tumor protein p73 (TP73) - coding DNA reference sequence

(used for variant description)

(last modified June 12, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_005427.3 in the TP73 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000001.10, covering TP73 transcript NM_005427.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5050
           aggggacgcagcgaaaccggggcccgcgccaggccagccgggacggacgc       c.-61

 .         .         .       | 02 .         .         .             g.34801
 cgatgcccggggctgcgacggctgcag | agcgagctgccctcggaggccggcgtggggaag    c.-1

          .         .         .         .         .         .       g.34861
 ATGGCCCAGTCCACCGCCACCTCCCCTGATGGGGGCACCACGTTTGAGCACCTCTGGAGC       c.60
 M  A  Q  S  T  A  T  S  P  D  G  G  T  T  F  E  H  L  W  S         p.20

       | 03  .         .         .         .         .         .    g.35550
 TCTCT | GGAACCAGACAGCACCTACTTCGACCTTCCCCAGTCAAGCCGGGGGAATAATGAG    c.120
 S  L  |  E  P  D  S  T  Y  F  D  L  P  Q  S  S  R  G  N  N  E      p.40

          .         .         .         .         .         .       g.35610
 GTGGTGGGCGGAACGGATTCCAGCATGGACGTCTTCCACCTGGAGGGCATGACTACATCT       c.180
 V  V  G  G  T  D  S  S  M  D  V  F  H  L  E  G  M  T  T  S         p.60

        | 04 .         .         .         .         .         .    g.60038
 GTCATG | GCCCAGTTCAATCTGCTGAGCAGCACCATGGACCAGATGAGCAGCCGCGCGGCC    c.240
 V  M   | A  Q  F  N  L  L  S  S  T  M  D  Q  M  S  S  R  A  A      p.80

          .         .         .         .         .         .       g.60098
 TCGGCCAGCCCCTACACCCCAGAGCACGCCGCCAGCGTGCCCACCCACTCGCCCTACGCA       c.300
 S  A  S  P  Y  T  P  E  H  A  A  S  V  P  T  H  S  P  Y  A         p.100

          .         .         .         .         .         .       g.60158
 CAACCCAGCTCCACCTTCGACACCATGTCGCCGGCGCCTGTCATCCCCTCCAACACCGAC       c.360
 Q  P  S  S  T  F  D  T  M  S  P  A  P  V  I  P  S  N  T  D         p.120

          .         .         .         .         .         .       g.60218
 TACCCCGGACCCCACCACTTTGAGGTCACTTTCCAGCAGTCCAGCACGGCCAAGTCAGCC       c.420
 Y  P  G  P  H  H  F  E  V  T  F  Q  Q  S  S  T  A  K  S  A         p.140

           | 05        .         .         .         .         .    g.74507
 ACCTGGACG | TACTCCCCGCTCTTGAAGAAACTCTACTGCCAGATCGCCAAGACATGCCCC    c.480
 T  W  T   | Y  S  P  L  L  K  K  L  Y  C  Q  I  A  K  T  C  P      p.160

          .         .         .         .         .         .       g.74567
 ATCCAGATCAAGGTGTCCACCCCGCCACCCCCAGGCACCGCCATCCGGGCCATGCCTGTT       c.540
 I  Q  I  K  V  S  T  P  P  P  P  G  T  A  I  R  A  M  P  V         p.180

          .         .         .         .         .         .       g.74627
 TACAAGAAAGCGGAGCACGTGACCGACGTCGTGAAACGCTGCCCCAACCACGAGCTCGGG       c.600
 Y  K  K  A  E  H  V  T  D  V  V  K  R  C  P  N  H  E  L  G         p.200

          .       | 06 .         .         .         .         .    g.75833
 AGGGACTTCAACGAAG | GACAGTCTGCTCCAGCCAGCCACCTCATCCGCGTGGAAGGCAAT    c.660
 R  D  F  N  E  G |   Q  S  A  P  A  S  H  L  I  R  V  E  G  N      p.220

          .         .         .         .         .         .       g.75893
 AATCTCTCGCAGTATGTGGATGACCCTGTCACCGGCAGGCAGAGCGTCGTGGTGCCCTAT       c.720
 N  L  S  Q  Y  V  D  D  P  V  T  G  R  Q  S  V  V  V  P  Y         p.240

          .   | 07     .         .         .         .         .    g.79598
 GAGCCACCACAG | GTGGGGACGGAATTCACCACCATCCTGTACAACTTCATGTGTAACAGC    c.780
 E  P  P  Q   | V  G  T  E  F  T  T  I  L  Y  N  F  M  C  N  S      p.260

          .         .         .         .         .         .       g.79658
 AGCTGTGTAGGGGGCATGAACCGGCGGCCCATCCTCATCATCATCACCCTGGAGATGCGG       c.840
 S  C  V  G  G  M  N  R  R  P  I  L  I  I  I  T  L  E  M  R         p.280

    | 08     .         .         .         .         .         .    g.80121
 GA | TGGGCAGGTGCTGGGCCGCCGGTCCTTTGAGGGCCGCATCTGCGCCTGTCCTGGCCGC    c.900
 D  |  G  Q  V  L  G  R  R  S  F  E  G  R  I  C  A  C  P  G  R      p.300

          .         .         .         .         .         .       g.80181
 GACCGAAAAGCTGATGAGGACCACTACCGGGAGCAGCAGGCCCTGAACGAGAGCTCCGCC       c.960
 D  R  K  A  D  E  D  H  Y  R  E  Q  Q  A  L  N  E  S  S  A         p.320

          .         .      | 09  .         .         .         .    g.80599
 AAGAACGGGGCCGCCAGCAAGCGTG | CCTTCAAGCAGAGCCCCCCTGCCGTCCCCGCCCTT    c.1020
 K  N  G  A  A  S  K  R  A |   F  K  Q  S  P  P  A  V  P  A  L      p.340

          .         .         .         .         .     | 10   .    g.81768
 GGTGCCGGTGTGAAGAAGCGGCGGCATGGAGACGAGGACACGTACTACCTTCAG | GTGCGA    c.1080
 G  A  G  V  K  K  R  R  H  G  D  E  D  T  Y  Y  L  Q   | V  R      p.360

          .         .         .         .         .         .       g.81828
 GGCCGGGAGAACTTTGAGATCCTGATGAAGCTGAAAGAGAGCCTGGAGCTGATGGAGTTG       c.1140
 G  R  E  N  F  E  I  L  M  K  L  K  E  S  L  E  L  M  E  L         p.380

          .         .         .         .         .       | 11 .    g.82439
 GTGCCGCAGCCACTGGTGGACTCCTATCGGCAGCAGCAGCAGCTCCTACAGAGGCC | GAGT    c.1200
 V  P  Q  P  L  V  D  S  Y  R  Q  Q  Q  Q  L  L  Q  R  P  |  S      p.400

          .         .         .         .         .         .       g.82499
 CACCTACAGCCCCCGTCCTACGGGCCGGTCCTCTCGCCCATGAACAAGGTGCACGGGGGC       c.1260
 H  L  Q  P  P  S  Y  G  P  V  L  S  P  M  N  K  V  H  G  G         p.420

          .         .         .         .         .         .       g.82559
 ATGAACAAGCTGCCCTCCGTCAACCAGCTGGTGGGCCAGCCTCCCCCGCACAGTTCGGCA       c.1320
 M  N  K  L  P  S  V  N  Q  L  V  G  Q  P  P  P  H  S  S  A         p.440

          .         .      | 12  .         .         .         .    g.83397
 GCTACACCCAACCTGGGGCCCGTGG | GCCCCGGGATGCTCAACAACCATGGCCACGCAGTG    c.1380
 A  T  P  N  L  G  P  V  G |   P  G  M  L  N  N  H  G  H  A  V      p.460

          .         .         .         .         .         .       g.83457
 CCAGCCAACGGCGAGATGAGCAGCAGCCACAGCGCCCAGTCCATGGTCTCGGGGTCCCAC       c.1440
 P  A  N  G  E  M  S  S  S  H  S  A  Q  S  M  V  S  G  S  H         p.480

          .         .         .         .     | 13   .         .    g.83914
 TGCACTCCGCCACCCCCCTACCACGCCGACCCCAGCCTCGTCAG | TTTTTTAACAGGATTG    c.1500
 C  T  P  P  P  P  Y  H  A  D  P  S  L  V  S  |  F  L  T  G  L      p.500

          .         .         .         .         .         .       g.83974
 GGGTGTCCAAACTGCATCGAGTATTTCACCTCCCAAGGGTTACAGAGCATTTACCACCTG       c.1560
 G  C  P  N  C  I  E  Y  F  T  S  Q  G  L  Q  S  I  Y  H  L         p.520

          .         | 14         .         .         .         .    g.85224
 CAGAACCTGACCATTGAG | GACCTGGGGGCCCTGAAGATCCCCGAGCAGTACCGCATGACC    c.1620
 Q  N  L  T  I  E   | D  L  G  A  L  K  I  P  E  Q  Y  R  M  T      p.540

          .         .         .         .         .         .       g.85284
 ATCTGGCGGGGCCTGCAGGACCTGAAGCAGGGCCACGACTACAGCACCGCGCAGCAGCTG       c.1680
 I  W  R  G  L  Q  D  L  K  Q  G  H  D  Y  S  T  A  Q  Q  L         p.560

          .         .         .         .         .         .       g.85344
 CTCCGCTCTAGCAACGCGGCCACCATCTCCATCGGCGGCTCAGGGGAACTGCAGCGCCAG       c.1740
 L  R  S  S  N  A  A  T  I  S  I  G  G  S  G  E  L  Q  R  Q         p.580

          .         .         .         .         .         .       g.85404
 CGGGTCATGGAGGCCGTGCACTTCCGCGTGCGCCACACCATCACCATCCCCAACCGCGGC       c.1800
 R  V  M  E  A  V  H  F  R  V  R  H  T  I  T  I  P  N  R  G         p.600

          .         .         .         .         .         .       g.85464
 GGCCCAGGCGGCGGCCCTGACGAGTGGGCGGACTTCGGCTTCGACCTGCCCGACTGCAAG       c.1860
 G  P  G  G  G  P  D  E  W  A  D  F  G  F  D  L  P  D  C  K         p.620

          .         .         .         .         .                 g.85515
 GCCCGCAAGCAGCCCATCAAGGAGGAGTTCACGGAGGCCGAGATCCACTGA                c.1911
 A  R  K  Q  P  I  K  E  E  F  T  E  A  E  I  H  X                  p.636

          .         .         .         .         .         .       g.85575
 gggcctcgcctggctgcagcctgcgccaccgcccagagacccaagctgcctcccctctcc       c.*60

          .         .         .         .         .         .       g.85635
 ttcctgtgtgtccaaaactgcctcaggaggcaggaccttcgggctgtgcccggggaaagg       c.*120

          .         .         .         .         .         .       g.85695
 caaggtccggcccatccccaggcacctcacaggccccaggaaaggcccagccaccgaagc       c.*180

          .         .         .         .         .         .       g.85755
 cgcctgtggacagcctgagtcacctgcagaaccttctggagctgccctagtgctgggctt       c.*240

          .         .         .         .         .         .       g.85815
 gtggggcgggggctggcccactctcagccctgccactgccccggcgtgctccatggcagg       c.*300

          .         .         .         .         .         .       g.85875
 cgtgggtggggaccgcagcgtcggctccgacttccaggcttcatcctagagactgtcatc       c.*360

          .         .         .         .         .         .       g.85935
 tcccaaccaggcgaggtccttccaaaggaaaggatcctctttgctgatggactgccaaaa       c.*420

          .         .         .         .         .         .       g.85995
 agtattttgcgacatcttttggttctggatagtagtgagcagccaagtgactgtgtctga       c.*480

          .         .         .         .         .         .       g.86055
 aacaccagtgtattttcagggaatgtccctaactgcgtcttgcccgcgccgggggctggg       c.*540

          .         .         .         .         .         .       g.86115
 gactctctctgctggacttgggactggcctctgcccccagcacgctgtattctgcaggac       c.*600

          .         .         .         .         .         .       g.86175
 cgcctccttcctgcccctaacaacaaccacagtgttgctgaaattggagaaaactgggga       c.*660

          .         .         .         .         .         .       g.86235
 gggcgcaaccccccccaggcgcggggaagcatgtggtaccgcctcagccagtgcccctca       c.*720

          .         .         .         .         .         .       g.86295
 gcctggccacagtcgcctctcctcggggacccctcagcagaaagggacagcctgtcctta       c.*780

          .         .         .         .         .         .       g.86355
 gaggactggaaattgtcaatatttgataaaatgatacccttttctacatggtgggtcagc       c.*840

          .         .         .         .         .         .       g.86415
 ttttttttttttttttttaactttctttctcagcattctctttggagttcaacctagcgc       c.*900

          .         .         .         .         .         .       g.86475
 ccatgagccaggctgaggaagctgagtgagaagccaggtgggcgggacttgttcccagga       c.*960

          .         .         .         .         .         .       g.86535
 aggccgggtggggaggaagcctagagggaaccccaggaagggcaaatccaggcaaatctg       c.*1020

          .         .         .         .         .         .       g.86595
 caggaatgctctgccatgggagcagctcctcccttgccacggccaccttctctagcactg       c.*1080

          .         .         .         .         .         .       g.86655
 caaggtccacagggcattgctttcctttctaggcggtggcagtcagggaacagactgagg       c.*1140

          .         .         .         .         .         .       g.86715
 taggtgtaggggggtctaggccttcgtggagcaccccagggagttagtaggccccgggga       c.*1200

          .         .         .         .         .         .       g.86775
 gacagagtctgcacaggccctttctggggccacctccatccacgaggagcagcctgagcc       c.*1260

          .         .         .         .         .         .       g.86835
 ttggtggccgaaccttgaccgtcccggagcacagcttcagggcagggaaccggagcccct       c.*1320

          .         .         .         .         .         .       g.86895
 ggggggcctcacgggtgtgacgaggcccttcattgcaggcaggtgggccaatgggagccc       c.*1380

          .         .         .         .         .         .       g.86955
 tcacccacgcaagccgagacaccacccagagtgcaggctgcctggccccttctggcacgg       c.*1440

          .         .         .         .         .         .       g.87015
 ccagctccacaccccctgcctagggtatgtgtggtcctaagggctaggagcttcccctac       c.*1500

          .         .         .         .         .         .       g.87075
 taacatctcccagaaaaagcagttaagcccctcagggcacagcaaggttagacacagccc       c.*1560

          .         .         .         .         .         .       g.87135
 ccatccccagatcaggactccatcttgctaagtggcatcaccgtcaccagcctcccctta       c.*1620

          .         .         .         .         .         .       g.87195
 tttaaaagcagcgactggtgttgccgcaggtacctggtctacgaagacgcaggcatccct       c.*1680

          .         .         .         .         .         .       g.87255
 ctcccaccgtccacctccccgggggccgctgacagcacagtcgcctgggtgcacgcttgt       c.*1740

          .         .         .         .         .         .       g.87315
 gggggcagcaggaacggggctgtcggctctcaggggatctggctgcagccagggcgaggg       c.*1800

          .         .         .         .         .         .       g.87375
 cctggcccttccttccagctccttccggctccttccagctgaagggcaggaagctctggc       c.*1860

          .         .         .         .         .         .       g.87435
 cgcttagcttctagggttccatctccctagaaaggtgcccacgcccagggcatcagtcag       c.*1920

          .         .         .         .         .         .       g.87495
 tagcggcagcagcagcagactcggggctttcccagggtggcgcagccaccccagctgcat       c.*1980

          .         .         .         .         .         .       g.87555
 gtcacctcagctctccatcttattgccattttgtagatgaggaagctgagaccagaaagg       c.*2040

          .         .         .         .         .         .       g.87615
 ctaagacccatgccccaggcaccacacccatctcttgggggctgggcacctgctacccga       c.*2100

          .         .         .         .         .         .       g.87675
 ggccacctcctgaagcccccactcttcccccatgttccacttcaggagccgcgggggccc       c.*2160

          .         .         .         .         .         .       g.87735
 atcctgacacccggggttcctcagcccagcgcagatgtgcttcagttccagagggcttgt       c.*2220

          .         .         .         .         .         .       g.87795
 tgatttgtttcttaggtacgttacctgtccaccctgagtccagtgaggctgtcccaagag       c.*2280

          .         .         .         .         .         .       g.87855
 cccctgtagtgtgctcctgggaagggctgggggggctgggggggctgggagaggcccagg       c.*2340

          .         .         .         .         .         .       g.87915
 ggcagctgtcactggaaccccagccagatgtccaaggaagccggccagaacacggagcag       c.*2400

          .         .         .         .         .         .       g.87975
 ccagatggccccagctgcacctgtctagggagcccatgcagcctccttgcactggagaag       c.*2460

          .         .         .         .         .         .       g.88035
 cagctgtgaaagtagacagagttgagacttcgccgtggtcaggagaaaatgcaaattccc       c.*2520

          .         .         .         .         .         .       g.88095
 aggaacaagaatcctttaagtgatatgtttttataaaactaaacaaatcaacaaataaat       c.*2580

          .         .         .         .         .         .       g.88155
 cttgaaggcggatggttttcccagcagtgcaggggttggagggaggctgctggcactcct       c.*2640

          .         .         .         .         .         .       g.88215
 ggggccaagggggacaggcagtggtcctgagtctgctcagagaggcaaggcagaaggagc       c.*2700

          .         .         .         .         .         .       g.88275
 tcgccaggcaggtcagctcacatctgtccaagtcgctctggtcagaaacagcgactctcc       c.*2760

          .         .         .         .         .         .       g.88335
 cccattcccccagcgttcccaccaggcctgggctgctgggaagcccttgctgtacccagg       c.*2820

          .         .         .         .         .         .       g.88395
 agcccgacccgcagtatcctggcacagagccacttgtcactcagaacagtcagtgtctcc       c.*2880

          .         .         .         .         .         .       g.88455
 aacgcacaaacatccactcctctgttaccagttaaagcactttaatgctttaaggtgaaa       c.*2940

          .         .         .         .         .         .       g.88515
 acgaaatcccatccgtgtttttcgtgtaagatcgtgcttctccgagcagtattaatggac       c.*3000

          .         .         .         .         .         .       g.88575
 gccctccaatgacataacaactgtttttggtaatgtaatcttgggaaaatgtgttatttt       c.*3060

          .         .         .         .         .         .       g.88635
 tttagctgtgtttcagtggggatttttgtttttgtaacataataaagtgtatgttccaat       c.*3120

                                                                    g.88637
 ga                                                                 c.*3122

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Tumor protein p73 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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