trafficking protein particle complex 4 (TRAPPC4) - coding DNA reference sequence

(used for variant description)

(last modified August 25, 2020)

This file was created to facilitate the description of sequence variants on transcript NM_016146.4 in the TRAPPC4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000011.9, covering TRAPPC4 transcript NM_016146.4.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                                         .         .                g.5025
                                    tgacgcatactatagcgctgttttc       c.-241

 .         .         .         .         .         .                g.5085
 ctgcactgataaacgaaaagcaatccaccaggtctcggcagctaactttccggcactact       c.-181

 .         .         .         .         .         .                g.5145
 tatgcccgagcgtgtcgctcccagtgcgcaagtgcagcaggtggctgcacggggggcgcg       c.-121

 .         .         .         .         .         .                g.5205
 ggaggaggaggaggaggaggaggaggctggggtggggccggcggcaagtgctgtgatgcg       c.-61

 .         .         .         .         .         .                g.5265
 gttccggggaggggccgtcgggtagaggctgaataccagtttccgagcggcaaggcagcg       c.-1

          .         .         .         .         .         .       g.5325
 ATGGCGATTTTTAGTGTGTATGTGGTGAACAAAGCTGGCGGCTTGATTTACCAGTTGGAC       c.60
 M  A  I  F  S  V  Y  V  V  N  K  A  G  G  L  I  Y  Q  L  D         p.20

          .         .         .         .         .         .       g.5385
 AGCTACGCGCCACGGGCTGAGGCTGAGAAAACTTTCAGTTATCCGCTGGATCTGCTGCTC       c.120
 S  Y  A  P  R  A  E  A  E  K  T  F  S  Y  P  L  D  L  L  L         p.40

          .         .         .         .         .      | 02  .    g.5617
 AAGCTACACGATGAGCGTGTGTTGGTTGCTTTCGGCCAGCGGGACGGCATCCGAG | TGGGT    c.180
 K  L  H  D  E  R  V  L  V  A  F  G  Q  R  D  G  I  R  V |   G      p.60

          .         .         .         .         .         .       g.5677
 CATGCAGTGCTGGCCATCAATGGCATGGACGTGAATGGCAGGTACACGGCCGACGGGAAA       c.240
 H  A  V  L  A  I  N  G  M  D  V  N  G  R  Y  T  A  D  G  K         p.80

          .         .         .         .         .         .       g.5737
 GAGGTGCTGGAGTATCTGGGTAACCCTGCTAATTACCCGGTGTCCATTCGATTTGGCCGG       c.300
 E  V  L  E  Y  L  G  N  P  A  N  Y  P  V  S  I  R  F  G  R         p.100

          .         .         .         .         . | 03       .    g.6629
 CCCCGCCTCACTTCTAATGAGAAGCTTATGCTGGCCTCCATGTTCCACTC | GCTCTTTGCC    c.360
 P  R  L  T  S  N  E  K  L  M  L  A  S  M  F  H  S  |  L  F  A      p.120

          .         .         .         .         .         .       g.6689
 ATCGGCTCCCAGCTGTCTCCTGAACAGGGAAGCTCAGGCATTGAGATGCTGGAGACAGAC       c.420
 I  G  S  Q  L  S  P  E  Q  G  S  S  G  I  E  M  L  E  T  D         p.140

          .         .         .     | 04   .         .         .    g.8255
 ACATTCAAATTGCACTGCTACCAGACACTGACAG | GGATCAAGTTTGTGGTTCTAGCAGAT    c.480
 T  F  K  L  H  C  Y  Q  T  L  T  G |   I  K  F  V  V  L  A  D      p.160

          .         .         .         .         .         .       g.8315
 CCTAGGCAAGCTGGAATAGATTCTCTTCTCCGAAAGATTTATGAGATTTACTCAGACTTT       c.540
 P  R  Q  A  G  I  D  S  L  L  R  K  I  Y  E  I  Y  S  D  F         p.180

          .         .         .         .  | 05      .         .    g.9809
 GCCCTCAAGAATCCATTCTATTCCTTAGAAATGCCTATCAG | GTGTGAGCTCTTTGACCAG    c.600
 A  L  K  N  P  F  Y  S  L  E  M  P  I  R  |  C  E  L  F  D  Q      p.200

          .         .         .         .         .         .       g.9869
 AACCTGAAGCTAGCTCTGGAGGTGGCAGAGAAGGCTGGAACTTTTGGACCTGGGTCATAG       c.660
 N  L  K  L  A  L  E  V  A  E  K  A  G  T  F  G  P  G  S  X         p.219

          .         .         .         .         .         .       g.9929
 gctgaacctgttatggacccccaaattctgagagttcctgcaacaagaatactgctgttg       c.*60

          .         .         .         .         .         .       g.9989
 acactccagtggaaatcccagcagccttgttagtgcacttgaaagtgggagaatgctgac       c.*120

          .         .         .         .         .         .       g.10049
 cctgatgacttgtactgattcctgagccttaacactgtgctctttccttctgtatatacc       c.*180

          .         .         .         .         .         .       g.10109
 atggtcttactttccaactctgtacagatttatttatggaggagctaggtccataaatgt       c.*240

          .         .         .                                     g.10144
 tgtaataaatattcctttgatcttggtgtttgcaa                                c.*275

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Trafficking protein particle complex 4 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.