transformer 2 beta homolog (Drosophila) (TRA2B) - coding DNA reference sequence

(used for variant description)

(last modified September 10, 2026)

This file was created to facilitate the description of sequence variants on transcript NM_004593.2 in the TRA2B gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000003.11, covering TRA2B transcript NM_004593.2.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                               .         .         .                g.5036
                         gtgcgggacgcgctgcagctggagaggaaaggcaga       c.-241

 .         .         .         .         .         .                g.5096
 gcgaggaggggcgaggccaagaaagcgcgcgtttctgggaggggaggagcctggctaagg       c.-181

 .         .         .         .         .         .                g.5156
 agcgccgcgtcacatccggtagagttagagcccgtgcggaggcggtgcggagcatttcgg       c.-121

 .         .         .         .         .         .                g.5216
 ctctgagcggctgggcgaccggcgcgtcgtgcggggctgcggcggagcctccttaaggaa       c.-61

 .         .         .         .         .         .                g.5276
 ggtgcaagaggttggcagcttcgattgaagcacatcgaccggcgacagcagccaggagtc       c.-1

          .         .         .       | 02 .         .         .    g.16426
 ATGAGCGACAGCGGCGAGCAGAACTACGGCGAGCGG | GAATCCCGTTCTGCTTCCAGAAGT    c.60
 M  S  D  S  G  E  Q  N  Y  G  E  R   | E  S  R  S  A  S  R  S      p.20

          .         .         .         .         .         .       g.16486
 GGAAGTGCTCACGGATCGGGGAAATCTGCAAGGCATACCCCTGCAAGGTCTCGCTCCAAG       c.120
 G  S  A  H  G  S  G  K  S  A  R  H  T  P  A  R  S  R  S  K         p.40

          .         .         .         .         . | 03       .    g.17520
 GAAGATTCCAGGCGTTCCAGATCAAAGTCCAGGTCCCGATCTGAATCTAG | GTCTAGATCC    c.180
 E  D  S  R  R  S  R  S  K  S  R  S  R  S  E  S  R  |  S  R  S      p.60

          .         .         .         .         .         .       g.17580
 AGAAGAAGCTCCCGAAGGCATTATACCCGGTCACGGTCTCGCTCCCGCTCCCATAGACGA       c.240
 R  R  S  S  R  R  H  Y  T  R  S  R  S  R  S  R  S  H  R  R         p.80

          .         .         .         .         .         .       g.17640
 TCACGTAGCAGGTCTTACAGTCGAGATTATCGTAGACGGCACAGCCACAGCCATTCTCCC       c.300
 S  R  S  R  S  Y  S  R  D  Y  R  R  R  H  S  H  S  H  S  P         p.100

          .         .         .    | 04    .         .         .    g.19179
 ATGTCTACTCGCAGGCGTCATGTTGGGAATCGG | GCAAATCCTGATCCTAACTGTTGTCTT    c.360
 M  S  T  R  R  R  H  V  G  N  R   | A  N  P  D  P  N  C  C  L      p.120

          .         .         .         .         .         .       g.19239
 GGAGTATTTGGGCTGAGCTTGTACACCACAGAAAGAGATCTAAGAGAAGTGTTCTCTAAA       c.420
 G  V  F  G  L  S  L  Y  T  T  E  R  D  L  R  E  V  F  S  K         p.140

          .         .         .         .         .         .       g.19299
 TATGGTCCCATTGCCGATGTGTCTATTGTATATGACCAGCAGTCTAGGCGTTCAAGAGGA       c.480
 Y  G  P  I  A  D  V  S  I  V  Y  D  Q  Q  S  R  R  S  R  G         p.160

          .         .         .         .   | 05     .         .    g.21028
 TTTGCCTTTGTATATTTTGAAAATGTAGATGATGCCAAGGAA | GCTAAAGAACGTGCCAAT    c.540
 F  A  F  V  Y  F  E  N  V  D  D  A  K  E   | A  K  E  R  A  N      p.180

          .         .         .         .         .         .       g.21088
 GGAATGGAGCTTGATGGGCGTAGGATCAGAGTTGATTTCTCTATAACAAAAAGACCACAT       c.600
 G  M  E  L  D  G  R  R  I  R  V  D  F  S  I  T  K  R  P  H         p.200

          .         .         .         | 06         .         .    g.21971
 ACGCCAACACCAGGAATTTACATGGGGAGACCTACCTA | TGGCAGCTCTCGCCGTCGGGAT    c.660
 T  P  T  P  G  I  Y  M  G  R  P  T  Y  |  G  S  S  R  R  R  D      p.220

          .         .         .         .         .         .       g.22031
 TACTATGACAGAGGATATGATCGGGGCTATGATGATCGGGACTACTATAGCAGATCATAC       c.720
 Y  Y  D  R  G  Y  D  R  G  Y  D  D  R  D  Y  Y  S  R  S  Y         p.240

    | 07     .         .         .         .         .         .    g.23698
 AG | AGGAGGAGGTGGAGGAGGAGGAGGATGGAGAGCTGCCCAAGACAGGGATCAGATTTAT    c.780
 R  |  G  G  G  G  G  G  G  G  W  R  A  A  Q  D  R  D  Q  I  Y      p.260

    | 08     .         .         .         .         .         .    g.24756
 AG | AAGGCGGTCACCTTCTCCTTACTATAGTCGTGGAGGATACAGATCACGTTCCAGATCT    c.840
 R  |  R  R  S  P  S  P  Y  Y  S  R  G  G  Y  R  S  R  S  R  S      p.280

          .       | 09 .                                            g.25455
 CGATCATACTCACCTC | GTCGCTATTAA                                     c.867
 R  S  Y  S  P  R |   R  Y  X                                       p.288

          .         .         .         .         .         .       g.25515
 agcatgaagactttctgaaacctgccctagagctgggatattgtttgtgggcaatatttt       c.*60

          .         .         .         .         .         .       g.25575
 ttattgtctcttgtttaaaaagtgaacagtgcctagtgaagttaggtgacttttacacct       c.*120

          .         .         .         .         .         .       g.25635
 tttacgatgactacttttggtggagttgaaatgctgttttcattctgcatttgtgtagtt       c.*180

          .         .         .         .         .         .       g.25695
 tggtgctttgttccaagttaagtgttttcagaaaagtatgttttgcatgtatttttttac       c.*240

          .         .         .         .         .         .       g.25755
 agtctaaattttgactgctgagaagtttctattgtacaaaacttcatttaaaaggttttt       c.*300

          .         .         .         .         .         .       g.25815
 ctactgaatccagggtattctgaagatcgaagcctgtgtaaaatgctaccaaatggcaaa       c.*360

          .         .         .         .         .         .       g.25875
 aagcaacaataaacagtttgatttttacttttctttctaacatatcaatgcttagcagaa       c.*420

          .         .         .         .         .         .       g.25935
 ctattcagattgtcagtagtaaatttaaagacaaatgcccgttttcctccagtccatgaa       c.*480

          .         .         .         .         .         .       g.25995
 acataccatacttatatacctgcaactaagtgtttaaaattatgctctgtaactctgtac       c.*540

          .         .         .         .         .         .       g.26055
 tgctagtattagaactaaaaatcttaaaatacagccagtgcttaatgcttatatcaatgt       c.*600

          .         .         .         .         .         .       g.26115
 ggatttgtcggcttttatgtaatctgtaatatgtatagcaggaaatacgaagagttacac       c.*660

          .         .         .         .         .         .       g.26175
 agtgtatgccttaaaaggctgtttcttaaaggtgttacaaggggataatggtatttcaac       c.*720

          .         .         .         .         .         .       g.26235
 tagttatcagcaagtgacaatacattccaccacaaatacactcttgttcttctagctttt       c.*780

          .         .         .         .         .         .       g.26295
 agactatatgaaaaaaccgggtgcttcaaagtacatgataagggaacactatacctgtca       c.*840

          .         .         .         .         .         .       g.26355
 tggatgaactgaagactttgcctgttcattttttaaatattattttcaggtcctttgctt       c.*900

          .         .         .         .         .         .       g.26415
 accaaaggaggcccaatttcactcaaatgttttgagaactgtgtttaaataaacgcaaat       c.*960

          .         .         .         .         .         .       g.26475
 gaaaagaaaaatgttggtgcagctgttcacaaagaagtgttcttgttctattataattag       c.*1020

          .         .         .         .         .         .       g.26535
 agttcttctgtagtttaatcgttagggcagtgtgttccttgggctgaggtgtatctttgc       c.*1080

          .         .         .         .         .         .       g.26595
 tattttgggctgggttgagggggggatgaatttctgtattcctggaaaattcagagtgca       c.*1140

          .         .         .         .         .         .       g.26655
 taactaggtattagagtgatctccatttggggatggagttacagtaaataactagactgc       c.*1200

          .         .         .         .         .         .       g.26715
 gggtactttaatacatgttcttattattttgcatttaagtaattttcatgaccaattgta       c.*1260

          .         .         .         .         .         .       g.26775
 gggatgttgctacaggtgggttattttgttgccttgctaacctttatcgcatctaggtat       c.*1320

          .         .         .         .         .         .       g.26835
 tagtatgtttcaggtactttgggaagaactttacatataatctttagcaatgaaatgatg       c.*1380

          .         .         .         .         .         .       g.26895
 tagagtaacttaccttagttcaaatagctgtttaagtggcaatgccacgatctgaattga       c.*1440

          .         .         .         .         .         .       g.26955
 acctaggtgatcttagtccacagttctcttgatcatgatgtctcaaatctgggtacctgg       c.*1500

          .         .         .         .         .         .       g.27015
 gtgatggaaaataccagtaatggagcataggcagtattggcaggtcttaatttgtaaaac       c.*1560

          .         .         .         .         .         .       g.27075
 ttactgtccagggtgttttcagtgtttgccaacttgtggtaaattaatatgcttagagaa       c.*1620

          .         .         .         .         .         .       g.27135
 ctacccttaggtttgtttctgataagcatgtggaaacaacttagtatatgcctgatgggt       c.*1680

          .         .         .         .         .         .       g.27195
 tatttcaaattgttctcaatgagttttgaaacaagaatttgtagtatttatatataaagt       c.*1740

          .         .         .         .         .         .       g.27255
 tgagttttagggtgtggtcccagagggggttgtgttatggatggatacattaaaggctga       c.*1800

          .         .         .         .         .         .       g.27315
 gaaacctggttttatcgtggtagtatatacaggcatcctttcctgaagtaactacattct       c.*1860

          .         .         .         .         .         .       g.27375
 ccaccattttctccccaaccaaacctctccccatcagttaactgatggcttgcgagttca       c.*1920

          .         .         .         .         .         .       g.27435
 cactcctgataatctcgaacataaccctcggtttctatcctaaagcctgagttttagccc       c.*1980

          .         .         .         .         .         .       g.27495
 tttagttgtgtagccatcctttatcctgctgattgaaagtttccttttttaggctagttt       c.*2040

          .         .         .         .         .         .       g.27555
 gagttgttttctggcttttagatttgaaagaattttagccatttgacatggctacaaaga       c.*2100

          .         .         .         .         .         .       g.27615
 gtgttaacaggcaaaagactgaggaaaatttggaattttaccaagttgagatagactgag       c.*2160

          .         .         .         .         .         .       g.27675
 aagtagtgagacaaagtggtagtcttttgatgtgctgtaatgctagtcgccagtttcatg       c.*2220

          .         .         .         .         .         .       g.27735
 aaagggaggcagcagttacccgtaggtaacccctaggtaactgctgccatgggcagctga       c.*2280

          .         .         .         .         .         .       g.27795
 atcagacaaaagccatgggaaaggataaatttgagtcttaaagttactgcctcaaggcaa       c.*2340

          .         .         .         .         .         .       g.27855
 agggacttggaggcttttatatgccaatacaaacaatccatttcttatagctgtagggct       c.*2400

          .         .         .         .         .         .       g.27915
 gagactactaaaaccaaatgtaaagttcatttggaagattgctaagttaaatagttttat       c.*2460

          .         .         .         .         .         .       g.27975
 actaggcttttgtgaaacttctcaggaaatcaacagggtcccagcaagtggaaataaggc       c.*2520

          .         .         .         .         .         .       g.28035
 tgtgtcaaaagatttgtagacctgggagcaggggtttccgatctcctggccatggattgc       c.*2580

          .         .         .         .         .         .       g.28095
 ctgagctccgccgcctgtcagatcagcaacagcagattttcatagcaggaatcctattgt       c.*2640

          .         .         .         .         .         .       g.28155
 gaagtgcgcttgagagggatctagcttgcacatttccttatggaaatctaactacatgtt       c.*2700

          .         .         .         .         .         .       g.28215
 agagaatgctcaaggtctgcaatgtttacattgttgcccctacataaggaatatatgcct       c.*2760

          .         .         .         .         .         .       g.28275
 taagataaaactaatagctcttagccctcttacaccattgactaggattccaattctgca       c.*2820

          .         .         .         .         .         .       g.28335
 aggcccaggaggagaaattgagaattagaagtttcaccgagaagaaataaaaagatttgg       c.*2880

          .         .         .         .         .         .       g.28395
 tttgcattatcaaaatttctgtaaattatatggaaattttgaggatggattaggctggat       c.*2940

          .         .         .         .         .         .       g.28455
 ttattagcagtggacacgcctccaatattccttcagcatgccatctcagtggattttgat       c.*3000

          .         .         .         .         .         .       g.28515
 tggctcttgtaggattggacttaatgctagcttatgccaaatgtcatcaaaaagccagaa       c.*3060

          .         .         .         .         .         .       g.28575
 tgctactacagtaatgtaaaggattattgtatatagtgtaaaggattattatgtgtaatc       c.*3120

          .         .                                               g.28602
 tttaatatataatgtaaagacttaaaa                                        c.*3147

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Transformer 2 beta homolog (Drosophila) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.