TP53 regulating kinase (TP53RK) - coding DNA reference sequence

(used for variant description)

(last modified February 6, 2023)

This file was created to facilitate the description of sequence variants on transcript NM_033550.3 in the TP53RK gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000020.10, covering TP53RK transcript NM_033550.3.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                     .         .         .         .                g.5043
                  ggggccacaagagcccttcctgcagggaacctcaggcttcaga       c.-181

 .         .         .         .         .         .                g.5103
 gagccgaaaagttgggaggcgtaaccacttacaggccggaagtgtccggggtggacgcat       c.-121

 .         .         .         .         .         .                g.5163
 tcgggtagccgaagaagtcccaggattgccgaagaagtcccaggatttccgaagcgagcc       c.-61

 .         .         .         .         .         .                g.5223
 gaagcatcgcgacagttttcagagacagctgatcggttggagctgttgcgccgagcagtc       c.-1

          .         .         .         .         .         .       g.5283
 ATGGCGGCGGCCAGAGCTACTACGCCGGCCGATGGCGAGGAGCCCGCCCCGGAGGCTGAG       c.60
 M  A  A  A  R  A  T  T  P  A  D  G  E  E  P  A  P  E  A  E         p.20

          .         .         .         .         .         .       g.5343
 GCTCTGGCCGCAGCCCGGGAGCGGAGCAGCCGCTTCTTGAGCGGCCTGGAGCTGGTGAAG       c.120
 A  L  A  A  A  R  E  R  S  S  R  F  L  S  G  L  E  L  V  K         p.40

          .         .         .         .         .         .       g.5403
 CAGGGTGCCGAGGCGCGCGTGTTCCGTGGCCGCTTCCAGGGCCGCGCGGCGGTGATCAAG       c.180
 Q  G  A  E  A  R  V  F  R  G  R  F  Q  G  R  A  A  V  I  K         p.60

          .         .         .         .         .         .       g.5463
 CACCGCTTCCCCAAGGGCTACCGGCACCCGGCGCTGGAGGCGCGGCTTGGCAGACGGCGG       c.240
 H  R  F  P  K  G  Y  R  H  P  A  L  E  A  R  L  G  R  R  R         p.80

          .         .         .         .    | 02    .         .    g.7423
 ACGGTGCAGGAGGCCCGGGCGCTCCTCCGCTGTCGCCGCGCTG | GAATATCTGCCCCAGTT    c.300
 T  V  Q  E  A  R  A  L  L  R  C  R  R  A  G |   I  S  A  P  V      p.100

          .         .         .         .         .         .       g.7483
 GTCTTTTTTGTGGACTATGCTTCCAACTGCTTATATATGGAAGAAATTGAAGGCTCAGTG       c.360
 V  F  F  V  D  Y  A  S  N  C  L  Y  M  E  E  I  E  G  S  V         p.120

          .         .         .         .         .         .       g.7543
 ACTGTTCGAGATTATATTCAGTCCACTATGGAGACTGAAAAAACTCCCCAGGGTCTCTCC       c.420
 T  V  R  D  Y  I  Q  S  T  M  E  T  E  K  T  P  Q  G  L  S         p.140

          .         .         .         .         .         .       g.7603
 AACTTAGCCAAGACAATTGGGCAGGTTTTGGCTCGAATGCACGATGAAGACCTCATTCAT       c.480
 N  L  A  K  T  I  G  Q  V  L  A  R  M  H  D  E  D  L  I  H         p.160

          .         .         .         .         .         .       g.7663
 GGTGATCTCACCACCTCCAACATGCTCCTGAAACCCCCCCTGGAACAGCTGAACATTGTG       c.540
 G  D  L  T  T  S  N  M  L  L  K  P  P  L  E  Q  L  N  I  V         p.180

          .         .         .         .         .         .       g.7723
 CTCATAGACTTTGGGCTGAGTTTCATTTCAGCACTTCCAGAGGATAAGGGAGTAGACCTC       c.600
 L  I  D  F  G  L  S  F  I  S  A  L  P  E  D  K  G  V  D  L         p.200

          .         .         .         .         .         .       g.7783
 TATGTCCTGGAGAAGGCCTTCCTCAGTACCCATCCCAACACTGAAACTGTGTTTGAAGCC       c.660
 Y  V  L  E  K  A  F  L  S  T  H  P  N  T  E  T  V  F  E  A         p.220

          .         .         .         .         .         .       g.7843
 TTTCTGAAGAGCTACTCCACCTCCTCCAAAAAGGCCAGGCCAGTGCTAAAAAAATTAGAT       c.720
 F  L  K  S  Y  S  T  S  S  K  K  A  R  P  V  L  K  K  L  D         p.240

          .         .         .         .                           g.7885
 GAAGTGCGCCTGAGAGGAAGAAAGAGGTCCATGGTTGGGTAG                         c.762
 E  V  R  L  R  G  R  K  R  S  M  V  G  X                           p.253

          .         .         .         .         .         .       g.7945
 aagaatgtgtatgacaaccacacacagtgaagctcttttttcaaagtaaatttgaagaaa       c.*60

          .         .         .         .         .         .       g.8005
 tgctacaagtatgagatgagatctaagtaaaggtgttaagatatttttaagtggtatgtg       c.*120

          .         .         .         .         .         .       g.8065
 atcgtgtcattatcatctgcacttcactcaagagcttactatgtgtctaagtcatgttct       c.*180

          .         .         .         .         .         .       g.8125
 aggcagaattgggtatttaaagtaaattgaggacaggcttctcccagattgtgacatgta       c.*240

          .         .         .         .         .         .       g.8185
 tatctcagatacatgggtgtggcattgaaccacataatgagaacattattctctttttag       c.*300

          .         .         .         .         .         .       g.8245
 tccttgtgagacaaggatgaagtctcagttgctgatactcgctgagcttactggccctct       c.*360

          .         .         .         .         .         .       g.8305
 aacccagtgtttttttttgttgttgttgtgtacatgttatatttattttgaaaccagttt       c.*420

          .         .         .         .         .         .       g.8365
 aatgggatacaaccagcattttaaaaaatgaaatagaatacagcatggaaaatatcagtg       c.*480

          .         .         .         .         .         .       g.8425
 tattgttttatgaaactttcacgtgtatatatagaccaaggatatgtgctgagttttgat       c.*540

          .         .         .         .         .         .       g.8485
 gtcaaatatatttctctttcagggtcatgatcaaaaaatgaaaagtctgcttaactccaa       c.*600

          .         .         .         .         .         .       g.8545
 tttctcttttaaaaaagcagacttacagctttcaggcaactgaaattcatgttaacatgt       c.*660

          .         .         .         .         .         .       g.8605
 ttttatttttattgctttgtatttttgtggttaccttctaagacaagtgattgatctaaa       c.*720

          .         .         .         .         .         .       g.8665
 gttccttttaagtttataccgctaaacaaactgagttgatttctatcacaggcagtaagt       c.*780

          .         .         .         .         .         .       g.8725
 aggtagagcaaaaatggtgaagtgacttgtgaagactgaagtttgatgaagtctggttta       c.*840

          .         .         .         .         .         .       g.8785
 aggcacaggtaaactgagtgtggatgcaaaagtaccaggagctagcttttaaccttgccc       c.*900

          .         .         .         .         .         .       g.8845
 agcctcagtttcttttcttagaagaagctatgtttgggtgggaagggaagagagggataa       c.*960

          .         .         .         .         .         .       g.8905
 gaaaatacctttcttccttgtaaactccaatcaacaaacatattttgagtgccttttgtg       c.*1020

          .         .         .         .         .         .       g.8965
 ttccttggcaccctgttgggtattgggtacttggcaccctgttgggtattgggtacaatg       c.*1080

          .         .         .         .         .         .       g.9025
 gtgagccagacagacacagcgcctgtccttttgtaagaatatttatttttataaaaaagt       c.*1140

          .         .         .         .         .         .       g.9085
 ataaagtatacagtgggatgttttgatatacattatgaaatgattgctacagctgagcta       c.*1200

          .         .         .         .         .         .       g.9145
 attaacacccatcacctcacatagttactgtcttgtttcttaatatggacatttgcagct       c.*1260

          .         .         .         .         .         .       g.9205
 atgaatttccctctgcacactgttgtcatcacacactctcagttttggtattttgtgttt       c.*1320

          .         .         .         .         .         .       g.9265
 ttgttttcattcatctcaaagtattttctaatttcccttgtgatttcttctttgacccct       c.*1380

          .         .         .         .         .         .       g.9325
 tgattgtttagaaatctgttaatttccacacatttgtaaatgttccaatttttcttttgt       c.*1440

          .         .         .         .         .         .       g.9385
 tattgccagcttcattccattgtgttcagagatgatacagtcagtgcctgttcttatgaa       c.*1500

          .         .         .         .         .         .       g.9445
 gcaaacattctataatagtaggaccagtaccctgtctgtttcattcaccacagtcagcat       c.*1560

          .         .         .         .         .         .       g.9505
 gccccaagtgcccagcatggggcggatggccaggaatgagtgaaaacttcccttcctggg       c.*1620

          .         .         .         .         .         .       g.9565
 tagttgtgactagtagagaggaaaaataatataattgcctgcttactgcatgccaggcat       c.*1680

          .         .         .         .         .         .       g.9625
 tgggctgggaatttttatattggatctaaaataactcttaagttaggcattatccccatt       c.*1740

          .         .         .         .         .         .       g.9685
 ttatagatggagaaactggccccaaaaggtgggaacttgtccaagacgtcacaggtagca       c.*1800

          .         .         .         .         .         .       g.9745
 agaggtacttttacctggctccaaatctgtgttctttccactgacaaatgagatatggga       c.*1860

          .         .         .         .         .         .       g.9805
 tatggtgcatctttacagtactataataagtattggcgtataacattattttcaaggaac       c.*1920

          .         .         .         .         .         .       g.9865
 tccaagggccacaggagctgacaggtttttcaattaatattcccaacatgaatgagatgc       c.*1980

          .         .         .         .         .         .       g.9925
 ctcattcctcagtttcctcacgtgtactataaggctagtacctgctttgttggggtatgg       c.*2040

          .         .         .         .         .         .       g.9985
 ttggctcgtgtgcattaagtcaacaaatccctagttgatagggtttggctgtgtccccat       c.*2100

          .         .         .         .         .         .       g.10045
 ccaaatctcatcttgaattgttcccgtaatccccacgtgacatgggagggacccagtggg       c.*2160

          .         .         .         .         .         .       g.10105
 aggtaatttaatcctcggggcggctacctccgtgctgttctcgtgatagcgagtgagttc       c.*2220

          .         .         .         .         .         .       g.10165
 tcacgagatctgatggttttataaggggcttttccctcttgttcggcacttcctgctgcc       c.*2280

          .         .         .         .         .         .       g.10225
 acgtggagaagggtgtgtttgtttccccatctgccatgattataagttttctgaggcatc       c.*2340

          .         .         .         .                           g.10273
 cccagccatgctgaactgtgagttattaaacttttcctttataaatta                   c.*2388

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The TP53 regulating kinase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.