transportin 2 (TNPO2) - coding DNA reference sequence

(used for variant description)

(last modified October 23, 2023)


This file was created to facilitate the description of sequence variants on transcript NM_013433.4 in the TNPO2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000019.9, covering TNPO2 transcript NM_013433.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.6756
          gagcagagcttagggggtggggcctcggagccaggccatgtcggggctcct       c.-121

 .         .         .         .         .         .                g.6816
 caagaagagggccagtgggactgctggggtcgggctggaggggatctgattgggggaagc       c.-61

 .         .         .         .         .       | 02 .             g.8019
 gtctggggactgcttggggcctgattgggggacgtcgcgaggatcgg | cttgccttgcgcc    c.-1

          .         .         .         .         .         .       g.8079
 ATGGACTGGCAGCCAGACGAGCAGGGCCTGCAGCAGGTCCTGCAGCTGCTCAAAGACTCA       c.60
 M  D  W  Q  P  D  E  Q  G  L  Q  Q  V  L  Q  L  L  K  D  S         p.20

          .         .         .          | 03        .         .    g.9681
 CAGTCGCCCAACACAGCCACTCAGCGCATCGTGCAGGAT | AAACTCAAACAACTCAATCAG    c.120
 Q  S  P  N  T  A  T  Q  R  I  V  Q  D   | K  L  K  Q  L  N  Q      p.40

          .         .         .         .         .      | 04  .    g.9823
 TTTCCTGACTTCAACAACTACCTGATTTTCGTCCTGACCAGACTCAAGTCAGAAG | ATGAG    c.180
 F  P  D  F  N  N  Y  L  I  F  V  L  T  R  L  K  S  E  D |   E      p.60

          .         .         .         .         .         .       g.9883
 CCAACGCGCTCTCTCAGTGGCCTCATCCTCAAGAACAACGTGAAGGCACACTATCAGAGC       c.240
 P  T  R  S  L  S  G  L  I  L  K  N  N  V  K  A  H  Y  Q  S         p.80

          .         .         .         .         .         .       g.9943
 TTCCCACCCCCTGTGGCAGACTTCATCAAACAGGAGTGTCTCAACAACATTGGCGATGCC       c.300
 F  P  P  P  V  A  D  F  I  K  Q  E  C  L  N  N  I  G  D  A         p.100

          .         .      | 05  .         .         .         .    g.13292
 TCCTCGCTCATCCGAGCCACCATTG | GCATTCTCATCACCACCATCGCTTCCAAGGGTGAG    c.360
 S  S  L  I  R  A  T  I  G |   I  L  I  T  T  I  A  S  K  G  E      p.120

          .         .         .         .         .         .       g.13352
 CTGCAGATGTGGCCCGAGCTGCTGCCCCAGCTCTGCAACCTGCTTAACTCGGAGGATTAC       c.420
 L  Q  M  W  P  E  L  L  P  Q  L  C  N  L  L  N  S  E  D  Y         p.140

          .   | 06     .         .         .         .         .    g.13506
 AACACTTGTGAG | GGAGCCTTTGGAGCCCTGCAGAAGATCTGTGAAGACTCATCAGAGCTT    c.480
 N  T  C  E   | G  A  F  G  A  L  Q  K  I  C  E  D  S  S  E  L      p.160

          .         .         .         .         .         .       g.13566
 CTGGACAGTGACGCCCTCAACAGGCCCCTCAACATCATGATCCCCAAGTTCCTGCAGTTC       c.540
 L  D  S  D  A  L  N  R  P  L  N  I  M  I  P  K  F  L  Q  F         p.180

          .         .       | 07 .         .         .         .    g.13706
 TTCAAGCACTGCAGTCCCAAGATCCG | GTCCCACGCCATCGCCTGCGTGAACCAGTTCATC    c.600
 F  K  H  C  S  P  K  I  R  |  S  H  A  I  A  C  V  N  Q  F  I      p.200

          .         .         .         .         | 08         .    g.13839
 ATGGACCGGGCCCAGGCGCTGATGGACAATATTGACACCTTCATCGAG | CACCTATTTGCC    c.660
 M  D  R  A  Q  A  L  M  D  N  I  D  T  F  I  E   | H  L  F  A      p.220

          .         .         .         .         .         .       g.13899
 CTGGCTGTGGATGATGACCCCGAGGTGCGGAAGAATGTGTGCCGTGCCCTGGTGATGCTT       c.720
 L  A  V  D  D  D  P  E  V  R  K  N  V  C  R  A  L  V  M  L         p.240

          .         .         .         .         .  | 09      .    g.14066
 CTGGAAGTGCGGATTGACAGGCTCATCCCCCACATGCACAGCATCATCCAG | TACATGCTG    c.780
 L  E  V  R  I  D  R  L  I  P  H  M  H  S  I  I  Q   | Y  M  L      p.260

          .         .         .         .         .         .       g.14126
 CAGAGGACCCAGGACCATGATGAGAACGTTGCCCTTGAGGCCTGTGAGTTCTGGCTGACG       c.840
 Q  R  T  Q  D  H  D  E  N  V  A  L  E  A  C  E  F  W  L  T         p.280

          .         .         .         .         . | 10       .    g.17393
 CTGGCCGAGCAGCCCATCTGCAAGGAAGTCCTGGCCTCCCATCTGGTCCA | GTTGATCCCC    c.900
 L  A  E  Q  P  I  C  K  E  V  L  A  S  H  L  V  Q  |  L  I  P      p.300

          .         .         .         .         .  | 11      .    g.17544
 ATCTTGGTGAATGGGATGAAGTACTCGGAAATTGACATCATCCTGCTCAAG | GGGGATGTG    c.960
 I  L  V  N  G  M  K  Y  S  E  I  D  I  I  L  L  K   | G  D  V      p.320

          .         .         .         .         .         .       g.17604
 GAGGAGGATGAGGCTGTCCCCGACAGTGAGCAGGACATCAAGCCACGCTTCCACAAGTCA       c.1020
 E  E  D  E  A  V  P  D  S  E  Q  D  I  K  P  R  F  H  K  S         p.340

          .         .         .         .         .         .       g.17664
 CGCACGGTCACACTGCCCCACGAGGCTGAGCGGCCTGATGGCTCCGAGGACGCGGAGGAT       c.1080
 R  T  V  T  L  P  H  E  A  E  R  P  D  G  S  E  D  A  E  D         p.360

          .         .         .        | 12.         .         .    g.18246
 GACGATGATGATGATGCTCTGTCCGACTGGAATTTGA | GGAAGTGCTCAGCGGCTGCACTG    c.1140
 D  D  D  D  D  A  L  S  D  W  N  L  R |   K  C  S  A  A  A  L      p.380

          .         .         .         .         .         .       g.18306
 GACGTCCTCGCCAATGTCTTCCGGGAGGAACTGCTGCCCCACCTACTCCCACTACTCAAA       c.1200
 D  V  L  A  N  V  F  R  E  E  L  L  P  H  L  L  P  L  L  K         p.400

          .         .         .         .         .         .       g.18366
 GGCCTCCTCTTCCACCCCGAGTGGGTGGTCAAGGAGTCGGGCATCCTGGTGCTGGGCGCC       c.1260
 G  L  L  F  H  P  E  W  V  V  K  E  S  G  I  L  V  L  G  A         p.420

          . | 13       .         .         .         .         .    g.22251
 ATTGCTGAGG | GCTGCATGCAGGGCATGGTGCCCTACCTGCCTGAGCTGATCCCGCACCTG    c.1320
 I  A  E  G |   C  M  Q  G  M  V  P  Y  L  P  E  L  I  P  H  L      p.440

          .         .         .         .         .         .       g.22311
 ATCCAGTGCCTGTCGGATAAGAAGGCCTTGGTCCGCTCCATCGCCTGCTGGACGCTGAGC       c.1380
 I  Q  C  L  S  D  K  K  A  L  V  R  S  I  A  C  W  T  L  S         p.460

          .         .         .         .         .         .       g.22371
 CGCTATGCCCACTGGGTGGTCAGCCAGCCACCCGACATGCACCTCAAGCCCCTGATGACA       c.1440
 R  Y  A  H  W  V  V  S  Q  P  P  D  M  H  L  K  P  L  M  T         p.480

          .         .         .         .         .       | 14 .    g.22633
 GAGCTGCTCAAACGCATCCTGGATGGCAACAAGAGGGTACAGGAGGCGGCCTGCAG | TGCT    c.1500
 E  L  L  K  R  I  L  D  G  N  K  R  V  Q  E  A  A  C  S  |  A      p.500

          .         .         .         .         .         .       g.22693
 TTTGCCACCCTGGAGGAAGAGGCCTGCACGGAGCTGGTGCCCTACCTCAGCTACATCCTG       c.1560
 F  A  T  L  E  E  E  A  C  T  E  L  V  P  Y  L  S  Y  I  L         p.520

          .         .         .         .         .         .       g.22753
 GACACCCTTGTCTTTGCCTTTGGGAAATACCAGCACAAGAACCTGCTCATCCTCTATGAC       c.1620
 D  T  L  V  F  A  F  G  K  Y  Q  H  K  N  L  L  I  L  Y  D         p.540

          .         .         .         .         | 15         .    g.23240
 GCCATTGGCACCCTGGCCGACTCTGTAGGCCACCACCTCAACCAGCCG | GAATACATCCAG    c.1680
 A  I  G  T  L  A  D  S  V  G  H  H  L  N  Q  P   | E  Y  I  Q      p.560

          .         .         .         .         .         .       g.23300
 AAGCTGATGCCCCCACTGATCCAGAAGTGGAATGAGCTCAAGGACGAAGACAAGGACCTC       c.1740
 K  L  M  P  P  L  I  Q  K  W  N  E  L  K  D  E  D  K  D  L         p.580

          .      | 16  .         .         .         .         .    g.23442
 TTCCCCCTGCTGGAG | TGTCTGTCATCGGTGGCCACCGCCCTGCAGAGTGGCTTCCTGCCT    c.1800
 F  P  L  L  E   | C  L  S  S  V  A  T  A  L  Q  S  G  F  L  P      p.600

          .         .         .         .         .         .       g.23502
 TACTGTGAGCCCGTCTACCAGCGCTGTGTCACCCTGGTGCAGAAGACACTGGCTCAGGCC       c.1860
 Y  C  E  P  V  Y  Q  R  C  V  T  L  V  Q  K  T  L  A  Q  A         p.620

     | 17    .         .         .         .         .         .    g.23655
 ATG | ATGTACACCCAGCACCCTGAGCAGTATGAGGCTCCCGACAAGGACTTCATGATCGTA    c.1920
 M   | M  Y  T  Q  H  P  E  Q  Y  E  A  P  D  K  D  F  M  I  V      p.640

          .         .         .         .         .         .       g.23715
 GCACTGGATCTGCTCAGCGGCCTGGCCGAGGGCCTGGGTGGTCACGTGGAGCAGCTGGTG       c.1980
 A  L  D  L  L  S  G  L  A  E  G  L  G  G  H  V  E  Q  L  V         p.660

          .         .         .         .   | 18     .         .    g.25213
 GCCCGCAGCAACATCATGACATTGCTGTTCCAGTGCATGCAG | GACTCGATGCCTGAGGTC    c.2040
 A  R  S  N  I  M  T  L  L  F  Q  C  M  Q   | D  S  M  P  E  V      p.680

          .         .         .         .         .         .       g.25273
 CGGCAGAGCTCCTTTGCCCTCCTGGGAGACCTCACCAAAGCCTGCTTCATCCATGTCAAG       c.2100
 R  Q  S  S  F  A  L  L  G  D  L  T  K  A  C  F  I  H  V  K         p.700

          . | 19       .         .         .         .         .    g.25520
 CCCTGTATCG | CCGAGTTCATGCCCATTCTGGGCACCAACCTGAACCCAGAGTTCATCTCC    c.2160
 P  C  I  A |   E  F  M  P  I  L  G  T  N  L  N  P  E  F  I  S      p.720

          .         .         .         .          | 20        .    g.26089
 GTCTGCAACAACGCCACCTGGGCCATTGGTGAAATCTGCATGCAGATGG | GGGCAGAGATG    c.2220
 V  C  N  N  A  T  W  A  I  G  E  I  C  M  Q  M  G |   A  E  M      p.740

          .         .         .         .         .         .       g.26149
 CAGCCTTATGTGCAGATGGTCCTCAACAACCTGGTGGAAATCATTAACCGACCCAACACA       c.2280
 Q  P  Y  V  Q  M  V  L  N  N  L  V  E  I  I  N  R  P  N  T         p.760

          .         .      | 21  .         .         .         .    g.26884
 CCCAAGACACTGCTGGAAAACACAG | CCATCACCATCGGCCGCTTGGGCTACGTGTGCCCC    c.2340
 P  K  T  L  L  E  N  T  A |   I  T  I  G  R  L  G  Y  V  C  P      p.780

          .         .         .         .  | 22      .         .    g.27164
 CAGGAGGTGGCACCCATGCTGCAGCAGTTCATCCGGCCTTG | GTGCACGTCCCTCAGGAAC    c.2400
 Q  E  V  A  P  M  L  Q  Q  F  I  R  P  W  |  C  T  S  L  R  N      p.800

          .         .         .         .         .         .       g.27224
 ATCAGGGACAACGAGGAGAAGGACTCAGCCTTCCGCGGCATCTGCATGATGATCGGTGTC       c.2460
 I  R  D  N  E  E  K  D  S  A  F  R  G  I  C  M  M  I  G  V         p.820

          .         .  | 23      .         .         .         .    g.27363
 AACCCGGGGGGCGTTGTGCAG | GACTTTATTTTCTTCTGCGATGCTGTAGCCTCCTGGGTG    c.2520
 N  P  G  G  V  V  Q   | D  F  I  F  F  C  D  A  V  A  S  W  V      p.840

          .         .         .       | 24 .         .         .    g.27567
 AGCCCGAAGGATGACCTTCGGGACATGTTTTATAAG | ATTCTCCACGGCTTCAAAGACCAA    c.2580
 S  P  K  D  D  L  R  D  M  F  Y  K   | I  L  H  G  F  K  D  Q      p.860

          .         .         .         .         .         .       g.27627
 GTTGGGGAAGATAACTGGCAGCAGTTCTCTGAGCAATTCCCGCCGCTGCTCAAGGAGAGG       c.2640
 V  G  E  D  N  W  Q  Q  F  S  E  Q  F  P  P  L  L  K  E  R         p.880

          .         .                                           g.27651
 CTGGCGGCTTTCTATGGGGTCTAG |                                        c.2665
 L  A  A  F  Y  G  V  X                                          p.887

          .         . | 25       .         .         .         .    g.27793
 gtgatcatggagactgccag | gtttctgtctgcgtcgtcgtcggagggattactggggagt    c.*60

          .         .         .         .         .         .       g.27853
 gcgctgcatccggaagtcgctgtgccctggttgaggggggttagggaggagtgagtggga       c.*120

          .         .         .         .         .         .       g.27913
 ctcaaatccagatgccttccccgtccgtccgtccgtccgtccatccgtccacttgccctc       c.*180

          .         .         .         .         .         .       g.27973
 ctggcaggtgggtggggccaccatgctcatcctacaaacggggaggtgggggggacttct       c.*240

          .         .         .         .         .         .       g.28033
 ggtgggcaagggcccctgggctctaatagggtcatctctggcagcccacttgggccagct       c.*300

          .         .         .         .         .         .       g.28093
 acgtgggagggaggaattacacagctgaccgaatccggcttcggatgaggtgagggagga       c.*360

          .         .         .         .         .         .       g.28153
 gcaggtcaggaggggggccctcgtagggacgcgtacactcacacggacacacatggccac       c.*420

          .         .         .         .         .         .       g.28213
 acgcatgtgcgggtgccataaccggcgaggctgggccagccgctccaccatttccccgac       c.*480

          .         .         .         .         .         .       g.28273
 tgcatggagacagtagaattagtgaacccctgagttaacccgtaaggccttccgtgtaac       c.*540

          .         .         .         .         .         .       g.28333
 ctgcatctagagtttaagaagcttctgctgttttgccggaattggcggtgactggggagg       c.*600

          .         .         .         .         .         .       g.28393
 gctgggtgggtggggggcctcaggcgggatctcggggcggggggaggaggatggtgacct       c.*660

          .         .         .         .         .         .       g.28453
 tgggagtcgccctgtcagcacgcacatgcttgggacccactccacacactccctgccagc       c.*720

          .         .         .         .         .         .       g.28513
 tttgttgcagcctcagctggtggtgtctccgtccttatcctagcctagctcgcagggtga       c.*780

          .         .         .         .         .         .       g.28573
 gaaccactggagtggctggggctggccagaggtcaccgtttctccttcctgtgtgctcca       c.*840

          .         .         .         .         .         .       g.28633
 gtggcttttgaagacactgggttgggacctttttcctgaagagagctgggtgtagccaga       c.*900

          .         .         .         .         .         .       g.28693
 gctactggcacctaccccgagcatctctctctgtaagcagcttcaggggcagtccgtttc       c.*960

          .         .         .         .         .         .       g.28753
 tctgtgcttctgaaacccccttctcacgtttcaggccccagttttaactcaaggcctggg       c.*1020

          .         .         .         .         .         .       g.28813
 gcaggggcgtttaattgatgatgacagaggacacaggtttttgccagcaaaaaggaaaac       c.*1080

          .         .         .         .         .         .       g.28873
 caaggcttggtggaagggaaaggtggtgtgtcccctgttccctattccatctccctggga       c.*1140

          .         .         .         .         .         .       g.28933
 cttcctgctcatcatagtacccagtgagcccagagatcctactagactgggtcagcaatt       c.*1200

          .         .         .         .         .         .       g.28993
 ctagagaaccttccggaatagtctgggaacatggtcaaggtggaaggggctcccctagag       c.*1260

          .         .         .         .         .         .       g.29053
 agggtgggggtgtagttacttcccagttggccagaaaactgggccttgcagaccccctta       c.*1320

          .         .         .         .         .         .       g.29113
 gcattttttccctttttttccttccctgctttctacttctttggggagccccttgtgttt       c.*1380

          .         .         .         .         .         .       g.29173
 tggagtctgactggagtctcgcatcctggggcctgctccatccatccctcctgggcgcca       c.*1440

          .         .         .         .         .         .       g.29233
 gaccctccatccaagccctgtgtctttccatagtcagggtcaggccctgcatctattcca       c.*1500

          .         .         .         .         .         .       g.29293
 aggggcactcagtacacattccataaattagctgggtgtccctgcacgcccaccccatga       c.*1560

          .         .         .         .         .         .       g.29353
 aactcgagcaggtctctggaagccatttgttaaaaaaaaaaaaaaaagttttaaaaatac       c.*1620

          .         .         .         .         .         .       g.29413
 cttttaattttctggtaattccagttctttgaagcatcctctgctgggtcttggggtgtg       c.*1680

          .         .         .         .         .         .       g.29473
 tggatggattggctgtctgatgggattggtaacccctcgctactcaagatggggggatac       c.*1740

          .         .         .         .         .         .       g.29533
 aaacaccttcagggaaggggagcctggttcttctcgttttccttttttttttttttttta       c.*1800

          .         .         .         .         .         .       g.29593
 aaaaaaaactatttaattttttaatttatttttggttgttttttgcacaatgaagtttca       c.*1860

          .         .         .         .         .         .       g.29653
 gcttctcaaccttctcccctacccagggctgtggacccagactggccttgagccacagtc       c.*1920

          .         .         .         .         .         .       g.29713
 cctctttccctcctcaccctcttccccctgcgggctcccgggtctgtccatttgttactg       c.*1980

          .         .         .         .         .         .       g.29773
 tgctgtgctggggattggcgccgaggtggcgtgagattccacttgtgtagaactttgttg       c.*2040

          .         .         .                                     g.29803
 agtaaagatcagtttcttgtgaactcctta                                     c.*2070

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Transportin 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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