thioredoxin-related transmembrane protein 2 (TMX2) - coding DNA reference sequence

(used for variant description)

(last modified December 7, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_015959.3 in the TMX2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_052993.1, covering TMX2 transcript NM_015959.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5036
                         gtacgtttgcgatatagcccaatagcagtcgttatg       c.-61

 .         .         .         .         .         .                g.5096
 gtgggggaggcggggcgagacctacgacgccggcgagcagtggccgttacggccgaaaag       c.-1

          .         .         .         .         .         .       g.5156
 ATGGCGGTCTTGGCACCTCTAATTGCTCTCGTGTATTCGGTGCCGCGACTTTCACGATGG       c.60
 M  A  V  L  A  P  L  I  A  L  V  Y  S  V  P  R  L  S  R  W         p.20

          .         .         .         .         .         .       g.5216
 CTCGCCCAACCTTACTACCTTCTGTCGGCCCTGCTCTCTGCTGCCTTCCTACTCGTGAGG       c.120
 L  A  Q  P  Y  Y  L  L  S  A  L  L  S  A  A  F  L  L  V  R         p.40

          .         .         .         .         .         .       g.5276
 AAACTGCCGCCGCTCTGCCACGGTCTGCCCACCCAACGCGAAGACGGTAACCCGTGTGAC       c.180
 K  L  P  P  L  C  H  G  L  P  T  Q  R  E  D  G  N  P  C  D         p.60

           | 02        .         .         .         .         .    g.30136
 TTTGACTGG | AGAGAAGTGGAGATCCTGATGTTTCTCAGTGCCATTGTGATGATGAAGAAC    c.240
 F  D  W   | R  E  V  E  I  L  M  F  L  S  A  I  V  M  M  K  N      p.80

          . | 03       .         .         .         .         .    g.30440
 CGCAGATCCA | TCACTGTGGAGCAACATATAGGCAACATTTTCATGTTTAGTAAAGTGGCC    c.300
 R  R  S  I |   T  V  E  Q  H  I  G  N  I  F  M  F  S  K  V  A      p.100

          .         .         .         .         .         .       g.30500
 AACACAATTCTTTTCTTCCGCTTGGATATTCGCATGGGCCTACTTTACATCACACTCTGC       c.360
 N  T  I  L  F  F  R  L  D  I  R  M  G  L  L  Y  I  T  L  C         p.120

      | 04   .         .         .         .         .         .    g.30887
 ATAG | TGTTCCTGATGACGTGCAAACCCCCCCTATATATGGGCCCTGAGTATATCAAGTAC    c.420
 I  V |   F  L  M  T  C  K  P  P  L  Y  M  G  P  E  Y  I  K  Y      p.140

          .         .  | 05      .         .         .         .    g.31180
 TTCAATGATAAAACCATTGAT | GAGGAACTAGAACGGGACAAGAGGGTCACTTGGATTGTG    c.480
 F  N  D  K  T  I  D   | E  E  L  E  R  D  K  R  V  T  W  I  V      p.160

          .         .         .         .         .         .       g.31240
 GAGTTCTTTGCCAATTGGTCTAATGACTGCCAATCATTTGCCCCTATCTATGCTGACCTC       c.540
 E  F  F  A  N  W  S  N  D  C  Q  S  F  A  P  I  Y  A  D  L         p.180

          | 06         .         .         .         .         .    g.31503
 TCCCTTAA | ATACAACTGTACAGGGCTAAATTTTGGGAAGGTGGATGTTGGACGCTATACT    c.600
 S  L  K  |  Y  N  C  T  G  L  N  F  G  K  V  D  V  G  R  Y  T      p.200

          .     | 07   .         .         .         .         .    g.31654
 GATGTTAGTACGCG | GTACAAAGTGAGCACATCACCCCTCACCAAGCAACTCCCTACCCTG    c.660
 D  V  S  T  R  |  Y  K  V  S  T  S  P  L  T  K  Q  L  P  T  L      p.220

          .         .         .         .         .         .       g.31714
 ATCCTGTTCCAAGGTGGCAAGGAGGCAATGCGGCGGCCACAGATTGACAAGAAAGGACGG       c.720
 I  L  F  Q  G  G  K  E  A  M  R  R  P  Q  I  D  K  K  G  R         p.240

          .         .     | 08   .         .         .         .    g.32612
 GCTGTCTCATGGACCTTCTCTGAG | GAGAATGTGATCCGAGAATTTAACTTAAATGAGCTA    c.780
 A  V  S  W  T  F  S  E   | E  N  V  I  R  E  F  N  L  N  E  L      p.260

          .         .         .         .         .         .       g.32672
 TACCAGCGGGCCAAGAAACTATCAAAGGCTGGAGACAATATCCCTGAGGAGCAGCCTGTG       c.840
 Y  Q  R  A  K  K  L  S  K  A  G  D  N  I  P  E  E  Q  P  V         p.280

          .         .         .         .         .                 g.32723
 GCTTCAACCCCCACCACAGTGTCAGATGGGGAAAACAAGAAGGATAAATAA                c.891
 A  S  T  P  T  T  V  S  D  G  E  N  K  K  D  K  X                  p.296

          .         .         .         .         .         .       g.32783
 gatcctcactttggcagtgcttcctctcctgtcaattccaggctctttccataaccacaa       c.*60

          .         .         .         .         .         .       g.32843
 gcctgaggctgcagccttttatttatgttttccctttggctgtgactgggtggggcagca       c.*120

          .         .         .         .         .         .       g.32903
 tgcagcttctgattttaaagaggcatctagggaattgtcaggcaccctacaggaaggcct       c.*180

          .         .         .         .         .         .       g.32963
 gccatgctgtggccaactgtttcactggagcaagaaagagatctcataggacggaggggg       c.*240

          .         .         .         .         .         .       g.33023
 aaatggtttccctccaagcttgggtcagtgtgttaactgcttatcagctattcagacatc       c.*300

          .         .         .         .         .         .       g.33083
 tccatggtttctccatgaaactctgtggtttcatcattccttcttagttgacctgcacag       c.*360

          .         .         .         .         .         .       g.33143
 cttggttagacctagatttaaccctaaggtaagatgctggggtatagaacgctaagaatt       c.*420

          .         .         .         .         .         .       g.33203
 ttcccccaaggactcttgcttccttaagcccttctggcttcgtttatggtcttcattaaa       c.*480

          .         .         .         .         .         .       g.33263
 agtataagcctaactttgtcgctagtcctaaggagaaacctttaaccacaaagtttttat       c.*540

          .         .         .         .         .         .       g.33323
 cattgaagacaatattgaacaaccccctattttgtggggattgagaaggggtgaatagag       c.*600

          .         .         .         .         .         .       g.33383
 gcttgagactttcctttgtgtggtaggacttggaggagaaatcccctggactttcactaa       c.*660

          .         .         .         .         .         .       g.33443
 ccctctgacatactccccacacccagttgatggctttccgtaataaaaagattgggattt       c.*720

                                                                    g.33451
 ccttttga                                                           c.*728

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Thioredoxin-related transmembrane protein 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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