TNNI3 interacting kinase (TNNI3K) - coding DNA reference sequence

(used for variant description)

(last modified March 9, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_015978.2 in the TNNI3K gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_032939.2, covering TNNI3K transcript NM_015978.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.42139
                                                        gcact       c.-61

 .         .         .         .         .         .                g.42199
 tgaacttggaatcttataacttgaagaactgccctggagaaaggaagaaacttataataa       c.-1

          .         .         .         . | 02       .         .    g.42869
 ATGGGAAATTATAAATCTAGACCAACCCAAACTTGTACTG | ATGAATGGAAGAAAAAAGTC    c.60
 M  G  N  Y  K  S  R  P  T  Q  T  C  T  D |   E  W  K  K  K  V      p.20

          .         .         .         .         .         .       g.42929
 AGTGAATCATATGTTATCACAATAGAAAGATTAGAAGATGACCTGCAGATCAAGGAAAAA       c.120
 S  E  S  Y  V  I  T  I  E  R  L  E  D  D  L  Q  I  K  E  K         p.40

          .         .          | 03        .         .         .    g.56237
 GAACTGACAGAACTAAGGAATATATTTGG | CTCTGATGAAGCCTTCAGTAAAGTCAATTTA    c.180
 E  L  T  E  L  R  N  I  F  G  |  S  D  E  A  F  S  K  V  N  L      p.60

          .         .         .         .         .      | 04  .    g.57424
 AATTACCGCACTGAAAATGGGCTGTCTCTACTTCATTTATGTTGCATTTGTGGAG | GCAAG    c.240
 N  Y  R  T  E  N  G  L  S  L  L  H  L  C  C  I  C  G  G |   K      p.80

          .         .         .         .         .         .       g.57484
 AAATCACATATTCGAACTCTTATGTTGAAAGGGCTCCGCCCATCTCGACTGACAAGAAAT       c.300
 K  S  H  I  R  T  L  M  L  K  G  L  R  P  S  R  L  T  R  N         p.100

          .         .         .    | 05    .         .         .    g.78372
 GGATTTACAGCCTTGCATTTAGCAGTTTACAAG | GATAATGCAGAATTGATCACTTCTCTG    c.360
 G  F  T  A  L  H  L  A  V  Y  K   | D  N  A  E  L  I  T  S  L      p.120

          .         .         .         .         .         .       g.78432
 CTTCACAGTGGAGCTGATATACAGCAGGTTGGATACGGTGGCCTCACTGCCCTCCATATT       c.420
 L  H  S  G  A  D  I  Q  Q  V  G  Y  G  G  L  T  A  L  H  I         p.140

          .         .     | 06   .         .         .         .    g.138233
 GCTACAATAGCTGGCCACCTAGAG | GCTGCTGATGTGCTGTTGCAACATGGAGCTAATGTC    c.480
 A  T  I  A  G  H  L  E   | A  A  D  V  L  L  Q  H  G  A  N  V      p.160

          .         .         .         .         .         .       g.138293
 AATATTCAAGATGCAGTTTTTTTCACTCCATTGCATATTGCAGCGTACTATGGACATGAA       c.540
 N  I  Q  D  A  V  F  F  T  P  L  H  I  A  A  Y  Y  G  H  E         p.180

     | 07    .         .         .         .         .         .    g.142815
 CAG | GTAACTCGCCTTCTTTTGAAATTTGGTGCTGATGTAAATGTAAGTGGTGAAGTTGGA    c.600
 Q   | V  T  R  L  L  L  K  F  G  A  D  V  N  V  S  G  E  V  G      p.200

          .         .         .         .         .         .       g.142875
 GATAGACCCCTCCACCTAGCATCTGCAAAAGGATTCTTGAATATTGCAAAACTCTTGATG       c.660
 D  R  P  L  H  L  A  S  A  K  G  F  L  N  I  A  K  L  L  M         p.220

          .         .   | 08     .         .         .         .    g.149627
 GAAGAAGGCAGCAAAGCAGATG | TGAATGCTCAAGATAATGAAGACCATGTCCCACTCCAT    c.720
 E  E  G  S  K  A  D  V |   N  A  Q  D  N  E  D  H  V  P  L  H      p.240

          .         .         .         .         .         .       g.149687
 TTCTGTTCTCGATTTGGACACCATGATATAGTTAAGTATCTGCTGCAAAGTGATTTGGAA       c.780
 F  C  S  R  F  G  H  H  D  I  V  K  Y  L  L  Q  S  D  L  E         p.260

          .         .         .         .        | 09.         .    g.149835
 GTTCAACCTCATGTTGTTAATATCTATGGAGATACCCCCTTACACCT | GGCATGCTACAAT    c.840
 V  Q  P  H  V  V  N  I  Y  G  D  T  P  L  H  L  |  A  C  Y  N      p.280

          .         .         .         .         .         .       g.149895
 GGCAAATTTGAAGTTGCCAAGGAAATCATCCAAATATCAGGAACAGAAAGTCTGACTAAG       c.900
 G  K  F  E  V  A  K  E  I  I  Q  I  S  G  T  E  S  L  T  K         p.300

          .         .         .   | 10     .         .         .    g.160041
 GAAAACATCTTCAGTGAAACAGCTTTTCATAG | TGCTTGTACCTATGGCAAGAGCATTGAC    c.960
 E  N  I  F  S  E  T  A  F  H  S  |  A  C  T  Y  G  K  S  I  D      p.320

          .         .         .         .         .         .       g.160101
 CTAGTCAAATTTCTTCTTGATCAGAATGTCATAAACATCAACCACCAAGGAAGGGATGGG       c.1020
 L  V  K  F  L  L  D  Q  N  V  I  N  I  N  H  Q  G  R  D  G         p.340

         | 11.         .         .         .         .         .    g.160780
 CACACTG | GATTACACTCTGCTTGCTACCACGGTCACATTCGCCTGGTTCAGTTCTTACTG    c.1080
 H  T  G |   L  H  S  A  C  Y  H  G  H  I  R  L  V  Q  F  L  L      p.360

          .         .         .         .         .         .       g.160840
 GATAATGGAGCTGATATGAATCTAGTGGCTTGTGATCCCAGCAGGTCTAGTGGTGAAAAA       c.1140
 D  N  G  A  D  M  N  L  V  A  C  D  P  S  R  S  S  G  E  K         p.380

          .         .         .        | 12.         .         .    g.174026
 GATGAGCAGACATGTTTGATGTGGGCTTATGAAAAAG | GGCATGATGCCATTGTCACACTC    c.1200
 D  E  Q  T  C  L  M  W  A  Y  E  K  G |   H  D  A  I  V  T  L      p.400

          .         .         .         .         .         .       g.174086
 CTGAAGCATTATAAGAGACCACAAGATGAATTGCCCTGTAATGAATATTCTCAGCCTGGA       c.1260
 L  K  H  Y  K  R  P  Q  D  E  L  P  C  N  E  Y  S  Q  P  G         p.420

      | 13   .         .         .         .         .         .    g.174711
 GGAG | ATGGCTCCTATGTGTCTGTTCCATCACCCTTGGGGAAGATTAAAAGCATGACAAAA    c.1320
 G  D |   G  S  Y  V  S  V  P  S  P  L  G  K  I  K  S  M  T  K      p.440

   | 14      .         .         .         .         .         .    g.175828
 G | AGAAGGCAGATATTCTCCTCCTAAGAGCTGGATTGCCTTCACATTTCCATCTTCAGCTC    c.1380
 E |   K  A  D  I  L  L  L  R  A  G  L  P  S  H  F  H  L  Q  L      p.460

          .         .         .     | 15   .         .         .    g.175980
 TCAGAAATTGAGTTCCATGAGATTATTGGCTCAG | GTTCTTTTGGGAAAGTATATAAAGGA    c.1440
 S  E  I  E  F  H  E  I  I  G  S  G |   S  F  G  K  V  Y  K  G      p.480

          .         .         .   | 16     .         .         .    g.176166
 CGATGCAGAAATAAAATAGTGGCTATAAAACG | TTATCGAGCCAATACCTACTGCTCCAAG    c.1500
 R  C  R  N  K  I  V  A  I  K  R  |  Y  R  A  N  T  Y  C  S  K      p.500

          .         .         .         .         .         .       g.176226
 TCAGATGTGGATATGTTTTGCCGAGAGGTGTCCATTCTCTGCCAGCTCAATCATCCCTGC       c.1560
 S  D  V  D  M  F  C  R  E  V  S  I  L  C  Q  L  N  H  P  C         p.520

          .         .         .         .         .         .       g.176286
 GTAATTCAGTTTGTGGGTGCTTGCTTGAATGATCCCAGCCAGTTTGCCATTGTCACTCAA       c.1620
 V  I  Q  F  V  G  A  C  L  N  D  P  S  Q  F  A  I  V  T  Q         p.540

          .         .         .         .        | 17.         .    g.177048
 TACATATCAGGGGGTTCTCTGTTCTCCCTCCTTCATGAGCAGAAGAG | GATTCTTGATTTG    c.1680
 Y  I  S  G  G  S  L  F  S  L  L  H  E  Q  K  R  |  I  L  D  L      p.560

          .         .         .         .         .         .       g.177108
 CAGTCTAAATTAATTATTGCAGTAGATGTTGCCAAAGGCATGGAGTACCTTCACAACCTG       c.1740
 Q  S  K  L  I  I  A  V  D  V  A  K  G  M  E  Y  L  H  N  L         p.580

          .         .         .   | 18     .         .         .    g.242855
 ACACAGCCAATTATACATCGTGACTTGAACAG | TCACAATATTCTTCTCTATGAGGATGGG    c.1800
 T  Q  P  I  I  H  R  D  L  N  S  |  H  N  I  L  L  Y  E  D  G      p.600

          .         .      | 19  .         .         .         .    g.243256
 CATGCTGTGGTGGCAGATTTTGGAG | AATCAAGATTTCTACAGTCTCTGGATGAAGACAAC    c.1860
 H  A  V  V  A  D  F  G  E |   S  R  F  L  Q  S  L  D  E  D  N      p.620

          .         | 20         .         .         .         .    g.246279
 ATGACAAAACAACCTGGG | AACCTCCGTTGGATGGCTCCTGAGGTGTTCACGCAGTGCACT    c.1920
 M  T  K  Q  P  G   | N  L  R  W  M  A  P  E  V  F  T  Q  C  T      p.640

          .         .         .         .         .         .       g.246339
 CGGTACACCATCAAAGCAGATGTCTTCAGCTATGCTCTGTGTCTGTGGGAAATTCTCACT       c.1980
 R  Y  T  I  K  A  D  V  F  S  Y  A  L  C  L  W  E  I  L  T         p.660

          .         .         .  | 21      .         .         .    g.270217
 GGCGAAATTCCATTCGCTCATCTCAAGCCAG | CGGCTGCGGCAGCAGACATGGCTTACCAC    c.2040
 G  E  I  P  F  A  H  L  K  P  A |   A  A  A  A  D  M  A  Y  H      p.680

          .         .         .         .         .         .       g.270277
 CACATCAGACCTCCCATTGGCTATTCCATTCCCAAGCCCATATCATCTCTGCTGATACGA       c.2100
 H  I  R  P  P  I  G  Y  S  I  P  K  P  I  S  S  L  L  I  R         p.700

          .         .  | 22      .         .         .         .    g.295975
 GGGTGGAACGCATGTCCTGAA | GGAAGACCCGAATTTTCTGAAGTTGTCATGAAGTTAGAA    c.2160
 G  W  N  A  C  P  E   | G  R  P  E  F  S  E  V  V  M  K  L  E      p.720

          .         .  | 23      .         .         .         .    g.298883
 GAGTGTCTCTGCAACATTGAG | CTGATGTCTCCTGCATCAAGTAACAGCAGTGGGTCTCTC    c.2220
 E  C  L  C  N  I  E   | L  M  S  P  A  S  S  N  S  S  G  S  L      p.740

          .         .         .         .         .         .       g.298943
 TCACCTTCTTCTTCTTCTGATTGCCTGGTGAACCGGGGAGGACCTGGCCGGAGTCATGTG       c.2280
 S  P  S  S  S  S  D  C  L  V  N  R  G  G  P  G  R  S  H  V         p.760

          .         .         .         .         .         .       g.299003
 GCAGCATTAAGAAGTCGTTTCGAATTGGAATATGCTCTAAATGCAAGGTCCTATGCTGCT       c.2340
 A  A  L  R  S  R  F  E  L  E  Y  A  L  N  A  R  S  Y  A  A         p.780

          .  | 24      .         .         .         .         .    g.347030
 TTGTCCCAAAG | TGCTGGACAATATTCCTCTCAAGGTCTGTCTTTGGAGGAGATGAAAAGA    c.2400
 L  S  Q  S  |  A  G  Q  Y  S  S  Q  G  L  S  L  E  E  M  K  R      p.800

          .         .         .  | 25      .         .         .    g.350682
 AGTCTTCAATACACACCCATTGACAAATATG | GCTATGTATCCGATCCCATGAGCTCAATG    c.2460
 S  L  Q  Y  T  P  I  D  K  Y  G |   Y  V  S  D  P  M  S  S  M      p.820

          .         .         .         .                           g.350730
 CATTTTCATTCTTGCCGAAATAGTAGCAGCTTTGAGGACAGCAGCTGA                   c.2508
 H  F  H  S  C  R  N  S  S  S  F  E  D  S  S  X                     p.835

          .         .         .         .         .         .       g.350790
 cagcattcggcgtatacctaaggagagttttttccccgaactgacagcaacgattccaac       c.*60

          .         .         .         .         .         .       g.350850
 cacggcaagctggcttccaactataacattttactctcaaaggtctccttaaattgggct       c.*120

          .         .         .         .         .         .       g.350910
 tgtttttacttgtcctatttaattccccactattagcaggctttggatttgtgcctaagg       c.*180

          .         .         .         .         .         .       g.350970
 aataatatgcaaaagaaccaagacagaatgtatatgaagaattgtttttaattttgtaaa       c.*240

          .         .         .         .         .         .       g.351030
 ttaaaaaaaaatttagatcgttacttggaaatggagcctaagtctgtggtggacagataa       c.*300

          .         .         .         .         .         .       g.351090
 taattatgttttcctgggctgaattatgtagacttgtgtttgacagctatgggtttattt       c.*360

          .         .         .         .         .         .       g.351150
 cttagaacattgttcattttcttttctcattatgttacttctagtgttcacctctgtgat       c.*420

          .         .         .                                     g.351180
 taaagattctttggtgaaatagaaaattga                                     c.*450

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The TNNI3 interacting kinase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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