tumor protein p63 (TP63) - coding DNA reference sequence

(used for variant description)

(last modified July 1, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_003722.4 in the TP63 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_007550.1, covering TP63 transcript NM_003722.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5029
                                cccggctttatatctatatatacacaggt       c.-61

 .         .         .         .         .         .                g.5089
 atatgtgtatattttatataattgttctccgttcgttgatatcaaagacagttgaaggaa       c.-1

          .         .         .         .         .         .       g.5149
 ATGAATTTTGAAACTTCACGGTGTGCCACCCTACAGTACTGCCCTGACCCTTACATCCAG       c.60
 M  N  F  E  T  S  R  C  A  T  L  Q  Y  C  P  D  P  Y  I  Q         p.20

    | 02     .         .         .         .         .         .    g.111371
 CG | TTTCGTAGAAACCCCAGCTCATTTCTCTTGGAAAGAAAGTTATTACCGATCCACCATG    c.120
 R  |  F  V  E  T  P  A  H  F  S  W  K  E  S  Y  Y  R  S  T  M      p.40

          .         .         .         .         .         .       g.111431
 TCCCAGAGCACACAGACAAATGAATTCCTCAGTCCAGAGGTTTTCCAGCATATCTGGGAT       c.180
 S  Q  S  T  Q  T  N  E  F  L  S  P  E  V  F  Q  H  I  W  D         p.60

          .  | 03      .         .         .         .         .    g.112264
 TTTCTGGAACA | GCCTATATGTTCAGTTCAGCCCATTGACTTGAACTTTGTGGATGAACCA    c.240
 F  L  E  Q  |  P  I  C  S  V  Q  P  I  D  L  N  F  V  D  E  P      p.80

          .         .         .         .         .         .       g.112324
 TCAGAAGATGGTGCGACAAACAAGATTGAGATTAGCATGGACTGTATCCGCATGCAGGAC       c.300
 S  E  D  G  A  T  N  K  I  E  I  S  M  D  C  I  R  M  Q  D         p.100

          .         .     | 04   .         .         .         .    g.181881
 TCGGACCTGAGTGACCCCATGTGG | CCACAGTACACGAACCTGGGGCTCCTGAACAGCATG    c.360
 S  D  L  S  D  P  M  W   | P  Q  Y  T  N  L  G  L  L  N  S  M      p.120

          .         .         .         .         .         .       g.181941
 GACCAGCAGATTCAGAACGGCTCCTCGTCCACCAGTCCCTATAACACAGACCACGCGCAG       c.420
 D  Q  Q  I  Q  N  G  S  S  S  T  S  P  Y  N  T  D  H  A  Q         p.140

          .         .         .         .         .         .       g.182001
 AACAGCGTCACGGCGCCCTCGCCCTACGCACAGCCCAGCTCCACCTTCGATGCTCTCTCT       c.480
 N  S  V  T  A  P  S  P  Y  A  Q  P  S  S  T  F  D  A  L  S         p.160

          .         .         .         .         .         .       g.182061
 CCATCACCCGCCATCCCCTCCAACACCGACTACCCAGGCCCGCACAGTTTCGACGTGTCC       c.540
 P  S  P  A  I  P  S  N  T  D  Y  P  G  P  H  S  F  D  V  S         p.180

          .         .         .          | 05        .         .    g.237826
 TTCCAGCAGTCGAGCACCGCCAAGTCGGCCACCTGGACG | TATTCCACTGAACTGAAGAAA    c.600
 F  Q  Q  S  S  T  A  K  S  A  T  W  T   | Y  S  T  E  L  K  K      p.200

          .         .         .         .         .         .       g.237886
 CTCTACTGCCAAATTGCAAAGACATGCCCCATCCAGATCAAGGTGATGACCCCACCTCCT       c.660
 L  Y  C  Q  I  A  K  T  C  P  I  Q  I  K  V  M  T  P  P  P         p.220

          .         .         .         .         .         .       g.237946
 CAGGGAGCTGTTATCCGCGCCATGCCTGTCTACAAAAAAGCTGAGCACGTCACGGAGGTG       c.720
 Q  G  A  V  I  R  A  M  P  V  Y  K  K  A  E  H  V  T  E  V         p.240

          .         .         .         .       | 06 .         .    g.240269
 GTGAAGCGGTGCCCCAACCATGAGCTGAGCCGTGAATTCAACGAGG | GACAGATTGCCCCT    c.780
 V  K  R  C  P  N  H  E  L  S  R  E  F  N  E  G |   Q  I  A  P      p.260

          .         .         .         .         .         .       g.240329
 CCTAGTCATTTGATTCGAGTAGAGGGGAACAGCCATGCCCAGTATGTAGAAGATCCCATC       c.840
 P  S  H  L  I  R  V  E  G  N  S  H  A  Q  Y  V  E  D  P  I         p.280

          .         .         .         .   | 07     .         .    g.241424
 ACAGGAAGACAGAGTGTGCTGGTACCTTATGAGCCACCCCAG | GTTGGCACTGAATTCACG    c.900
 T  G  R  Q  S  V  L  V  P  Y  E  P  P  Q   | V  G  T  E  F  T      p.300

          .         .         .         .         .         .       g.241484
 ACAGTCTTGTACAATTTCATGTGTAACAGCAGTTGTGTTGGAGGGATGAACCGCCGTCCA       c.960
 T  V  L  Y  N  F  M  C  N  S  S  C  V  G  G  M  N  R  R  P         p.320

          .         .         .   | 08     .         .         .    g.242181
 ATTTTAATCATTGTTACTCTGGAAACCAGAGA | TGGGCAAGTCCTGGGCCGACGCTGCTTT    c.1020
 I  L  I  I  V  T  L  E  T  R  D  |  G  Q  V  L  G  R  R  C  F      p.340

          .         .         .         .         .         .       g.242241
 GAGGCCCGGATCTGTGCTTGCCCAGGAAGAGACAGGAAGGCGGATGAAGATAGCATCAGA       c.1080
 E  A  R  I  C  A  C  P  G  R  D  R  K  A  D  E  D  S  I  R         p.360

          .         .         .         .          | 09        .    g.242908
 AAGCAGCAAGTTTCGGACAGTACAAAGAACGGTGATGGTACGAAGCGCC | CGTTTCGTCAG    c.1140
 K  Q  Q  V  S  D  S  T  K  N  G  D  G  T  K  R  P |   F  R  Q      p.380

          .         .         .         .         .         .       g.242968
 AACACACATGGTATCCAGATGACATCCATCAAGAAACGAAGATCCCCAGATGATGAACTG       c.1200
 N  T  H  G  I  Q  M  T  S  I  K  K  R  R  S  P  D  D  E  L         p.400

          .   | 10     .         .         .         .         .    g.246480
 TTATACTTACCA | GTGAGGGGCCGTGAGACTTATGAAATGCTGTTGAAGATCAAAGAGTCC    c.1260
 L  Y  L  P   | V  R  G  R  E  T  Y  E  M  L  L  K  I  K  E  S      p.420

          .         .         .         .         .         .       g.246540
 CTGGAACTCATGCAGTACCTTCCTCAGCACACAATTGAAACGTACAGGCAACAGCAACAG       c.1320
 L  E  L  M  Q  Y  L  P  Q  H  T  I  E  T  Y  R  Q  Q  Q  Q         p.440

          .         .          | 11        .         .         .    g.259998
 CAGCAGCACCAGCACTTACTTCAGAAACA | GACCTCAATACAGTCTCCATCTTCATATGGT    c.1380
 Q  Q  H  Q  H  L  L  Q  K  Q  |  T  S  I  Q  S  P  S  S  Y  G      p.460

          .         .         .         .         .         .       g.260058
 AACAGCTCCCCACCTCTGAACAAAATGAACAGCATGAACAAGCTGCCTTCTGTGAGCCAG       c.1440
 N  S  S  P  P  L  N  K  M  N  S  M  N  K  L  P  S  V  S  Q         p.480

          .         .         .         .         .         .       g.260118
 CTTATCAACCCTCAGCAGCGCAACGCCCTCACTCCTACAACCATTCCTGATGGCATGGGA       c.1500
 L  I  N  P  Q  Q  R  N  A  L  T  P  T  T  I  P  D  G  M  G         p.500

         | 12.         .         .         .         .         .    g.262966
 GCCAACA | TTCCCATGATGGGCACCCACATGCCAATGGCTGGAGACATGAATGGACTCAGC    c.1560
 A  N  I |   P  M  M  G  T  H  M  P  M  A  G  D  M  N  G  L  S      p.520

          .         .         .         .         .         .       g.263026
 CCCACCCAGGCACTCCCTCCCCCACTCTCCATGCCATCCACCTCCCACTGCACACCCCCA       c.1620
 P  T  Q  A  L  P  P  P  L  S  M  P  S  T  S  H  C  T  P  P         p.540

          .         .         .   | 13     .         .         .    g.264390
 CCTCCGTATCCCACAGATTGCAGCATTGTCAG | TTTCTTAGCGAGGTTGGGCTGTTCATCA    c.1680
 P  P  Y  P  T  D  C  S  I  V  S  |  F  L  A  R  L  G  C  S  S      p.560

          .         .         .         .         .         .       g.264450
 TGTCTGGACTATTTCACGACCCAGGGGCTGACCACCATCTATCAGATTGAGCATTACTCC       c.1740
 C  L  D  Y  F  T  T  Q  G  L  T  T  I  Y  Q  I  E  H  Y  S         p.580

        | 14 .         .         .         .         .         .    g.267833
 ATGGAT | GATCTGGCAAGTCTGAAAATCCCTGAGCAATTTCGACATGCGATCTGGAAGGGC    c.1800
 M  D   | D  L  A  S  L  K  I  P  E  Q  F  R  H  A  I  W  K  G      p.600

          .         .         .         .         .         .       g.267893
 ATCCTGGACCACCGGCAGCTCCACGAATTCTCCTCCCCTTCTCATCTCCTGCGGACCCCA       c.1860
 I  L  D  H  R  Q  L  H  E  F  S  S  P  S  H  L  L  R  T  P         p.620

          .         .         .         .         .         .       g.267953
 AGCAGTGCCTCTACAGTCAGTGTGGGCTCCAGTGAGACCCGGGGTGAGCGTGTTATTGAT       c.1920
 S  S  A  S  T  V  S  V  G  S  S  E  T  R  G  E  R  V  I  D         p.640

          .         .         .         .         .         .       g.268013
 GCTGTGCGATTCACCCTCCGCCAGACCATCTCTTTCCCACCCCGAGATGAGTGGAATGAC       c.1980
 A  V  R  F  T  L  R  Q  T  I  S  F  P  P  R  D  E  W  N  D         p.660

          .         .         .         .         .         .       g.268073
 TTCAACTTTGACATGGATGCTCGCCGCAATAAGCAACAGCGCATCAAAGAGGAGGGGGAG       c.2040
 F  N  F  D  M  D  A  R  R  N  K  Q  Q  R  I  K  E  E  G  E         p.680

                                                                    g.268076
 TGA                                                                c.2043
 X                                                                  p.680

          .         .         .         .         .         .       g.268136
 gcctcaccatgtgagctcttcctatccctctcctaactgccagccccctaaaagcactcc       c.*60

          .         .         .         .         .         .       g.268196
 tgcttaatcttcaaagccttctccctagctcctccccttcctcttgtctgatttcttagg       c.*120

          .         .         .         .         .         .       g.268256
 ggaaggagaagtaagaggctacctcttacctaacatctgacctggcatctaattctgatt       c.*180

          .         .         .         .         .         .       g.268316
 ctggctttaagccttcaaaactatagcttgcagaactgtagctgccatggctaggtagaa       c.*240

          .         .         .         .         .         .       g.268376
 gtgagcaaaaaagagttgggtgtctccttaagctgcagagatttctcattgacttttata       c.*300

          .         .         .         .         .         .       g.268436
 aagcatgttcacccttatagtctaagactatatatataaatgtataaatatacagtatag       c.*360

          .         .         .         .         .         .       g.268496
 atttttgggtggggggcattgagtattgtttaaaatgtaatttaaatgaaagaaaattga       c.*420

          .         .         .         .         .         .       g.268556
 gttgcacttattgaccattttttaatttacttgttttggatggcttgtctatactccttc       c.*480

          .         .         .         .         .         .       g.268616
 ccttaaggggtatcatgtatggtgataggtatctagagcttaatgctacatgtgagtgac       c.*540

          .         .         .         .         .         .       g.268676
 gatgatgtacagattctttcagttctttggattctaaatacatgccacatcaaacctttg       c.*600

          .         .         .         .         .         .       g.268736
 agtagatccatttccattgcttattatgtaggtaagactgtagatatgtattcttttctc       c.*660

          .         .         .         .         .         .       g.268796
 agtgttggtatattttatattactgacatttcttctagtgatgatggttcacgttggggt       c.*720

          .         .         .         .         .         .       g.268856
 gatttaatccagttataagaagaagttcatgtccaaacgtcctctttagtttttggttgg       c.*780

          .         .         .         .         .         .       g.268916
 gaatgaggaaaattcttaaaaggcccatagcagccagttcaaaaacacccgacgtcatgt       c.*840

          .         .         .         .         .         .       g.268976
 atttgagcatatcagtaacccccttaaatttaataccagataccttatcttacaatattg       c.*900

          .         .         .         .         .         .       g.269036
 attgggaaaacatttgctgccattacagaggtattaaaactaaatttcactactagattg       c.*960

          .         .         .         .         .         .       g.269096
 actaactcaaatacacatttgctactgttgtaagaattctgattgatttgattgggatga       c.*1020

          .         .         .         .         .         .       g.269156
 atgccatctatctagttctaacagtgaagttttactgtctattaatattcagggtaaata       c.*1080

          .         .         .         .         .         .       g.269216
 ggaatcattcagaaatgttgagtctgtactaaacagtaagatatctcaatgaaccataaa       c.*1140

          .         .         .         .         .         .       g.269276
 ttcaactttgtaaaaatcttttgaagcatagataatattgtttggtaaatgtttcttttg       c.*1200

          .         .         .         .         .         .       g.269336
 tttggtaaatgtttcttttaaagaccctcctattctataaaactctgcatgtagaggctt       c.*1260

          .         .         .         .         .         .       g.269396
 gtttacctttctctctctaaggtttacaataggagtggtgatttgaaaaatataaaatta       c.*1320

          .         .         .         .         .         .       g.269456
 tgagattggttttcctgtggcataaattgcatcactgtatcattttcttttttaaccggt       c.*1380

          .         .         .         .         .         .       g.269516
 aagagtttcagtttgttggaaagtaactgtgagaacccagtttcccgtccatctccctta       c.*1440

          .         .         .         .         .         .       g.269576
 gggactacccatagacatgaaaggtccccacagagcaagagataagtctttcatggctgc       c.*1500

          .         .         .         .         .         .       g.269636
 tgttgcttaaaccacttaaacgaagagttcccttgaaactttgggaaaacatgttaatga       c.*1560

          .         .         .         .         .         .       g.269696
 caatattccagatctttcagaaatataacacatttttttgcatgcatgcaaatgagctct       c.*1620

          .         .         .         .         .         .       g.269756
 gaaatcttcccatgcattctggtcaagggctgtcattgcacataagcttccattttaatt       c.*1680

          .         .         .         .         .         .       g.269816
 ttaaagtgcaaaagggccagcgtggctctaaaaggtaatgtgtggattgcctctgaaaag       c.*1740

          .         .         .         .         .         .       g.269876
 tgtgtatatattttgtgtgaaattgcatactttgtattttgattattttttttttcttct       c.*1800

          .         .         .         .         .         .       g.269936
 tgggatagtgggatttccagaaccacacttgaaacctttttttatcgtttttgtattttc       c.*1860

          .         .         .         .         .         .       g.269996
 atgaaaataccatttagtaagaataccacatcaaataagaaataatgctacaattttaag       c.*1920

          .         .         .         .         .         .       g.270056
 aggggagggaagggaaagtttttttttattatttttttaaaattttgtatgttaaagaga       c.*1980

          .         .         .         .         .         .       g.270116
 atgagtccttgatttcaaagttttgttgtacttaaatggtaataagcactgtaaacttct       c.*2040

          .         .         .         .         .         .       g.270176
 gcaacaagcatgcagctttgcaaacccattaaggggaagaatgaaagctgttccttggtc       c.*2100

          .         .         .         .         .         .       g.270236
 ctagtaagaagacaaactgcttcccttactttgctgagggtttgaataaacctaggactt       c.*2160

          .         .         .         .         .         .       g.270296
 ccgagctatgtcagtactattcaggtaacactagggccttggaaattcctgtactgtgtc       c.*2220

          .         .         .         .         .         .       g.270356
 tcatggatttggcactagccaaagcgaggcacccttactggcttacctcctcatggcagc       c.*2280

          .         .         .         .         .         .       g.270416
 ctactctccttgagtgtatgagtagccagggtaaggggtaaaaggatagtaagcatagaa       c.*2340

          .         .         .         .         .         .       g.270476
 accactagaaagtgggcttaatggagttcttgtggcctcagctcaatgcagttagctgaa       c.*2400

          .         .         .         .         .         .       g.270536
 gaattgaaaagtttttgtttggagacgtttataaacagaaatggaaagcagagttttcat       c.*2460

          .         .         .         .         .         .       g.270596
 taaatccttttaccttttttttttcttggtaatcccctaaaataacagtatgtgggatat       c.*2520

          .         .         .         .         .         .       g.270656
 tgaatgttaaagggatatttttttctattatttttataattgtacaaaattaagcaaatg       c.*2580

          .         .         .         .         .         .       g.270716
 ttaaaagttttatatgctttattaatgttttcaaaaggtattatacatgtgatacatttt       c.*2640

          .         .         .         .         .         .       g.270776
 ttaagcttcagttgcttgtcttctggtactttctgttatgggcttttggggagccagaag       c.*2700

          .         .         .         .         .         .       g.270836
 ccaatctacaatctctttttgtttgccaggacatgcaataaaatttaaaaaataaataaa       c.*2760

          .                                                         g.270853
 aactaattaagaaattg                                                  c.*2777

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Tumor protein p63 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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