TNFAIP3 interacting protein 1 (TNIP1) - coding DNA reference sequence

(used for variant description)

(last modified January 23, 2016)

This file was created to facilitate the description of sequence variants on transcript NM_001252385.1 in the TNIP1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_030590.1, covering TNIP1 transcript NM_001252385.1.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                                                                    g.11577
                                                            a       c.-241

 .         .         .         .         .         .                g.11637
 gtctccggggactttcccaggggtggggcggcccggccaggcccccggcacttcctcgtc       c.-181

 .         .         .         .         .         .                g.11697
 ctcggcccgggtgccctgcccccgtccaggagccctaggagtgctacggggggccggagc       c.-121

 .         .         .         .         .         .                g.11757
 cttgcccgggccgctgccccgtccctggattcggggctggacgcagcaagcggggcgctg       c.-61

 .         .         .    | 02    .         .         .             g.27565
 tgtccccaagctccccgtcctcgg | ccaggcgggcaccacggcaggggctgagctaccctc    c.-1

          .         .         .         .         .         .       g.27625
 ATGGAAGGGAGAGGACCGTACCGGATCTACGACCCTGGGGGCAGCGTGCCCTCAGGAGAG       c.60
 M  E  G  R  G  P  Y  R  I  Y  D  P  G  G  S  V  P  S  G  E         p.20

          .         .         .         .         .         .       g.27685
 GCATCCGCAGCTTTTGAGCGCCTAGTGAAGGAGAATTCCCGGCTGAAGGAAAAAATGCAA       c.120
 A  S  A  A  F  E  R  L  V  K  E  N  S  R  L  K  E  K  M  Q         p.40

          .       | 03 .         .         .         .         .    g.28957
 GGGATAAAGATGTTAG | GGGAGCTTTTGGAAGAGTCCCAGATGGAAGCGACCAGGCTCCGG    c.180
 G  I  K  M  L  G |   E  L  L  E  E  S  Q  M  E  A  T  R  L  R      p.60

          .         .         .         .         .         .       g.29017
 CAGAAGGCAGAGGAGCTAGTGAAGGACAACGAGCTGCTCCCACCACCTTCTCCCTCCTTG       c.240
 Q  K  A  E  E  L  V  K  D  N  E  L  L  P  P  P  S  P  S  L         p.80

          .         .         .  | 04      .         .         .    g.30477
 GGCTCCTTCGACCCCCTGGCTGAGCTCACAG | GAAAGGACTCAAATGTCACAGCATCTCCC    c.300
 G  S  F  D  P  L  A  E  L  T  G |   K  D  S  N  V  T  A  S  P      p.100

          .         .         .         .         .        | 05.    g.32268
 ACAGCCCCTGCATGCCCCAGTGACAAGCCAGCACCAGTCCAGAAGCCTCCATCCAGT | GGC    c.360
 T  A  P  A  C  P  S  D  K  P  A  P  V  Q  K  P  P  S  S   | G      p.120

          .         .         .         .         .         .       g.32328
 ACCTCCTCTGAATTTGAAGTGGTCACTCCTGAGGAGCAGAATTCACCAGAGAGCAGCAGC       c.420
 T  S  S  E  F  E  V  V  T  P  E  E  Q  N  S  P  E  S  S  S         p.140

          .      | 06  .         .         .         .         .    g.35748
 CATGCCAATGCGATG | GCGCTGGGCCCCCTGCCCCGTGAGGACGGCAACCTGATGCTGCAC    c.480
 H  A  N  A  M   | A  L  G  P  L  P  R  E  D  G  N  L  M  L  H      p.160

          .         .         .         .         .         .       g.35808
 CTGCAGCGCCTGGAGACCACGCTGAGTGTGTGTGCCGAGGAGCCGGACCACGGCCAGCTC       c.540
 L  Q  R  L  E  T  T  L  S  V  C  A  E  E  P  D  H  G  Q  L         p.180

          .         .         .         .         .         .       g.35868
 TTCACCCACCTGGGCCGCATGGCCCTGGAGTTCAACCGACTGGCATCCAAGGTGCACAAG       c.600
 F  T  H  L  G  R  M  A  L  E  F  N  R  L  A  S  K  V  H  K         p.200

          .         .        | 07.         .         .         .    g.40434
 AATGAGCAGCGCACCTCCATTCTGCAG | ACCCTGTGTGAGCAGCTTCGGAAGGAGAACGAG    c.660
 N  E  Q  R  T  S  I  L  Q   | T  L  C  E  Q  L  R  K  E  N  E      p.220

          .         .         .         .         .         .       g.40494
 GCTCTGAAGGCCAAGTTGGATAAGGGCCTGGAACAGCGGGATCAGGCTGCCGAGAGGCTG       c.720
 A  L  K  A  K  L  D  K  G  L  E  Q  R  D  Q  A  A  E  R  L         p.240

    | 08     .         .         .         .         .         .    g.42771
 CG | GGAGGAAAATTTGGAGCTCAAGAAGTTGTTGATGAGCAATGGCAACAAAGAGGGTGCG    c.780
 R  |  E  E  N  L  E  L  K  K  L  L  M  S  N  G  N  K  E  G  A      p.260

          .         .         .         .         .         .       g.42831
 TCTGGGCGGCCAGGCTCACCGAAGATGGAAGGGACAGGCAAGAAGGCAGTGGCTGGACAG       c.840
 S  G  R  P  G  S  P  K  M  E  G  T  G  K  K  A  V  A  G  Q         p.280

        | 09 .         .         .         .         .         .    g.46764
 CAGCAG | GCTAGTGTGACGGCAGGTAAGGTCCCAGAGGTGGTGGCCTTGGGCGCAGCCGAG    c.900
 Q  Q   | A  S  V  T  A  G  K  V  P  E  V  V  A  L  G  A  A  E      p.300

          .         .         .       | 10 .         .         .    g.49723
 AAGAAGGTGAAGATGCTGGAGCAGCAGCGCAGTGAG | CTGCTGGAAGTGAACAAGCAGTGG    c.960
 K  K  V  K  M  L  E  Q  Q  R  S  E   | L  L  E  V  N  K  Q  W      p.320

          .         .         .         .   | 11     .         .    g.50007
 GACCAGCATTTCCGGTCCATGAAGCAGCAGTATGAGCAGAAG | ATCACTGAGCTGCGTCAG    c.1020
 D  Q  H  F  R  S  M  K  Q  Q  Y  E  Q  K   | I  T  E  L  R  Q      p.340

          .         .         .         .         .         .       g.50067
 AAGCTGGCTGATTTGCAGAAGCAGGTGACTGACCTGGAGGCCGAGCGGGAGCAGAAGCAG       c.1080
 K  L  A  D  L  Q  K  Q  V  T  D  L  E  A  E  R  E  Q  K  Q         p.360

          .         .         .         .         .     | 12   .    g.53441
 CGTGACTTTGACCGCAAGCTCCTCCTGGCCAAGTCCAAGATTGAAATGGAGGAG | ACCGAC    c.1140
 R  D  F  D  R  K  L  L  L  A  K  S  K  I  E  M  E  E   | T  D      p.380

          .         .         .         .         .         .       g.53501
 AAGGAGCAGCTGACAGCAGAGGCCAAGGAGCTGCGCCAAAAGGTCAAGTACCTGCAGGAT       c.1200
 K  E  Q  L  T  A  E  A  K  E  L  R  Q  K  V  K  Y  L  Q  D         p.400

          .         .         .         .         .         .       g.53561
 CAGCTGAGCCCACTCACCCGACAGCGTGAGTACCAGGAAAAGGAGATCCAGCGGCTCAAC       c.1260
 Q  L  S  P  L  T  R  Q  R  E  Y  Q  E  K  E  I  Q  R  L  N         p.420

     | 13    .         .         .         .         .         .    g.55796
 AAG | GCCCTGGAGGAAGCACTGAGCATCCAAACCCCGCCATCATCTCCACCAACAGCATTT    c.1320
 K   | A  L  E  E  A  L  S  I  Q  T  P  P  S  S  P  P  T  A  F      p.440

          .         .         .         .         .         .       g.55856
 GGGAGCCCAGAAGGAGCAGGGGCCCTCCTAAGGAAACAGGAGCTGGTCACGCAGAATGAG       c.1380
 G  S  P  E  G  A  G  A  L  L  R  K  Q  E  L  V  T  Q  N  E         p.460

          .      | 14  .         .         .         .         .    g.56998
 TTGCTGAAACAGCAG | GTGAAGATCTTCGAGGAGGACTTCCAGAGGGAGCGCAGTGATCGT    c.1440
 L  L  K  Q  Q   | V  K  I  F  E  E  D  F  Q  R  E  R  S  D  R      p.480

          .         .         .         .         .         .       g.57058
 GAGCGCATGAATGAGGAGAAGGAAGAGCTGAAGAAGCAAGTGGAGAAGCTGCAGGCCCAG       c.1500
 E  R  M  N  E  E  K  E  E  L  K  K  Q  V  E  K  L  Q  A  Q         p.500

          .         .  | 15      .         .         .         .    g.57632
 GTCACCCTGTCAAATGCCCAG | CTAAAAGCATTCAAAGATGAGGAGAAGGCAAGAGAAGCC    c.1560
 V  T  L  S  N  A  Q   | L  K  A  F  K  D  E  E  K  A  R  E  A      p.520

          .         .        | 16.         .         .         .    g.58894
 CTCAGACAGCAGAAGAGGAAAGCAAAG | GCCTCAGGAGAGCGTTACCATGTGGAGCCCCAC    c.1620
 L  R  Q  Q  K  R  K  A  K   | A  S  G  E  R  Y  H  V  E  P  H      p.540

          .         .         .         .         .         .       g.58954
 CCAGAACATCTCTGCGGGGCCTACCCCTACGCCTACCCGCCCATGCCAGCCATGGTGCCA       c.1680
 P  E  H  L  C  G  A  Y  P  Y  A  Y  P  P  M  P  A  M  V  P         p.560

          .         .         .         .         .         .       g.59014
 CACCATGGCTTCGAGGACTGGTCCCAGATCCGCTACCCCCCTCCCCCCATGGCCATGGAG       c.1740
 H  H  G  F  E  D  W  S  Q  I  R  Y  P  P  P  P  M  A  M  E         p.580

          .         .         .          | 17        .         .    g.60281
 CACCCGCCCCCACTCCCCAACTCGCGCCTCTTCCATCTG | CACCAGTTTTGTCGCAGCCGG    c.1800
 H  P  P  P  L  P  N  S  R  L  F  H  L   | H  Q  F  C  R  S  R      p.600

          .         .         .         .         .         .       g.60341
 AATACACCTGGCGTCTACCCTGTGGAGGGGTTCGAAATCCAAATCAGAGCTCCCAAGTGA       c.1860
 N  T  P  G  V  Y  P  V  E  G  F  E  I  Q  I  R  A  P  K  X         p.619

          .         .         .    | 18    .         .         .    g.61940
 tggaccctcccacagccaggcctacagaaccag | agtctccaaaaaatgaccgtgaggggc    c.*60

          .         .         .         .         .         .       g.62000
 ctcagtgagaccagattgtgtcatttggctccaccttcatcttgcagagccagctgatct       c.*120

          .         .         .         .         .         .       g.62060
 cagattgccaagaaactagaagccacttgcacggtgtggccagagcctcagctggatgag       c.*180

          .         .         .         .         .         .       g.62120
 aggctgagatgggtggccagcttgtacaccagtccctgaactgagctgtttacaggactg       c.*240

          .         .         .         .         .         .       g.62180
 gggaggctccacccagaaggctttcatttgtactctgctgggagtgactgggaaaaactc       c.*300

          .         .         .         .         .         .       g.62240
 cttccctgctgctgagtggagagaggcctcatccggctttgacccaccatccgttgcaga       c.*360

          .         .         .         .         .         .       g.62300
 agcctccaggagcagcaatcctaagagtgggaggcagccaagacccccttccttcaaaac       c.*420

          .         .         .         .         .         .       g.62360
 ctcccggaagtggtttcaggccctctagttgccatgaccaatttgtgtgtgtgtttaatt       c.*480

          .         .         .         .         .         .       g.62420
 tttgcttcaagctctgtagcaggacctgccccacgcacacccctacccctctgtgaggag       c.*540

          .         .         .         .         .         .       g.62480
 ctgtgggaagtgtgggtttgtctccagaacagaagagaatgatggatattctggctctgg       c.*600

          .         .         .         .         .         .       g.62540
 ggccctctccaccaccactcacagtagccttgctgaagccatcacagatgggagaaggcc       c.*660

          .         .         .         .         .         .       g.62600
 atgccagccacgtccgccgaggggcgccagcctgaagctgccaggccctgaggttcagac       c.*720

          .         .         .         .         .         .       g.62660
 cctggaccccatagctggaggcctgtggtgccagaagcccagattagggtggctgtccat       c.*780

          .         .         .         .         .                 g.62718
 ccctggatagctatttgcacgaatcatggacataaatccaagttgaagaagatcaaca         c.*838

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The TNFAIP3 interacting protein 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.