .         .         .    g.49834
  | GTTGTGGGATTCAAGAACTTAGCATTAATGGACTCATCTTCTAGTCTTTCTAGAAACCCA    c.2160
  | V  V  G  F  K  N  L  A  L  M  D  S  S  S  S  L  S  R  N  P      p.720

          .         .         .         .         .         .       g.49894
 CCTAGCTACATAGCTCCTTATAGCTGCATTTTGAGATATGCAGTGTCTGCTGCTCTTTGG       c.2220
 P  S  Y  I  A  P  Y  S  C  I  L  R  Y  A  V  S  A  A  L  W         p.740

          .         .  | 22      .         .         .         .    g.53799
 CTAGCCATTGGAATTATACAG | GTCGTGTTCTTTGCTGTCTTTTATGAGAGATTTATAGAA    c.2280
 L  A  I  G  I  I  Q   | V  V  F  F  A  V  F  Y  E  R  F  I  E      p.760

          .         .         .         .   | 23     .         .    g.54936
 GATAAAATTCGACAGTTCGTTGATTTATGCTCTATGAGTAAT | ATATCAGTGTTTCTGTTA    c.2340
 D  K  I  R  Q  F  V  D  L  C  S  M  S  N   | I  S  V  F  L  L      p.780

          .         .         .         .         .         .       g.54996
 TCCCACAAATGTTTTGGATATTACATTCATGGTAGATCAGTACATGGGCATGCAGATACT       c.2400
 S  H  K  C  F  G  Y  Y  I  H  G  R  S  V  H  G  H  A  D  T         p.800

          .         .         .          | 24        .         .    g.59017
 AATATGGAAGAAATGAATATGAACCTTAAAAGAGAAGCG | GAAAATTTGTGTAGCCAGAGA    c.2460
 N  M  E  E  M  N  M  N  L  K  R  E  A   | E  N  L  C  S  Q  R      p.820

          .         .         .         .         .         .       g.59077
 GGTTTGGTACCCAACACAGATGGTCAGACTTTTGAGATTGCAATTTCTAACCAGATGAGA       c.2520
 G  L  V  P  N  T  D  G  Q  T  F  E  I  A  I  S  N  Q  M  R         p.840

          .         .         .       | 25 .         .         .    g.59237
 CAACATTATGACAGAATTCATGAGACACTAATAAGG | AAAAATGGTCCTGCTAGACTACTG    c.2580
 Q  H  Y  D  R  I  H  E  T  L  I  R   | K  N  G  P  A  R  L  L      p.860

          .         .         .         .         .         .       g.59297
 AGTTCATCAGCAAGTACTTTTGAGCAGAGTATAAAAGCATATCATATGATGAATAAATTT       c.2640
 S  S  S  A  S  T  F  E  Q  S  I  K  A  Y  H  M  M  N  K  F         p.880

          .         .  | 26      .         .         .         .    g.59980
 CTTGGCTCCTTCATTGACCAT | GTTCATAAGGAAATGGATTACTTTATAAAAGATAAGTTG    c.2700
 L  G  S  F  I  D  H   | V  H  K  E  M  D  Y  F  I  K  D  K  L      p.900

          .         .         .         .         .         .       g.60040
 CTTCTTGAAAGAATTCTTGGAATGGAATTCATGGAACCAATGGAAAAAAGCATCTTTTAC       c.2760
 L  L  E  R  I  L  G  M  E  F  M  E  P  M  E  K  S  I  F  Y         p.920

      | 27   .         .         .         .         .         .    g.65517
 AATG | ATGAAGGTTATTCTTTCAGCAGTGTCCTGTATTATGGAAATGAAGCTACTCTTCTT    c.2820
 N  D |   E  G  Y  S  F  S  S  V  L  Y  Y  G  N  E  A  T  L  L      p.940

          .         .         .         .         .         .       g.65577
 ATTTTTGATCTGCTGTTCTTCTGTGTTGTGGATTTGGCTTGCCAAAATTTTATTTTAGCA       c.2880
 I  F  D  L  L  F  F  C  V  V  D  L  A  C  Q  N  F  I  L  A         p.960

          .         .        | 28.         .         .         .    g.66561
 TCCTTCCTTACATATCTACAACAAGAG | ATTTTTAGATATATCCGTAATACAGTAGGACAA    c.2940
 S  F  L  T  Y  L  Q  Q  E   | I  F  R  Y  I  R  N  T  V  G  Q      p.980

          .         .         .         .                           g.66609
 AAGAATTTGGCATCCAAAACATTGGTGGATCAAAGATTTTTGATTTAA                   c.2988
 K  N  L  A  S  K  T  L  V  D  Q  R  F  L  I  X                     p.995

          .         .         .         .         .         .       g.66669
 cttcctgaataaataacttaaagactcagtataatcatggccaaaaaaaagtcatgatat       c.*60

          .         .         .         .         .         .       g.66729
 caggttagtttgccatattttttaaaacttataatgcagactattctgtttttgtttttt       c.*120

          .         .         .         .         .         .       g.66789
 atttgcagaaagatttatttttataacttgggaatatataacctgatataatagaaaata       c.*180

          .         .         .         .         .         .       g.66849
 ctgttttcccattgtgtgtagtatttaatgcagtaaataataaattaatactgacagtga       c.*240

          .         .         .         .         .         .       g.66909
 ggccaaaaaaaatctaaatgttgctttcagcataatactttttaatgctaattaaaacag       c.*300

          .         .         .         .         .         .       g.66969
 tccccatcatttgtctctgtagattattttataaactgagagctgcctgaatcttctcac       c.*360

          .         .         .         .         .         .       g.67029
 attgacaaagtaatttgattccaagtttaagactagttttcagtttgatattttcatgtt       c.*420

          .         .         .         .         .         .       g.67089
 ttgtgtgcttatggttaaataaatgttgaaagatattttcaagtttacttagaaatttta       c.*480

          .         .         .         .         .         .       g.67149
 aattgtattattgctgattcaatttgcatcattctaattgctcatcctctttggcagtgg       c.*540

          .         .         .         .         .         .       g.67209
 attaattcactgttgggttaatatgcatctcatgaaatgatatcttttcattcctttgta       c.*600

          .         .         .         .         .         .       g.67269
 tacctgtattaggtcagtatacgctttccatgaaatatatttgcatttctaatatagttt       c.*660

          .         .         .         .         .         .       g.67329
 acatttattaagttataacgtatgacatttttcccaatatcattttttatacattttaat       c.*720

          .         .         .         .         .         .       g.67389
 tacttaatgttttaagagttctcttccagagttttgcttttcaattacgtttaaagactg       c.*780

          .         .         .         .         .         .       g.67449
 taaataacaaacagtaaggctgggcgctgtggcttacgcctgtaatcccagcactttgga       c.*840

          .         .         .         .         .         .       g.67509
 aggccaaggcacgtggatcactttaggtcaggagttcaagaacagcctggccaacatgga       c.*900

          .         .         .         .         .         .       g.67569
 aaaccccatctctacaaaaaatacaaaaattagttggatgtggtggcctgtaatcccagc       c.*960

          .         .         .         .         .         .       g.67629
 tatttgggaggctgaggcatgagaatagcttgaaaccaggaggtggaggctgtagtgagc       c.*1020

          .         .         .         .         .         .       g.67689
 cagatagcaccactgcactccagccaggatgacagagcaagaccctgtctcagaaaaaac       c.*1080

          .         .         .         .         .         .       g.67749
 aaaaacaaaacactgtaaatgtatcatgtttctcactgctttctatgttaatgctgtgta       c.*1140

          .         .         .         .         .         .       g.67809
 aatacttaaaatggaatactgtataaatattatttatattttctcagatgaaaatatata       c.*1200

          .         .         .         .         .         .       g.67869
 ctaaaacatttggtatttctgttttctgtttcattaatgtatatctgatggagtaccatt       c.*1260

          .         .         .         .         .         .       g.67929
 taggaatataacattattggggcagaggtcccagccattgccaaagttgaatcttttaca       c.*1320

          .         .         .         .         .         .       g.67989
 tttccctgaatcttgaggatgactgaaaaggaagtctttgaaactgcagtttctgaagga       c.*1380

          .         .         .         .         .         .       g.68049
 tcacagtacaggaatgcctttataaaagctgcagagataaatacatgtacttatatggca       c.*1440

          .         .         .         .         .         .       g.68109
 tggatatttaaaaccactcactcagaagcatatgaaagaaattcaaccatcattcaacat       c.*1500

          .         .         .         .         .         .       g.68169
 agaagaagttaattttagtgcaaaagtttttaagtattaaatttcacaataaaggatcaa       c.*1560

          .         .         .         .         .         .       g.68229
 ttggcttacttgctgataaattaaaacagaaaacatttaaaatcattctaaattttgtat       c.*1620

          .         .         .         .                           g.68276
 gatatttttattttggctaggtgcataaaaatgtgttcagattttca                    c.*1667

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Transmembrane protein 67 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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