transmembrane protease, serine 3 (TMPRSS3) - coding DNA reference sequence

(used for variant description)

(last modified October 17, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_024022.2 in the TMPRSS3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011629.1, covering TMPRSS3 transcript NM_024022.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5021
                                        accgggcaccggacggctcgg       c.-181

 .         .         .         .         .         .                g.5081
 gtactttcgttcttaattaggtcatgcccgtgtgagccaggaaagggctgtgtttatggg       c.-121

 .         .         .         .         .         .                g.5141
 aagccagtaacactgtggcctactatctcttccgtggtgccatctacatttttgggactc       c.-61

 .         | 02         .         .         .         .             g.5674
 gggaattat | gaggtagaggtggaggcggagccggatgtcagaggtcctgaaatagtcacc    c.-1

          .         .         .         .         .         .       g.5734
 ATGGGGGAAAATGATCCGCCTGCTGTTGAAGCCCCCTTCTCATTCCGATCGCTTTTTGGC       c.60
 M  G  E  N  D  P  P  A  V  E  A  P  F  S  F  R  S  L  F  G         p.20

          .         .         .     | 03   .         .         .    g.11080
 CTTGATGATTTGAAAATAAGTCCTGTTGCACCAG | ATGCAGATGCTGTTGCTGCACAGATC    c.120
 L  D  D  L  K  I  S  P  V  A  P  D |   A  D  A  V  A  A  Q  I      p.40

          .         .         .         .         .         .       g.11140
 CTGTCACTGCTGCCATTGAAGTTTTTTCCAATCATCGTCATTGGGATCATTGCATTGATA       c.180
 L  S  L  L  P  L  K  F  F  P  I  I  V  I  G  I  I  A  L  I         p.60

          .         .      | 04  .         .         .         .    g.12081
 TTAGCACTGGCCATTGGTCTGGGCA | TCCACTTCGACTGCTCAGGGAAGTACAGATGTCGC    c.240
 L  A  L  A  I  G  L  G  I |   H  F  D  C  S  G  K  Y  R  C  R      p.80

          .         .         .         .         .         .       g.12141
 TCATCCTTTAAGTGTATCGAGCTGATAGCTCGATGTGACGGAGTCTCGGATTGCAAAGAC       c.300
 S  S  F  K  C  I  E  L  I  A  R  C  D  G  V  S  D  C  K  D         p.100

          .         .   | 05     .         .         .         .    g.12603
 GGGGAGGACGAGTACCGCTGTG | TCCGGGTGGGTGGTCAGAATGCCGTGCTCCAGGTGTTC    c.360
 G  E  D  E  Y  R  C  V |   R  V  G  G  Q  N  A  V  L  Q  V  F      p.120

          .         .         .         .         .         .       g.12663
 ACAGCTGCTTCGTGGAAGACCATGTGCTCCGATGACTGGAAGGGTCACTACGCAAATGTT       c.420
 T  A  A  S  W  K  T  M  C  S  D  D  W  K  G  H  Y  A  N  V         p.140

          .         .       | 06 .         .         .         .    g.15591
 GCCTGTGCCCAACTGGGTTTCCCAAG | CTATGTGAGTTCAGATAACCTCAGAGTGAGCTCG    c.480
 A  C  A  Q  L  G  F  P  S  |  Y  V  S  S  D  N  L  R  V  S  S      p.160

          .         .         .         .         .         .       g.15651
 CTGGAGGGGCAGTTCCGGGAGGAGTTTGTGTCCATCGATCACCTCTTGCCAGATGACAAG       c.540
 L  E  G  Q  F  R  E  E  F  V  S  I  D  H  L  L  P  D  D  K         p.180

          .         .         .   | 07     .         .         .    g.17106
 GTGACTGCATTACACCACTCAGTATATGTGAG | GGAGGGATGTGCCTCTGGCCACGTGGTT    c.600
 V  T  A  L  H  H  S  V  Y  V  R  |  E  G  C  A  S  G  H  V  V      p.200

          .       | 08 .         .         .         .         .    g.17937
 ACCTTGCAGTGCACAG | CCTGTGGTCATAGAAGGGGCTACAGCTCACGCATCGTGGGTGGA    c.660
 T  L  Q  C  T  A |   C  G  H  R  R  G  Y  S  S  R  I  V  G  G      p.220

          .         .         .         .         .         .       g.17997
 AACATGTCCTTGCTCTCGCAGTGGCCCTGGCAGGCCAGCCTTCAGTTCCAGGGCTACCAC       c.720
 N  M  S  L  L  S  Q  W  P  W  Q  A  S  L  Q  F  Q  G  Y  H         p.240

          .         .         .         .         .         .       g.18057
 CTGTGCGGGGGCTCTGTCATCACGCCCCTGTGGATCATCACTGCTGCACACTGTGTTTAT       c.780
 L  C  G  G  S  V  I  T  P  L  W  I  I  T  A  A  H  C  V  Y         p.260

    | 09     .         .         .         .         .         .    g.18915
 GA | CTTGTACCTCCCCAAGTCATGGACCATCCAGGTGGGTCTAGTTTCCCTGTTGGACAAT    c.840
 D  |  L  Y  L  P  K  S  W  T  I  Q  V  G  L  V  S  L  L  D  N      p.280

          .         .         .         .         .         .       g.18975
 CCAGCCCCATCCCACTTGGTGGAGAAGATTGTCTACCACAGCAAGTACAAGCCAAAGAGG       c.900
 P  A  P  S  H  L  V  E  K  I  V  Y  H  S  K  Y  K  P  K  R         p.300

          .         .         .         .         .   | 10     .    g.20887
 CTGGGCAATGACATCGCCCTTATGAAGCTGGCCGGGCCACTCACGTTCAATG | AAATGATC    c.960
 L  G  N  D  I  A  L  M  K  L  A  G  P  L  T  F  N  E |   M  I      p.320

          .         .         .         .         .         .       g.20947
 CAGCCTGTGTGCCTGCCCAACTCTGAAGAGAACTTCCCCGATGGAAAAGTGTGCTGGACG       c.1020
 Q  P  V  C  L  P  N  S  E  E  N  F  P  D  G  K  V  C  W  T         p.340

          .         .         | 11         .         .         .    g.24437
 TCAGGATGGGGGGCCACAGAGGATGGAG | CAGGTGACGCCTCCCCTGTCCTGAACCACGCG    c.1080
 S  G  W  G  A  T  E  D  G  A |   G  D  A  S  P  V  L  N  H  A      p.360

          .         .         .         .         .         .       g.24497
 GCCGTCCCTTTGATTTCCAACAAGATCTGCAACCACAGGGACGTGTACGGTGGCATCATC       c.1140
 A  V  P  L  I  S  N  K  I  C  N  H  R  D  V  Y  G  G  I  I         p.380

          .         .         .         .         .     | 12   .    g.25229
 TCCCCCTCCATGCTCTGCGCGGGCTACCTGACGGGTGGCGTGGACAGCTGCCAG | GGGGAC    c.1200
 S  P  S  M  L  C  A  G  Y  L  T  G  G  V  D  S  C  Q   | G  D      p.400

          .         .         .         .         .         .       g.25289
 AGCGGGGGGCCCCTGGTGTGTCAAGAGAGGAGGCTGTGGAAGTTAGTGGGAGCGACCAGC       c.1260
 S  G  G  P  L  V  C  Q  E  R  R  L  W  K  L  V  G  A  T  S         p.420

          .         .         .         .         .         .       g.25349
 TTTGGCATCGGCTGCGCAGAGGTGAACAAGCCTGGGGTGTACACCCGTGTCACCTCCTTC       c.1320
 F  G  I  G  C  A  E  V  N  K  P  G  V  Y  T  R  V  T  S  F         p.440

          .         .        | 13.         .                        g.28345
 CTGGACTGGATCCACGAGCAGATGGAG | AGAGACCTAAAAACCTGA                   c.1365
 L  D  W  I  H  E  Q  M  E   | R  D  L  K  T  X                     p.454

          .         .         .         .         .         .       g.28405
 agaggaaggggacaagtagccacctgagttcctgaggtgatgaagacagcccgatcctcc       c.*60

          .         .         .         .         .         .       g.28465
 cctggactcccgtgtaggaacctgcacacgagcagacacccttggagctctgagttccgg       c.*120

          .         .         .         .         .         .       g.28525
 caccagtagcaggcccgaaagaggcacccttccatctgattccagcacaaccttcaagct       c.*180

          .         .         .         .         .         .       g.28585
 gctttttgttttttgtttttttgagatggagtctcgctctgttgcccaggctggagtgca       c.*240

          .         .         .         .         .         .       g.28645
 gtggcgaaatccctgctcactgcagcctccgcttccctggttcaagcgattctcttgcct       c.*300

          .         .         .         .         .         .       g.28705
 cagcttccccagtagctgggaccacaggtgcccgccaccacacccaactaatttttgtat       c.*360

          .         .         .         .         .         .       g.28765
 ttttagtagagacagggtttcaccatgttggccaggctgctctcaaacccctgacctcaa       c.*420

          .         .         .         .         .         .       g.28825
 atgatgtgcctgcttcagcctcccacagtgctgggattacaggcatgggccaccacgcct       c.*480

          .         .         .         .         .         .       g.28885
 agcctcacgctcctttctgatcttcactaagaacaaaagaagcagcaacttgcaagggcg       c.*540

          .         .         .         .         .         .       g.28945
 gcctttcccactggtccatctggttttctctccaggggtcttgcaaaattcctgacgaga       c.*600

          .         .         .         .         .         .       g.29005
 taagcagttatgtgacctcacgtgcaaagccaccaacagccactcagaaaagacgcacca       c.*660

          .         .         .         .         .         .       g.29065
 gcccagaagtgcagaactgcagtcactgcacgttttcatctctagggaccagaaccaaac       c.*720

          .         .         .         .         .         .       g.29125
 ccaccctttctacttccaagacttattttcacatgtggggaggttaatctaggaatgact       c.*780

          .         .         .         .         .         .       g.29185
 cgtttaaggcctattttcatgatttctttgtagcatttggtgcttgacgtattattgtcc       c.*840

          .         .         .                                     g.29220
 tttgattccaaataatatgtttccttccctcattg                                c.*875

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Transmembrane protease, serine 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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