tripartite motif containing 2 (TRIM2) - coding DNA reference sequence

(used for variant description)

(last modified January 26, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_015271.3 in the TRIM2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000004.11, covering TRIM2 transcript NM_015271.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.56353
                                    agcttgatgactataatgggcccag       c.-61

 .         .         .         .         .         .                g.56413
 ttgtctgcgggctgcggggagctaagtccccagattggaggaggctggctctggtcttcg       c.-1

          .         .         . | 02       .         .         .    g.122247
 ATGCACAGGAGTGGCCGTTATGGAACGCAG | CAGCAGCGTGCAGGGTCAAAGACAGCCGGC    c.60
 M  H  R  S  G  R  Y  G  T  Q   | Q  Q  R  A  G  S  K  T  A  G      p.20

          .         .         .         .         .         .       g.122307
 CCCCCATGTCAGTGGTCTAGGATGGCCAGTGAAGGCACCAACATCCCAAGTCCTGTGGTG       c.120
 P  P  C  Q  W  S  R  M  A  S  E  G  T  N  I  P  S  P  V  V         p.40

          .         .         .         .         .         .       g.122367
 CGCCAGATTGACAAGCAGTTTCTGATTTGCAGTATATGCCTGGAACGGTACAAGAATCCC       c.180
 R  Q  I  D  K  Q  F  L  I  C  S  I  C  L  E  R  Y  K  N  P         p.60

          .         .         .      | 03  .         .         .    g.127800
 AAGGTTCTCCCCTGTCTGCACACTTTCTGCGAGAG | GTGCCTGCAGAACTACATTCCTGCC    c.240
 K  V  L  P  C  L  H  T  F  C  E  R  |  C  L  Q  N  Y  I  P  A      p.80

          .         .         .         .         .         .       g.127860
 CACAGTTTAACCCTCTCCTGCCCAGTGTGCCGCCAGACCTCCATCCTGCCCGAGAAAGGG       c.300
 H  S  L  T  L  S  C  P  V  C  R  Q  T  S  I  L  P  E  K  G         p.100

          .         .         .         .         .         .       g.127920
 GTGGCCGCGCTCCAGAACAATTTCTTCATCACAAACCTGATGGACGTGCTGCAGCGAACT       c.360
 V  A  A  L  Q  N  N  F  F  I  T  N  L  M  D  V  L  Q  R  T         p.120

          .         .         .         .         .         .       g.127980
 CCAGGCAGCAACGCTGAGGAGTCTTCCATCCTGGAGACAGTCACTGCTGTGGCTGCGGGA       c.420
 P  G  S  N  A  E  E  S  S  I  L  E  T  V  T  A  V  A  A  G         p.140

          .         .         .    | 04    .         .         .    g.144891
 AAGCCTCTCTCTTGCCCAAACCACGATGGGAAT | GTGATGGAATTTTACTGCCAGTCCTGT    c.480
 K  P  L  S  C  P  N  H  D  G  N   | V  M  E  F  Y  C  Q  S  C      p.160

          .         .         .         .         .         .       g.144951
 GAGACTGCCATGTGTCGGGAGTGCACGGAGGGGGAGCACGCAGAGCACCCCACAGTTCCA       c.540
 E  T  A  M  C  R  E  C  T  E  G  E  H  A  E  H  P  T  V  P         p.180

          .         .         .         .         .         .       g.145011
 CTCAAGGATGTGGTGGAACAGCACAAGGCCTCGCTCCAGGTCCAGCTGGATGCTGTCAAC       c.600
 L  K  D  V  V  E  Q  H  K  A  S  L  Q  V  Q  L  D  A  V  N         p.200

       | 05  .         .         .         .         .         .    g.146242
 AAAAG | GCTCCCAGAAATAGATTCTGCTCTTCAGTTCATCTCTGAAATCATTCATCAGTTA    c.660
 K  R  |  L  P  E  I  D  S  A  L  Q  F  I  S  E  I  I  H  Q  L      p.220

          .         .         .         .         .         .       g.146302
 ACCAACCAAAAGGCCAGCATCGTGGATGACATTCATTCCACCTTTGATGAGCTCCAGAAG       c.720
 T  N  Q  K  A  S  I  V  D  D  I  H  S  T  F  D  E  L  Q  K         p.240

          .         .         .         .         .         .       g.146362
 ACTTTAAATGTGCGCAAGAGTGTGCTGCTTATGGAATTGGAGGTCAACTATGGCCTCAAA       c.780
 T  L  N  V  R  K  S  V  L  L  M  E  L  E  V  N  Y  G  L  K         p.260

        | 06 .         .         .         .         .         .    g.147249
 CACAAA | GTCCTCCAGTCGCAGCTGGATACTCTGCTCCAGGGGCAGGAGAGCATTAAGAGC    c.840
 H  K   | V  L  Q  S  Q  L  D  T  L  L  Q  G  Q  E  S  I  K  S      p.280

          .         .         .         .         .         .       g.147309
 TGCAGCAACTTCACAGCGCAGGCCCTCAACCATGGCACGGAGACCGAGGTCCTACTGGTG       c.900
 C  S  N  F  T  A  Q  A  L  N  H  G  T  E  T  E  V  L  L  V         p.300

          .         .         .         .         .         .       g.147369
 AAGAAGCAGATGAGCGAGAAGCTGAACGAGCTGGCCGACCAGGACTTCCCCTTGCACCCG       c.960
 K  K  Q  M  S  E  K  L  N  E  L  A  D  Q  D  F  P  L  H  P         p.320

          .         .         .         .         .         .       g.147429
 CGGGAGAACGACCAGCTGGATTTCATCGTGGAAACCGAGGGGCTGAAGAAGTCCATCCAC       c.1020
 R  E  N  D  Q  L  D  F  I  V  E  T  E  G  L  K  K  S  I  H         p.340

          .         .         .         .         .         .       g.147489
 AACCTCGGGACGATCTTAACCACCAACGCCGTTGCCTCAGAGACAGTGGCCACGGGCGAG       c.1080
 N  L  G  T  I  L  T  T  N  A  V  A  S  E  T  V  A  T  G  E         p.360

          .         .         .         .         .         .       g.147549
 GGGCTGCGGCAGACCATCATCGGGCAGCCCATGTCCGTCACCATCACCACCAAGGACAAA       c.1140
 G  L  R  Q  T  I  I  G  Q  P  M  S  V  T  I  T  T  K  D  K         p.380

          .         .         .         .         .         .       g.147609
 GACGGTGAGCTGTGCAAAACCGGCAACGCCTACCTCACCGCCGAACTGAGCACCCCCGAC       c.1200
 D  G  E  L  C  K  T  G  N  A  Y  L  T  A  E  L  S  T  P  D         p.400

          .         .         .         .         .         .       g.147669
 GGGAGCGTGGCAGACGGGGAGATCCTGGACAACAAGAACGGCACCTATGAGTTTTTGTAC       c.1260
 G  S  V  A  D  G  E  I  L  D  N  K  N  G  T  Y  E  F  L  Y         p.420

          .         .         .         .         .         .       g.147729
 ACTGTCCAGAAGGAAGGGGACTTTACCCTGTCTCTGAGACTCTATGACCAGCACATCCGA       c.1320
 T  V  Q  K  E  G  D  F  T  L  S  L  R  L  Y  D  Q  H  I  R         p.440

          .         .         .         .         .         .       g.147789
 GGCAGCCCGTTTAAGCTGAAAGTGATCCGATCCGCTGATGTGTCTCCCACCACAGAAGGC       c.1380
 G  S  P  F  K  L  K  V  I  R  S  A  D  V  S  P  T  T  E  G         p.460

          .         .         .         .         .         .       g.147849
 GTGAAGAGGCGCGTTAAGTCCCCGGGGAGCGGCCACGTCAAGCAGAAAGCTGTGAAAAGA       c.1440
 V  K  R  R  V  K  S  P  G  S  G  H  V  K  Q  K  A  V  K  R         p.480

          .         .         .         .         .         .       g.147909
 CCCGCAAGCATGTACAGCACTGGAAAACGAAAAGAGAATCCCATCGAAGACGATTTGATC       c.1500
 P  A  S  M  Y  S  T  G  K  R  K  E  N  P  I  E  D  D  L  I         p.500

          . | 07       .         .         .         .         .    g.167417
 TTTCGAGTGG | GTACCAAAGGAAGAAATAAAGGAGAGTTTACAAATCTTCAGGGGGTAGCT    c.1560
 F  R  V  G |   T  K  G  R  N  K  G  E  F  T  N  L  Q  G  V  A      p.520

          .         .         .         .         .     | 08   .    g.167720
 GCATCTACAAATGGAAAGATATTAATTGCAGACAGTAACAACCAATGTGTGCAG | ATATTT    c.1620
 A  S  T  N  G  K  I  L  I  A  D  S  N  N  Q  C  V  Q   | I  F      p.540

          .         .         .         .         .         .       g.167780
 TCCAATGATGGCCAGTTCAAAAGTCGTTTTGGCATACGGGGACGCTCTCCGGGGCAGCTG       c.1680
 S  N  D  G  Q  F  K  S  R  F  G  I  R  G  R  S  P  G  Q  L         p.560

          .         .         .         .         .         .       g.167840
 CAGCGGCCCACAGGAGTGGCTGTACATCCCAGTGGGGACATAATCATTGCCGATTATGAT       c.1740
 Q  R  P  T  G  V  A  V  H  P  S  G  D  I  I  I  A  D  Y  D         p.580

          .         .         .         .   | 09     .         .    g.174548
 AATAAATGGGTCAGCATTTTCTCCTCCGATGGGAAATTTAAG | ACAAAAATTGGATCAGGA    c.1800
 N  K  W  V  S  I  F  S  S  D  G  K  F  K   | T  K  I  G  S  G      p.600

          .         .         .         .         .         .       g.174608
 AAGCTGATGGGACCCAAAGGAGTTTCTGTGGACCGCAATGGGCACATTATTGTTGTGGAC       c.1860
 K  L  M  G  P  K  G  V  S  V  D  R  N  G  H  I  I  V  V  D         p.620

          .         .         .         .         .         .       g.174668
 AACAAGGCGTGCTGCGTGTTTATCTTCCAGCCAAACGGGAAAATAGTCACCAGGTTTGGT       c.1920
 N  K  A  C  C  V  F  I  F  Q  P  N  G  K  I  V  T  R  F  G         p.640

          .         .         .  | 10      .         .         .    g.175989
 AGCCGAGGAAATGGGGACAGGCAGTTTGCAG | GTCCCCATTTTGCAGCTGTAAATAGCAAT    c.1980
 S  R  G  N  G  D  R  Q  F  A  G |   P  H  F  A  A  V  N  S  N      p.660

          .         .         .         .   | 11     .         .    g.180430
 AATGAGATTATTATTACAGATTTCCATAATCATTCTGTCAAG | GTGTTTAATCAGGAAGGA    c.2040
 N  E  I  I  I  T  D  F  H  N  H  S  V  K   | V  F  N  Q  E  G      p.680

          .         .         .         .         .         .       g.180490
 GAATTCATGTTGAAGTTTGGCTCAAATGGAGAAGGAAATGGGCAGTTTAATGCTCCAACA       c.2100
 E  F  M  L  K  F  G  S  N  G  E  G  N  G  Q  F  N  A  P  T         p.700

          .         .         .         .         .         .       g.180550
 GGTGTAGCAGTGGATTCAAATGGAAACATCATTGTGGCCGACTGGGGAAACAGCAGGATC       c.2160
 G  V  A  V  D  S  N  G  N  I  I  V  A  D  W  G  N  S  R  I         p.720

     | 12    .         .         .         .         .         .    g.186753
 CAG | GTTTTTGATGGGAGTGGATCATTTTTGTCCTACATTAACACATCTGCTGACCCACTC    c.2220
 Q   | V  F  D  G  S  G  S  F  L  S  Y  I  N  T  S  A  D  P  L      p.740

          .         .         .         .         .         .       g.186813
 TATGGCCCCCAAGGCCTGGCCCTAACTTCAGATGGTCATGTTGTGGTTGCAGACTCTGGA       c.2280
 Y  G  P  Q  G  L  A  L  T  S  D  G  H  V  V  V  A  D  S  G         p.760

          .         .         .                                     g.186849
 AATCACTGTTTCAAAGTCTATCGATACTTACAGTAA                               c.2316
 N  H  C  F  K  V  Y  R  Y  L  Q  X                                 p.771

          .         .         .         .         .         .       g.186909
 tggtgggcaggtggatacccgcttccatggtcttgcactataaactggaatggatttctc       c.*60

          .         .         .         .         .         .       g.186969
 aatgcgggaccagattatgactagagtttttatgccagaaggaatcattggtgaactttc       c.*120

          .         .         .         .         .         .       g.187029
 caaggttatttctgaatgtaacaatttccttaaaaatgacttatccaatttctgtatttc       c.*180

          .         .         .         .         .         .       g.187089
 acctttagggttaaaaaaaactcttctactgaatctataaaaactgcagttttacatctg       c.*240

          .         .         .         .         .         .       g.187149
 tgaactatggcttaagggacaggatttatgtagctaaactaattttgcaaatcaaacaga       c.*300

          .         .         .         .         .         .       g.187209
 cacttaaaaaactagcatatgtaaaggtattcgttaatcctgtgaatggtagcttttgca       c.*360

          .         .         .         .         .         .       g.187269
 cagaacttccaaaagcaaaacaaaaacaaaatctattgtagttatatacttcatttaacc       c.*420

          .         .         .         .         .         .       g.187329
 taggtcacaagacccagggaatcttctaacctcacttttacagtaggtattactcttgtg       c.*480

          .         .         .         .         .         .       g.187389
 acatttttttggttatcaacaactaaatataaattactttggaaaaagtaaggctgtctt       c.*540

          .         .         .         .         .         .       g.187449
 gcaaaatgatcccagctctgattagcagccctctggagttcagaacttaagtatcagtgc       c.*600

          .         .         .         .         .         .       g.187509
 aaatttctcaacctttctgggttagacaaagatccttttttgtgtgttcttttcaccacc       c.*660

          .         .         .         .         .         .       g.187569
 cctttggctcaccttgtatcagcaaacaaagtacttcttcagggaaacctgaaatttcta       c.*720

          .         .         .         .         .         .       g.187629
 atgccttgaaaagcatattacaaaagtaatgctaccttttgggaaacaaactgccccgtt       c.*780

          .         .         .         .         .         .       g.187689
 aactccagatcattgcactggaatgtaatcaagaaagttagtcatgttttatgtaccatg       c.*840

          .         .         .         .         .         .       g.187749
 ttttcacacgtgtctcttctcttcgacttcctgaaagcgaaagctttacctcctgcaaat       c.*900

          .         .         .         .         .         .       g.187809
 gtcagcacatgtagtaggacaccagtatcctaggacagagagccataagtagccctttgg       c.*960

          .         .         .         .         .         .       g.187869
 aggactgatggtgtcaaccaaaggcatgtgattgattaatgattcccccttagaaagcaa       c.*1020

          .         .         .         .         .         .       g.187929
 gtgttaccaaagttgtgttatcttgaaagcattacaggtaagggcatgttatggttattt       c.*1080

          .         .         .         .         .         .       g.187989
 atcattgtttaatgaatagtagaggtgtcaagggactatgtatacatgattagggtaaga       c.*1140

          .         .         .         .         .         .       g.188049
 tagaatgtattatatatatatatatatacacacacacatatatatagctgaatctttggt       c.*1200

          .         .         .         .         .         .       g.188109
 gtattgaaataggcagcactctgaaagacagaagcttcgtccagccactcttcagcacat       c.*1260

          .         .         .         .         .         .       g.188169
 tcctttactaagcagtttaaagccgtcctagtggagcaagccctaaagcagatttaattt       c.*1320

          .         .         .         .         .         .       g.188229
 ttgccattttccaagaatgacggtggtggcttttagtcagaaaatggccttctgtgcttt       c.*1380

          .         .         .         .         .         .       g.188289
 caaaaaaaaaaacaaaaaaaaaaccacacacacacataaaaaacccaacaggtcaaaata       c.*1440

          .         .         .         .         .         .       g.188349
 aaagttgaacttgagttacatttaatttaaatataaatgcattttgagaaatgttaagaa       c.*1500

          .         .         .         .         .         .       g.188409
 caatttagtcaatcgttcatctgtcattggtactgtaaaataagctgtggtctatttcca       c.*1560

          .         .         .         .         .         .       g.188469
 ctgtttaattttctactcagttctaccaaataggatgtcatgtttgacatttttgatagt       c.*1620

          .         .         .         .         .         .       g.188529
 gactttggggtcttcttcactgaaagcaccttagaactgtactataagaaaacatttccc       c.*1680

          .         .         .         .         .         .       g.188589
 ctatgtataattatatgaatgtgatgtttattgcttattaatttataattcagtcattct       c.*1740

          .         .         .         .         .         .       g.188649
 ctatataggacttcttaaaatttagaagggaaatctagctacttcaaattgtctgttaaa       c.*1800

          .         .         .         .         .         .       g.188709
 tttattatgcccaaatcaacctctgaaaaaaggtttttccaggaagatttacatttaggt       c.*1860

          .         .         .         .         .         .       g.188769
 ttaatatttttttagttaggtagagttttaaaaaatacttgagcctgtccgtgataaagc       c.*1920

          .         .         .         .         .         .       g.188829
 tataaaattcaataactttttagaatgttaaatgaagacactgtttcctaacatcagtga       c.*1980

          .         .         .         .         .         .       g.188889
 gatacatctttgaatttaaacattcatatttactgagtacctactaggtaccaagtactc       c.*2040

          .         .         .         .         .         .       g.188949
 ttttaggcactggaaatacagtgatggacaaaacaggtaaaaaatcgctgccccctcaga       c.*2100

          .         .         .         .         .         .       g.189009
 gctgacattctggggtgggaatttcattttgccacgtactaacgttctgcacaaaagaca       c.*2160

          .         .         .         .         .         .       g.189069
 ggctagactcttgtctagattgtttaaaagaaacttttcaaattggttacattaatttta       c.*2220

          .         .         .         .         .         .       g.189129
 gtttattttcacaagtaaaaatggctttttatttagattctttctgtcccaggctgttga       c.*2280

          .         .         .         .         .         .       g.189189
 tcttaaaactagttgatttaaagagtttttttgcacaacatttcaattatatttgtgaac       c.*2340

          .         .         .         .         .         .       g.189249
 ttagaaattaacttacaatctaaccagccatcatatcatatcctatcaggctagatatct       c.*2400

          .         .         .         .         .         .       g.189309
 caatagtagactgaatacaaagctaattttttttacatgtcaatattggcacaaactgga       c.*2460

          .         .         .         .         .         .       g.189369
 atgaaagaatagtttgattcagacctgctccactatgtgttgctaaaacacatgctatga       c.*2520

          .         .         .         .         .         .       g.189429
 gcactccaggaaacactatattttttccaaaaaatatgtgattatatatgttaaagtata       c.*2580

          .         .         .         .         .         .       g.189489
 gataacatttcacacttggatacatatgtgcatttactgtatttcttggtaagcatattt       c.*2640

          .         .         .         .         .         .       g.189549
 ttgggggaaagtgctgctgatatgatacaagtagacaaaatttaaatgaaattttgtcac       c.*2700

          .         .         .         .         .         .       g.189609
 attctatggaaaatggtttctggtaaactgagaaggatattaaaataagtggcttttttc       c.*2760

          .         .         .         .         .         .       g.189669
 tgggctaccattattgtttgatttctctttgtcaagtgtatagaacctgtcatacattca       c.*2820

          .         .         .         .         .         .       g.189729
 tgataagtagcactgaaaaattactcattcaaatttcccctgggcacgtaaggcaaaata       c.*2880

          .         .         .         .         .         .       g.189789
 ttgccggttgggatttcaaggtcagtgacgacgcatttcctcccagtacagaccccccag       c.*2940

          .         .         .         .         .         .       g.189849
 ccccccttgctggacatggggaggcagagagtcacttgaccatccagaaatacatgacta       c.*3000

          .         .         .         .         .         .       g.189909
 caagtcctttatgactgtttgccattttttttaatggtacttagtattttgatcaaactt       c.*3060

          .         .         .         .         .         .       g.189969
 tagtctccagaactaaacaagtccctaagtttccttattttaatttactgtgactagatt       c.*3120

          .         .         .         .         .         .       g.190029
 tgaagcaaataaatactccagatccatgcagctagaacacacttgcttccactactaaat       c.*3180

          .         .         .         .         .         .       g.190089
 atacagggtatgtcctaacatggagttaactggaatagcagtacactagcaagtatctgt       c.*3240

          .         .         .         .         .         .       g.190149
 gaatccttagcactgacgggttaacagaaatgctttggtaatacctacttagttaattgg       c.*3300

          .         .         .         .         .         .       g.190209
 aggaagtagtaaataaacattaggtaatctgcagattacttcaaatgggaaaaatctttt       c.*3360

          .         .         .         .         .         .       g.190269
 tgtagactctatagtaccctctctattcactagcttctgaaaagggaggagtatttttag       c.*3420

          .         .         .         .         .         .       g.190329
 tttgacaatttaataatttaaaaacaagacatctccaggtaggaaaaaatgaaagctatt       c.*3480

          .         .         .         .         .         .       g.190389
 tcatgcaaacattatctaatttagcttaaaagtgaaagtggtaatactgttggtttctgt       c.*3540

          .         .         .         .         .         .       g.190449
 aaatgttgcagggttttaaactttataattactttaatatttttgataactagaaatcta       c.*3600

          .         .         .         .         .         .       g.190509
 gtattgccataaaggaaactaagtgcccatcaaagatttgtttggtataaataaagaatt       c.*3660

          .         .         .         .         .         .       g.190569
 atttgttttgttttcaatgacagtaagctacaaatcatgatgcttaaaaactttctaaag       c.*3720

          .         .         .         .         .         .       g.190629
 atgaattgtgtggcagtgattggtctgtttgtggagaatgtatgaaagctattaatattc       c.*3780

          .         .         .         .         .         .       g.190689
 tagaatagattaataaattggctatgttgttccaatgaatgtacagcacttccattaact       c.*3840

          .         .         .         .         .         .       g.190749
 tttgaaagcaacacagccttaaactcaatgcttttgctttatgacatgggaatgttctgt       c.*3900

          .         .         .         .         .         .       g.190809
 catcaatggagtgtattcttgtaatagaattctttatatcgttctcaattctatagactt       c.*3960

          .         .         .         .         .         .       g.190869
 tcaagcctatgtatgaatatgaaggggttttttttttttgctttgttttctttttagatt       c.*4020

          .         .         .         .         .         .       g.190929
 ttgtacattccatctttataggtctgtttcatatgttttatgtatagaacactaagtctt       c.*4080

          .         .         .         .         .         .       g.190989
 gcactctctgacattgatactgatatattctcgtcatttgttcttttatgaatcaaaatg       c.*4140

          .         .         .         .         .         .       g.191049
 ttgactgcctatttaaagaaaagaatgaacgctgtgcatcaaagtgtttgtatgttcgta       c.*4200

          .         .         .         .         .         .       g.191109
 gctacatacgtaccacagtattttggatgctttagtctacaatgaaactttcaattaatt       c.*4260

          .         .         .         .         .         .       g.191169
 ctgtcttgaaacataggagaaacaggattcatgtgtatctctttaccatgcacaaaatct       c.*4320

          .         .         .                                     g.191205
 caaatcattataataaagcttgttttctccatttgc                               c.*4356

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Tripartite motif containing 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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