thymopoietin (TMPO) - coding DNA reference sequence

(used for variant description)

(last modified September 19, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_003276.2 in the TMPO gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_021393.1, covering TMPO transcript NM_003276.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5055
      gttcttggggcgtgggcgaagcaggctgctcgcctcctgcctgtagtgtgtgggc       c.-241

 .         .         .         .         .         .                g.5115
 tggggttggtgcgagcttccagcttggccgcagttggttcgtagttcggctctggggtct       c.-181

 .         .         .         .         .         .                g.5175
 tttgtgtccgggtctggcttggctttgtgtccgcgagtttttgttccgctccgcagcgct       c.-121

 .         .         .         .         .         .                g.5235
 cttcccgggcaggagccgtgaggctcggaggcggcagcgcggtccccggccaggagcaag       c.-61

 .         .         .         .         .         .                g.5295
 cgcgccggcgtgagcggcggcggcaaaggctgtggggagggggcttcgcagatccccgag       c.-1

          .         .         .         .         .         .       g.5355
 ATGCCGGAGTTCCTGGAAGACCCCTCGGTCCTGACAAAAGACAAGTTGAAGAGTGAGTTG       c.60
 M  P  E  F  L  E  D  P  S  V  L  T  K  D  K  L  K  S  E  L         p.20

          .         .         .         .         .         .       g.5415
 GTCGCCAACAATGTGACGCTGCCGGCCGGGGAGCAGCGCAAAGACGTGTACGTCCAGCTC       c.120
 V  A  N  N  V  T  L  P  A  G  E  Q  R  K  D  V  Y  V  Q  L         p.40

          .         .         .         .         .         .       g.5475
 TACCTGCAGCACCTCACGGCTCGCAACCGGCCGCCGCTCCCCGCCGGCACCAACAGCAAG       c.180
 Y  L  Q  H  L  T  A  R  N  R  P  P  L  P  A  G  T  N  S  K         p.60

          .         .         .         .         .         .       g.5535
 GGGCCCCCGGACTTCTCCAGTGACGAAGAGCGCGAGCCCACCCCGGTCCTCGGCTCTGGG       c.240
 G  P  P  D  F  S  S  D  E  E  R  E  P  T  P  V  L  G  S  G         p.80

          .         .         .          | 02        .         .    g.17334
 GCCGCCGCCGCGGGCCGGAGCCGAGCAGCCGTCGGCAGG | AAAGCCACAAAAAAAACTGAT    c.300
 A  A  A  A  G  R  S  R  A  A  V  G  R   | K  A  T  K  K  T  D      p.100

          .         .         .         .         .         .       g.17394
 AAACCCAGACAAGAAGATAAAGATGATCTAGATGTAACAGAGCTCACTAATGAAGATCTT       c.360
 K  P  R  Q  E  D  K  D  D  L  D  V  T  E  L  T  N  E  D  L         p.120

          .         .         .         .       | 03 .         .    g.21121
 TTGGATCAGCTTGTGAAATACGGAGTGAATCCTGGTCCTATTGTGG | GAACAACCAGGAAG    c.420
 L  D  Q  L  V  K  Y  G  V  N  P  G  P  I  V  G |   T  T  R  K      p.140

          .         .         .         .         .         .       g.21181
 CTATATGAGAAAAAGCTTTTGAAACTGAGGGAACAAGGAACAGAATCAAGATCTTCTACT       c.480
 L  Y  E  K  K  L  L  K  L  R  E  Q  G  T  E  S  R  S  S  T         p.160

          .         .         .         .         .         .       g.21241
 CCTCTGCCAACAATTTCTTCTTCAGCAGAAAATACAAGGCAGAATGGAAGTAATGATTCT       c.540
 P  L  P  T  I  S  S  S  A  E  N  T  R  Q  N  G  S  N  D  S         p.180

          .         .      | 04  .         .         .         .    g.22285
 GACAGATACAGTGACAATGAAGAAG | GAAAGAAGAAAGAACACAAGAAAGTGAAGTCCACT    c.600
 D  R  Y  S  D  N  E  E  G |   K  K  K  E  H  K  K  V  K  S  T      p.200

          .         .         .         .         .         .       g.22345
 AGGGATATTGTTCCTTTTTCTGAACTTGGAACTACTCCCTCTGGTGGTGGATTTTTTCAG       c.660
 R  D  I  V  P  F  S  E  L  G  T  T  P  S  G  G  G  F  F  Q         p.220

          .         .         .         .         .         .       g.22405
 GGTATTTCTTTTCCTGAAATCTCCACCCGTCCTCCTTTGGGCAGTACCGAACTACAGGCA       c.720
 G  I  S  F  P  E  I  S  T  R  P  P  L  G  S  T  E  L  Q  A         p.240

          .         .         .         .         .         .       g.22465
 GCTAAGAAAGTACATACTTCTAAGGGAGACCTACCTAGGGAGCCTCTTGTTGCCACAAAC       c.780
 A  K  K  V  H  T  S  K  G  D  L  P  R  E  P  L  V  A  T  N         p.260

          .         .         .         .         .         .       g.22525
 TTGCCTGGCAGGGGACAGTTGCAGAAGTTAGCCTCTGAAAGGAATTTGTTTATTTCATGC       c.840
 L  P  G  R  G  Q  L  Q  K  L  A  S  E  R  N  L  F  I  S  C         p.280

          .         .         .         .         .         .       g.22585
 AAGTCTAGCCATGATAGGTGTTTAGAGAAAAGTTCTTCGTCATCTTCTCAGCCTGAACAC       c.900
 K  S  S  H  D  R  C  L  E  K  S  S  S  S  S  S  Q  P  E  H         p.300

          .         .         .         .         .         .       g.22645
 AGTGCCATGTTGGTCTCTACTGCAGCTTCTCCTTCACTGATTAAAGAAACCACCACTGGT       c.960
 S  A  M  L  V  S  T  A  A  S  P  S  L  I  K  E  T  T  T  G         p.320

          .         .         .         .         .         .       g.22705
 TACTATAAAGACATAGTAGAAAATATTTGCGGTAGAGAGAAAAGTGGAATTCAACCATTA       c.1020
 Y  Y  K  D  I  V  E  N  I  C  G  R  E  K  S  G  I  Q  P  L         p.340

          .         .         .         .         .         .       g.22765
 TGTCCTGAGAGGTCCCATATTTCAGATCAATCGCCTCTCTCCAGTAAAAGGAAAGCACTA       c.1080
 C  P  E  R  S  H  I  S  D  Q  S  P  L  S  S  K  R  K  A  L         p.360

          .         .         .         .         .         .       g.22825
 GAAGAGTCTGAGAGCTCACAACTAATTTCTCCGCCACTTGCCCAGGCAATCAGAGATTAT       c.1140
 E  E  S  E  S  S  Q  L  I  S  P  P  L  A  Q  A  I  R  D  Y         p.380

          .         .         .         .         .         .       g.22885
 GTCAATTCTCTGTTGGTCCAGGGTGGGGTAGGTAGTTTGCCTGGAACTTCTAACTCTATG       c.1200
 V  N  S  L  L  V  Q  G  G  V  G  S  L  P  G  T  S  N  S  M         p.400

          .         .         .         .         .         .       g.22945
 CCCCCACTGGATGTAGAAAACATACAGAAGAGAATTGATCAGTCTAAGTTTCAAGAAACT       c.1260
 P  P  L  D  V  E  N  I  Q  K  R  I  D  Q  S  K  F  Q  E  T         p.420

          .         .         .         .         .         .       g.23005
 GAATTCCTGTCTCCTCCAAGAAAAGTCCCTAGACTGAGTGAGAAGTCAGTGGAGGAAAGG       c.1320
 E  F  L  S  P  P  R  K  V  P  R  L  S  E  K  S  V  E  E  R         p.440

          .         .         .         .         .         .       g.23065
 GATTCAGGTTCCTTTGTGGCATTTCAGAACATACCTGGATCCGAACTGATGTCTTCTTTT       c.1380
 D  S  G  S  F  V  A  F  Q  N  I  P  G  S  E  L  M  S  S  F         p.460

          .         .         .         .         .         .       g.23125
 GCCAAAACTGTTGTCTCTCATTCACTCACTACCTTAGGTCTAGAAGTGGCTAAGCAATCA       c.1440
 A  K  T  V  V  S  H  S  L  T  T  L  G  L  E  V  A  K  Q  S         p.480

          .         .         .         .         .         .       g.23185
 CAGCATGATAAAATAGATGCCTCAGAACTATCTTTTCCCTTCCATGAATCTATTTTAAAA       c.1500
 Q  H  D  K  I  D  A  S  E  L  S  F  P  F  H  E  S  I  L  K         p.500

          .         .         .         .         .         .       g.23245
 GTAATTGAAGAAGAATGGCAGCAAGTTGACAGGCAGCTGCCTTCACTGGCATGCAAATAT       c.1560
 V  I  E  E  E  W  Q  Q  V  D  R  Q  L  P  S  L  A  C  K  Y         p.520

          .         .         .         .         .         .       g.23305
 CCAGTTTCTTCCAGGGAGGCAACACAGATATTATCAGTTCCAAAAGTAGATGATGAAATC       c.1620
 P  V  S  S  R  E  A  T  Q  I  L  S  V  P  K  V  D  D  E  I         p.540

          .         .         .         .         .         .       g.23365
 CTAGGGTTTATTTCTGAAGCCACTCCACTAGGAGGTATTCAAGCAGCCTCCACTGAGTCT       c.1680
 L  G  F  I  S  E  A  T  P  L  G  G  I  Q  A  A  S  T  E  S         p.560

          .         .         .         .         .         .       g.23425
 TGCAATCAGCAGTTGGACTTAGCACTCTGTAGAGCATATGAAGCTGCAGCATCAGCATTG       c.1740
 C  N  Q  Q  L  D  L  A  L  C  R  A  Y  E  A  A  A  S  A  L         p.580

          .         .         .         .         .         .       g.23485
 CAGATTGCAACTCACACTGCCTTTGTAGCTAAGGCTATGCAGGCAGACATTAGTCAAGCT       c.1800
 Q  I  A  T  H  T  A  F  V  A  K  A  M  Q  A  D  I  S  Q  A         p.600

          .         .         .         .         .         .       g.23545
 GCACAGATTCTTAGCTCAGATCCTAGTCGTACCCACCAAGCGCTTGGGATTCTGAGCAAA       c.1860
 A  Q  I  L  S  S  D  P  S  R  T  H  Q  A  L  G  I  L  S  K         p.620

          .         .         .         .         .         .       g.23605
 ACATATGATGCAGCCTCATATATTTGTGAAGCTGCATTTGATGAAGTGAAGATGGCTGCC       c.1920
 T  Y  D  A  A  S  Y  I  C  E  A  A  F  D  E  V  K  M  A  A         p.640

          .         .         .         .         .         .       g.23665
 CATACCATGGGAAATGCCACTGTAGGTCGTCGATACCTCTGGCTGAAGGATTGCAAAATT       c.1980
 H  T  M  G  N  A  T  V  G  R  R  Y  L  W  L  K  D  C  K  I         p.660

          .         .         .         .         .         .       g.23725
 AATTTAGCTTCTAAGAATAAGCTGGCTTCCACTCCCTTTAAAGGTGGAACATTATTTGGA       c.2040
 N  L  A  S  K  N  K  L  A  S  T  P  F  K  G  G  T  L  F  G         p.680

          .         .         .         .                           g.23770
 GGAGAAGTATGCAAAGTAATTAAAAAGCGTGGAAATAAACACTAG                      c.2085
 G  E  V  C  K  V  I  K  K  R  G  N  K  H  X                        p.694

          .         .         .         .         .         .       g.23830
 taaaattaaggacaaaaagacatctatcttatctttcaggtactttatgccaacattttc       c.*60

          .         .         .         .         .         .       g.23890
 ttttctgttaaggttgttttagtttccagatagggctaattacaaaatgttaagcttcta       c.*120

          .         .         .         .         .         .       g.23950
 cccatcaaattacagtataaaagtaattgcctgtgtagaactacttgtcttttctaaaga       c.*180

          .         .         .         .         .         .       g.24010
 tttgcgtagataggaagcctggtacaaacaatttaacgctttctagatcacatattagtc       c.*240

          .         .         .         .         .         .       g.24070
 tctaagttgttttctgtttcctgctttacttatgtttttacaattctccaaaactaagaa       c.*300

          .         .         .         .         .         .       g.24130
 aattctaattaggatataaggagtatttactgttcaatagaataatatgcatcctccttt       c.*360

          .         .         .         .         .         .       g.24190
 atacctaggacagaattaaacatttgttacacattcagaacagtgatgttgttctttttg       c.*420

          .         .         .         .         .         .       g.24250
 atacttttatctcagtatcttttcacgttccataacttgtccatatttttgctcatattt       c.*480

          .         .         .         .         .         .       g.24310
 tcttacttttctttgttatttattcatgtctgcaacatcaatcatagtagtctagatcaa       c.*540

          .         .         .         .         .         .       g.24370
 tgcaactcaaagcaccagtctacaaactgttacttatccacaggcaagataagcatgcac       c.*600

          .         .         .         .         .         .       g.24430
 aagaatttaaatctagagatactttttaggtcaatgacaggatttgattttttagcaaaa       c.*660

          .         .         .         .         .         .       g.24490
 ttttattaatagctaaagcaatgtattgatttacactctgatgcaagtaatttatctctt       c.*720

          .         .         .         .         .         .       g.24550
 cattgactggtagcaaccaattcatggaccagtaccatggaccacactttgagaaacact       c.*780

          .         .         .         .         .         .       g.24610
 tctttggataataatagatatcctgggatagtgcatgttcaccatctattttgtcagata       c.*840

          .         .         .         .         .         .       g.24670
 atggggccttttaaaaaataatactttgctttcatgatatattgtattttgtggaaagtt       c.*900

          .         .         .         .         .         .       g.24730
 aagtttagcaatatagactctaaaagcaaattaaatttttttaagccataagaaattata       c.*960

          .         .         .         .         .         .       g.24790
 ctatatcccagtatctgtatgtctgtataaagcagtgtattatcatgttttcatttctgt       c.*1020

          .         .         .         .         .         .       g.24850
 gattgtaagttaagagtcttaactgcagaggtattgtggaaagtagtagccttaagcata       c.*1080

          .         .         .         .         .         .       g.24910
 ataaaatatggtctcttgggtactccctctggccattaccacattcttagattatatgtg       c.*1140

          .         .         .         .         .         .       g.24970
 tccatctttgcagctttctgagagtaattttatttgttgtcttctgaaatgtacatgtat       c.*1200

          .         .         .         .         .         .       g.25030
 acatgtacctactgagtgctatgtgatttttaaaaatgtattactgtagaatgcttctgc       c.*1260

          .         .         .                                     g.25062
 aaattcaataaagttgttaaatttgaacagtg                                   c.*1292

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Thymopoietin protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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