tumor necrosis factor receptor superfamily, member 11a, NFKB activator (TNFRSF11A) - coding DNA reference sequence

(used for variant description)

(last modified March 22, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_003839.3 in the TNFRSF11A gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000018.9, covering TNFRSF11A transcript NM_003839.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5006
                                                       ggcagc       c.-61

 .         .         .         .         .         .                g.5066
 cgcgcccgctgggccacagaggccgctgaggccgcggcgcccgccagcctgtcccgcgcc       c.-1

          .         .         .         .         .         .       g.5126
 ATGGCCCCGCGCGCCCGGCGGCGCCGCCCGCTGTTCGCGCTGCTGCTGCTCTGCGCGCTG       c.60
 M  A  P  R  A  R  R  R  R  P  L  F  A  L  L  L  L  C  A  L         p.20

          .      | 02  .         .         .         .         .    g.27926
 CTCGCCCGGCTGCAG | GTGGCTTTGCAGATCGCTCCTCCATGTACCAGTGAGAAGCATTAT    c.120
 L  A  R  L  Q   | V  A  L  Q  I  A  P  P  C  T  S  E  K  H  Y      p.40

          .         .         .        | 03.         .         .    g.29548
 GAGCATCTGGGACGGTGCTGTAACAAATGTGAACCAG | GAAAGTACATGTCTTCTAAATGC    c.180
 E  H  L  G  R  C  C  N  K  C  E  P  G |   K  Y  M  S  S  K  C      p.60

          .         .         .         .         .         .       g.29608
 ACTACTACCTCTGACAGTGTATGTCTGCCCTGTGGCCCGGATGAATACTTGGATAGCTGG       c.240
 T  T  T  S  D  S  V  C  L  P  C  G  P  D  E  Y  L  D  S  W         p.80

          .         .         .         .    | 04    .         .    g.34121
 AATGAAGAAGATAAATGCTTGCTGCATAAAGTTTGTGATACAG | GCAAGGCCCTGGTGGCC    c.300
 N  E  E  D  K  C  L  L  H  K  V  C  D  T  G |   K  A  L  V  A      p.100

          .         .         .         .         .         .       g.34181
 GTGGTCGCCGGCAACAGCACGACCCCCCGGCGCTGCGCGTGCACGGCTGGGTACCACTGG       c.360
 V  V  A  G  N  S  T  T  P  R  R  C  A  C  T  A  G  Y  H  W         p.120

          .         .         .         .         .         .       g.34241
 AGCCAGGACTGCGAGTGCTGCCGCCGCAACACCGAGTGCGCGCCGGGCCTGGGCGCCCAG       c.420
 S  Q  D  C  E  C  C  R  R  N  T  E  C  A  P  G  L  G  A  Q         p.140

         | 05.         .         .         .         .         .    g.38014
 CACCCGT | TGCAGCTCAACAAGGACACAGTGTGCAAACCTTGCCTTGCAGGCTACTTCTCT    c.480
 H  P  L |   Q  L  N  K  D  T  V  C  K  P  C  L  A  G  Y  F  S      p.160

          .         .         .         .  | 06      .         .    g.39687
 GATGCCTTTTCCTCCACGGACAAATGCAGACCCTGGACCAA | CTGTACCTTCCTTGGAAAG    c.540
 D  A  F  S  S  T  D  K  C  R  P  W  T  N  |  C  T  F  L  G  K      p.180

          .         .         .         .         .         .       g.39747
 AGAGTAGAACATCATGGGACAGAGAAATCCGATGCGGTTTGCAGTTCTTCTCTGCCAGCT       c.600
 R  V  E  H  H  G  T  E  K  S  D  A  V  C  S  S  S  L  P  A         p.200

          .       | 07 .         .         .         .         .    g.41437
 AGAAAACCACCAAATG | AACCCCATGTTTACTTGCCCGGTTTAATAATTCTGCTTCTCTTC    c.660
 R  K  P  P  N  E |   P  H  V  Y  L  P  G  L  I  I  L  L  L  F      p.220

          .         .         .         .         .         .       g.41497
 GCGTCTGTGGCCCTGGTGGCTGCCATCATCTTTGGCGTTTGCTATAGGAAAAAAGGGAAA       c.720
 A  S  V  A  L  V  A  A  I  I  F  G  V  C  Y  R  K  K  G  K         p.240

          . | 08       .         .         .         .         .    g.46471
 GCACTCACAG | CTAATTTGTGGCACTGGATCAATGAGGCTTGTGGCCGCCTAAGTGGAGAT    c.780
 A  L  T  A |   N  L  W  H  W  I  N  E  A  C  G  R  L  S  G  D      p.260

     | 09    .         .         .         .         .         .    g.48471
 AAG | GAGTCCTCAGGTGACAGTTGTGTCAGTACACACACGGCAAACTTTGGTCAGCAGGGA    c.840
 K   | E  S  S  G  D  S  C  V  S  T  H  T  A  N  F  G  Q  Q  G      p.280

          .         .         .         .         .         .       g.48531
 GCATGTGAAGGTGTCTTACTGCTGACTCTGGAGGAGAAGACATTTCCAGAAGATATGTGC       c.900
 A  C  E  G  V  L  L  L  T  L  E  E  K  T  F  P  E  D  M  C         p.300

          .         .         .         .         .         .       g.48591
 TACCCAGATCAAGGTGGTGTCTGTCAGGGCACATGTGTAGGAGGTGGTCCCTACGCACAA       c.960
 Y  P  D  Q  G  G  V  C  Q  G  T  C  V  G  G  G  P  Y  A  Q         p.320

          .         .         .         .         .         .       g.48651
 GGCGAAGATGCCAGGATGCTCTCATTGGTCAGCAAGACCGAGATAGAGGAAGACAGCTTC       c.1020
 G  E  D  A  R  M  L  S  L  V  S  K  T  E  I  E  E  D  S  F         p.340

          .         .         .         .         .         .       g.48711
 AGACAGATGCCCACAGAAGATGAATACATGGACAGGCCCTCCCAGCCCACAGACCAGTTA       c.1080
 R  Q  M  P  T  E  D  E  Y  M  D  R  P  S  Q  P  T  D  Q  L         p.360

          .         .         .         .         .         .       g.48771
 CTGTTCCTCACTGAGCCTGGAAGCAAATCCACACCTCCTTTCTCTGAACCCCTGGAGGTG       c.1140
 L  F  L  T  E  P  G  S  K  S  T  P  P  F  S  E  P  L  E  V         p.380

          .         .         .         .         .         .       g.48831
 GGGGAGAATGACAGTTTAAGCCAGTGCTTCACGGGGACACAGAGCACAGTGGGTTCAGAA       c.1200
 G  E  N  D  S  L  S  Q  C  F  T  G  T  Q  S  T  V  G  S  E         p.400

          .         .         .         .         .         .       g.48891
 AGCTGCAACTGCACTGAGCCCCTGTGCAGGACTGATTGGACTCCCATGTCCTCTGAAAAC       c.1260
 S  C  N  C  T  E  P  L  C  R  T  D  W  T  P  M  S  S  E  N         p.420

          .         .         .         .         .         .       g.48951
 TACTTGCAAAAAGAGGTGGACAGTGGCCATTGCCCGCACTGGGCAGCCAGCCCCAGCCCC       c.1320
 Y  L  Q  K  E  V  D  S  G  H  C  P  H  W  A  A  S  P  S  P         p.440

          .         .         .         .         .         .       g.49011
 AACTGGGCAGATGTCTGCACAGGCTGCCGGAACCCTCCTGGGGAGGACTGTGAACCCCTC       c.1380
 N  W  A  D  V  C  T  G  C  R  N  P  P  G  E  D  C  E  P  L         p.460

          .         .         .         .         .         .       g.49071
 GTGGGTTCCCCAAAACGTGGACCCTTGCCCCAGTGCGCCTATGGCATGGGCCTTCCCCCT       c.1440
 V  G  S  P  K  R  G  P  L  P  Q  C  A  Y  G  M  G  L  P  P         p.480

          .         .         .         .         .         .       g.49131
 GAAGAAGAAGCCAGCAGGACGGAGGCCAGAGACCAGCCCGAGGATGGGGCTGATGGGAGG       c.1500
 E  E  E  A  S  R  T  E  A  R  D  Q  P  E  D  G  A  D  G  R         p.500

          .         .         .         .         .         .       g.49191
 CTCCCAAGCTCAGCGAGGGCAGGTGCCGGGTCTGGAAGCTCCCCTGGTGGCCAGTCCCCT       c.1560
 L  P  S  S  A  R  A  G  A  G  S  G  S  S  P  G  G  Q  S  P         p.520

         | 10.         .         .         .         .         .    g.64517
 GCATCTG | GAAATGTGACTGGAAACAGTAACTCCACGTTCATCTCCAGCGGGCAGGTGATG    c.1620
 A  S  G |   N  V  T  G  N  S  N  S  T  F  I  S  S  G  Q  V  M      p.540

          .         .         .         .         .         .       g.64577
 AACTTCAAGGGCGACATCATCGTGGTCTACGTCAGCCAGACCTCGCAGGAGGGCGCGGCG       c.1680
 N  F  K  G  D  I  I  V  V  Y  V  S  Q  T  S  Q  E  G  A  A         p.560

          .         .         .         .         .         .       g.64637
 GCGGCTGCGGAGCCCATGGGCCGCCCGGTGCAGGAGGAGACCCTGGCGCGCCGAGACTCC       c.1740
 A  A  A  E  P  M  G  R  P  V  Q  E  E  T  L  A  R  R  D  S         p.580

          .         .         .         .         .         .       g.64697
 TTCGCGGGGAACGGCCCGCGCTTCCCGGACCCGTGCGGCGGCCCCGAGGGGCTGCGGGAG       c.1800
 F  A  G  N  G  P  R  F  P  D  P  C  G  G  P  E  G  L  R  E         p.600

          .         .         .         .         .                 g.64748
 CCGGAGAAGGCCTCGAGGCCGGTGCAGGAGCAAGGCGGGGCCAAGGCTTGA                c.1851
 P  E  K  A  S  R  P  V  Q  E  Q  G  G  A  K  A  X                  p.616

          .         .         .         .         .         .       g.64808
 gcgccccccatggctgggagcccgaagctcggagccagggctcgcgagggcagcaccgca       c.*60

          .         .         .         .         .         .       g.64868
 gcctctgccccagccccggccacccagggatcgatcggtacagtcgaggaagaccacccg       c.*120

          .         .         .         .         .         .       g.64928
 gcattctctgcccactttgccttccaggaaatgggcttttcaggaagtgaattgatgagg       c.*180

          .         .         .         .         .         .       g.64988
 actgtccccatgcccacggatgctcagcagcccgccgcactggggcagatgtctcccctg       c.*240

          .         .         .         .         .         .       g.65048
 ccactcctcaaactcgcagcagtaatttgtggcactatgacagctatttttatgactatc       c.*300

          .         .         .         .         .         .       g.65108
 ctgttctgtgggggggggggtctgttttccccccatatttgtattccttttcataacttt       c.*360

          .         .         .         .         .         .       g.65168
 tcttgatatctttcctccctcttttttaatgtaaaggttttctcaaaaattctcctaaag       c.*420

          .         .         .         .         .         .       g.65228
 gtgagggtctctttcttttctcttttccttttttttttctttttttggcaacctggctct       c.*480

          .         .         .         .         .         .       g.65288
 ggcccaggctagagtgcagtggtgcgattatagcccggtgcagcctctaactcctgggct       c.*540

          .         .         .         .         .         .       g.65348
 caagcaatccaagtgatcctcccacctcaaccttcggagtagctgggatcacagctgcag       c.*600

          .         .         .         .         .         .       g.65408
 gccacgcccagcttcctccccccgactccccccccagagacacggtcccaccatgttacc       c.*660

          .         .         .         .         .         .       g.65468
 cagcctggtctcaaactccccagctaaagcagtcctccagcctcggcctcccaaagtact       c.*720

          .         .         .         .         .         .       g.65528
 gggattacaggcgtgagcccccacgctggcctgctttacgtattttcttttgtgcccctg       c.*780

          .         .         .         .         .         .       g.65588
 ctcacagtgttttagagatggctttcccagtgtgtgttcattgtaaacacttttgggaaa       c.*840

          .         .         .         .         .         .       g.65648
 gggctaaacatgtgaggcctggagatagttgctaagttgctaggaacatgtggtgggact       c.*900

          .         .         .         .         .         .       g.65708
 ttcatattctgaaaaatgttctatattctcatttttctaaaagaaagaaaaaaggaaacc       c.*960

          .         .         .         .         .         .       g.65768
 cgatttatttctcctgaatctttttaagtttgtgtcgttccttaagcagaactaagctca       c.*1020

          .         .         .         .         .         .       g.65828
 gtatgtgaccttacccgctaggtggttaatttatccatgctggcagaggcactcaggtac       c.*1080

          .         .         .         .         .         .       g.65888
 ttggtaagcaaatttctaaaactccaagttgctgcagcttggcattcttcttattctaga       c.*1140

          .         .         .         .         .         .       g.65948
 ggtctctctggaaaagatggagaaaatgaacaggacatggggctcctggaaagaaagggc       c.*1200

          .         .         .         .         .         .       g.66008
 ccgggaagttcaaggaagaataaagttgaaattttaatttgcattttttttgtctagata       c.*1260

          .         .         .         .         .         .       g.66068
 agaatagcgtgaatagatcctcttttattcgtaaataatcgtgcatctgtgggttagcct       c.*1320

          .         .         .         .         .         .       g.66128
 tgtagaagtggaaaacattccattttccaatgcatttaaatgtaaagccaaatctgcatg       c.*1380

          .         .         .         .         .         .       g.66188
 ttgtgaatttaagaaaacttattatcctaaaggtgcctttctcttggcatcatcccgctt       c.*1440

          .         .         .         .         .         .       g.66248
 gtgagaagcctagaggacgctccaggtggaaggaaatcccctgggtggttttatcttttg       c.*1500

          .         .         .         .         .         .       g.66308
 ttacccagtgagcactggttccccgcaaatactggggaaaagcaaaaatacacaagcaag       c.*1560

          .         .         .         .         .         .       g.66368
 ttaaaattaattttgcacatctgggaggttataaaagaaagcactaatagtagtcactgc       c.*1620

          .         .         .         .         .         .       g.66428
 ccagactttactggccacaaatgcccagctgaagagcatgactgtggatcactggttttt       c.*1680

          .         .         .         .         .         .       g.66488
 ccctcctgctggaaatgctggggtggtagcggtcgattaggattttcagtggagaagcac       c.*1740

          .         .         .         .         .         .       g.66548
 aggacagttctgtaatttatgggactccttagccaacataaagaactgcaggaaataact       c.*1800

          .         .         .         .         .         .       g.66608
 gcacagccaggaggatccgttggtgggaatttaccgtcattcctgcccttttatttaaca       c.*1860

          .         .         .         .         .         .       g.66668
 tcatccacagagagatgttatacaaatggaggaaaccattataccttttgatatggaata       c.*1920

          .         .         .         .         .         .       g.66728
 tattacagagttacagttcacaaagtagaatgctgagctgaaaacccgagtttctgctgt       c.*1980

          .         .         .         .         .         .       g.66788
 gactgtcatctcactgagcacttcgcttttctttgcttttattttttccttctataaaaa       c.*2040

          .         .         .         .         .         .       g.66848
 ggcaataatgataatttataatagtttccctacccagagatattagaagtatgctacagt       c.*2100

          .         .         .         .         .         .       g.66908
 gaatgttaaagtaccttgagatccttaaatcaaaggtgctatatacataagtaagactct       c.*2160

          .         .         .         .         .         .       g.66968
 actttcagaaaaaggtaatattatttcctgcactgatccctactaattctatattgatcc       c.*2220

          .         .         .         .         .         .       g.67028
 aaaggcaactcaatgctaaaaaatgtatagaaaatataagtctgtgtctgtgtactgtag       c.*2280

          .         .         .         .         .         .       g.67088
 agatgtatgtgacaagtgtaaacaaaatgaactgaagcagtaatgaacagttattagggg       c.*2340

          .         .         .         .         .         .       g.67148
 gaacatgataaagagattatattaagcttatgtttcaccataaaatcctttttatggctt       c.*2400

          .         .         .         .         .         .       g.67208
 actaaaaccgagctcactgtaaaatcatgatccaacttattgctaatctttatgatatgc       c.*2460

          .         .         .         .         .         .       g.67268
 ttattcctaatctttatggtatggtgtcaaccgttcatttgtatcttattgctcattccc       c.*2520

          .         .         .         .         .         .       g.67328
 tggaccacagactagggacagaaaatacttgctttaataatatatatgctgttgatttca       c.*2580

          .         .         .         .         .         .       g.67388
 caaaaatttattaaaatacagcctgggtacccagtgaaagagctgaaatggaaatggagt       c.*2640

          .         .         .                                     g.67424
 atcatgtttcctactcacattttactcagctgtcgg                               c.*2676

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Tumor necrosis factor receptor superfamily, member 11a, NFKB activator protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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